Multiplexed Dilute-and-Shoot Liquid Chromatography–Multiple-Reaction Monitoring Mass Spectrometry Clinical Assay for Metanephrines and Catecholamines in Human Urine

Multiplexed Dilute-and-Shoot Liquid Chromatography–Multiple-Reaction Monitoring Mass Spectrometry Clinical Assay for Metanephrines and Catecholamines in Human Urine

<b>Background:</b> Quantifying urinary catecholamines and metanephrines is essential for the clinical screening and diagnosis of neuroendocrine tumours. HPLC with electrochemical detection (HPLC-ECD) is commonly used for this type of analysis but requires extensive sample cleanup. Simple...

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Bibliographic Details
Main Authors: Deema O. Qasrawi, Adriano M. C. Pimenta, Evgeniy V. Petrotchenko, Shaun Eintracht, Christoph H. Borchers
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Metabolites
Subjects:
liquid chromatography–multiple-reaction monitoring mass spectrometry (LC-MRM-MS)
metanephrines
catecholamines
adrenal gland
pheochromocytoma
urine
Online Access:https://www.mdpi.com/2218-1989/15/1/30
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