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    Lutetium-177 labeled iPD-L1 as a novel immunomodulator for cancer-targeted radiotherapy by Myrna Luna-Gutiérrez, Erika Azorín-Vega, Rigoberto Oros-Pantoja, Blanca Ocampo-García, Pedro Cruz-Nova, Nallely Jiménez-Mancilla, Gerardo Bravo-Villegas, Clara Santos-Cuevas, Laura Meléndez-Alafort, Guillermina Ferro-Flores

    Published 2025-01-01
    “…In vitro and in vivo studies demonstrated radiotracer stability in human serum (> 97% after 24 h evaluated by radio-HPLC), adequate affinity by the PDL1 protein (IC50 = 4.21 nM), and specific detection for PD-L1 assessed in 4T1, HCT116, and AR42J cancer cells, in which PD-L1 expression was verified by immunofluorescence and Western Blot assays. …”
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    Association of systemic immune-inflammatory index with in-stent restenosis in patients with and without diabetes mellitus by Xunwei Deng, Xunwei Deng, Xunwei Deng, Qiaoting Deng, Qiaoting Deng, Qiaoting Deng, Qunji Zhang, Qunji Zhang, Qunji Zhang, Jingyuan Hou, Jingyuan Hou, Jingyuan Hou

    Published 2025-01-01
    “…After adjusting for confounders, the multivariate logistic regression analysis revealed that participants with higher SII levels had a significantly increased risk of ISR for diabetics (all P < 0.05), and this significant association was observed in patients with more severe ISR (triple-coronary artery lesions). Additionally, RCS analysis reveals that there is a J-shaped nonlinear correlation between SII and ISR in the entire study cohort with (P for overall <0.001, and P for nonlinearity = 0.0058, respectively). …”
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