Unexpected renal influence on isavuconazole trough concentrations: two case reports and literature review by Hui Li, Xiaoshuang He, Qiuya Lu, Ling Wang, Jieling Jiang, Wenhui Gao, Lining Wang, Jiong Hu, Jie Fang, Xiaolan Bian

“…Trough concentrations exceeding the reported toxicity threshold were associated with adverse drug reactions (ADRs). …”
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Renal function affects the plasma concentration and hematological toxicity of linezolid in elderly patients: a propensity-matched cohort analysis by Bing Liu, Guangrui Geng, Tingting Liu, Lingli Zhou, Fang Wang, Ping Yang, Jiaxin Liu, Junshuai Zhao, Cheng Zhao, Yue Wang, Minna Yang, Jing Fu, Jingyue Chen, Xiaomin Chen, Xiangqun Fang, Lixin Xie, Hongxia Li

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Geochemistry and provenance of core sediments from the southwestern Okinawa Trough by Huang Kuo-Ming, Lee Yung-Tan, Chang I-An, Huang Ren-Yi, Lin Meng-Lung, Hu Yen-Tsui

“…Understanding the sedimentary processes and provenance in the Okinawa Trough is critical for reconstructing regional tectonic evolution and sediment transport dynamics in this active back-arc basin. …”
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Risk factors for voriconazole-associated hepatotoxicity in patients with liver dysfunction: a retrospective nested case–control study by Jing Ren, Xinfeng Cai, Wei Ge, Jinlin Guo, Shan Wang, Qinhui Wang, Linna Liu, Le Yang, Qi Yang

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The establishment of an expected concentration reference range for eltrombopag in the individualized treatment of pediatric immune thrombocytopenia by Nan Wang, Nan Wang, Shuyue Dong, Yixin Sun, Yixin Sun, Jingjing Liu, Jingjing Liu, Zhifa Wang, Jingyao Ma, Xiaoling Wang, Runhui Wu, Xiaoling Cheng

“…BackgroundDifferences in the clinical efficacy and adverse drug reactions (ADRs) of eltrombopag (ELT) in children with immune thrombocytopenia (ITP) may be positively correlated with the serum trough concentration of ELT. Individual pharmacokinetic variations primarily contribute to differences in ELT concentration among individuals. …”
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Spatiotemporal Distribution Characteristics and Influencing Factors of Negative Air Ion (NAI) Concentrations in Yunnan by Xiaodong Dou, Shengfang Hou, Yinghua Shen, Qiyang Peng, Huajun Liu, Qi Yi, Yujie Liu

“…The results show that NAI concentrations in Yunnan Province has a significant temporal distribution pattern, presenting “dual-peak-dual-trough” and a “single-peak-single-trough” characteristics on the hourly and monthly scales respectively, and the concentration in the rainy season is generally higher than that in the dry season. …”
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Therapeutic drug monitoring vs. pharmacogenetic testing in the context of elevated olanzapine concentrations and prior clozapine intolerability: a case study by Farah Khorassani, Ricardo Azevedo, Reza Farokhpay

“…As expected, the patient exhibited higher clozapine trough concentrations for someone of his age, ethnicity, and gender. …”
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PHARMACOGENETIC ASPECTS OF NEW ORAL ANTICOAGULANTS APPLICATION by A. V. Kryukov, D. A. Sychev, O. V. Tereshchenko

“…Further study of CES1 gene rs8192935 polymorphism showed a 3% decrease in trough dabigatran concentration in heterozygotes and 11% in homozygotes. …”
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CYP2C19‐Guided Voriconazole Therapy: A Precision Medicine Approach to Mitigate Adverse Effects in Japanese Patients by Yoshiki Katada, Daiki Hira, Keisuke Umemura, Yurie Katsube, Hiroki Ishimura, Yusuke Kojima, Machiko Hirai, Moto Kajiwara, Mitsuhiro Sugimoto, Hiroki Endo, Junru Cao, Saki Ohta, Kinuka Kotani, Sakiko Hatazoe, Masahiro Tsuda, Shunsaku Nakagawa, Koh Shinohara, Yasuhiro Tsuchido, Miki Nagao, Tomohiro Terada

“…Secondary outcomes included the proportion of patients maintaining VRCZ trough concentrations within the therapeutic range (1–4 μg/mL) and the treatment response at 28 days. …”
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Population Pharmacokinetic/Pharmacodynamic Study of Linezolid in Hospital-Acquired Pneumonia Patients with Renal Insufficiency by Xu J, Chen X, Zhang Q, Zhuang Z, Yuan Y, Duan L, Shi L, Zhu C, Li J, Lu J, Yu Y, Tang L

“…For the comparative pharmacodynamic study, effectiveness, safety and target attainment of trough concentration (Cmin) for teicoplanin versus linezolid treatment in HAP patients with document Gram-positive bacteria and renal insufficiency were compared. …”
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A Multicenter Randomized Controlled Study on Pharmacokinetic‐Guided Vancomycin Use in Children With Severe Infections by Fuxiang He, Ya Yang, Bo Zhou, Chengcheng Li, Yu Feng, Xuexin Wang, Haifeng Liu, Yuhang Hu, Hongmin Fu, Yingbo Zou, Guoying Zhang, Jianli Chen, Yueqiang Fu, Shufang Xiao, Lan Hu, Chengjun Liu

“…ABSTRACT This study is a multicenter, randomized controlled prospective trial aimed at evaluating the effects of two vancomycin pharmacokinetics/pharmacodynamics (PK/PD) parameters on clinical outcomes in children with different severe infections: trough concentration (Cmin) and the area under the curve (AUC0‐24/MIC). …”
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Thrombodynamics Test in Assessing the Risk of Thrombus Formation in Patients with Atrial Fibrillation Taking Direct Oral Anticoagulants by Z. A. Gebekova, I. I. Ivanov, A. Asambayeva, A. I. Skripka, A. A. Sokolova, D. A. Napalkov, T. A. Vuimo

“…For analysis samples of fresh citrated platelet-free plasma were taken just before regular DOACs dose intake (trough concentration). Statistical data processing was carried out using R software packages.Results. …”
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The role of proactive therapeutic drug monitoring in guiding infliximab therapeutic optimization in pediatric patients with Crohn's disease: A retrospective study by Junya Song, Huihui Zhang, Huihua Zhang, Ximing Xu, Xiaohua Liang, Yongfang Liu, Xiaomei Song, Hong Guo, Xue Zhan, Jinlin Song, Xiaoqin Zhou

“…Baseline influencing factors for infliximab trough concentration (TC) and clinical outcomes before and after the treatment change were analyzed to assess the value of adjusting treatment in the patients. …”
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The Association Between Elevated Estimated Glomerular Filtration Rate and Poor Clinical Outcomes of Pediatric Patients with Community-Acquired Bacterial Meningitis Receiving Vancom... by Cuiyao He, Yuhua Deng, Tingsong Li, Dongmei Deng, Fengjun Lv, Yuan Qu, Li Jiang, Siqi Hong, Xiaogang Hu, Yuanyuan Luo

“…The initial vancomycin trough concentration in the elevated eGFR group was significantly lower than that in the normal eGFR group [5.600 (4.590; 8.060) mg/L vs. 9.205 (7.500; 12.070) mg/L]. …”
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