Exploring the Impact of Backward and Forward Locomotor Treadmill Training in Chronic Stroke Survivors with Severe Post-Stroke Walking Impairment: A Single-Center Pilot Randomized C... by Saiprasad Naidu, Khwahish Singh, Tamiel Murray, Colin Drury, Erin Palermo, Heidi J. Sucharew, Changchun Xie, Pierce Boyne, Kari Dunning, Oluwole O. Awosika

“…Future well-powered dosing trials and mechanistically driven studies are needed to optimize and identify predictors of training response.…”
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Clinical management and analysis of immune-related adverse events in neoadjuvant immunotherapy for locally advanced rectal cancer by AN Yang, WANG Chentong, QIU Xiaoyuan, ZHOU Jiaolin, LIN Guole

“…This study aimed to investigate the characteristics, clinical management strategies, and outcomes of irAEs during neoadjuvant immunotherapy for rectal cancer, providing a basis for optimizing irAEs monitoring and intervention. Methods: We retrospectively analyzed clinical data from LARC patients who developed irAEs after receiving neoadjuvant immunotherapy at Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, between July 2022 and June 2024. …”
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Pharmacokinetic Properties and Therapeutic Effectiveness of Remimazolam in ICU Patients With Mechanical Ventilation: A Preliminary Study by Jing Hu, Yuhan Zhao, Litao Shao, Wenhui Zhang, Han Wang, Yun Liu, Mengxiang Su, Xiangrong Zuo

“…The half‐life was 101.791 min in ventilated patients, while its metabolites had a slower clearance rate of 0.49 mL/kg/min and an longer half‐life of 656.02 min. …”
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Augmenting Naïve Bayes Classifiers with <i>k</i>-Tree Topology by Fereshteh R. Dastjerdi, Liming Cai

“…In such cases, however, the selection of the <i>k</i> parent features for each variable is often made through heuristic search methods (such as sorting), which do not guarantee an optimal approximation of network topology. …”
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Evaluating Manganese-Doped Magnetic Nanoflowers for Biocompatibility and In Vitro Magnetic Hyperthermia Efficacy by Andreea-Elena Petru, Cristian Iacovita, Ionel Fizeșan, Roxana Dudric, Ionut-Valentin Crestin, Constantin Mihai Lucaciu, Felicia Loghin, Bela Kiss

“…Cellular uptake was quantified via a colorimetric iron determination method, while in vitro MH efficacy was tested by subjecting Mn-NF-loaded A549 cells to AMF exposure at different field strengths and nanoparticle concentrations. …”
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Dual Role of Quercetin in Promoting Early Wound Healing via Inhibiting Inflammatory Factors and Attenuating Scar Formation by Suppressing Myofibroblast Differentiation by Dan Wu, Mengyuan Jiang, Jing Zhang

“…Further efforts should focus on optimizing its bioavailability to enhance clinical translation.…”
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Randomized, controlled trial comparing the efficacy of intercostal nerve block in thoracoscopic surgery by timing: study protocol for a randomized clinical trial by Yasuharu Sekine, Hideo Ichimura, Sho Ueda, Shinsuke Kitazawa, Naohiro Kobayashi, Yuya Murata, Kumiko Yamada, Shinichi Inomata, Kazushi Maruo, Yukio Sato

“…Abstract Background Even minimally invasive thoracic surgeries carry a postoperative cost in pain. While regional anesthesia may alleviate this anticipated pain, especially intercostal nerve blocks (ICNB), the timing of block administration for optimal effect (at the beginning of surgery vs. before wound closure) remains controversial. …”
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Accuracy of 7 intraocular lens power calculation formulas in primary angle-closure glaucoma eyes, according to axial length and anterior chamber depth by Han Xu, Yuanjin Zheng, Xinlei Lu, Longyuan Liu, Rui Wan, Shaodan Zhang, Guoxing Li, Rongrong Le, Yuanbo Liang

“…Design Retrospective, consecutive case series. Methods Patients who underwent cataract surgery diagnosed with PACG or not were included. …”
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Intraoperative titration of positive end-expiratory pressure in urological patients undergoing laparoscopic procedures under lateral position: a randomized controlled trial by Lili Pan, Xing Wu, Lingling Gao, Zhanqi Zhao, Li Yang, Jun Zhang

“…Further, PEEPEIT group had higher plateau pressure and dynamic compliance, while lower driving pressure at both T1 (all P < 0.05) and T2 (P < 0.05) time points. …”
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Direct comparison of cardioprotective effects of necroptosis inhibitors against global ischemia-reperfusion in the isolated rat heart by Yu. V. Dmitriev, S. M. Minasian, V. K. Bayrasheva, E. A. Demchenko, M. M. Galagudza

“…The study was aimed at comparative assessment of cardioprotective properties of various necroptosis inhibitors in the isolated perfused rat heart subjected to global ischemia-reperfusion.Materials and Methods. The study was performed on 38 male Wistar rats weighting 250–300 g. …”
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A nomogram for predicting malnutrition risk in patients with chronic heart failure and correlation study between GHRL, MSTN, CRP, Hs-CRP by Yuling Zha, Chengshuai Liu, Yuping Zhou, Miao Kong, Jinlei Liu, Lu Jing, Hailati Gulimila

“…Additionally, MSTN was positively correlated with CRP and Hs-CRP, while GHRL was negatively correlated with MSTN, CRP, and Hs-CRP. …”
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Impact of SGLT2 inhibitors on survival in gastrointestinal cancer patients undergoing chemotherapy and/or radiotherapy: a real-world data retrospective cohort study by Lucas E. Flausino, Alexis Germán Murillo Carrasco, Tatiane Katsue Furuya, Wen-Jan Tuan, Roger Chammas

“…Further clinical trials are needed to confirm these findings and establish the optimal condition for its application in GI cancer treatment.…”
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Intraoperative Intraluminal Endoscopy in the Surgical Treatment of Patients with Esophageal Diverticula of Various Localization by A. L. Shestakov, M. V. Khrustaleva, M. E. Shahbanov, N. A. Bulganina, T. T. Bitarov, I. A. Boeva, A. T. Tskhovrebov, I. A. Tarasova, O. V. Rykov, I. M. Selivanova, A. A. Bezaltynnykh

“…The patients were divided into two groups: 31 people (41.9 %) in the main group underwent diverticulectomy with intraoperative intraluminal endoscopic assistance (IVEA), while 43 (58.1 %) people in the control group underwent diverticulectomy without IVEA. …”
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AI-Driven Smart Agriculture: An Integrated Approach for Soil Analysis, Irrigation, and Crop-Fertilizer Recommendations by Ayesha Khaliq, Atif Khan, Salman Jan, Muhammad Umair, Asad Gulshair, Ahmad Ali, Usman Ali Shah

“…For soil analysis, the TabNet regressor achieved a root mean square error (RMSE) of 1.51 and an R2 score of 98.7%, while XAI techniques were used to explain and interpret its predictions. …”
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Emergency Nursing Didactics – Opinions, Resource, and Skill Exchange (E.N.D.O.R.S.E) – A collaborative academic initiative in the Emergency Department by Mohammad Anzal Rehman, Elrasheed Salih, Honey Mathew, Ramna Abdulrahman, Ahmad Chahla, Rishi Prasad

“…What seemed to be trivial tasks became optimized through collaborative learning and idea exchange. …”
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Understanding the acute care context to inform palliative care improvements: a qualitative study of hospital-based multidisciplinary clinicians by Claudia Virdun, Gursharan K. Singh, Patsy Yates, Jane L. Phillips, Alison Mudge

“…Many of these people are hospitalised more than once in their last year of life. While there is sound evidence on what patients and their families require for safe and high-quality hospital palliative care, enabling this remains a challenge. …”
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Profile of Eye Injuries in Patients Examined at a Tertiary Eye Care Center in Peru by Sánchez-Huamash CM, Alvarez-Torres YM, Salavarría-Castillo J, Sanca-Valeriano S, Campaña-Acuña A, Espinola-Sánchez M

“…Francisco Contreras Campos’ in 2023.Patients and Methods: This cross-sectional, descriptive, and retrospective study was conducted in patients diagnosed in 2023 with eye injuries at the Emergency Room of the National Institute of Ophthalmology “Dr. …”
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Air-gap membrane distillation to desalinate seawater and hypersaline-produced water by Prashan M. Rodrigo, Sana Fatima, Raghava R. Kommalapati, Shankararaman Chellam

“…AGMD utilizes a thermal gradient to transport water vapor across a hydrophobic membrane, while an air gap improves separation efficiency by minimizing conductive heat loss. …”
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Relationship between intact parathyroid hormone，fetal globulin A，serum creatinine/hemoglobin ratio and disorder of calcium and phosphorus metabolism in maintenance hemodialysis pat... by Wang Xiao-hui, Cai Chun-tian, He Juan, Zhao Xiao-fan, He Liang-ping, Li Ming-hu, Li Xue-ying

“…ObjectiveTo explore the relationship between intact parathyroid hormone （iPTH），fetal globulin A （FA），serum creatinine/hemoglobin ratio （Scr/Hb） and calcium and phosphorus metabolism disorder in chronic renal failure patients with chronic kidney disease （CKD） on maintenance hemodialysis （MHD） and examine the predictive value of each parameter for carotid atherosclerosis.MethodsFrom July 2014 to July 2020，113 CKD patients on MHD were recruited and divided into two groups of sclerosis （<italic>n</italic>=30） and non-sclerosis （<italic>n</italic>=83）.The baseline levels of iPTH，FA and Scr/Hb of two groups were recorded.The related influencing factors of carotid atherosclerosis，parameters of calcium and phosphorus metabolism and their correlations were examined.ResultsBaseline phosphorus，iPTH and Scr/Hb in sclerosis group were higher than those in non-sclerosis group ［（1.89±0.42）mmol/L、305.26（152.63，608.19）μg/L、7.16±2.19 <italic>vs </italic>（1.30±0.36）mmol/L、238.47（118.05，506.11）μg/L、4.38±1.38，<italic>P</italic>&lt;0.001］，FA was lower than that of non-sclerosis group ［（74.62±20.61）mg/L <italic>vs </italic>（95.33±25.80）mg/L，<italic>P</italic>&lt;0.05］； mean values of iPTH，FA and Scr/Hb were selected as boundary，&lt;mean value was low level，≥ mean value high level.High levels of iPTH and Scr/Hb were higher than those with low levels ［（1.60±0.39）mmol/L <italic>vs </italic>（1.18±0.33）mmol/L，（1.71±0.55）mmol/L <italic>vs </italic>（0.97±0.31）mmol/L］ and those with high levels of FA lower than those with low levels ［（1.25±0.34）mmol/L <italic>vs </italic>（1.72±0.40）mmol/L，<italic>P</italic>&lt;0.05］； iPTH，Scr/Hb and phosphorus were positively correlated while FA was negatively correlated with phosphorus （<italic>P</italic>&lt;0.05）；iPTH，FA，Scr/Hb were still associated with IMT （<italic>P</italic>&lt;0.05）； the area under the curve （AUC） of iPTH，FA and Scr/Hb for predicting carotid atherosclerosis were 0.742，0.776 and 0.790 respectively.It was the largest at 0.918 for combined predicting.The optimal predictive sensitivity and specificity were 93.33% and 85.54% respectively.ConclusioniPTH，FA and Scr/Hb are closely correlated with disorder of calcium and phosphorus metabolism in chronic renal failure patients with CKD on MHD.These parameters offer high application values in predicting carotid atherosclerosis.…”
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When is Growth the Greatest? Spine and Total Body Growth in Idiopathic Scoliosis Through Sanders Maturation Stages 2, 3A, 3B, and 4 by Yusuke Hori, MD, PhD, Bryan Menapace, MD, Norihiro Isogai, MD, Sadettin Ciftci, MD, Burak Kaymaz, MD, Luiz Carlos Almeida da Silva, MD, Kenneth J. Rogers, PhD, ATC, Petya K. Yorgova, MS, Peter G. Gabos, MD, Suken A. Shah, MD, FAOA

“…This study demonstrated that spinal growth was most pronounced in patients at SMS 3A, while total body height growth was greatest during SMS 2 and 3A. …”
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