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441
Gastrodin Suppresses the Amyloid β-Induced Increase of Spontaneous Discharge in the Entorhinal Cortex of Rats
Published 2014-01-01“…Moreover, whole-cell patch clamp results indicated that the protective function of GAS on abnormal hyperexcitability may be partially mediated by its inhibitory action on Aβ1−42-elicited inward currents in EC neurons. Our study suggested that GAS may provide neuroprotective effects on Aβ1−42-induced hyperactivity in EC neurons of rats.…”
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442
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443
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444
Effects of Simvastatin on Glucose Metabolism in Mouse MIN6 Cells
Published 2014-01-01“…Real-time PCR and western blotting were performed to measure the mRNA and protein levels of inward rectifier potassium channel 6.2 (Kir6.2), voltage-dependent calcium channel 1.2 (Cav1.2), and glucose transporter-2 (GLUT2), respectively. …”
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445
Clonal Heterogeneity in the Neuronal and Glial Differentiation of Dental Pulp Stem/Progenitor Cells
Published 2016-01-01“…Neuronally differentiated DPSCs possessed a membrane capacitance comparable with primary cultured striatal neurons and small inward voltage-activated K+ but not outward Na+ currents were recorded suggesting a functionally immature phenotype. …”
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446
Multi‐Year Statistics of LEO Energetic Electrons as Observed by the Korean NextSat‐1
Published 2021-08-01“…For <80 keV electrons, the slot‐region outer edge at LEO moves inward with increasing geomagnetic activity, which agrees with previous Van Allen Probes reports. …”
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447
Investigating Fire Collapse Early Warning Systems for Portal Frames
Published 2025-01-01“…When the collapse mode of a portal frame is an overall inward collapse, transverse and longitudinal wave velocities are reduced to 2635 m/s and 5308 m/s, respectively. …”
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448
Your brain on art, nature, and meditation: a pilot neuroimaging study
Published 2025-01-01“…ObjectivesExposure to art, nature, or meditation, all transcending human experiences, has beneficial effects on health and wellbeing. Focusing inward or watching art and nature videos elicits positive emotions that can help heal stress-related conditions. …”
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449
Angiotensin IV Receptors in the Rat Prefrontal Cortex: Neuronal Expression and NMDA Inhibition
Published 2024-12-01“…NMDA (30 μM) induced stable inward cation currents, significantly inhibited by Ang IV (1 nM–1 µM) in a subset of pyramidal neurons. …”
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450
A Dichotomy in the 1–24 GHz Parsec-scale Radio Spectra of Radio-quiet Quasars
Published 2025-01-01“…Future submillimeter observations can further constrain the inward radial extent of the radio emission down to the coronal scale.…”
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451
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Structure of WzxE the lipid III flippase for Enterobacterial Common Antigen polysaccharide
Published 2025-01-01“…Here, we present the first X-ray structures of WzxE from Escherichia coli in complex with nanobodies. Both inward- and outward-facing conformations highlight two pairs of arginine residues that move in a reciprocal fashion, enabling flipping. …”
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453
A New Four‐Component L*‐Dependent Model for Radial Diffusion Based on Solar Wind and Magnetospheric Drivers of ULF Waves
Published 2023-07-01“…This includes Ultra Low Frequency (ULF) waves that interact with electrons via radial diffusion which can lead to electron dropouts via outward transport and rapid electron acceleration via inward transport. In radiation belt simulations, the strength of this interaction is specified by ULF wave radial diffusion coefficients. …”
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454
Molecular determinants of Neu5Ac binding to a tripartite ATP independent periplasmic (TRAP) transporter
Published 2025-02-01“…Both structures are in an inward (cytoplasmic side) facing conformation. The Neu5Ac-bound structure reveals the interactions of Neu5Ac with the transporter and its relationship with the Na+ binding sites. …”
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455
On the substrate turnover rate of NBCe1 and AE1 SLC4 transporters: structure-function considerations
Published 2025-01-01“…NBCe1-A had a TOR value of ∼30,400 s−1 whereas kAE1 and eAE1 had significantly higher values (62,000 s−1 and 60,500 s−1 respectively). We modeled the inward-facing (IF) conformation of NBCe1-A to determine conformational changes during its transport cycle. …”
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456
Structural insights into the LGR4-RSPO2-ZNRF3 complexes regulating WNT/β-catenin signaling
Published 2025-01-01“…Particularly, in the assembly complex with a 2:2:2 ratio, two LGR4 protomers induce and stabilize the inactive state of ZNRF3, characterized by a wide inward-open conformation of two transmembrane helices (TM helices). …”
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457
Evaluating Whether Nonimmersion Virtual Reality Simulation Training Improves Nursing Competency in Isolation Wards: Randomized Controlled Trial
Published 2025-01-01“…Notably, they completed task 3 (patient reception inward) and task 6 (exiting the isolation area) significantly quicker (t88=3.22, P=.002; Cohen d=0.68; t88=3.03, P=.003; Cohen d=0.64, respectively), with no significant differences for the other tasks. …”
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458
Potassium Current Signature of Neuronal/Glial Progenitors in Amniotic Fluid Stem Cells
Published 2025-01-01“…By using patch clamp technique we characterized a fibroblast-like morphology that display a barium-sensitive inward-rectifying potassium current (Kir) and calcium-activated potassium currents (KCa). …”
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459
Identification of Lauric Acid as a Potent Sodium Channel NaV1.5 Blocker from Compound Chinese Medicine Wenxin Keli
Published 2025-01-01“…Molecular docking and molecular dynamics simulation suggested that LA binds to the NaV 1.5 protein, with a significant binding affinity forming interactions with functionally essential residues and blocks the inward flow of Na+. Mechanistically, lauric acid acts on the fast inactivation of NaV 1.5 alter electrophysiology conduction of hiPSC-derived cardiomyocytes and contribute to the antiarrhythmic effect of WXKL.Conclusion: Lauric acid is a potent blocker for sodium channel NaV 1.5 and alleviates arrhythmia via inhibiting INa. …”
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460
Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3
Published 2024-12-01“…Here we present ten cryo-EM structures of human thiamine transporters SLC19A3 and SLC19A2 in outward- and inward-facing conformations, complexed with thiamine, pyridoxine, metformin, fedratinib, and amprolium. …”
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