Dual Role of Quercetin in Promoting Early Wound Healing via Inhibiting Inflammatory Factors and Attenuating Scar Formation by Suppressing Myofibroblast Differentiation by Dan Wu, Mengyuan Jiang, Jing Zhang

“…Further efforts should focus on optimizing its bioavailability to enhance clinical translation.…”
Get full text

Randomized, controlled trial comparing the efficacy of intercostal nerve block in thoracoscopic surgery by timing: study protocol for a randomized clinical trial by Yasuharu Sekine, Hideo Ichimura, Sho Ueda, Shinsuke Kitazawa, Naohiro Kobayashi, Yuya Murata, Kumiko Yamada, Shinichi Inomata, Kazushi Maruo, Yukio Sato

“…Abstract Background Even minimally invasive thoracic surgeries carry a postoperative cost in pain. While regional anesthesia may alleviate this anticipated pain, especially intercostal nerve blocks (ICNB), the timing of block administration for optimal effect (at the beginning of surgery vs. before wound closure) remains controversial. …”
Get full text

Accuracy of 7 intraocular lens power calculation formulas in primary angle-closure glaucoma eyes, according to axial length and anterior chamber depth by Han Xu, Yuanjin Zheng, Xinlei Lu, Longyuan Liu, Rui Wan, Shaodan Zhang, Guoxing Li, Rongrong Le, Yuanbo Liang

“…Design Retrospective, consecutive case series. Methods Patients who underwent cataract surgery diagnosed with PACG or not were included. …”
Get full text

Direct comparison of cardioprotective effects of necroptosis inhibitors against global ischemia-reperfusion in the isolated rat heart by Yu. V. Dmitriev, S. M. Minasian, V. K. Bayrasheva, E. A. Demchenko, M. M. Galagudza

“…The study was aimed at comparative assessment of cardioprotective properties of various necroptosis inhibitors in the isolated perfused rat heart subjected to global ischemia-reperfusion.Materials and Methods. The study was performed on 38 male Wistar rats weighting 250–300 g. …”
Get full text

A nomogram for predicting malnutrition risk in patients with chronic heart failure and correlation study between GHRL, MSTN, CRP, Hs-CRP by Yuling Zha, Chengshuai Liu, Yuping Zhou, Miao Kong, Jinlei Liu, Lu Jing, Hailati Gulimila

“…Additionally, MSTN was positively correlated with CRP and Hs-CRP, while GHRL was negatively correlated with MSTN, CRP, and Hs-CRP. …”
Get full text

Impact of SGLT2 inhibitors on survival in gastrointestinal cancer patients undergoing chemotherapy and/or radiotherapy: a real-world data retrospective cohort study by Lucas E. Flausino, Alexis Germán Murillo Carrasco, Tatiane Katsue Furuya, Wen-Jan Tuan, Roger Chammas

“…Further clinical trials are needed to confirm these findings and establish the optimal condition for its application in GI cancer treatment.…”
Get full text

Intraoperative Intraluminal Endoscopy in the Surgical Treatment of Patients with Esophageal Diverticula of Various Localization by A. L. Shestakov, M. V. Khrustaleva, M. E. Shahbanov, N. A. Bulganina, T. T. Bitarov, I. A. Boeva, A. T. Tskhovrebov, I. A. Tarasova, O. V. Rykov, I. M. Selivanova, A. A. Bezaltynnykh

“…The patients were divided into two groups: 31 people (41.9 %) in the main group underwent diverticulectomy with intraoperative intraluminal endoscopic assistance (IVEA), while 43 (58.1 %) people in the control group underwent diverticulectomy without IVEA. …”
Get full text

AI-Driven Smart Agriculture: An Integrated Approach for Soil Analysis, Irrigation, and Crop-Fertilizer Recommendations by Ayesha Khaliq, Atif Khan, Salman Jan, Muhammad Umair, Asad Gulshair, Ahmad Ali, Usman Ali Shah

“…For soil analysis, the TabNet regressor achieved a root mean square error (RMSE) of 1.51 and an R2 score of 98.7%, while XAI techniques were used to explain and interpret its predictions. …”
Get full text

Emergency Nursing Didactics – Opinions, Resource, and Skill Exchange (E.N.D.O.R.S.E) – A collaborative academic initiative in the Emergency Department by Mohammad Anzal Rehman, Elrasheed Salih, Honey Mathew, Ramna Abdulrahman, Ahmad Chahla, Rishi Prasad

“…What seemed to be trivial tasks became optimized through collaborative learning and idea exchange. …”
Get full text

Understanding the acute care context to inform palliative care improvements: a qualitative study of hospital-based multidisciplinary clinicians by Claudia Virdun, Gursharan K. Singh, Patsy Yates, Jane L. Phillips, Alison Mudge

“…Many of these people are hospitalised more than once in their last year of life. While there is sound evidence on what patients and their families require for safe and high-quality hospital palliative care, enabling this remains a challenge. …”
Get full text

Air-gap membrane distillation to desalinate seawater and hypersaline-produced water by Prashan M. Rodrigo, Sana Fatima, Raghava R. Kommalapati, Shankararaman Chellam

“…AGMD utilizes a thermal gradient to transport water vapor across a hydrophobic membrane, while an air gap improves separation efficiency by minimizing conductive heat loss. …”
Get full text

Relationship between intact parathyroid hormone，fetal globulin A，serum creatinine/hemoglobin ratio and disorder of calcium and phosphorus metabolism in maintenance hemodialysis pat... by Wang Xiao-hui, Cai Chun-tian, He Juan, Zhao Xiao-fan, He Liang-ping, Li Ming-hu, Li Xue-ying

“…ObjectiveTo explore the relationship between intact parathyroid hormone （iPTH），fetal globulin A （FA），serum creatinine/hemoglobin ratio （Scr/Hb） and calcium and phosphorus metabolism disorder in chronic renal failure patients with chronic kidney disease （CKD） on maintenance hemodialysis （MHD） and examine the predictive value of each parameter for carotid atherosclerosis.MethodsFrom July 2014 to July 2020，113 CKD patients on MHD were recruited and divided into two groups of sclerosis （<italic>n</italic>=30） and non-sclerosis （<italic>n</italic>=83）.The baseline levels of iPTH，FA and Scr/Hb of two groups were recorded.The related influencing factors of carotid atherosclerosis，parameters of calcium and phosphorus metabolism and their correlations were examined.ResultsBaseline phosphorus，iPTH and Scr/Hb in sclerosis group were higher than those in non-sclerosis group ［（1.89±0.42）mmol/L、305.26（152.63，608.19）μg/L、7.16±2.19 <italic>vs </italic>（1.30±0.36）mmol/L、238.47（118.05，506.11）μg/L、4.38±1.38，<italic>P</italic>&lt;0.001］，FA was lower than that of non-sclerosis group ［（74.62±20.61）mg/L <italic>vs </italic>（95.33±25.80）mg/L，<italic>P</italic>&lt;0.05］； mean values of iPTH，FA and Scr/Hb were selected as boundary，&lt;mean value was low level，≥ mean value high level.High levels of iPTH and Scr/Hb were higher than those with low levels ［（1.60±0.39）mmol/L <italic>vs </italic>（1.18±0.33）mmol/L，（1.71±0.55）mmol/L <italic>vs </italic>（0.97±0.31）mmol/L］ and those with high levels of FA lower than those with low levels ［（1.25±0.34）mmol/L <italic>vs </italic>（1.72±0.40）mmol/L，<italic>P</italic>&lt;0.05］； iPTH，Scr/Hb and phosphorus were positively correlated while FA was negatively correlated with phosphorus （<italic>P</italic>&lt;0.05）；iPTH，FA，Scr/Hb were still associated with IMT （<italic>P</italic>&lt;0.05）； the area under the curve （AUC） of iPTH，FA and Scr/Hb for predicting carotid atherosclerosis were 0.742，0.776 and 0.790 respectively.It was the largest at 0.918 for combined predicting.The optimal predictive sensitivity and specificity were 93.33% and 85.54% respectively.ConclusioniPTH，FA and Scr/Hb are closely correlated with disorder of calcium and phosphorus metabolism in chronic renal failure patients with CKD on MHD.These parameters offer high application values in predicting carotid atherosclerosis.…”
Get full text

When is Growth the Greatest? Spine and Total Body Growth in Idiopathic Scoliosis Through Sanders Maturation Stages 2, 3A, 3B, and 4 by Yusuke Hori, MD, PhD, Bryan Menapace, MD, Norihiro Isogai, MD, Sadettin Ciftci, MD, Burak Kaymaz, MD, Luiz Carlos Almeida da Silva, MD, Kenneth J. Rogers, PhD, ATC, Petya K. Yorgova, MS, Peter G. Gabos, MD, Suken A. Shah, MD, FAOA

“…This study demonstrated that spinal growth was most pronounced in patients at SMS 3A, while total body height growth was greatest during SMS 2 and 3A. …”
Get full text

Potential of ciprofol as an alternative to propofol in elderly patients undergoing gastrointestinal endoscopy: a meta-analysis and trial sequential analysis by Yunfeng Yu, Min Liao, Juan Deng, Xinyu Yang, Yuman Yin, Zhenjie Liu, Guomin Zhang

“…This study aimed to compare the safety of ciprofol with propofol in elderly patients undergoing gastrointestinal endoscopy.MethodsEight common databases were used to search the relevant literature up to 1 January 2025. …”
Get full text

CT-based radiomics model to predict platinum sensitivity in epithelial ovarian carcinoma: a multicentre study by Mengge He, Rahul Singh, Mandi Wang, Grace Ho, Esther M. F. Wong, Keith W. H. Chiu, Anthony K. T. Leung, Ka Yu Tse, Philip P. C. Ip, Andy Hwang, Lujun Han, Elaine Y. P. Lee

“…All patients underwent standard platinum-based chemotherapy and optimal cytoreduction. Platinum sensitivity was determined by whether it recurred within six months after platinum-based chemotherapy. …”
Get full text

Reactive Behaviour of Platinum(II) Salts with Ethylenediamine in Sustainable Water/Choline Chloride-Based Deep Eutectic Solvents Mixtures by Nicola Garofalo, Francesco Messa, Alessandra Barbanente, Francesco Paolo Fanizzi, Antonio Salomone, Nicola Margiotta, Paride Papadia

“…This study investigates the simple model reaction between K₂PtCl₄ and ethylenediamine (<i>en</i>), exploring the behaviour in DES environment, to optimize the synthesis of simple cisplatin-like platinum compounds with the potential objective of improving the traditional methods, decreasing the number of steps required for obtaining target compounds and reducing chemical waste. …”
Get full text

Calibrating multiplex serology for Helicobacter pylori by Emmanuelle A. Dankwa, Martyn Plummer, Daniel Chapman, Rima Jeske, Julia Butt, Michael Hill, Tim Waterboer, Iona Y. Millwood, Ling Yang, Christiana Kartsonaki

“…Immunoblot outputs a binary positive/negative serostatus classification, while multiplex outputs a vector of continuous antigen measurements. …”
Get full text

Antithrombotic Treatment After Valve-in-Valve, Valve-in-Ring, and Valve-in-MAC Procedures: A Systematic Review and Meta-Analysis by Gonçalo Terleira Batista, Gonçalo Costa, Joana Delgado Silva, Lino Gonçalves

“…Introduction: While antithrombotic therapy following transcatheter valve implantation has been extensively studied in various clinical trials, there remains a notable gap in evidence regarding the optimal approach following valve-in-valve (ViV), valve-in-ring (ViR) and valve-in-mitral annular calcification (ViMAC) procedures, warranting further assessment. …”
Get full text

Effects of acupuncture versus moxibustion on functional dyspepsia: a randomized clinical trial by Yangke Mao, Pan Zhang, Zhaoxuan He, Yuke Teng, Zilei Tian, Sha Yang, Kuan Fang, Wei Zhang, Yuting Wang, Tao Yin, Fang Zeng

“…However, the differences of acupuncture and moxibustion in FD are unclear. Methods A total of 144 eligible FD patients were enrolled and randomly assigned to either the acupuncture or moxibustion group to receive 20 treatment sessions. …”
Get full text

Grouping Digital Health Apps Based on Their Quality and User Ratings Using K-Medoids Clustering: Cross-Sectional Study by Maciej Marek Zych, Raymond Bond, Maurice Mulvenna, Lu Bai, Jorge Martinez-Carracedo, Simon Leigh

“…K-medoids clustering identified app typologies, with the optimal number of clusters determined using the elbow method. …”
Get full text