Lung function impairment and eosinophilia in patients with eosinophilic chronic rhinosinusitis by Yuki Sonoda, MD, Yoshimasa Imoto, MD, PhD, Ayako Maegawa, MD, Anna Shimizu, MD, Masanori Kidoguchi, MD, PhD, Rikako Gozawa, MD, Keisuke Koyama, MD, Naoto Adachi, MD, Taiyo Morikawa, MD, PhD, Yuto Miyazaki, MD, Takahiro Tokunaga, MD, PhD, Masafumi Sakashita, MD, PhD, Shigeharu Ueki, MD, PhD, Takechiyo Yamada, MD, PhD, Shigeharu Fujieda, MD, PhD

“…The Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis score correlated with lung function and Feno. …”
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Treatment of chronic lymphocytic leukaemia and autoimmune complications with antibody targeted to the CD52 antigen (Campath) - the first Russian experience by T. E. Byalik, O. L. Timofeeva, M. A. Volkova

“…It shows efficacy with response rate of 35% in treatment of patients with chronic lymphocytic leukemia (CLL) who were refractory to fludarabine. A first-line therapy with Campath demonstrates efficacy in more than 80% of CLL patients. …”
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Mutation in the CREBBP Gene in the Girl with Toe Walking Syndrome: Clinical Case by David Pomarino, Anneke Thren, Johanna R. Thren, Kevin Rostasy, Anna A. Emelina

“…The pathogenic nucleotide variant c.5600G>A in heterozygous state in the CREBBP gene was revealed in our 9-year-old female patient with refractory toe walking and developmental speech delay. …”
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Duodenal Mucosa-associated Lymphoid Tissue Lymphoma Treated with Chemotherapy by Jee young An, Joon Sung Kim, Byung Wook Kim

“…A 58-year-old man was treated for a refractory duodenal ulcer. Based on repeated biopsy, a diagnosis of MALT lymphoma was made. …”
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Editorial: Advances in nanotechnology for water treatment by Samuel Eshorame Sanni, Samuel Eshorame Sanni, Emmanuel Emeka Okoro, Emmanuel Rotimi Sadiku, Kolawole Oluseyi Ajanaku, Mithun Nath, Shivani Pandya

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Successful treatment of recurrent knee hemarthrosis after total knee arthroplasty using Bactisure wound lavage during synovectomy: A novel intervention by Jayson Messieh

“…This report highlights the first documented use of Bactisure lavage during synovectomy, suggesting a novel, effective approach for managing refractory hemarthrosis in patients after undergoing total knee arthroplasty.…”
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EXPERIENCE OF RITUXIMAB USE IN A PATIENT WITH SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS by E. I. Alekseeva, E. V. Mitenko, T. M. Bzarova, S. I. Valieva, R. V. Denisova, T. V. Sleptsova, K. B. Isaeva, E. L. Semykina, E. G. Chistyakova, A. N. Fetisova

“…The article presents a case of early onset and severe systemic form of juvenile idiopathic arthritis refractory to classical immunosuppressive therapy, including pulse therapy with methotrexate and combined therapy with methotrexate and cyclosporine. …”
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Vaccinoprophylaxis of infections and activity of immuno-inflammatory rheumatic diseases: pro et contra by B. S. Belov, N. V. Muravyeva

“…However, a number of patients with IIRD have a refractory course of the disease, and achieving remission in them turns out to be a difficult task, and therefore the problem of vaccination of such patients against the background of an active inflammatory process is very relevant. …”
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Development of technology for lining steel-tapping hole of steel-teeming ladles with the use of nesting well blocks by D. N. Khvesenja, A. L. Artamoshin, A. K. Turygin, D. V. Danilov

“…The purpose of the tests is to replace the «traditional» filling of the steel outlet with refractory concrete manually by molded nesting wellblocks due to the reduced risk of accident due to the lack of probability of metal «penetration» into the concrete, as well as reducing the volume and duration of repair of the working lining of steel ladles.…”
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Efficacy and safety of fluocinolone acetonide intravitreal implant (0.2 µg/day) in patients with post-surgical inflammation associated with macular edema: a case series study by Maria Madeira, Ana Cabugueira, Helena Urbano, Miguel Cordeiro, Marta Guedes

“…This study aimed to evaluate the effectiveness and safety of the fluocinolone acetonide intravitreal (FAc) implant (0.2 µg/day) in patients with refractory PCME. Methods Retrospective, non-interventional, and single center study conducted on patients with PCME treated with 0.2 µg/day FAc implant. …”
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Biological foundations of successful bacteriophage therapy by Carola Venturini, Aleksandra Petrovic Fabijan, Alicia Fajardo Lubian, Stefanie Barbirz, Jonathan Iredell

“…Abundant and ubiquitous in nature, phages can be used to treat bacterial infections (phage therapy), including refractory infections and those resistant to antibiotics. …”
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Paraneoplastic Pemphigus: A Case Report by Nidhi Shah, Rosina Paudel, Arpana Rijal

“…Targetoid lesions, intractable stomatitis and refractory course of disease are some of the characteristic features of paraneoplastic pemphigus. …”
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Paraneoplastic Pemphigus: A Case Report by Nidhi Shah, Rosina Paudel, Arpana Rijal

“…Targetoid lesions, intractable stomatitis and refractory course of disease are some of the characteristic features of paraneoplastic pemphigus. …”
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PO44 | Emicizumab in acquired haemophilia A

“…We describe the successful treatment of a refractory patient who had been hospitalized for an extended period and was discharged after just one week following the initiation of Emicizumab. …”
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A rare case of acute destructive pancreatitis in a patient with chronic kidney disease on peritoneal dialysis: diagnostic and treatment challenges by V. A. Stepanov, O. N. Vetchinnikova

“…Repeated ultrasound examination revealed signs of diffuse changes in the pancreas and multi-chamber formation of the small pelvis. Refractory peritonitis, inadequate ultrafiltration, and unclear nature of formation in the pelvic were the grounds for diagnostic laparoscopy and removal of the peritoneal catheter. …”
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Imaging insights in acute iron toxicity by Shiyam Sundaran, Murugan Gopalakrishnan, Venkatraman Indiran, Baskar A, Vetri Vignesh, Anchal Gupta

“…Despite treatment with deferoxamine chelation and hemodialysis, the patient's condition worsened over 72 hours, further progressing to multi-organ failure with refractory shock, culminating in cardiac failure. Despite aggressive supportive care, she succumbed to her illness. …”
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Dysmasema: Persistent Decline in Masticatory Function Related to Aging and Systemic Factors by Chia-Shu Lin, Ta-Chung Chen

“…In this narrative review, the authors review of the current research on masticatory dysfunction associated with systemic factors, and proposed the concept of Dysmasema - a persistent condition of masticatory dysfunction refractory to dental treatment and associated with aging and systemic factors. …”
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Highlights on immune checkpoint inhibitors in non–small cell lung cancer by Meng Shen, Xiubao Ren

“…The treatment of advanced or refractory non–small cell lung cancer has been historically difficult owing to the lack of studies on effective systemic cure. …”
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Evaluation of linear alteration of NiCr castings using two phosphate - bonded investments with different compositions by Carlos M. Goshi, Eduardo E. S. Almeida, Fernando E. Takahashi, Alexandre H. de M. Dias

“…The aim of this work was to verify the linear alteration of castings using two phosphate – bonded investments, one with granuled ceramic – based refractory (Microfine 1700), and the other by cristobalite (Bellavest – T). …”
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A case of buccal squamous cell carcinoma recurrence repaired by giant anterolateral thigh flap under the cooperation of multi-disciplinary team by XIANG Feng, KANG Xiao, LU Liguang, WU Dong

“…[Conclusion:] For patients with refractory oral cancer such as recurrence and advanced periods, a "personalized" treatment plan can be formulated in the MDT mode, which is worthy of clinical promotion.…”
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