Integrating high-throughput phenotyping and genome-wide association analyses to unravel Mediterranean maize resilience to combined drought and high temperatures by Rongli Shi, Ana López-Malvar, Dominic Knoch, Henning Tschiersch, Marc C. Heuermann, Salar Shaaf, Delphine Madur, Rogelio Santiago, Carlotta Balconi, Elisabetta Frascaroli, Sekip Erdal, Carine Palaffre, Alain Charcosset, Pedro Revilla, Thomas Altmann

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Comprehensive genomic and phenotypic analyses reveal the genetic basis of fruit quality in litchi by Qian Yan, Junting Feng, Jiezhen Chen, Yingjie Wen, Yonghua Jiang, Yingxiao Mai, Kan Huang, Hailun Liu, Hongsen Liu, Fachao Shi, Yanwei Hao, Changhe Cai, Canye Yu, Liangxi Ou, Rui Xia

“…We then analyze the population structure and reveal four main subgroups within the population. By phenotypic profiling of 21 fruit-quality-related traits, followed with genome-wide association study, we identify a plethora of candidate genes and genomic loci that are responsible for regulating seed and fruit quality traits. …”
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Association of new Life’s Essential 8 with biological aging among the national health and nutrition examination surveys by Xiaoli Chen, Xin Yin, Xin Chen, Yajie Gao, Nan Ye, Xingkang He

“…Linear and logistic regression analyses were used to examine the association between the LE8 score and biological age. …”
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Potential role of SLC6A3 in neurodevelopmental impairments associated with corpus callosum abnormalities: insights from CNV analysis and clinical phenotyping by Shan-yu Liu, Wei Huang, Hui-lin Ou, Li Wang, Dan-dan Wang, Wei-he Tan, Qin She

“…We focused primarily on SLC6A3 associated mechanisms and aimed to delineate genotype-phenotype correlations in our cases. …”
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Unsupervised clustering of biochemical markers reveals health profiles associated with function and survival in active aging by Raquel González-Martos, Javier Galeano, Carmen Ramirez-Castillejo, Narcis Gusi, Eva Gesteiro, German Vicente-Rodriguez, Ignacio Ara, Amelia Guadalupe-Grau

“…Abstract This study explores the relationships between biochemical phenotypes identified using machine learning, and key health outcomes, including body composition, physical function, and mortality risk. …”
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Genome-wide association and fine-mapping analyses identify novel candidate genes affecting serum cortisol levels using imputed whole-genome sequencing data in pigs by Tae-Hee Kim, Hyeon-ah Kim, Jae-Bong Lee, Dongwon Seo, Yuju Lee, Yong Jun Kang, Sang-Geum Kim, Sang-Hyun Han, Seung-Hwan Lee, Cedric Gondro, Hee-Bok Park, In-Cheol Cho

“…We utilized imputed whole-genome sequencing data for our analyses. GWAS results revealed a genome-wide significant quantitative trait locus (q-value < 0.05) located within a ~2.46 Mb region between single nucleotide polymorphisms 7:114031215 and 7:116497417 on pig chromosome 7, which accounted for 12.65% of the phenotypic variation. …”
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High levels of a comprehensive set of matrix metalloproteinases in endometriotic lesions: validating the key role of cellular senescence in endometriosis pathogenesis by Laura Palmieri, Helena Malvezzi, Bruna Cestari de Azevedo, Eduardo Varejão Díaz Placencia, Eliane Antonioli, Sérgio Podgaec

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Gain of bipolar disorder-related lncRNA AP1AR-DT in mice induces depressive and anxiety-like behaviors by reducing Negr1-mediated excitatory synaptic transmission by Shufen Li, Hongyu Ni, Yaping Wang, Xiaohui Wu, Jianqiang Bi, Haiyan Ou, Zhongwei Li, Junjiao Ping, Zhongju Wang, Renhao Chen, Qiong Yang, Meijun Jiang, Liping Cao, Tingyun Jiang, Siqiang Ren, Cunyou Zhao

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EXPRESSION OF PIEZO1 IN CLEAR CELL RENAL CELL CARCINOMA: INSIGHTS FROM BIOINFORMATIC AND IMMUNOHISTOCHEMICAL ANALYSES

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A murine model lacking Lyst recapitulates Chediak-Higashi syndrome with an earlier-onset neurodegenerative phenotype by Sunny Greene, Mackenzie L. Talbert, F. Graeme Frost, Patricia M. Zerfas, Danielle Springer, Audrey Noguchi, Marie Morimoto, Dawn Maynard, Lisa Garrett, Gene Elliot, Maria Traver, David Yarnell, Petcharat Leoyklang, John D. Burke, Elena-Raluca Nicoli, William A. Gahl, Wendy J. Introne, May Christine V. Malicdan

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Introducing the UK Crop Microbiome Cryobank data resource, AgMicrobiomeBase, with case studies and methods on metabarcoding analyses by Payton To Yau, Rodrigo G. Taketani, J. Miguel Bonnin, Helen Stewart, Catriona M.A. Thompson, Ian M. Clark, Tim H. Mauchline, Jacob G. Malone, Matthew J. Ryan, Susan Jones, Nicola Holden

“…Results The focus of this paper is the amplicon sequencing, associated bioinformatics workflows, and development of the project data catalogue. …”
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An Explainable Multimodal Artificial Intelligence Model Integrating Histopathological Microenvironment and EHR Phenotypes for Germline Genetic Testing in Breast Cancer by Zijian Yang, Changyuan Guo, Jiayi Li, Yalun Li, Lei Zhong, Pengming Pu, Tongxuan Shang, Lin Cong, Yongxin Zhou, Guangdong Qiao, Ziqi Jia, Hengyi Xu, Heng Cao, Yansong Huang, Tianyi Liu, Jian Liang, Jiang Wu, Dongxu Ma, Yuchen Liu, Ruijie Zhou, Xiang Wang, Jianming Ying, Meng Zhou, Jiaqi Liu

“…Mechanistic interpretability analyses revealed that BRCA1/2‐mutated associated tumors may exhibit distinct microenvironment patterns, including increased inflammatory cell infiltration, stromal proliferation and necrosis, and nuclear heterogeneity. …”
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High-dimensional single-cell phenotyping unveils persistent differences in immune cell profiles between severe and moderate seasonal influenza by Johanna Bodin, Gro Tunheim, Anja B. Kristoffersen, Tove K. Herstad, Eleonora Vianello, Mariëlle C. Haks, Suzanne van Veen, Torgun Wæhre, Anne-Marte B. Kran, Anne-Marte B. Kran, Sarah L. Lartey, Fan Zhou, Rebecca J. Cox, Rebecca J. Cox, Tom H. M. Ottenhoff, Anne M. Dyrhol-Riise, Anne M. Dyrhol-Riise, Unni C. Nygaard, Fredrik Oftung, Siri Mjaaland

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Obesity induces phenotypic switching of gastric smooth muscle cells through the activation of the PPARD/PDK4/ANGPTL4 pathway by Sanaa Dekkar, Kamilia Mahloul, Amandine Falco, Karidia Konate, Romane Pisteur, Sarah Maurel, Laurent Maïmoun, Norbert Chauvet, Prisca Boisguérin, David Nocca, Ariane Sultan, Florian Pallot, Guillaume Walther, Nicolas Cenac, Cyril Breuker, Sandrine Faure, Pascal de Santa Barbara

“…Conclusions Obesity triggers a phenotypic change in gastric SMCs, driven by the activation of the PPARD/PDK4/ANGPTL4 pathway. …”
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Supplement-driven iron overload accelerates phenotypic aging via inflammatory biomarkers: Potential counteraction through anti-inflammatory or antioxidant diets by Bin Li, Zhu Ming, Yina Wang, Yingfeng Zhang, Runyi Zhou, Can Zhang, Yue Wu, Guoliang Wang, Hongquan Xie, Ying Li, Ran Li

“…Multivariable-adjusted analyses were performed using weighted generalized linear models (GLMs). …”
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White Matter Imaging Phenotypes Mediate the Negative Causality of Mitochondrial DNA Copy Number on Sleep Apnea: A Bidirectional Mendelian Randomization Study and Mediation Analysis by Ying Q, Wang M, Zhao Z, Wu Y, Sun C, Huang X, Zhang X, Guo J

“…Among 3935 BIPs, two features related to white matter microstructure served as partial mediators: the second eigenvalue from diffusion MRI data analysed by tract-based spatial statistics in the right posterior thalamic radiation, with a mediation proportion of 11.37% (P = 0.0450), and fractional anisotropy in the right sagittal stratum, with a mediation proportion of 12.79% (P = 0.0323).Conclusion: This study demonstrated a causal relationship between mtDNA-CN and SA, with specific brain white matter microstructure phenotypes potentially acting as mediators. …”
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DNA methylation patterns associated with prior tuberculosis infection in people with HIV by Joseph Baruch Baluku, Sharon Namiiro, Daphine Kigongo Zawedde, Brenda Namanda, Hakiimu Kawalya, Irene Najjingo, Waiswa Geoffrey, Nixon Niyonzima, Naghib Bogere, Edwin Nuwagira, Joshua Rhein, Nick Jones, Christian Kraef, Megan Shaughnessy, Arohi Chauhan, Immaculate Nankya, Sayoki Mfinanga, Stanton Gerson, Bruce Kirenga

“…DisGeNET analysis linked prior TB DNAm patterns to lymphoid leukemia, while dbGaP analysis identified associations with phenotypes like asthma, body mass index, tunica media, and lymphocyte count. …”
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Identification of RNA binding protein genes associated with colorectal cancer by bioinformatics analysis by Rong-Chao He, Haibo Wang, Jun He, Hou-Dong Wang, Zhong Shen

“…Analysis of the tumor microenvironment (TME) indicated that high-risk patients exhibited elevated stromal and immune scores, alongside reduced tumor purity, which is associated with more aggressive phenotypic characteristics. …”
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Dimensions of music use motivations: Genetic and environmental underpinnings, and associations with Big Five and Empathy traits. by Heidi Marie Umbach Hansen, Espen Røysamb, Olav Mandt Vassend, Nikolai Olavi Czajkowski, Tor Endestad, Jonna Katariina Vuoskoski, Anne Danielsen, Bruno Laeng

“…We also examined their phenotypic associations, as well as genetic and environmental overlap with general personality traits, including the Big Five and Trait Empathy facets. …”
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Prevalence of paediatric diarrhoea in Arba minch government health institutions, Southern Ethiopia and associated factors by Matusal Mengistu, Melat Woldemariam, Aseer Manilal, Addis Aklilu, Tsegaye Yohannes, Akbar Idhayadhulla, Hissah Abdulrahman Alodaini

“…Descriptive and inferential statistical analyses were done using SPSS, and P-values ≤ 0.05 were considered statistically significant. …”
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