Molecular mechanism of human α1A-adrenoceptor inhibition by Mamba snake toxin AdTx1 by Mingyu Shi, Shuhao Zhang, Angqi Zhu, Yosuke Toyoda, Fang Kong, Xiaoou Sun, Xinyu Xu, Chuangye Yan, Xiangyu Liu

“…Abstract There is growing interest in peptide or small protein based drugs targeting G protein-coupled receptors (GPCRs) for improved subtype selectivity over small molecules. Naturally occurring toxins represent rich sources of such ligands. AdTx1 (ρ-Da1a), a three-finger toxin (3FTx) from the green Mamba Snake, selectively binds and antagonizes α-adrenoceptors. …”
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Clinical experience with heterologous serum products by O. V. Perelygina, E. I. Komarovskaya, A. V. Mukhacheva, L. V. Sayapina, Yu. I. Obukhov, V. P. Bondarev

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Structural mechanisms behind the neutralisation of long-chain α-neurotoxins by broadly neutralising VHHs discovered using a consensus antigen by Anna Damsbo, Nick J. Burlet, Monica L. Fernández-Quintero, Melisa Benard-Valle, Max D. Overath, Alid Guadarrama-Martínez, Anneline Vlamynck, Ida Bisbo, Cesar Villalobos, Tulika Tulika, Alejandro Alagón, Johannes R. Loeffler, Andrew B. Ward, Kim Boddum, Jens Preben Morth, Esperanza Rivera-de-Torre, Andreas H. Laustsen

“…Our findings highlight that the use of a consensus toxin as an antigen coincided with the discovery of broadly neutralising VHHs against snake venom toxins.…”
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Neuro- and Cardiotoxins from Sea Anemones: Structure, Function and Potential of Application in Research and Medical Practice by R. S. Kalina, M. M. Monastyrnaya

“…The toxicity of some biologically active sea anemone peptides (RpI, RpIII) at intravenous administration to experimental animals is comparable with that of the most well-known and dangerous representatives of natural toxins with the similar mechanism of action (an alpha-hemolysine and tetrodotoxin), or chemical warfare agents, such as sarin and hydrogen cyanide. …”
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Structure-based design of an antibacterial peptide from the Myotoxin II sequence, evaluating its effectiveness against Gram-negative bacteria and its safety by Tatiana Huertas, Diana Millán, Angela V. Fonseca-Benítez, James Guevara-Pulido

“…There has been growing interest in exploring animal toxins as potential alternatives to antibiotics. This study centers on the rational design of an antibiotic peptide based on the sequence 115–129 from Myotoxin II, sourced from the venom of the snake Bothrops asper. …”
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A clinical quiz that turns heads by Richard Foster

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