Modeling tumor relapse using proliferation tracing and ablation transgenic mouse by Chuang Zhao, Xin-nan Zheng, Han-ying Huang, Lin Tian

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Sex-specific changes in energy demand during the preplaque stage in a transgenic Alzheimer’s mouse model by Rongwan Sun, Leonie-Kim Zimbalski, Stefanie Schreyer, David Baidoe-Ansah, Aida Harutyunyan, Arnd Heuser, Rachel N. Lippert, Joachim Spranger, Knut Mai, Sebastian Brachs

“…Data from our previous research indicate that transgenic mice of the APP23 line, a murine AD model, exhibited higher energy expenditure and mitochondrial dysregulation in the liver as early as 3 months of age, which is considered the preplaque stage. …”
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A murine model lacking Lyst recapitulates Chediak-Higashi syndrome with an earlier-onset neurodegenerative phenotype by Sunny Greene, Mackenzie L. Talbert, F. Graeme Frost, Patricia M. Zerfas, Danielle Springer, Audrey Noguchi, Marie Morimoto, Dawn Maynard, Lisa Garrett, Gene Elliot, Maria Traver, David Yarnell, Petcharat Leoyklang, John D. Burke, Elena-Raluca Nicoli, William A. Gahl, Wendy J. Introne, May Christine V. Malicdan

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Use of constitutive and inducible oncogene-containing iPSCs as surrogates for transgenic mice to study breast oncogenesis by Christine Nguyen, Julie P. T. Nguyen, Arnav P. Modi, Ihsaan Ahmad, Sarah C. Petrova, Stuart D. Ferrell, Sabrina R. Wilhelm, Yin Ye, Dorthe Schaue, Sanford H. Barsky

“…Abstract Background Powerful constitutive and inducible transgenic / bitransgenic / tritransgenic murine models of breast cancer have been used over the past two decades to shed light on the molecular mechanisms by which the given transgenic oncogenes have interacted with other cellular genes and set in motion breast cancer initiation and progression. …”
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IL-6 regulates CCR5 expression and immunosuppressive capacity of MDSC in murine melanoma by Xiaoying Hu, Viktor Umansky, Peter Altevogt, Jochen S Utikal, Alina Siebenmorgen, Christopher Groth, Carsten Sticht, Rebekka Weber, Zeno Riester, Laura Hüser

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Brain cross‐protection against SARS‐CoV‐2 variants by a lentiviral vaccine in new transgenic mice by Min‐Wen Ku, Pierre Authié, Maryline Bourgine, François Anna, Amandine Noirat, Fanny Moncoq, Benjamin Vesin, Fabien Nevo, Jodie Lopez, Philippe Souque, Catherine Blanc, Ingrid Fert, Sébastien Chardenoux, llta Lafosse, Delphine Cussigh, David Hardy, Kirill Nemirov, Françoise Guinet, Francina Langa Vives, Laleh Majlessi, Pierre Charneau

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P79 | AN INNOVATIVE FUNCTIONAL COOKIE MODULATES THE MUCOSA AND MYENTERIC PLEXUS IN THE GUT OF 3xTg-AD MOUSE MODEL OF ALZHEIMER’S DISEASE

“…It has been proposed that gut dysbiosis, dysfunction of the intestinal epithelial barrier, and vascular deposition of amyloid-beta (Aβ) in the gut may precede the cerebral deposition of Aβ in a transgenic mouse model of AD.1 A hypocaloric cookie with prebiotic-rich ingredients (red lentils) coated with a multi-strain probiotic (SLAB51®) enriched chocolate2 was tested on 3xTg-AD mice, a murine model of AD, to evaluate the protective effects on the mucosa and ENS of the ileum and colon. 8-week-old 3xTg-AD gender-balanced mice were divided into five groups and organized for the supplementation of functional cookies. …”
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Post-sepsis chronic muscle weakness can be prevented by pharmacological protection of mitochondria by Meagan S. Kingren, Alexander R. Keeble, Alyson M. Galvan-Lara, Jodi M. Ogle, Zoltán Ungvári, Daret K. St Clair, Timothy A. Butterfield, Allison M. Owen, Christopher S. Fry, Samir P. Patel, Hiroshi Saito

“…To investigate this medical condition in detail, we previously developed a murine severe sepsis-survival model that exhibits long-term post-sepsis skeletal muscle weakness. …”
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An oncolytic herpes simplex virus armed with IL-12 for treatment of preclinical glioblastoma by Joseph W. Jackson, Bonnie L. Hall, Chaim Sneiderman, Amy Webb, Trevor J. Hancock, Marina Vlasyuk, Lisa Bailey, Molly Xiaokui, Isaac H. Solomon, Keith Ligon, William F. Goins, Gary Kohanbash, E. Antonio Chiocca, Joseph C. Glorioso

“…Here we used an oHSV (KOS strain) armed with interleukin (IL)-12 (oHSV:IL-12) in an attempt to overcome this immunosuppression and analyzed the immunological and therapeutic impact in murine CT2A and GL261N4 orthotopic syngeneic glioma models. …”
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