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Identification of Lauric Acid as a Potent Sodium Channel NaV1.5 Blocker from Compound Chinese Medicine Wenxin Keli
Published 2025-01-01“…Weiwei Xie,1,* Jiaming Gao,2,* Yingran Liang,1,* Chenxing Huang,3 Boyong Zhang,1 Xiaonan Chen,1 Xi Yao,1 Guo Nan,1 Honghua Wu,1 Yuefei Wang,1 Lin Wu,4 Taiyi Wang,3,5 Yan Zhu1 1State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, People’s Republic of China; 2Institute of Basic Medical Sciences of Xiyuan Hospital, Beijing Key Laboratory of Pharmacology of Chinese Materia, Beijing, 100091, People’s Republic of China; 3Institute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan, 250355, People’s Republic of China; 4Department of Cardiology, Peking University First Hospital, Beijing, 100034 People’s Republic of China; 5Shandong Key Laboratory of Innovation and Application Research in Basic Theory of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yan Zhu, State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Beihua South Road, JingHai District, Tianjin, 301617, People’s Republic of China, Tel +86 22 59596168, Email yanzhu.harvard@icloud.com Taiyi Wang, Shandong Key Laboratory of Innovation and Application Research in Basic Theory of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355, People’s Republic of China, Email wangtaiyi@sdutcm.edu.cnPurpose: The major cardiac voltage-gated sodium channel NaV 1.5 (INa) is essential for cardiac action potential initiation and subsequent propagation. …”
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Unveiling the role of lncRNA ERDR1 in immune cell regulation
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Uso e ocupação do solo em São Paulo, alterações climáticas e os riscos ambientais contemporâneos
Published 2018-03-01“…Human interventions in nature, particularly in the last century, with intense use and degradation of environmental resources contributed for the emergence of the actual environmental crisis; that is, changes to the Earth's climate system. …”
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Anthelmintic activity of 1,10-phenanthroline-5,6-dione-based metallodrugs
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ORCHAMP: an observation network for monitoring biodiversity and ecosystem functioning across space and time in mountainous regions
Published 2024-11-01“…Recent climate and land use change, and pollution have led to concerning alterations in biodiversity and ecosystem functions, jeopardizing nature’s contributions to people. Mountainous regions are not immune to these threats, experiencing the impacts of global warming, increased recreational activities, and changes in agricultural practices. …”
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Legality as a principle of court activity in respecting the rights, freedoms and interests of minors in cases of administrative offences
Published 2024-12-01“…At the same time, it should be noted that the representation of a minor's interests is caused by the fact that he or she does not have full legal capacity and the capacity to act, and therefore is not able to independently use and exercise his or her rights and freedoms. The fiduciary nature of decisions resonates with the parties to the case and the social environment, contributing to the establishment of the authority of the government through trust in its institutions and entities authorised to resolve disputes and eliminate conflict in relevant social relations. …”
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Economic Burden of HIV in a Commercially Insured Population in the United States
Published 2023-01-01“…**Conclusions:** Despite advances in ART, patients with newly diagnosed HIV and at-risk patients receiving PrEP continue to incur HRU costs. The chronic nature of HIV warrants further exploration of factors contributing to disease burden and opportunities to improve prevention strategies.…”
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In-Situ Electrospinning Dressings Loaded with Kaempferol for Reducing MMP9 to Promote Diabetic Ulcer Healing
Published 2025-01-01“…Jianwen Li,1,2,* Hongqi Meng,3,* Wenlai Guo,3 Lubin Zhou,4 Siyu Wu,3 Guanghui Gao,4 Quanzhe Liu,3 Di You,5 Wenrui Qu2,3 1Gastroenteric Medicine and Digestive Endoscopy Center, the Second Hospital of Jilin University, Changchun, 130041, People’s Republic of China; 2Joint International Research Laboratory of Ageing Active Strategy and Bionic Health in Northeast Asia of Ministry of Education, Changchun, 130041, People’s Republic of China; 3Department of Hand Surgery, the Second Hospital of Jilin University, Changchun, 130041, People’s Republic of China; 4Polymeric and Soft Materials Laboratory, Advanced Institute of Materials Science, School of Chemical Engineering, Changchun University of Technology, Changchun, 130012, People’s Republic of China; 5Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun, 130012, People’s Republic of China*These authors contributed equally to this workCorrespondence: Di You; Guanghui Gao, Email youdi1118@jlu.edu.cn; ghgao@ccut.edu.cnBackground: Diabetic foot ulcers (DFUs) are often associated with persistent inflammatory response, impaired macrophage polarization, and slow vascular regeneration. …”
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Mountains at Work. The Geopolitics of Refuge in the Clarée Valley
Published 2020-10-01“…This article examines the discourses produced around these struggles, as well as people’s memories – in particular, that of Émilie Carles (1900–1979). …”
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Montagnes en bataille. Une géopolitique du refuge depuis la vallée de la Clarée
Published 2020-10-01“…This article examines the discourses produced around these struggles, as well as people’s memories –in particular, that of Émilie Carles (1900–1979). …”
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The results of many years of complex use of cycle- and power-ergometry in determining the physical capacity of young athletes
Published 2024-12-01“…The fact of possible prediction of sports results at competitions of adolescents in sports chosen by them, depending on the nature of changes in indicators of aerobic and anaerobic-aerobic performance PWC170, was established. …”
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