Cohesive data analysis for the identification of prognostic hub genes and significant pathways associated with HER2 + and TN breast cancer types by Mahrukh Zakir, Alishbah Saddiqa, Mawara Sheikh, Lalarukh Zakir, Fatima Sami, Faisal Sardar Ahmad, Sadaf Abdul Rauf, Iqra Ali, Zahid Muneer, Wadi B. Alonazi, Abdul Rauf Siddiqi

“…The KEGG (Kyoto Encyclopedia of Genes and Genomes) and GO (Gene Ontology) analyses of DEGs were conducted on DAVID (the Database for Annotation, Visualization and Integrated Discovery) and interaction network was constructed through Cytoscape. Ten hub genes were obtained based on maximum clique centrality (MCC), maximum neighborhood component (MNC), degree, closeness and betweenness using cytoHubba which included ACTB, ATM, ESR1, GAPDH, HNRNPK, KRAS, MDM2, SIRT1, TP53, and H3F3C (H3-5). …”
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