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  1. 441

    Gastrodin Suppresses the Amyloid β-Induced Increase of Spontaneous Discharge in the Entorhinal Cortex of Rats by Peng-zhi Chen, Hui-hui Jiang, Bo Wen, Shuan-cheng Ren, Yang Chen, Wei-gang Ji, Bo Hu, Jun Zhang, Fenglian Xu, Zhi-ru Zhu

    Published 2014-01-01
    “…Moreover, whole-cell patch clamp results indicated that the protective function of GAS on abnormal hyperexcitability may be partially mediated by its inhibitory action on Aβ1−42-elicited inward currents in EC neurons. Our study suggested that GAS may provide neuroprotective effects on Aβ1−42-induced hyperactivity in EC neurons of rats.…”
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  2. 442
  3. 443
  4. 444

    Effects of Simvastatin on Glucose Metabolism in Mouse MIN6 Cells by Jieqiong Zhou, Weihua Li, Qiang Xie, Yuxi Hou, Shaopeng Zhan, Xi Yang, Xiaofeng Xu, Jun Cai, Zhengrong Huang

    Published 2014-01-01
    “…Real-time PCR and western blotting were performed to measure the mRNA and protein levels of inward rectifier potassium channel 6.2 (Kir6.2), voltage-dependent calcium channel 1.2 (Cav1.2), and glucose transporter-2 (GLUT2), respectively. …”
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  5. 445

    Clonal Heterogeneity in the Neuronal and Glial Differentiation of Dental Pulp Stem/Progenitor Cells by Fraser I. Young, Vsevolod Telezhkin, Sarah J. Youde, Martin S. Langley, Maria Stack, Paul J. Kemp, Rachel J. Waddington, Alastair J. Sloan, Bing Song

    Published 2016-01-01
    “…Neuronally differentiated DPSCs possessed a membrane capacitance comparable with primary cultured striatal neurons and small inward voltage-activated K+ but not outward Na+ currents were recorded suggesting a functionally immature phenotype. …”
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  6. 446

    Multi‐Year Statistics of LEO Energetic Electrons as Observed by the Korean NextSat‐1 by Jaeheung Park, Kyoung Wook Min, Hoonkyu Seo, Eo‐Jin Kim, Kwangsun Ryu, Jongdae Sohn, Jongho Seon, Ji‐Hyeon Yoo, Seunguk Lee, Brian Kress, Junchan Lee, Changho Woo, Dae‐Young Lee

    Published 2021-08-01
    “…For <80 keV electrons, the slot‐region outer edge at LEO moves inward with increasing geomagnetic activity, which agrees with previous Van Allen Probes reports. …”
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  7. 447

    Investigating Fire Collapse Early Warning Systems for Portal Frames by Ming Xie, Fangbo Xu, Zhangdong Wang, Li’e Yin, Xiangdong Wu, Mengqi Xu, Xiang Li

    Published 2025-01-01
    “…When the collapse mode of a portal frame is an overall inward collapse, transverse and longitudinal wave velocities are reduced to 2635 m/s and 5308 m/s, respectively. …”
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  8. 448

    Your brain on art, nature, and meditation: a pilot neuroimaging study by Beatrix Krause-Sorio, Sergio Becerra, Prabha Siddarth, Stacey Simmons, Taylor Kuhn, Helen Lavretsky

    Published 2025-01-01
    “…ObjectivesExposure to art, nature, or meditation, all transcending human experiences, has beneficial effects on health and wellbeing. Focusing inward or watching art and nature videos elicits positive emotions that can help heal stress-related conditions. …”
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  9. 449

    Angiotensin IV Receptors in the Rat Prefrontal Cortex: Neuronal Expression and NMDA Inhibition by Zsolt Tamás Papp, Polett Ribiczey, Erzsébet Kató, Zsuzsanna E. Tóth, Zoltán V. Varga, Zoltán Giricz, Adrienn Hanuska, Mahmoud Al-Khrasani, Ákos Zsembery, Tibor Zelles, Laszlo G. Harsing, László Köles

    Published 2024-12-01
    “…NMDA (30 μM) induced stable inward cation currents, significantly inhibited by Ang IV (1 nM–1 µM) in a subset of pyramidal neurons. …”
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  10. 450

    A Dichotomy in the 1–24 GHz Parsec-scale Radio Spectra of Radio-quiet Quasars by Sina Chen, Ari Laor, Ehud Behar, Ranieri D. Baldi, Joseph D. Gelfand, Amy E. Kimball

    Published 2025-01-01
    “…Future submillimeter observations can further constrain the inward radial extent of the radio emission down to the coronal scale.…”
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  11. 451
  12. 452

    Structure of WzxE the lipid III flippase for Enterobacterial Common Antigen polysaccharide by Audrey Le Bas, Bradley R. Clarke, Tanisha Teelucksingh, Micah Lee, Kamel El Omari, Andrew M. Giltrap, Stephen A. McMahon, Hui Liu, John H. Beale, Vitaliy Mykhaylyk, Ramona Duman, Neil G. Paterson, Philip N. Ward, Peter J. Harrison, Miriam Weckener, Els Pardon, Jan Steyaert, Huanting Liu, Andrew Quigley, Benjamin G. Davis, Armin Wagner, Chris Whitfield, James H. Naismith

    Published 2025-01-01
    “…Here, we present the first X-ray structures of WzxE from Escherichia coli in complex with nanobodies. Both inward- and outward-facing conformations highlight two pairs of arginine residues that move in a reciprocal fashion, enabling flipping. …”
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  13. 453

    A New Four‐Component L*‐Dependent Model for Radial Diffusion Based on Solar Wind and Magnetospheric Drivers of ULF Waves by Kyle R. Murphy, Jasmine Sandhu, I. Jonathan Rae, Thomas Daggitt, Sarah Glauert, Richard B. Horne, Clare E. J. Watt, Sarah Bentley, Adam Kellerman, Louis Ozeke, Alexa J. Halford, Sheng Tian, Aaron Breneman, Leonid Olifer, Ian R. Mann, Vassilis Angelopoulos, John Wygant

    Published 2023-07-01
    “…This includes Ultra Low Frequency (ULF) waves that interact with electrons via radial diffusion which can lead to electron dropouts via outward transport and rapid electron acceleration via inward transport. In radiation belt simulations, the strength of this interaction is specified by ULF wave radial diffusion coefficients. …”
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  14. 454

    Molecular determinants of Neu5Ac binding to a tripartite ATP independent periplasmic (TRAP) transporter by Parveen Goyal, KanagaVijayan Dhanabalan, Mariafrancesca Scalise, Rosmarie Friemann, Cesare Indiveri, Renwick CJ Dobson, Kutti R Vinothkumar, Subramanian Ramaswamy

    Published 2025-02-01
    “…Both structures are in an inward (cytoplasmic side) facing conformation. The Neu5Ac-bound structure reveals the interactions of Neu5Ac with the transporter and its relationship with the Na+ binding sites. …”
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  15. 455

    On the substrate turnover rate of NBCe1 and AE1 SLC4 transporters: structure-function considerations by Alexander Pushkin, Liyo Kao, Hristina R. Zhekova, Rustam Azimov, Natalia Abuladze, Xuesi M. Shao, D. Peter Tieleman, Ira Kurtz, Ira Kurtz

    Published 2025-01-01
    “…NBCe1-A had a TOR value of ∼30,400 s−1 whereas kAE1 and eAE1 had significantly higher values (62,000 s−1 and 60,500 s−1 respectively). We modeled the inward-facing (IF) conformation of NBCe1-A to determine conformational changes during its transport cycle. …”
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  16. 456

    Structural insights into the LGR4-RSPO2-ZNRF3 complexes regulating WNT/β-catenin signaling by Lu Wang, Fangzheng Hu, Qianqian Cui, Huarui Qiao, Lingyun Li, Tengjie Geng, Yuying Li, Zengchao Sun, Siyu Zhou, Zhongyun Lan, Shaojue Guo, Ying Hu, Jiqiu Wang, Qilun Yang, Zenan Wang, Yuanyuan Dai, Yong Geng

    Published 2025-01-01
    “…Particularly, in the assembly complex with a 2:2:2 ratio, two LGR4 protomers induce and stabilize the inactive state of ZNRF3, characterized by a wide inward-open conformation of two transmembrane helices (TM helices). …”
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  17. 457

    Evaluating Whether Nonimmersion Virtual Reality Simulation Training Improves Nursing Competency in Isolation Wards: Randomized Controlled Trial by Dandan Zhang, MuLi Fu, Jianzhong Zhang, Yuxuan Li, Li Chen, Yong-Jun Chen, Zhefeng Zhong, Yin-Ping Zhang

    Published 2025-01-01
    “…Notably, they completed task 3 (patient reception inward) and task 6 (exiting the isolation area) significantly quicker (t88=3.22, P=.002; Cohen d=0.68; t88=3.03, P=.003; Cohen d=0.64, respectively), with no significant differences for the other tasks. …”
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  18. 458

    Potassium Current Signature of Neuronal/Glial Progenitors in Amniotic Fluid Stem Cells by Paola Sabbatini, Sabrina Cipriani, Andrea Biagini, Luana Sallicandro, Cataldo Arcuri, Rita Romani, Paolo Prontera, Alessandra Mirarchi, Rosaria Gentile, Diletta Del Bianco, Elko Gliozheni, Sandro Gerli, Irene Giardina, Maurizio Arduini, Alessandro Favilli, Antonio Malvasi, Andrea Tinelli, Bernard Fioretti

    Published 2025-01-01
    “…By using patch clamp technique we characterized a fibroblast-like morphology that display a barium-sensitive inward-rectifying potassium current (Kir) and calcium-activated potassium currents (KCa). …”
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  19. 459

    Identification of Lauric Acid as a Potent Sodium Channel NaV1.5 Blocker from Compound Chinese Medicine Wenxin Keli by Xie W, Gao J, Liang Y, Huang C, Zhang B, Chen X, Yao X, Nan G, Wu H, Wang Y, Wu L, Wang T, Zhu Y

    Published 2025-01-01
    “…Molecular docking and molecular dynamics simulation suggested that LA binds to the NaV 1.5 protein, with a significant binding affinity forming interactions with functionally essential residues and blocks the inward flow of Na+. Mechanistically, lauric acid acts on the fast inactivation of NaV 1.5 alter electrophysiology conduction of hiPSC-derived cardiomyocytes and contribute to the antiarrhythmic effect of WXKL.Conclusion: Lauric acid is a potent blocker for sodium channel NaV 1.5 and alleviates arrhythmia via inhibiting INa. …”
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  20. 460

    Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3 by Peipei Li, Zhini Zhu, Yong Wang, Xuyuan Zhang, Chuanhui Yang, Yalan Zhu, Zixuan Zhou, Yulin Chao, Yonghui Long, Yina Gao, Songqing Liu, Liguo Zhang, Pu Gao, Qianhui Qu

    Published 2024-12-01
    “…Here we present ten cryo-EM structures of human thiamine transporters SLC19A3 and SLC19A2 in outward- and inward-facing conformations, complexed with thiamine, pyridoxine, metformin, fedratinib, and amprolium. …”
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