Research progress on the mechanisms of apolipoprotein E in Alzheimer’s disease by Jiayuan Li, Ting Liu, Shengxi Meng

“…Alzheimer’s disease (AD) is a degenerative disorder of the central nervous system that predominantly affects the elderly.The Apolipoprotein E (ApoE) gene is identified as the most significant genetic factor associated with AD.This article reviews current findings on the relationship between ApoE and AD, the impact of APOE gene polymorphisms on AD, the interaction between ApoE and other pathogenic factors, and the role of ApoE in AD.Additionally, it discusses the diagnosis and treatment of AD to enhance the understanding of its pathogenesis and to provide new perspectives for the prevention and management of the disease.…”
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La rebelión de los tibios. Dos reacciones anti-progresistas en la Francia de inicios del siglo XXI by José Antonio Rubio Caballero

“…Ideological apathy has aroused little interest among historians and sociologists. …”
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Analysis of the Correlations between the Characteristics of miRNAs Expression in Serum or Plasma and Hyperactivity of Liver-YANG Syndrome of Hypertension by Changgeng FU

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Changes in sensor recorded activity patterns and neuropsychiatric symptoms after deep brain stimulation for Parkinson’s disease: 5 case reports by Lena C. Bruhin, Michael Single, Aileen C. Naef, Katrin Petermann, Mario Sousa, Matilde Castelli, Ines Debove, Marie E. Maradan-Gachet, Andreia D. Magalhães, Andreas A. Diamantaras, M. Lenard Lachenmayer, Gerd Tinkhauser, Julia Waskönig, Christopher M. el Achkar, Alia Lemkaddem, Mathieu Lemay, Paul Krack, Tobias Nef, Deborah Amstutz

“…In the two patients without baseline ICDs, mild anxiety and apathy improved postoperatively, and no new neuropsychiatric symptoms occurred. …”
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Neuropsychiatric Symptoms in Clinically Defined Parkinson’s Disease: An Updated Review of Literature by Paloma Macías-García, Raúl Rashid-López, Álvaro J. Cruz-Gómez, Elena Lozano-Soto, Florencia Sanmartino, Raúl Espinosa-Rosso, Javier J. González-Rosa

“…The most frequent NPS were mood disorders (apathy, depression, and anxiety), psychosis, and impulse control disorders (ICD). …”
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Rediscovering Mikola Husouski: Carmen De Statura Feritate Ac Venatione Bisontis In The Light Of Niccolo Machiavelli’s The Prince by Volha Korbut Salman

“…The dawn of the Renaissance saw the appearance of two literary masterpieces – The Prince by Niccolo Machiavelli in the Florenti ne Republic and Carmen de Statura Feritate ac Venatione Bisontis [The Song about the Bison, Its Stature, Ferocity and Hunt] by Mikola Husouski in the Grand Duchy of Lithuania. Nevertheless, the destiny that awaited the two works was fundamentally different. …”
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Guillaume de Volpiano en Normandie : état des questions by Véronique Gazeau

“…One cannot forget that other foreign reformers came to Normandy before William of Volpiano and after his death (1031) who had a part in the settling of monasticism in the duchy.…”
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L’affaire Flavy-Choinet, un exemple de résolution des conflits au lendemain de la reconquête de la Normandie par Charles VII by Lydwine Scordia

“…The act of May 20, 1464, passed before the tabellion of Rouen, reconstructs a conflict of about half a century (between the time of the Lancastrian monarchy and the after-reconquest of the duchy by Charles VII) between two families, one noble (Flavy) and the other bourgeois (Choinet), about the possession and property of the noble fief of Cliponville (Pays de Caux). …”
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Vigabatrin-Induced Encephalopathy in a 5.5-Month-Old Girl with Infantile Spasms due to Tuberous Sclerosis by Eleni Klinaki, Ioanna Argyri, Georgia Amountza, Gerina Ioannidou, Despoina Maritsi, Anastasia Garoufi, George Vartzelis

“…However, she developed encephalopathy with apathy, drowsiness, and generalized slowing in the EEG. …”
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Les actes des évêques d’Avranches, ca. 990-1253 : esquisse d’un premier bilan by Richard Allen

“…Of course, the history of the diocese of Avranches, which was the smallest as well as the poorest of the ecclesiastical province of Rouen, is marked by some of the greatest misfortunes to befall the duchy’s patrimony (the collapse of the cathedral, the destruction of the archives of Saint-Lô), but enough material does survive to allow not only for an insight into one of the lesser-known episcopal chanceries of Normandy, but also for the opportunity to better understand numerous historical, diplomatic, archaeological, prosopographical and topographical facts.…”
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Handbook of Florida Fence and Property Law: Adjoining Landowners by Christopher A. Hill, Michael T. Olexa, Jeffery Van Treese II

“…Of interest to farmers and farmland owners in particular, this handbook is designed to inform property owners of their rights and responsibilities in terms of their duty to fence. Discussed areas include a property owner’s responsibility to fence when livestock is kept on the property, the rights of adjoining landowners to fence, the placement of fences, encroachments, boundary lines, easements, contracts, nuisances, and a landowner’s responsibilities towards persons who enter his property. …”
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Virtue and vice in environmental discourse by Dominika Dzwonkowska

“…On the opposite side of the barricade are the following vices: egoism, greed, arrogance, ignorance (stupidity), and apathy.…”
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Резолюция Экспертного совета «Диагностика и лечение больных со сладжем в желчном пузыре» by V. T. Ivashkin, Alexey V. Okhlobystin, Dmitry S. Bordin, M. F. Osipenko, E. Ya. Seleznyova, Yu. O. Shulpekova, S. R. Abdulkhakov, O. P. Alexseyeva, I. G. Bakulin, L. G. Vologjhanina, V. B. Grinevich, N. V. Bakulina, T. A. Kolesova, N. V. Korochanskaya, I. V. Putintseva, A. S. Sarsenbayeva, N. S. Yazenok

“…Primary treatment course that should include combination of hymecromone and UDCA is indicated for those patients with asymptomatic sludge, who have putty-like bile in the gallbladder or bile ducts. …”
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Handbook of Florida Fence and Property Law: Visitors and Responsibilities to Visitors by Christopher A. Hill, Michael T. Olexa, Jeffery Van Treese II

“…Of interest to farmers and farmland owners in particular, this handbook is designed to inform property owners of their rights and responsibilities in terms of their duty to fence. Discussed areas include a property owner’s responsibility to fence when livestock is kept on the property, the rights of adjoining landowners to fence, the placement of fences, encroachments, boundary lines, easements, contracts, nuisances, and a landowner’s responsibilities towards persons who enter his property. …”
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Naravovarstveno vrednotenje avifavne ob Savi med Krškim in Jesenicami na Dolenjskem s predlogom novega mednarodno pomembnega območja (IBA) za ptice v Sloveniji by Damijan Denac, Jakob Smole, Al Vrezec

“…Kvalifikacijskim kriterijem za opredelitev IBA/SPA Sava med Krškim in Jesenicami na Dolenjskem – (1) vrste dosegajo na območju več kot 1% nacionalne populacije, (2) vrste so zastopane na območju z najmanj dvema paroma, pri čemer je celotna nacionalna populacija večja od pet parov, in (3) vrsta je lahko kvalifikacijska le na petih najpomembnejših območjih v dani evropski regiji (Slovenija) – so ustrezale 3 vrste, kvakač Nycticorax nycticorax, črni škarnik Milvus migrans in vodomec Alcedo atthis. …”
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Impact of Sex on the Nonmotor Symptoms and the Health-Related Quality of Life in Parkinson’s Disease by Márton Kovács, Attila Makkos, Zsuzsanna Aschermann, József Janszky, Sámuel Komoly, Rita Weintraut, Kázmér Karádi, Norbert Kovács

“…Anxiety, pain, sleep disturbances, and orthostatic symptoms were more frequent among females while sexual dysfunction, apathy, and daytime sleepiness were more severe among males. …”
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Bedřich ze Strážnice a husitské posádky ve Slezsku by Martin Čapský

“… In his study, the author focuses on the activity of the Hussite military garrisons in the Silesian duchies in 1428–1435. After a synopsis of the basic stages of the Hussite raids in Silesia, he pays attention to the presence of garrisons deep in the enemy territory and repeatedly returns to the issue of supplying them with military equipment and provisions. …”
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Wady środowiskowe jako etyczne i antropologiczne źródła kryzysu środowiskowego by Dominika Dzwonkowska

“…Thus the five crucial environmental vices are defined as egoism, greed, arrogance, ignorance, and apathy.…”
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Environmental vices as ethical and anthropological roots of the environmental crisis by Dominika Dzwonkowska

“…Thus the five crucial environmental vices are defined as egoism, greed, arrogance, ignorance and apathy.…”
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La « féodalité » et la seigneurie dans la Calabre méridionale normande : une institution politique pour bâtir la paix ? by Riccardo Berardi

“…Robert Guiscard with his brother the Great Count Roger, conquered Calabria: the centre and the north were incorporated in the duchy of Puglia and governed by Guiscard, whereas the south was united to Sicily (as definitively conquered in the last years of the 11th century) and donated to Roger I. …”
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