Digoxigenin activates autophagy in hepatocellular carcinoma cells by regulating the PI3K/AKT/mTOR pathway

Digoxigenin activates autophagy in hepatocellular carcinoma cells by regulating the PI3K/AKT/mTOR pathway

Abstract Hepatocellular carcinoma (HCC) is recognized as a highly malignant tumor. Targeted combination immunotherapy, the initially approved regimen, is compromised by adverse side effects and low response rates during clinical treatment. Traditional Chinese medicine and its derived natural compoun...

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Main Authors: Mengqing Ma, Rui Hu, Qi Huang, Jing Li, Minling Lv, Jialing Sun, Xin Zhong, Jinyu Yi, Lanfen Peng, Wenxing Feng, Wenfeng Ma, Zhiyi Han, Wei Zhang, Xinfeng Sun, Bolin Zhan, Xingning Liu, Xiaozhou Zhou
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cancer Cell International
Subjects:
Hepatocellular carcinoma
DIG
Autophagy
PI3K/AKT/mTOR pathway
Small-molecule compounds
Online Access:https://doi.org/10.1186/s12935-024-03602-z
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https://doi.org/10.1186/s12935-024-03602-z

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