Effect of Bacillus Calmette-Guérin vaccination against Mycobacterium tuberculosis infection in children: an updated systematic review and meta-analysis by Shunli Cai, Qingyi Luo, Guozhong Zhou, Xin Guo, Yan Dong, Hongbo Chen, Shiqi Luo, Jian He, Yuan Xia, Hanse Li, Yingchen Zhou, Chao Song

“…Objectives: To update the understanding of the effectiveness of the Bacillus Calmette-Guérin (BCG) vaccine in preventing tuberculosis (TB) infection in children. Methods: PubMed, Web of Science, Cochrane, and Embase were searched from their inception to January 12, 2025. …”
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Quantification of rehabilitation for patients with Parkinson’s disease and related disorders using wearable devices; a proof of concept by Hikaru Kamo, Hikaru Kamo, Genko Oyama, Genko Oyama, Genko Oyama, Genko Oyama, Genko Oyama, Genko Oyama, Koichi Nagaki, Koichi Nagaki, Koichi Nagaki, Nobutaka Hattori, Nobutaka Hattori, Nobutaka Hattori, Nobutaka Hattori, Nobutaka Hattori, Nobutaka Hattori, Nobutaka Hattori, Nobutaka Hattori, Nobutaka Hattori, Nobutaka Hattori

“…Therefore, this study aimed to quantify rehabilitation interventions and identify optimal approaches based on patient characteristics.MethodsParticipants diagnosed with PD or related disorders and residing in an elderly care facility received various rehabilitation therapies—including water stimulation bed, therapeutic massage, sit-to-stand training, gait training, cycle ergometer training, aerobic training using treadmill, stretching, balance training, calisthenics, and resistance training—while wearing a wearable device between April and May 2022. …”
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Formulation of zein nanoparticles for augmenting the anti-inflammatory activity of dexketoprofen by Mahmoud A. El Hassab, Mona H. Ibrahim, Sherif S. Abdel Mageed, Abdulla M. A. Mahmoud, Zainab Sabry Othman Ahmed, Zainab Sabry Othman Ahmed, Shaimaa Mosallam, Manar Adel Abdelbari, Eman F. Khaleel, Maram A. El Hasab, Asmaa Elsayyad, Asmaa Elsayyad, Shady Allam, Shady Allam, Moaz A. Eltabeeb, Ahmed T. Negmeldin, Ahmed T. Negmeldin, Wagdy M. Eldehna, Rofida Albash

“…IntroductionTopical delivery of anti-inflammatory drugs is an important strategy for enhancing therapeutic efficacy while minimizing systemic side effects. This study focuses on improving the anti-inflammatory activity of Dexketoprofen by developing zein nanoparticles (ZNs) as a novel topical carrier system, aiming to optimize drug delivery and patient outcomes.MethodsDexketoprofen-loaded ZNs were prepared using an ethanol injection technique and optimized via a 23 full factorial design. …”
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Calcium and silicon nanofertilizers improved morphological attributes and fatty acid composition in olive; an insight to synergistic interaction between these elements by Javad Erfani-Moghadam, Abdolkarim Zarei

“…The utilization of nano-fertilizers for targeted and controlled nutrient release represents a promising strategy to advance sustainable agricultural practices while minimizing environmental impact. Method The effects of foliar application of Ca and Si nanoparticles were investigated on the morphological attributes and fatty acid composition of olive tree cultivar ‘Zard’. …”
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Emission Characteristics of Concrete Mixer Trucks Under Real-world Operating Conditions by Xinbo SHI, Yao CHEN, Jin LI, Peixuan LI, Zihang ZHOU, Bin WANG, Xue CHEN

“…Therefore, conducting emission studies based on real-world conditions is essential for analyzing emission variations under different operating scenarios and for effectively controlling emissions from mobile sources.Methods This study selected concrete mixer trucks with high activity levels and representative operating areas in Chengdu to investigate the real emission characteristics of these vehicles during actual task processes. …”
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Optical properties of Gd3+ doped bismuth silicate crystals based on first principles by Yan Huang, Xuefeng Xiao, Yan Zhang, Jiashun Si, Shuaijie Liang, Qingyan Xu, Huan Zhang, Lingling Ma, Cui Yang, Xuefeng Zhang, Jiayue Xu, Tian Tian, Hui Shen

“…In order to further improve its performance, this study adopts a first principles calculation method based on density functional theory (DFT), selects Gd3+ as the dopant, and calculates and explores the changes in optical properties of BSO crystals after doping with 1/12, 1/6, and 1/3Gd3+. …”
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Robustness of Machine Learning Predictions for Determining Whether Deep Inspiration Breath-Hold Is Required in Breast Cancer Radiation Therapy by Wlla E. Al-Hammad, Masahiro Kuroda, Ghaida Al Jamal, Mamiko Fujikura, Ryo Kamizaki, Kazuhiro Kuroda, Suzuka Yoshida, Yoshihide Nakamura, Masataka Oita, Yoshinori Tanabe, Kohei Sugimoto, Irfan Sugianto, Majd Barham, Nouha Tekiki, Miki Hisatomi, Junichi Asaumi

“…<b>Results</b>: Our findings indicate that the decision tree (DT) model demonstrated consistently high robustness at 240 and 270 cGy, while the random forest model performed optimally at 300 cGy. …”
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Long-Term Outcomes of Patients Undergoing Conversion Surgery After Induction Chemotherapy: Turkish Oncology Group Study by Furkan Ceylan, Selin Aktürk Esen, Olçun Ümit Ünal, Ferit Aslan, İlknur Deliktaş Onur, Öztürk Ateş, Erkut Demirciler, İlkay Tuğba Ünek, Ahmet Gülmez, Esra Özen Engin, Semra Taş, Gamze Gököz Doğu, Melih Şimşek, Hacı Mehmet Türk, Ali İnal, Gökhan Şahin, Haydar Çağatay Yüksel, Ateş Kutay Tenekeci, Mutlu Hızal, Mehmet Ali Nahit Şendur, Doğan Uncu

“…This study aimed to evaluate the efficacy and safety of integrating biological therapies with fluorouracil-based induction chemotherapy in patients with isolated liver mCRC who subsequently underwent curative resection of both the primary tumor and liver metastases. <i>Materials and Methods:</i> This multicenter, retrospective study, conducted by the Turkish Oncology Group (TOG), included 116 patients from 11 tertiary centers who underwent conversion surgery following induction chemotherapy between 2009 and 2024. …”
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From colorless to pink: Structural insights into vitamin B12-induced color change in monoclonal antibodies by Kai-feng He, Hao-dong Cui, Wen-hui Deng, Na Xing, Guo-jian Liu, Abdallah Iddy Chaurembo, Li-dan Fu, Yuan Li, Xin-yue Tong, Han-bin Lin, Chun-he Wang

“…This study investigated the mechanism linking this color change to Vitamin B12 (VB12), which converts to hydroxycobalamin (OH-Cbl) under light and binds covalently to cysteine residues in antibodies via cobalt-sulfur bonds. Methods: Three batches of IgG1 antibodies (SP1, SP2, and NL)—were expressed in CHO cells, exposed to light, and purified. …”
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Two sides of the same coin: recruitment performance and perceived workload in primary care trials-insights from the AgeWell.de study by Linda Sanftenberg, Robert Philipp Kosilek, Lorenz Birnberger, Hannah Schillok, Felix Wittmann, Melanie Luppa, Anne Blawert, Melanie Boekholt, Christian Brettschneider, Hans-Helmut König, Alexander Bauer, Solveig Weise, Thomas Frese, Hanna Kaduszkiewicz, Juliane Döhring, Catharina Escales, Jochen René Thyrian, Birgitt Wiese, Steffi G. Riedel-Heller, Jochen Gensichen

“…Methods We analysed publicly available data on GPs participating in the AgeWell.de trial, including their sociodemographic characteristics, practice structures, and socioeconomic indicators of their practice locations, alongside recruitment and survey data. …”
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External Validation of 3 Prediction Models for Mortality in Out‐of‐Hospital Cardiac Arrest Survivors: A Retrospective Multicenter Study by Chun‐Hsiang Huang, Edward Pei‐Chuan Huang, Cheng‐Yi Fan, Yi‐Chien Kuo, Chien‐Tai Huang, Ching‐Yu Chen, Chi‐Hsin Chen, Yi‐Ju Ho, Chun‐Ju Lien, Yun‐Chang Chen, Sih‐Shiang Huang, Tzu‐Hsueh Wang, Wen‐Chu Chiang, Wei‐Tien Chang, Chien‐Hua Huang, Chih‐Wei Sung

“…This study aims to externally validate and compare their predictive performance to determine their clinical utility upon emergency department admission. Methods This retrospective multicenter cohort study included out‐of‐hospital cardiac arrest patients admitted to the National Taiwan University Hospital and its branches between January 2016 and March 2024. …”
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Arginine depletion potentiates standard-of-care chemo-immunotherapy in preclinical models of high-risk neuroblastoma by Kimberley M. Hanssen, Jayne Murray, Ruby Pandher, Stephanie Alfred, Laura D. Gamble, Jennifer Brand, Erin Mosmann, Frances K. Kusuma, Crystal Mak, Adam Kearns, Alvin Kamili, Caroline Atkinson, Alexis Z. Minchaca, Jean Bertoldo, David S. Ziegler, Francis Mussai, Paul N. M. Cheng, Murray D. Norris, Jamie I. Fletcher, Michelle Haber

“…Methods The anti-tumor effects of BCT-100, a pegylated human arginase, were studied in neuroblastoma cell models by metabolite profiling, proteomics, and viability, clonogenicity, and protein translation assays. …”
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Gymnadenia conopsea orchid: a systematic review by Jing-Yi Wu, Jing-Yi Wu, Ruo-Nan Tang, Ruo-Nan Tang, Jia-Wen Wang, Jia-Wen Wang, Wan-Ying Chen, Wan-Ying Chen, Xing Liu, Ji-Wen Wang, Mei-Ya Li, Fu-Sheng Jiang, Fu-Sheng Jiang

“…For propagation, wild-simulated cultivation should be adopted for resource conservation, while optimizing symbiotic germination techniques is critical to overcome propagation bottlenecks, ultimately enabling sustainable utilization.…”
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The Extended Flexor Carpi Radialis Approach for Distal Radius Fracture Fixation: A Prospective Study by Sulaiman Alrefai, MD, Dionne Hsu, MD(c), Jonathan Persitz, MD, Atefeh Noori, PhD, Andrea Chan, MD, FRCSC, Ryan Paul, MD, FRCSC

“…This approach ensures optimal radial and dorsal exposure by releasing the radial septum and simplifies reduction by releasing deforming forces while providing access to the critical volar ulnar corner. …”
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Impact of Storage Conditions on Bronchoalveolar Lavage Fluid Analysis: A Human Study by Yu Shionoya, Kanae Maruyama, Takeshi Kawasaki, Mayumi Ono, Yushi Murai, Ryutaro Hirama, Dai Horiuchi, Noriko Sakuma, Shinsuke Kitahara, Shun Sato, Kohei Takahashi, Yoshihito Ozawa, Takuji Suzuki

“…This study aimed to evaluate how different storage conditions impact BALF cell counts and differentials to guide optimal sample handling practices. <b>Methods</b>: Forty patients who underwent BAL at Chiba University Hospital from June to December 2024 were included. …”
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Assessment of salt tolerance in peas using machine learning and multi-sensor data by Zehao Liu, Qiyan Jiang, Yishan Ji, Rong Liu, Hongquan Liu, Xiuxiu Ya, Zhenxing Liu, Zhirui Wang, Xiuliang Jin, Tao Yang

“…The results show that: 1) multi-source data fusion significantly improved the accuracy of AGB and SPAD estimation; 2) the CatBoost algorithm achieved the highest performance for AGB estimation (R² = 0.70, RMSE = 1.59 t/hm2, NRMSE = 13.94 %), while the LightGBM algorithm performed best for SPAD estimation (R² = 0.60, RMSE = 2.33, NRMSE = 14.53 %); and 3) The PSTS established based on the optimal estimation data exhibits a strong consistency with the ground-measured data. …”
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Clinical features of non-compaction cardiomyopathy across age groups: a retrospective study of 415 patients by Ying Li, Jimei Chen, Min Qiu, Miao Tian, Ziqin Zhou, Ruyue Zhang, Jiazichao Tu, Linjiang Han, Shuheng Zhou, Xinming Li, Jian Zhuang, Shusheng Wen

“…This investigation aims to systematically analyse the clinical characteristics of patients with NCM across various age demographics.Methods A retrospective analysis was conducted on 415 patients with NCM treated at the Guangdong Institute of Cardiovascular Disease from January 2013 to January 2023. …”
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Longitudinal analysis of hsa-miR-3163, hsa-miR-124-3p, hsa-miR-548c-3p, and hsa-miR-27a-3p as prognostic biomarkers in HIV-infected patients by Ilker Inanç Balkan, Ilker Inanç Balkan, Ilker Inanç Balkan, Andleeb Shahzadi, Haktan Sönmez, Burhaneddin Oktan, Muhammad Ihtisham Umar, Bilgül Mete, Fehmi Tabak, Günnur Deniz, Umut Can Küçüksezer

“…This study aimed to evaluate the expression and diagnostic potential of in silico-identified miRNAs (miR-124-3p, miR-27a-3p, miR-548ac-3p, miR-3163) before and during antiretroviral treatment (ART), together with their correlations with immunological markers (CD4 count, CD4/CD45 ratio) and virological parameters (HIV RNA load).MethodsBlood samples and clinical data of 16 patients were collected at 4 different time points; before the initiation of ART (baseline), 1st, 2nd and 6th months following HIV diagnosis. 16 healthy controls were enrolled to this study. …”
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The effect of taurine supplementation on markers of muscle damage and muscle pain in an athletic population: A systematic review and meta-analysis of randomized controlled trials a... by Elaheh Dehghani, Fatemeh Naeini, Sakineh Shab Bidar, Mohammad Beba, Erfan Mortezapour, Ruhollah Nourian, Khashayar Danandeh, Zahra Gohari Dezfuli, Kurosh Djafarian

“…Conclusion: TS may support post-exercise muscle recovery by reducing CK and LDH levels, but its effect on muscle pain remains unclear. While it shows potential as a recovery aid for athletes, further research is needed to optimize dosing and practical applications in sports performance and rehabilitation.…”
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Cerebrospinal Fluid Aβ Biomarkers Predict Recurrent Hemorrhage and Identify Cerebral Amyloid Angiopathy in Patients With Lobar Hemorrhage by Philipp Arndt, Malte Pfister, Frank Schreiber, Valentina Perosa, Hendrik Mattern, Jose Bernal, Berkant Bay, Marc Dörner, Marwa Al‐Dubai, Vanessa Swiatek, Belal Neyazi, Erol Sandalcioglu, Cornelia Garz, Sven G. Meuth, Michael Goertler, Stefan Vielhaber, Katja Neumann, Stefanie Schreiber

“…However, it remains unknown, whether cerebrospinal fluid biomarkers of β‐amyloid (Aβ) retention, predict recurrent hemorrhagic events in these patients. Methods In this retrospective study, we evaluated patients with first‐ever lobar intracerebral hemorrhage or convexity subarachnoid hemorrhage who underwent cerebrospinal fluid analysis of Aβ40, Aβ42, and Aβ42/40 ratio. …”
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