Knowledge, attitudes, and barriers regarding health promotion of ovarian cancer among community pharmacists in Jordan by Khaled Alrosan, Mohanad Odeh, Tahani Alwidyan, Amjad Z Alrosan, Saba Madae’en

“…The perceived lack of pharmacist’ s knowledge and the absence of a private area in pharmacies for confidential conversations represent the major barriers (72.1% and 69.6%, respectively).Conclusion Despite limited knowledge about the symptoms and risk factors of ovarian cancer, as well as barriers hindering the full realization of community pharmacists’ roles, they demonstrated a positive attitude toward educating patients about ovarian cancer health.…”
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Preconditioning of the tumor microenvironment with oncolytic reovirus converts CD3-bispecific antibody treatment into effective immunotherapy by Rob C Hoeben, Sjoerd H van der Burg, Thorbald van Hall, Christianne Groeneveldt, Priscilla Kinderman, Diana J M van den Wollenberg, Ruben L van den Oever, Jim Middelburg, Dana A M Mustafa, Nadine van Montfoort

“…Although this therapy has reached clinical practice for hematological malignancies, the absence of sufficient infiltrating T cells is a major barrier for efficacy in solid tumors. In this study, we exploited oncolytic reovirus as a strategy to enhance the efficacy of CD3-bsAbs in immune-silent solid tumors.Methods The mutant p53 and K-ras induced murine pancreatic cancer model KPC3 resembles human pancreatic ductal adenocarcinomas with a desmoplastic tumor microenvironment, low T-cell density and resistance to immunotherapy. …”
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