Human saliva exerts strong type-dependent effects on adenovirus infectivity by Erwan Sallard, Wenli Zhang, Nikita Chilakamarri, Setareh Farzanehkari, Setareh Farzanehkari, Inga Marte Charlott Seuthe, Anja Ehrhardt, Malik Aydin, Malik Aydin

“…Consequently, our study underscores the importance of identifying and utilizing saliva-resistant Ad vectors to optimize Ad-based vaccination strategies.…”
Get full text

Sugammadex versus neostigmine on postoperative adverse respiratory events in elderly patients undergoing lung resection: study protocol for a randomized controlled trial by Yuxin Wang, Xiang Li, Huimin Deng, Di Feng, Liuyuan Zhao, Feihong Lin, Tian Jin, Sheng Wang, Xin Lv, Juan Wei

“…Given the growing elderly surgical population and the high incidence of RNMB and pulmonary complications in this group, the findings of this study will offer valuable insight into optimizing neuromuscular blockade reversal strategies.Trial registration This study is registered at Chinese clinical trial registry (ChiCTR2400094005).…”
Get full text

Return to care of children and adolescents living with HIV who missed their clinic visits or were lost to follow-up: a continuous quality improvement study in Uganda by Jonathan Izudi, Kenneth Mugisha, Ssentongo Mugerwa Saadick, Boniface Oryokot, Ronald Opito, Baker Bakashaba, Abel Munina, kokas Opolot, Daniel Ogwal, Julius Ssendiwala

“…Background While the UNAIDS 95-95-95 targets have been met among adults, those for children and adolescents remain suboptimal. …”
Get full text

Pasireotide after Surgery for Persistent Cushing’s Disease by Dan Nicolae PADURARU, Carla SCANTEIE, Alexandra BOLOCAN, Octavian ANDRONIC, Andra MORAR, Cristina GHERVAN, Raluca CIUNT, Bogdan SOCEA, Ovidiu BRATU, Laura Maria DRAGOMIR, Mara CARSOTE, Ana VALEA

“…Conclusion: In persistent Cushing’s disease, the challenge lies in identifying the optimal therapeutic methods in order to achieve a cure while, at the same time, limiting their side effects. …”
Get full text

Efficacy and safety of omega-3-enriched lickable treats as adjunctive therapy for feline chronic gingivostomatitis: A randomized controlled trial by Panithi Sukho, Sekkarin Ploypetch, Chakkarin Satthathum, Phirom Prompiram, Warunya Chakritbudsabong

“…Further research with larger cohorts, extended durations, and sensitive scoring systems is warranted to optimize treatment protocols.…”
Get full text

The therapeutic efficacy comparison of MSCs derived different tissues unveilings anti-apoptosis more crucial than angiogenesis in treating acute myocardial infarction by Mingjie Pan, Yueyue Xu, Yaping Wang, Yue Jiang, Yuanyuan Xie, Chenxu Tai, Wenqing Wang, Bin Wang

“…Our study provides new insights into therapeutic strategies and suggests that the optimal type of MSCs can be screened based on their tissue heterogeneity for precise clinical applications in acute MI.…”
Get full text

Multimodal Deep Learning Integrating Tumor Radiomics and Mediastinal Adiposity Improves Survival Prediction in Non‐Small Cell Lung Cancer: A Prognostic Modeling Study by Ye Niu, Han‐bing Xie, Hao‐bo Jia, Lin Zhao, Le Liu, Ping‐ping Liu, Xue‐meng Li, Rui‐tao Wang, Yuan‐zhou Li

“…Tumor radiomic features were extracted using a DenseNet121 convolutional neural network architecture, while mediastinal fat area (MFA) was quantified through semiautomated segmentation using ImageJ software. …”
Get full text

Psychometric properties of the Persian version of the training needs assessment for critical care nurses by Amir Jalali, Mostafa Bafandeh Zendeh, Azam Sharifi, Amirhossein Naghibzadeh, Leila Moradi, Jalal Karimi, Nazanin Mardani Taghvostani, Khalil Moradi

“…Abstract Background Identifying the training needs of critical care nurses is crucial for enhancing their performance and optimizing patient outcomes. This process requires a comprehensive understanding of their specific knowledge gaps and skill deficiencies. …”
Get full text

Association of dietary quality, biological aging, progression and mortality of cardiovascular-kidney-metabolic syndrome: insights from mediation and machine learning approaches by Junfeng Ge, Lin Zhu, Sijie Jiang, Wenyan Li, Rongzhan Lin, Jun Wu, Fengying Dong, Jin Deng, Yi Lu

“…Abstract Background To investigate the association between the Dietary Inflammatory Index (DII), biological aging, and the staging and mortality of cardiovascular-kidney-metabolic (CKM) syndrome. Methods Data of 7,918 participants were derived from the National Health and Nutrition Examination Survey 2005–2018. …”
Get full text

In-Silico discovery of novel cephalosporin antibiotic conformers via ligand-based pharmacophore modelling and de novo molecular design by Rayhan Chowdhury, Samia Akter Saima, Md. Al Amin, Md. Kawsar Habib, Ramisa Binti Mohiuddin, Ali Mohamod Wasaf Hasan, Roksana Khanam, Shahin Mahmud

“…This research aims to predict new compounds using ligand-based pharmacophore models while optimizing existing drugs. We employed a de novo approach to synthesize models of cephalosporin structural motifs, integrating the β-lactam core with potential antibiotic candidates. …”
Get full text

Bridging Knowledge Gaps: The Influence of Structured Education on Parental Knowledge and Attitude towards the Right to Education in Community by Neha Anil Katakwar, Darshana Wankhede, Bibin Kurian, Archana Maurya

“…Education plays a major role in creating an optimal environment and encouraging openness and effective governance within an entity. …”
Get full text

Does the Urinary Calcium/Citrate Ratio Help in the Diagnosis of Children at Risk of Urolithiasis? by Utku Dönger, Aysun Çaltık Yılmaz, Caner İncekaş, Kaan Gülleroğlu, Esra Baskın

“…Results: In this study, 198 patients (60.9%) had stones detected by the first ultrasound, while 127 (39.1%) did not. We compared urinary metabolic parameters between the two groups. …”
Get full text

Intrathecal hydromorphone vs. transversus abdominis plane block for upper abdominal surgery: a propensity score-matching study by Yue-xin Huang, Yu Chen, Wei Wang, Ting-ting Li, Lin Ding, Fang Gao, Xiao-chuan Zou, Fei Liu

“…Abstract Background Multimodal analgesia is vital for enhanced recovery after upper-abdominal surgery. While both Intrathecal hydromorphone (ITH) and transversus abdominis plane (TAP) block are widely applied in upper-abdominal surgery, evidence comparing the two techniques remains limited. …”
Get full text

Analysis of mitochondrial-targeted antioxidant SkQ1 effectiveness on myocardial ischemia-reperfusion injury in a rat model: Focus on morphological and ultrastructural tissue study by E. A. Senokosova, E. A. Velikanova, R. A. Mukhamadiyarov, O. D. Sidorova, E. O. Krivkina, L. V. Antonova, E. V. Grigoriev

“…The quantitative data were processed using GraphPad Prism 7 (Graph Pad Software, USA).Results. The optimal myocardial preservation was discovered while using 12 ng/mL of SkQ1: the lowest concentrations of MDA (49.5 [41.1; 58.9] mmol/g), Troponin-I (22.3 [20.3; 23.9] pg/mL) and H-FABP (0.8 [0.6; 16.0] ng/mL) were associated with extensive areas of tissues with preserved transverse dark and light bands and a moderate interstitial edema. …”
Get full text

Exploring the Impact of Backward and Forward Locomotor Treadmill Training in Chronic Stroke Survivors with Severe Post-Stroke Walking Impairment: A Single-Center Pilot Randomized C... by Saiprasad Naidu, Khwahish Singh, Tamiel Murray, Colin Drury, Erin Palermo, Heidi J. Sucharew, Changchun Xie, Pierce Boyne, Kari Dunning, Oluwole O. Awosika

“…Future well-powered dosing trials and mechanistically driven studies are needed to optimize and identify predictors of training response.…”
Get full text

Clinical management and analysis of immune-related adverse events in neoadjuvant immunotherapy for locally advanced rectal cancer by AN Yang, WANG Chentong, QIU Xiaoyuan, ZHOU Jiaolin, LIN Guole

“…This study aimed to investigate the characteristics, clinical management strategies, and outcomes of irAEs during neoadjuvant immunotherapy for rectal cancer, providing a basis for optimizing irAEs monitoring and intervention. Methods: We retrospectively analyzed clinical data from LARC patients who developed irAEs after receiving neoadjuvant immunotherapy at Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, between July 2022 and June 2024. …”
Get full text

Pharmacokinetic Properties and Therapeutic Effectiveness of Remimazolam in ICU Patients With Mechanical Ventilation: A Preliminary Study by Jing Hu, Yuhan Zhao, Litao Shao, Wenhui Zhang, Han Wang, Yun Liu, Mengxiang Su, Xiangrong Zuo

“…The half‐life was 101.791 min in ventilated patients, while its metabolites had a slower clearance rate of 0.49 mL/kg/min and an longer half‐life of 656.02 min. …”
Get full text

Augmenting Naïve Bayes Classifiers with <i>k</i>-Tree Topology by Fereshteh R. Dastjerdi, Liming Cai

“…In such cases, however, the selection of the <i>k</i> parent features for each variable is often made through heuristic search methods (such as sorting), which do not guarantee an optimal approximation of network topology. …”
Get full text

Evaluating Manganese-Doped Magnetic Nanoflowers for Biocompatibility and In Vitro Magnetic Hyperthermia Efficacy by Andreea-Elena Petru, Cristian Iacovita, Ionel Fizeșan, Roxana Dudric, Ionut-Valentin Crestin, Constantin Mihai Lucaciu, Felicia Loghin, Bela Kiss

“…Cellular uptake was quantified via a colorimetric iron determination method, while in vitro MH efficacy was tested by subjecting Mn-NF-loaded A549 cells to AMF exposure at different field strengths and nanoparticle concentrations. …”
Get full text

Dual Role of Quercetin in Promoting Early Wound Healing via Inhibiting Inflammatory Factors and Attenuating Scar Formation by Suppressing Myofibroblast Differentiation by Dan Wu, Mengyuan Jiang, Jing Zhang

“…Further efforts should focus on optimizing its bioavailability to enhance clinical translation.…”
Get full text