An 8-week physical exercise intervention for e'athletes improves physical performance rather than short-term esports performance parameters - a randomized controlled trial by Felix Wachholz, Nicole Gamper, Martin Schnitzer

“…Participants reported that engaging in physical activity within the context of esports and gaming positively contributed to their overall well-being. Clinical Trial RegistrationClinicalTrials.gov, identifier (NCT06264375).…”
Get full text

Rivaroxaban versus low molecular weight heparin for managing lower extremity deep vein thrombosis following thoracoscopic lung cancer surgery: a randomized controlled trial by Lidan Zhang, Di Wu, Liang Li, Qin Zhao, Hailing Yang, Xiaoyong Han, Liang Liu, Lu Gao

Get full text

The anti-PD-L1/CTLA-4 bispecific antibody KN046 plus lenvatinib in advanced unresectable or metastatic hepatocellular carcinoma: a phase II trial by Da Xu, Hongwei Wang, Quan Bao, Kemin Jin, Ming Liu, Wei Liu, Xiaoluan Yan, Lijun Wang, Yanqiao Zhang, Guangyu Wang, Yue Ma, Zhigang Ma, Chunhui Zhang, Jiebing Tang, Sha Wang, Jiaohui Pang, Ting Xu, Kun Wang, Baocai Xing

“…Abstract This open-label phase II trial (NCT04542837) aimed to evaluate the efficacy and safety of KN046 combined with lenvatinib in patients with advanced hepatocellular carcinoma (HCC), and explore the potential response biomarkers. …”
Get full text

Heavy slow resistance training, radial extracorporeal shock wave therapy or advice for patients with tennis elbow in the Norwegian secondary care: a randomised controlled feasibili... by Jens Ivar Brox, Marianne Bakke Johnsen, Cecilie Roe, Aasne Fenne Hoksrud, Håkon Sveinall, Kaia B Engebretsen

“…Shock wave therapy and information and advice should be investigated further in a full-scale randomised controlled trial including sham shock wave therapy.Trial registration number NCT04803825.…”
Get full text

Effect of knee extension constraint training on walking biomechanics 6 months after anterior cruciate ligament reconstruction: a double-blind randomized controlled clinical trial by Tianyu Gao, Hongshi Huang, Yuanyuan Yu, Hui Liu, Yingfang Ao

Get full text

Comparison of the two treatment methods in primary hyperparathyroidism due to solitary parathyroid adenoma, Ultrasound-guided percutaneous alcohol ablation vs. parathyroidectomy: a... by Mohammad Eslamian, Babak Tavakoli, Alireza Firouzfar, Alireza Pouramini, Bijan Iraj, Mohsen Kolahdouzan, Marjan Mansourian

“…Method A single-centered randomized, not-blinded parallel clinical trial in consecutive patients with pHPT treated with percutaneous alcohol ablation (PEA) between January 2020 and November 2021. …”
Get full text

Comparison of the effectiveness of the helmet interface using flow meters versus the mechanical ventilator for non-invasive ventilation in patients with coronavirus disease 2019. C... by Fernanda dos Reis Ferreira, João Carlos Ferrari Correa, Eduardo Storopoli, Diego Restivo Faria, Karina Cassaro, Natália Feitosa da Hora, Raphael Ritti, Rafael Akira Becker, Simone Dal Corso, Ivan Peres Costa, Luciana Maria Malosá Sampaio

“…Material and methods We conducted a single-center randomized clinical trial involving 100 adult SARS-CoV-2 patients in a specialized private hospital. …”
Get full text

Effects on impulsivity and delay discounting of intermittent theta burst stimulation add-on to dialectical behavioral therapy in borderline personality disorder: a randomized, sham... by Milenko Kujovic, Christian Bahr, Mathias Riesbeck, Daniel Benz, Martina Deiß, Zsofia Margittai, Sebastian Henges, Dirk Reinermann, Christian Plewnia, Eva Meisenzahl

“…Results A mixed model repeated measures analysis with a 2 × 2 factorial between-subjects design showed a significant overall improvement over time in impulsivity but not in decision-making/delay discounting. …”
Get full text

Chinese patent medicine tongxinluo capsule as a supplement to treat chronic coronary syndromes: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials by Shi-Bing Liang, Shi-Bing Liang, Shi-Bing Liang, Yi-Fei Wang, Yi-Fei Wang, Yi-Fei Wang, Zhen-Chao Niu, Zhen-Chao Niu, Yu-Fei Li, Hui-Min Zheng, Hui-Min Zheng, Jia-Ming Huan, Jie Yuan, Nicola Robinson, Nicola Robinson, Jian-Ping Liu, Yun-Lun Li, Yun-Lun Li, Yun-Lun Li

“…Tongxinluo capsules (TXL) are widely used in China for treating CCS.ObjectivesTo systematically evaluate the therapeutic effects and safety of adding TXL to Western medical treatment (WM) for CCS.MethodsWe searched PubMed, Cochrane Library, CNKI, VIP, and Wanfang databases up to August 2024 for randomized controlled trials (RCTs) investigating the therapeutic effects and safety of combining TXL with WM compared to WM alone for CCS. …”
Get full text

Clinical benefits of modifying the evening light environment in an acute psychiatric unit: A single-centre, two-arm, parallel-group, pragmatic effectiveness randomised controlled t... by Håvard Kallestad, Knut Langsrud, Melanie Rae Simpson, Cecilie Lund Vestergaard, Daniel Vethe, Kaia Kjørstad, Patrick Faaland, Stian Lydersen, Gunnar Morken, Ingvild Ulsaker-Janke, Simen Berg Saksvik, Jan Scott

“…Modifying inpatient evening light exposure may be a low-intensity intervention for mental disorders, but few randomised controlled trials (RCTs) exist. We report a large-scale pragmatic effectiveness RCT exploring whether individuals with acute psychiatric illnesses experience additional benefits from admission to an inpatient ward where changes in the evening light exposure are integrated into the therapeutic environment.…”
Get full text

Effectiveness of Different Intervention Modes in Lifestyle Intervention for the Prevention of Type 2 Diabetes and the Reversion to Normoglycemia in Adults With Prediabetes: Systema... by Yachen Wang, Xin Chai, Yueqing Wang, Xuejun Yin, Xinying Huang, Qiuhong Gong, Juan Zhang, Ruitai Shao, Guangwei Li

“…This review included randomized controlled trials (RCTs) that studied the effectiveness of lifestyle interventions in adults with prediabetes. …”
Get full text

Factors influencing role preferences in decision-making of healthy women with BRCA1/2 pathogenic variants: subanalysis from a randomised controlled decision coaching trial by Sibylle Kautz-Freimuth, Arim Shukri, Claudia Stracke, Anna Isselhard, Birte Berger-Höger, Anke Steckelberg, Frank Vitinius, Nicola Dikow, Marion Kiechle, Cornelia Meisel, Achim Wöckel, Marion Tina von Mackelenbergh, Rita Schmutzler, Kerstin Rhiem, Stephanie Stock

“…With this profile, the DC programme expands the existing counselling and care concept to include a measure that can also specifically cover the support needs of younger women and those with a lower education level. Trial registration DRKS-ID: DRKS00015527. Registered 30/10/2019.…”
Get full text

PReventing Idiopathic SCOliosis PROgression (PRISCOPRO): A protocol for a quadruple-blinded, randomized controlled trial comparing 3D designed Boston brace to standard Boston brace... by Elias Diarbakerli, Anastasios Charalampidis, Allan Abbott, Paul Gerdhem

“…<h4>Trial registration</h4>The protocol has been registered on ClinicalTrials.gov, identifier: NCT04805437.…”
Get full text

Effectiveness of Contralaterally Controlled Functional Electrical Stimulation versus Neuromuscular Electrical Stimulation on Upper Limb Motor Functional Recovery in Subacute Stroke... by Songhua Huang, Peile Liu, Yinglun Chen, Beiyao Gao, Yingying Li, Chan Chen, Yulong Bai

Get full text

Application and Clinical Effectiveness of Antibiotic-Loaded Bone Cement to Promote Soft Tissue Granulation in the Treatment of Neuropathic Diabetic Foot Ulcers Complicated by Osteo... by Regis Ernest Mendame Ehya, Hao Zhang, Baiwen Qi, Aixi Yu

Get full text

Efficacy and safety of dexamethasone or triamcinolone in combination with anti-vascular endothelial growth factor therapy for diabetic macular edema: A systematic review and meta-a... by Bo Zhou, Hua Liu, Feng Xiong

Get full text

Raising awareness of alcohol as a modifiable risk factor for breast cancer: A randomized controlled trial comparing the efficacy of accessing an interactive website with a non-inte... by Claudia Sardu, Fabrizio Angius, Paolo Contu, Sofia Cosentino, Monica Deiana, Matteo Fraschini, Clelia Madeddu, Elena Massa, Alessandra Mereu, Luigi Minerba, Carola Politi, Silvia Puxeddu, Francesco Salis, Julia M.A. Sinclair, Roberta Agabio

“…Conclusion: Our results show that accessing an interactive website may increase the percentage of women who acquire the knowledge that alcohol is a BC risk factor especially among women of lower levels of education.…”
Get full text

HER-SAFE study design: an open-label, randomised controlled trial to investigate the safety of withdrawal of pharmacological treatment for recovered HER2-targeted therapy-related c... by Robin Chung, James C Moon, Alexander R Lyon, Charlotte H Manisty, Muhummad Sohaib Nazir, Malcolm Walker, Peter Kellman, Benjamin Dowsing, Daniel Chen, Jessica Artico, Mark Westwood, Hakim-Moulay Dehbi, Rebecca Roylance, Tom Crake, Peter Schmid, Arjun Ghosh, Maria Sol Andres, Joanna Pedra, Orla Worn

“…Introduction A quarter of breast cancers show human epidermal growth factor-2 (HER2) overexpression, where targeted therapy dramatically improves survival. …”
Get full text

Effect of mechanical debridement with and without adjunct antimicrobial photodynamic therapy for the treatment of peri-implant disease in obese patients: A systematic review and me... by Sultan Albeshri, Raed AlRowis

“…Results: Three randomized controlled trials (RCTs) were included. The number of participants ranged between 49 and 80 individuals. …”
Get full text

Effect of General Anesthesia Combined with Transversus Abdominis Plane Block on Postoperative Sleep Disorders in Elderly Patients Undergoing Gastrointestinal Tumor Surgery: A Prosp... by Pu J, Guo C, Xiao Y, Cao Y, Liu Z, Jin Y, Hu Y

Get full text