Increasing Access to Mental Health Supports for 18- to 25-Year-Old Indigenous Youth With the JoyPop Mobile Mental Health App: Study Protocol for a Randomized Controlled Trial by Angela MacIsaac, Teagan Neufeld, Ishaq Malik, Elaine Toombs, Janine V Olthuis, Fred Schmidt, Crystal Dunning, Kristine Stasiuk, Tina Bobinski, Arto Ohinmaa, Sherry H Stewart, Amanda S Newton, Aislin R Mushquash

“… BackgroundTransitional-aged youth have a high burden of mental health difficulties in Canada, with Indigenous youth, in particular, experiencing additional circumstances that challenge their well-being. …”
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Occurrence of Taenia species and Toxoplasma gondii in pigs slaughtered in Bujumbura city, Kayanza and Ngozi provinces, Burundi by Salvator Minani, Emma Spiessens, Alyssa Labarrière, Pascal Niyokwizera, Anastasie Gasogo, Jean-Bosco Ntirandekura, Chiara Trevisan, Sarah Gabriël

“…The magnitude of the burden of these parasites in pigs in Burundi is not known. …”
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Quality of Life with Late-Onset Pompe Disease: Qualitative Interviews and General Public Utility Estimation in the United Kingdom by Lena Hubig, Anna-Katrine Sussex, Alasdair MacCulloch, Derralynn Hughes, Ryan Graham, Liz Morris, Syed Raza, Andrew J. Lloyd, Amanda Sowinski, Katy Gallop

“…Our findings highlight the high disease burden of LOPD and reinforce the societal value of slowing disease progression.…”
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Risk Factors Associated with Pyogenic Spinal Infections among Intravenous Drug Users and Nonusers by Vivek K. Bilolikar, Brendan Gleason, Lee Kripke, Robert Merrill, Colin Whitaker, Jon Handal

“…Spinal infections are major clinical problems with a substantial financial burden on healthcare systems. Recent increases in primary pyogenic spine infections can be attributed to the opioid epidemic and an aging and increasingly unhealthy population. …”
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Trends for Clinical Trials on Medicinal Products for Neurological Disorders in Lithuania and Europe by Emilijus Žilinskas, Arūnas Vaitkevičius

“… Background. As the global burden of neurological diseases has been increasing, clinical trials have become more important. …”
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Home high-flow therapy during recovery from severe chronic obstructive pulmonary disease (COPD) exacerbation: a mixed-methods feasibility randomised control trial by Nicholas Hart, Louise Rose, Abdel Douiri, Georgios Kaltsakas, Eui-Sik Suh, Patrick B Murphy, Anne Rossel, Rebecca F D'Cruz

“…Higher HFT usage was associated with lower symptom burden (CAT p=0.01). Interviews highlighted ease of device use, reduced salbutamol usage, and improved sputum production and clearance.Conclusions The data from this feasibility study support the progression to a phase 3 randomised clinical trial investigating the effect of home (HFT) on admission-free survival in COPD patients recovering from a severe exacerbation.Trial registration number The study received ethical approval (REC19/LO/0194) and was prospectively registered (ISRCTN15949009).…”
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Exploring the clinical profiles and management of juvenile dermatomyositis in Africa: a survey of African rheumatology care providers by Jessica Perfetto, Laura B. Lewandowski, Dawn M. Wahezi, Vanessa Ogega, Joan Ahimbisibwe, Kate Webb, Christiaan Scott, Angela Migowa

“…Our objectives are to understand the burden of JDM in Africa and provider access to diagnostic tools and therapy through survey methodology. …”
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A comprehensive analysis of erectile dysfunction prevalence and the impact of prostate conditions on ED among US adults: evidence from NHANES 2001-2004 by Yuhao Zhang, Nan Zang, Yingyue Xiang, Fanlu Lin, Xue Liu, Jing Zhang, Jing Zhang

“…This finding highlights the necessity for tailored screening and management protocols for individuals with BPH and PCa to mitigate the burden of ED.…”
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Risk Factors Associated with Falls and Fractures Following Prescription of Opioids Among Privately Insured Patients with Osteoarthritis by Stuart Silverman, Patricia Schepman, J. Bradford Rice, Craig G. Beck, William Pajerowski, Alan G. White, Sheena Thakkar, Rebecca L. Robinson, Birol Emir

“…**Results:** Of 16 663 patients meeting inclusion criteria, 3886 (23%) had at least 1 fall or fracture during follow-up. Of these 3886 patients, 1349 (35%) had at least 1 fall with an average of 3 fall claims, and 3299 (85%) patients had at least 1 fracture with an average of 8 claims during follow-up. …”
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Nationwide representative serosurvey of third-grade school children to evaluate the hepatitis B vaccination impact in Kyrgyzstan, 2022 by Michael Brandl, Gulnara Zhumagulova, Gulbara Ishenapysova, Zuridin Nurmatov, Tatiana Enverovna Kuchuk, Nurzhan Zamirbekova, Gulsunai Sattarova, Saikal Temirbekova, Zhanara Bekenova, Martyna Gassowski, Liudmila Mosina, Antons Mozalevskis, Sandra Dudareva, Siddhartha Sankar Datta

“…Abstract Background Kyrgyzstan introduced universal hepatitis B childhood vaccination in 1999 to reduce the burden of hepatitis B. In 2016, aligned with the goal of controlling hepatitis B in the WHO European Region, a regional target of 0.5% was set for seroprevalence of hepatitis B surface antigen (HBsAg) among targeted birth cohorts. …”
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Enhancing Health Equity and Patient Engagement in Diabetes Care: Technology-Aided Continuous Glucose Monitoring Pilot Implementation Project by Madhur Thakur, Eric W Maurer, Kim Ngan Tran, Anthony Tholkes, Sripriya Rajamani, Roli Dwivedi

“… Federally Qualified Health Centers (FQHCs) provide service to medically underserved areas and communities, providing care to over 32 million patients annually. The burden of diabetes is increasing, but often, the vulnerable communities served by FQHCs lag in the management of the disease due to limited resources and related social determinants of health. …”
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Preferences for and acceptability of long-acting HIV prevention products among pregnant and lactating women accessing health services in Kenya: a mixed method cross-sectional analy... by Vallery Ogello, Paul Mwangi, Zachary Kwena, Nicholas Thuo, Catherine Makokha, Emmah Owidi, Nelson Muteti, Catherine Kiptinness, Nelly R. Mugo, Kenneth Ngure

“…Abstract Background Increased risk of HIV acquisition during pregnancy and lactation among women is evident, necessitating their inclusion in the evaluation of new HIV prevention interventions. …”
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Immune and genomic biomarkers of immunotherapy response in cancer of unknown primary by Madhu Singh, Linda Mileshkin, Penelope Schofield, Bo Gao, Gary Richardson, Andrew Pattison, Rodney J Hicks, Niko Thio, Mark Warren, Colin Wood, Stephen B Fox, Anna DeFazio, Andrew Fellowes, Christopher Steer, David Bowtell, Nicholas Wilcken, Tharani Sivakumaran, Atara Posner, Dariush Etemadmoghadam, Krista Fisher, Samantha Webb, Christos S Karapetis, Ian M Collins, Narayan Karanth, Owen W J Prall, Richard William Tothill

“…ICI responsive cancer types were assigned based on Food and Drug Administration-approved indications, and either detection of a latent primary tumor or the TOO was suspected based on genomics informed pathology review. Tumor mutation burden (TMB) and gene mutations were also assessed.Results A total of 219 patients with CUP were included, 215 assessed for TOO in a previous study, with the majority (163) receiving both RNA and DNA tests. …”
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The temporal change of heat exposure and adaptation capacity in Chinese adults from 1994 to 2023 by Xiaohui Ji, Haomin Tan, Shaoli Huang, Zhongguo Huang, Jianxiong Hu, Jianxiong Hu, Guanhao He, Fengrui Jing, Ziqiang Lin, Mengen Guo, Tao Liu, Wenjun Ma, Wenjun Ma

“…Heat exposure significantly decreased and temperature adaptation capacity significantly increased during the last decades. The findings implied that heat-related health risk and burden driven by global warming may not increase in the future.…”
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Association study of the JAK/STAT signaling pathway with susceptibility to COVID-19 in moroccan patient and in-silico analysis of rare variants by Meriem El Houdi, Hanaa Skhoun, Meriem El Fessikh, Reda Benmansour, Fatima-Zahra El Yousfi, Chaimae Nebhani, Mohamed Rida Tagajdid, Idriss Lahlou Amine, Hicham El Annaz, Rabii Ameziane El Hassani, Zohra Ouzzif, Redouane Abouqal, Khalid Ennibi, Ahmed Bouhouche, Jamila El Baghdadi

“…Notably, IFNAR1 p.Val168Leu mutated C allele was significantly associated with reduced susceptibility to COVID-19 severity (p=0.028, OR=0.5936 [0.3725 – 0.9461]), under the additive model (p=0.045, OR=0.626 [0.3958 – 0.9899]).Rare variants IFNAR1 p.Trp318Cys, p.Ser476Phe, and IFNAR2 p.Cys271Tyr were predicted deleterious, impacting protein structure via hydrogen bond and hydrophobic interaction alterations. Burden analysis of rare variants revealed a protective cumulative effect against COVID-19 severity for TYK2 (p=0.0013, OR=0.1438 [0.04237 – 0.4803]) under the dominant model.This study underscores the role of genetic factors in COVID-19 susceptibility and advocates further explorations regarding functional impacts of JAK/STAT pathway rare variants.…”
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When Infodemic Meets Epidemic: Systematic Literature Review by Chaimae Asaad, Imane Khaouja, Mounir Ghogho, Karim Baïna

“…The significant medical, emotional, and financial burden associated with epidemics creates feelings of distrust, fear, and loss of control, making vulnerable populations prone to exploitation and manipulation through misinformation, rumors, and conspiracies. …”
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Trajectories of asthma symptom presenting as wheezing and their associations with family environmental factors among children in Australia: evidence from a national birth cohort st... by Peter D Sly, Md Jobayer Chisti, Abdullah Mamun, K M Shahunja

“…Objectives Asthma is one of the greatest health burdens, yet contributors to asthma symptom trajectories are understudied in Australian children. …”
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Acceptability and feasibility of pre-exposure prophylaxis for bacterial STIs: a systematic review. by Julie-Anne Carroll, Amy B Mullens, Sarah Warzywoda, Philip R A Baker, Meika Stafford, Faye McMillan, Jacintha Manton, Daniel Demant

“…<h4>Background</h4>A recent resurgence of bacterial sexually transmitted infections (STIs) is placing a major burden on high-risk populations, physicians, and the healthcare system. …”
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Disulfidptosis-related gene signatures as prognostic biomarkers and predictors of immunotherapy response in HNSCC by Haotian Qin, Haotian Qin, Juan Xu, Yaohang Yue, Yaohang Yue, Meiling Chen, Zheng Zhang, Panpan Xu, Yan Zheng, Hui Zeng, Jian Weng, Jian Weng, Jun Yang, Fei Yu

“…Various analyses are conducted, including the relationship between the risk scores model and clinicopathological features, immune status, immune checkpoints, tumor mutational burden (TMB), microsatellite instability (MSI), ESTIMATE, mRNAsi, and drug sensitivity. …”
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Ten-year trends in clinical characteristics and outcome of children hospitalized with severe wasting or nutritional edema in Malawi (2011-2021): Declining admissions but worsened c... by Mphatso Nancy Chisala, Celine Bourdon, Emmanuel Chimwezi, Allison I Daniel, Chikondi Makwinja, Dominic Wang, Linnea Weise, Isabel Potani, Emmie Mbale, Robert J H Bandsma, Wieger P Voskuijl

“…<h4>Background</h4>Severe acute malnutrition (SAM) constitutes a substantial burden in African hospitals. Despite adhering to international guidelines, high inpatient mortality rates persist and the underlying contributing factors remain poorly understood.…”
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