Identification and modulation of a PI3K/AKT/mTOR pathway-targeting microRNA in order to increase colorectal cancer cells radiosensitivity in vitro by Seyedeh Nasibeh Mousavikia, Maryam M. Matin, Mohammad Taghi Bahreyni Tossi, Seyed Hamid Aghaee-Bakhtiari, Hosein Azimian

“…Abstract Background The progression of colorectal cancer (CRC) occurs via the PI3K/AKT/mTOR signaling pathway. Recent evidence suggests that microRNAs (miRNAs) can modulate gene expression, potentially offering new treatment options. …”
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Exogenous melatonin enhances Lr10-mediated resistance to Puccinia triticina by upregulating TaRAR1 and potentiating salicylic acid pathway and antioxidant defense system by Johannes Mapuranga, Lulu Song, Ruolin Li, Hao Li, Jiaying Chang, Jiaojie Zhao, Yingdan Zhang, Na Zhang, Wenxiang Yang

“…RAR1 serves as an initial convergence point in signaling pathways activated by several R genes. Herein, TaRAR1 was strongly upregulated during early stages of infection in incompatible interactions, and this was associated with increased endogenous SA and melatonin levels, correlating with enhanced defense responses. …”
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Targeting ferroptosis in cancer stem cells: A novel strategy to improve cancer treatment by Luyao Wang, Ye Zhu, Chengying Huang, Qiuming Pan, Junxi Wang, Hongrui Li, Yudi Huang, Guozhong Yi, Zhiyong Li, Songtao Qi, Guanglong Huang, Shanqiang Qu

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Calcium ion-binding genes can predict tumor mutation burden and immune checkpoint blockade response in a pan-cancer model by Wan-Yu Lin, Chien-Jung Huang, Yu-Chao Wang

“…Enrichment analysis further suggested that calcium ion-binding genes may influence TMB through signal transduction pathways. Conclusions These findings establish a novel association between calcium ion-binding genes and TMB, demonstrating the feasibility of a pan-cancer TMB estimation model based on calcium ion-binding genes. …”
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PLD1 is a key player in cancer stemness and chemoresistance: Therapeutic targeting of cross-talk between the PI3K/Akt and Wnt/β-catenin pathways by Seong Hun Lim, Hyesung Lee, Hyun Ji Lee, Kuglae Kim, Junjeong Choi, Jung Min Han, Do Sik Min

“…Among the aberrantly activated pathways, the PI3K-Akt/Wnt/β-catenin signaling pathway is clinically implicated in malignancies such as colorectal cancer (CRC) and glioblastoma multiforme (GBM). …”
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The anionic surfactant Sodium Dodecyl Benzene Sulfonate alleviates inflammatory responses in atopic dermatitis via NFκB/MAPK pathways in a STAT3-dependent manner by Han Zhang, Zizhuo Li, Zhanglei Mu, You Wu, Suli Zhang, Yaguang Zhou, Dongdong Zhang, Xiaojing Zhao, Weiwei Xing, Yanan Wang, Biwen Lin, Xiaoqiang Liang, Chunfu Zheng, Chengxin Li, Jianzhong Zhang

“…Furthermore, our results showed that SDBS alleviated AD via the nuclear factor kappa B/mitogen-activated protein kinase pathways in a signal transducer and activator of transcription 3-dependent manner. …”
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Self-assembled transdermal nanogels control scar formation by inhibiting fibroblast proliferation and fibrosis with glycolysis regulation via the PI3K/Akt/mTOR pathway by Xinxian Meng, Zhixi Yu, Shiqi Wu, Wanyu Xu, Yuzhen Tang, Zixuan Chen, Yixin Zhang, Yunsheng Chen, Zheng Zhang

“…Mechanistically, HA-IR808 regulates glycolysis by silencing the phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of the rapamycin (mTOR) signaling pathway. In conclusion, this research elucidates a strategy for controlling HS formation via glycolysis regulation using self-assembled HA-IR808 nanogels to inhibit HF activation. …”
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USP6NL and MSX2 as the novel diagnostic markers in gastric cancer patients by Zahra Basirat, Negin Taghehchian, Mohammad Reza Abbaszadegan, Meysam Moghbeli

“…Gastric cancer (GC) is one of the most frequent gastrointestinal malignancies in the world. WNT signaling pathway has a key role in the occurrence and progression of GC. …”
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Exploring new mechanisms in cancer molecular pathways and pathogenic cell transformation: PIP4K2A as a prognostic marker and therapeutic target in cutaneous malignant melanoma by Wen-fei Luo, Ding-ming Song, Tong Shen, Yi-bo He, Hong-yang Du, Ming-jue Si, Lu-Wei Fang

“…Methods Samples from cutaneous melanoma patients were analysed by single-cell transcriptome for differentially expressed genes and signalling pathways associated with cutaneous melanoma. …”
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Non-canonical activation of MAPK signaling by the lncRNA ASH1L-AS1-encoded microprotein APPLE through inhibition of PP1/PP2A-mediated ERK1/2 dephosphorylation in hepatocellular car... by Lei Zhao, Ke Si, Shenjian Luo, Lantian Zhang, Shuai Mao, Wenliang Zhang

“…Mechanistically, APPLE binds to ERK1/2 and phosphatases PP1/PP2A, preventing ERK1/2 dephosphorylation and sustaining MAPK pathway activation. Additionally, the transcription factor E2F1 directly binds to the ASH1L-AS1 promoter (− 300 to − 290 bp), upregulating APPLE expression and further amplifying ERK1/2 signaling. …”
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9th surgery decoction alleviates psoriasis-like inflammation through the downregulation of angiogenesis induced by HIF-1α and the EGFR-PI3K-AKT-mTOR pathways by Shengjie Zhu, Xinyi Feng, Ge Yan, Xin Liu, Yuanran Chen, Likun Zhang, Kan Ze

“…Additionally, the decoction inhibited angiogenesis by downregulating hypoxia-induced factor 1-alpha and the epidermal growth factor receptor-phosphoinositide 3-kinase-protein kinase B-mechanistic target of rapamycin signaling pathways. Conclusions: The 9SD demonstrates significant anti-psoriatic effects by targeting inflammation and angiogenesis through multiple pathways. …”
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Methyl Indole-3-Acetate (MEIAA) mediated stem curvature and apical meristem necrosis in Ageratina adenophora: impacts on cell wall components, vascular system integrity, and key me... by Yanan Ruan, Xi Gao, Mehboob Hussain, Xiaoping Qin, Jingyi Ning, Dewei Yang, Tao Zhu, Deqiang Qin, Min Ye, Guoxing Wu

“…., elevated D-mannose, D-galactose; altered starch/sucrose pathways) and phenylpropanoid biosynthesis (suppressed lignin precursors: coniferaldehyde, sinapaldehyde). …”
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An exhaustive examination of the research progress in identifying potential JAK inhibitors from natural products: a comprehensive overview by Wendong Yang, Jiabin Lu, Peihua Luo, Zhifei Xu, Hao Yan, Bo Yang, Qiaojun He, Jialin Zhou, Xiaochun Yang

“…Abstract The JAK-STAT signaling pathway serves as a central regulator of diverse cellular processes encompassing proliferation, apoptosis, inflammation, and differentiation. …”
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High-intensity training and irisin response: A possible molecular cross-talk for irisin response by Ping Li, Ligang Tong, Xuecui Bi

“…The present review discussed how high-intensity training (HIT) triggers the irisin response by activating its upstream and downstream molecular signaling pathways and how HIT helps to cross-talk these signaling pathways to improve irisin response.…”
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Targeting STARD4/EGFR axis inhibits growth and overcomes lenvatinib resistance in hepatocellular carcinoma by Mengting Liu, Yixin Liu, Jiahui Zheng, Xiangping An, Jiayong Wen, Fengchi Zhu, Jin Jia, Dan Guo, Nana Chen

“…This study aims to investigate the impact of STARD4, a crucial cholesterol transporter, on HCC growth and lenvatinib resistance, as well as explore the involvement of the EGFR/PI3K/AKT signaling pathway in STARD4's role. Analysis of clinical samples from HCC patients revealed increased expression of both STARD4 and EGFR in tumor tissues, with a strong correlation between STARD4 expression and malignancy progression. …”
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CD19+CD11c+T-bet+ B cells in myasthenia gravis: a potential biomarker by Yaru Lu, Huimin Shen, Yiye Wang, Kai Ma, Ruihua Sun, Ying Zhao, Yaqiong Li, Qian Ma, Jiewen Zhang

“…Statistical analyses included differential protein expression, pathway enrichment, and receiver operating characteristic (ROC) curve evaluation.ResultsProteomics revealed significant activation of the B cell receptor and NF-κB/c-Rel signaling pathways in MG patients, validated by upregulated NF-κB/c-Rel expression (p < 0.01). …”
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FGF15/FGFR4 signaling suppresses M1 macrophage polarization and multi-organ inflammation in septic mice by inhibiting H3K18 lactylation-driven Irf7 expression through NF2-Hippo act... by Bo Li, Jiayu Li, Zexiang Zhu, Yong Tang, Yun Zhou, Geshu Du, Xing Li

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Targeting Wnt-driven metabolic adaptations in cancer: integrating glycolysis, glutaminolysis, IDO1-mediated immune evasion, and therapeutic delivery strategies by Eric Flores-Hernández, Grace Binder, Kuo-Ching Mei, Kuo-Ching Mei, Nydia Tejeda-Muñoz, Nydia Tejeda-Muñoz

“…The Wnt pathway is an evolutionarily conserved signaling cascade that regulates a wide range of fundamental cellular processes, including proliferation, differentiation, polarity, migration, metabolism, and survival. …”
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QSOX2‐Mediated Disulfide Bond Modification Enhances Tumor Stemness and Chemoresistance by Activating TSC2/mTOR/c‐Myc Feedback Loop in Esophageal Squamous Cell Carcinoma by Wo‐Ming Chen, Xiao‐Ping Zhang, Xiao Sun, Hai‐Cheng Liu, Yuan‐Yuan Yan, Xue Wei, Yu Liang, Yue Feng, Zhengjie Chen, Yongxu Jia, Chen Jiang, Qian Yan, Lei Li

“…Mechanistically, QSOX2 enhances disulfide bond formation in TSC Complex Subunit 2 (TSC2), stabilizing TSC2‐Akt interactions, facilitating phosphorylation of TSC2 at the Ser939 by Akt, and further activating mTOR/4E‐BP1/c‐Myc signaling axis. Intriguingly, cancer‐associated fibroblasts‐secreted IGF‐1 upregulates QSOX2 expression via IGF1R/Akt/mTOR/c‐Myc pathway, establishing a positive feedback loop that sustains ESCC cell stemness. …”
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A fibrin gel-loaded Gouqi-derived nanovesicle (GqDNV) repairs the heart after myocardial infarction by inhibiting p38 MAPK/NF-κB p65 pathway by Huan-Huan Zhou, Xiaolei Zhou, Jianqiu Pei, Shiyin Xu, Biyu Jin, Jiuling Chen, Zixuan Zhang, Mingmeng Tang, Yan Liu, Andreas K. Nüssler, Liegang Liu, Qin Xu, Anxin Wang, Min Xia, Wei Yang

“…Through a combination of transcriptomics and proteomics analyses, alongside in vitro and in vivo experiments, we identified that the cardioprotective effect of GqDNVs are mediated through the inhibition of the p38 MAPK-NF-κB p65 signaling pathway. Furthermore, GqDNVs contain abundant bioactive compounds, including proteins, genetic materials, lipids, polysaccharides, and flavonoids. …”
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