Prefrontal cortex synchronization with the hippocampus and parietal cortex is strategy-dependent during spatial learning by Francisca García, Maria-José Torres, Lorena Chacana-Véliz, Nelson Espinosa, Wael El-Deredy, Pablo Fuentealba, Ignacio Negrón-Oyarzo

“…However, the mechanism underlying the prefrontal coordination with HPC and PPC during spatial learning is poorly understood. Here we show that during navigation trials, mice displayed two sequential behavioral stages: searching and exploration. …”
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Dietary Solid-state-fermentation product of Bacillus velezensis T23 alleviate hepatic steatosis, oxidative stress, gut barrier damage, and microbiota dysbiosis in juvenile genetica... by Qiang Hao, Rolf Erik Olsen, Einar Ringø, Qianwen Ding, Tsegay Teame, Yuanyuan Yao, Chao Ran, Yalin Yang, Zhen Zhang, Zhigang Zhou

“…After 4 weeks of the feeding trial, the results showed that T23 supplementation notably reduced the hepatocytes vacuolization and the content of liver TAGs by downregulated the mRNA expression of the lipogenesis gene (fas), while upregulated the mRNA expression of lipid degradation genes (cpt1 and pparα) (p < 0.05). …”
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Pumpkin seed oil-loaded chitosan nanoparticles enhance growth, digestive enzymes, and immune response in whiteleg shrimp (Litopenaeus vannamei): Impacts on histopathology and survi... by El-Sayed Hemdan Eissa, Wesam Mohamed Salama, Samia Elbahnaswy, Mai A.M. El-Son, Zienab E. Eldin, Sara Amer, Layla A. Almutairi, Fatma Mohamed Ameen Khalil, Safia M.A. Bahshwan, Mada M. AL-Qurashi, Yasmin M. Abd El-Aziz, Moaheda E.H. Eissa, Aiman A. Alsaegh, Roshmon Thomas Mathew, El Sayed Taha Rizk

“…At the end of the feeding trial, shrimp juveniles were exposed to V. parahaemolyticus. …”
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Evaluation of single and multispecies probiotic applications for the prevention of Motile Aeromonads Septicaemia in gourami, Osphronemus gourami by Agista Tsani Untsa, Widanarni Widanarni, Sukenda Sukenda, Usamah Afiff, Munti Yuhana

“…In vitro test results showed that single and multispecies probiotics significantly (P<0.05) inhibited A.hydrophila RifR. …”
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Distinct immune cell infiltration patterns in pancreatic ductal adenocarcinoma (PDAC) exhibit divergent immune cell selection and immunosuppressive mechanisms by Shivan Sivakumar, Ashwin Jainarayanan, Edward Arbe-Barnes, Piyush Kumar Sharma, Maire Ni Leathlobhair, Sakina Amin, David J. Reiss, Lara Heij, Samarth Hegde, Assaf Magen, Felicia Tucci, Bo Sun, Shihong Wu, Nithishwer Mouroug Anand, Hubert Slawinski, Santiago Revale, Isar Nassiri, Jonathon Webber, Gerard D. Hoeltzel, Adam E. Frampton, Georg Wiltberger, Ulf Neumann, Philip Charlton, Laura Spiers, Tim Elliott, Maria Wang, Suzana Couto, Thomas Lila, Pallavur V. Sivakumar, Alexander V. Ratushny, Mark R. Middleton, Dimitra Peppa, Benjamin Fairfax, Miriam Merad, Michael L. Dustin, Enas Abu-Shah, Rachael Bashford-Rogers

“…Analysis of patients from the APACT clinical trial shows that myeloid enrichment had a shorter overall survival compared to those with adaptive cell enrichment. …”
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Multimodal machine learning enables AI chatbot to diagnose ophthalmic diseases and provide high-quality medical responses by Ruiqi Ma, Qian Cheng, Jing Yao, Zhiyu Peng, Mingxu Yan, Jie Lu, Jingjing Liao, Lejin Tian, Wenjun Shu, Yunqiu Zhang, Jinghan Wang, Pengfei Jiang, Weiyi Xia, Xiaofeng Li, Lu Gan, Yue Zhao, Jiang Zhu, Bing Qin, Qin Jiang, Xiawei Wang, Xintong Lin, Haifeng Chen, Weifang Zhu, Dehui Xiang, Baoqing Nie, Jingtao Wang, Jie Guo, Kang Xue, Hongguang Cui, Jinwei Cheng, Xiangjia Zhu, Jiaxu Hong, Fei Shi, Rui Zhang, Xinjian Chen, Chen Zhao

“…This proof-of-concept study highlights the potential of chatbot-based multimodal AI for self-diagnosis and self-triage. (The clinical trial was registered on June 26, 2023, on ClinicalTrials.gov under the registration number NCT05930444.).…”
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Busting the Breast Cancer with AstraZeneca’s Gefitinib by S. Chemmalar, A. R. Intan Shameha, Che Azurahanim Che Abdullah, Nor Asma Ab Razak, Loqman Mohamad Yusof, Mokrish Ajat, Kim Wei Chan, Md Zuki Abu Bakar Zakaria

“…Unfortunately, in clinical trials, GEF did not show the outcomes expected with complete response and disease progress. …”
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Gamma delta T cells in acute myeloid leukemia: biology and emerging therapeutic strategies by Venkata Lokesh Battula, Abhishek Maiti, Adishwar Rao, Akriti Agrawal, Gautam Borthakur

“…Clinical trials leveraging γδ T cell biology have used unmodified and modified allogeneic cells as well as bispecific engagers and monoclonal antibodies. …”
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A non-randomised open-label exploratory ‘window of opportunity’ study of TG02 treatment in patients with locally advanced primary and recurrent RAS mutant colorectal cancer by Sara Roth, Kasmira Claire Wilson, Robert George Ramsay, Catherine Mitchell, Shienny Sampurno, Toan Duc Pham, Joseph Cherng Huei Kong, Stephen Q. Wong, Alexander Graham Heriot, Sanjeev Deva, Matthew Burge, Cecilie Sverdrup, Anne-Sophie Moller, Lukasz Kuryk, Jon Amund Eriksen, Magnus Jaderberg, John Raymond Zalcberg, Michael Michael

“…This phase 1 clinical trial (NCT02933944) assessed the safety and immunological efficacy of TG02 adjuvanted by GM-CSF in patients with KRAS-mutant colorectal cancer. …”
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How effective is undergraduate palliative care teaching for medical students? A systematic literature review by Jason W Boland, Jane Gibbins, Megan E L Brown, Gabrielle M Finn, Angelique Duenas

“…Screening, data extraction and quality assessment (mixed methods and Cochrane risk of bias tool) were performed in duplicate.Data sources Embase, MEDLINE, PsycINFO, Web of Science, ClinicalTrials.gov, Cochrane and grey literature in August 2019. …”
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Effect of implant abutment surface treatments on bacterial biofilm composition and structure by Eduardo Anitua, Alia Murias-Freijo, Roberto Tierno, Ricardo Tejero, Mohammad Hamdan Alkhraisat

“…Titanium nitride (TiN) coatings show antimicrobial properties. Nevertheless, there is a lack of clinical trials that assess the biofilm formation on TiN abutments in the context of clinical practice. …”
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Adjuvant Hormonal Therapy in Postmenopausal Women with Breast Cancer: Physician’s Choices by Asim Jamal Shaikh, Shiyam Kumar, Sajjad Raza, Maria Mehboob, Osama Ishtiaq

“…Clinical trials leading to firm recommendations to set standards from which patients benefit the most are needed.…”
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Employing the Oncolytic Vesicular Stomatitis Virus in Cancer Virotherapy: Resistance and Clinical Considerations by Alaa A. Abdelmageed, Stephen Dewhurst, Maureen C. Ferran

“…Several VSV-based phase I/II clinical trials show promise; however, addressing resistance and developing novel strategies to enhance therapeutic efficacy are essential for realizing the full potential of VSV oncolytic virotherapy. …”
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Control of Magnetic Manipulator Using Reinforcement Learning Based on Incrementally Adapted Local Linear Models by Martin Brablc, Jan Žegklitz, Robert Grepl, Robert Babuška

“…However, having a model brings benefits, mainly in terms of a reduced number of unsuccessful trials before achieving acceptable control performance. …”
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From Bench to Bedside to Bug: An Update of Clinically Relevant Advances in the Care of Persons with Helicobacter pylori Associated Diseases by N Chiba, ABR Thomson, P Sinclair

“…The role of H pylori eradication in persons with uninvestigated dyspepsia remains controversial. New clinical trials of H pylori treatment show symptom relief and improvement in the quality of life of persons with functional dyspepsia, especially in those with ulcer-like or reflux-like dyspepsia. …”
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Research on treatment-related aspects of depression from India in the preceding decade (2014–2023): An updated systematic review by Alankrit Jaiswal, S Umesh, Nishant Goyal

“…Neuro-modulation studies show promise, but larger-scale studies are needed. …”
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Natural products as anticancer agents and enhancing their efficacy by a mechanism-based precision approach by Stephen Safe

“…Many of the compounds perform poorly in clinical trials due to pharmacokinetic consideration and limited uptake (e.g., curcumin) and these are issues that can be addressed. …”
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Bolder together: conformity drives behavioral plasticity in eastern gartersnakes by Morgan Skinner, Gokulan Nagabaskaran, Tom Gantert, Noam Miller

“…Pairs were assigned based on the data from the solo trials, such that each snake was paired once with a bolder and once with a less bold partner. …”
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Temperature and Humidity Monitoring in Hydroponic Cultivation Based on Internet of Things: Dataset Development for Smart Agriculture by Simon Prananta Barus, Jeriko Ichtus Seo

“…The results of the research show that the developed system can monitor temperature and humidity in real-time with a good level of accuracy. …”
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Cost-effectiveness analysis of romosozumab for severe postmenopausal osteoporosis at very high risk of fracture in Mexico. by Juan Pablo Diaz Martinez, Therese Aubry de Maraumont, Elly Natty Sánchez, Luis Miguel Camacho Cordero, Eric Yeh

“…<h4>Conclusions</h4>Results show that romosozumab/ denosumab produces greater health benefits at a lower total cost than teriparatide/ denosumab.…”
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