Functional Analysis and Experimental Validation of the Prognostic and Immune Effects of the Oncogenic Protein CDC45 in Breast Cancer by Zhang JN, Li LW, Cao MQ, Liu X, Yi ZL, Liu SS, Liu H

“…Jia-Ning Zhang,1,2,* Lin-Wei Li,1,2,* Man-Qing Cao,1,2,* Xin Liu,1,2 Zi-Lu Yi,1,2 Sha-Sha Liu,1,2 Hong Liu1,2 1The Second Surgical Department of Breast Cancer, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, People’s Republic of China; 2Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hong Liu, Email liuhong_submit@tjmuch.comPurpose: Cell division cycle protein 45 (CDC45) plays a crucial role in DNA replication. …”
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Elucidating the pharmacological foundations and mechanisms of the Sihai Shuyu formula in treating Graves’ disease through integrated serum metabolomics and network pharmacology wit... by Xiaoju Liu, Xingjia Li, Wenbin Huang, Yifan Cui, Fengyun Cheng, Guofang Chen, Guofang Chen, Xiaodong Mao, Chao Liu, Chao Liu, Shuhang Xu

“…Ethnopharmacological relevanceThe Sihai Shuyu Formula (SHSY) shows promising potential for treating Graves’ disease (GD), although the therapeutic mechanisms and pharmacological basis of SHSY have not been thoroughly evaluated.ObjectiveThis work is aim to investigate the pharmacological basis and mechanism of SHSY in the treatment of GD by integrating non-targeted serum metabolomics and network pharmacology coupled with molecular docking technology.Materials and methodsGD was induced in mice through injections of Ad-TSH289. …”
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A conserved element in the first intron of Cd4 has a lineage specific, TCR signal-responsive, canonical enhancer function that matches the timing of cell surface CD4 upregulation r... by Gregory A. Swan, Gregory A. Swan, Chika Fujii, Mia E. Guzynski, Sheridan M. Page, Isabelle V. Meyers, Yordan P. Penev, Sejiro Littleton, Sejiro Littleton, Adinda Azzahra, Christine Richardson, Sophia D. Sarafova, Sophia D. Sarafova

“…In this study, we investigate whether a conserved region, here called NCE, that is proximal to the Cd4 silencer and contains E4m has the required developmental-stage-specific canonical enhancer function and TCR responsiveness to mediate the CD4 upregulation required to prevent lineage errors.MethodsTo investigate the role of NCE, transient transfection of reporter plasmids was performed in thymoma cell lines arrested at the double-positive (DP, CD4+CD8+) and intermediate (INT, CD4+CD8lo) stages of development. …”
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Work-related burnout and its associated factors among kindergarten teachers: a multi-center cross-sectional study in Ethiopia by Anmut Endalkachew Bezie, Girum Tareke Zewude, Amensisa Hailu Tesfaye, Amensisa Hailu Tesfaye, Asmare Asrat Yirdaw, Alebachew Bitew Abie, Giziew Abere

“…In the past 6 months, the total prevalence of WRB was 39.7% [95% CI (34.8, 44.6)]. …”
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Gαi1/3 signaling mediates IL-5-induced eosinophil activation and type 2 inflammation in eosinophilic chronic rhinosinusitis by Huanxia Xie, Jiang Ji, Zhichen Liu, Ning Lu, Yuqian Wei, Aina Zhou, Jisheng Liu, Qingqing Jiao, Qingqing Jiao

“…In a CRS murine model, immune cell infiltration and type 2 inflammation were largely impaired in Gαi1/3-double-knockout mice.ConclusionIncreased Gαi1/3 expression levels in nasal tissue are linked to eosinophil infiltration and increased disease severity in CRS patients. …”
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Academic Pressure and Psychological Imbalance in High School Students: Predictors of Depression via Polynomial Regression and Response Surface Analysis by Ye Y, Zhang Z, Tao Z, Liping C, Wang Y, Chen H, Li S, Chen X, Tang H, Zhou J, Zhou J

“…Yanyue Ye,1,* Zheng Zhang,1,* Zhen Tao,3 Cui Liping,2 Yuxin Wang,1 Hui Chen,1 Sihong Li,1 Xianliang Chen,1 Huajia Tang,1 Jiawei Zhou,1 Jiansong Zhou1,* 1Department of Psychiatry, the Second Xiangya Hospital of Central South University, National Center for Mental Disorders, National Clinical Research Center for Mental Disorders, Changsha, People’s Republic of China; 2Department of Psychiatry, Liuyang Brain Hospital, Liuyang, People’s Republic of China; 3Human Resources Department, Hebei Vocational University of Technology and Engineering, Hebei, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jiansong Zhou, Email zhoujs2003@csu.edu.cnObjective: The purpose of this study was to explore how the congruence between academic pressure and psychological imbalance affects depressive symptoms in adolescents and to further explore grade-level differences in these effects among high school students.Methods: The study population consisted of 29,975 high school students from 20 schools in Liuyang City, Hunan Province. …”
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Clastic facies classification using machine learning-based algorithms: A case study from Rawat Basin, Sudan by Anas Mohamed Abaker Babai, Olugbenga Ajayi Ehinola, Omer.I.M. Fadul Abul Gebbayin, Mohammed Abdalla Elsharif Ibrahim

“…In comparison, the Decision Tree coupled with grid search yielded better results, with a training score of 69.91% and a testing score of 67.89%. …”
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«Green-Ligand» in Metallodrugs Design—Cu(II) Complex with Phytic Acid: Synthetic Approach, EPR-Spectroscopy, and Antimycobacterial Activity by Kseniya A. Koshenskova, Natalia V. Makarenko, Fedor M. Dolgushin, Dmitriy S. Yambulatov, Olga B. Bekker, Matvey V. Fedin, Sergei A. Dementev, Olesya A. Krumkacheva, Igor L. Eremenko, Irina A. Lutsenko

“…Continuous wave (CW) EPR spectra in water/glycerol frozen solution clearly indicate a presence of an exchange-coupled Cu(II)-Cu(II) dimeric unit, as well as a Cu(II) monomer-like signal arising from spins sufficiently distant from each other, with comparable contributions of two types of signals. …”
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Interaction between Nuclear Receptor and Alpha-Adrenergic Agonist Subtypes in Metabolism and Systemic Hemodynamics of Spontaneously Hypertensive Rats by Sheryar Afzal, Munavvar Abdul Sattar, Ibrahim Albokhadaim, Ali Attiq, Mahmoud Kandeel, Aimi Syamima Abdul Manap, Sameer M. Alhojaily

“…Groups III (SHR) and IV (SHR) received irbesartan (30 mg/kg) and pioglitazone (10 mg/kg) orally for 28 days, and groups V (SHR), VI (SHR), and VII (SHR) were treated with adiponectin (2.5 μg/kg) intraperitoneally alone, in combination with irbesartan, and in combination with pioglitazone, respectively, from days 21 to 28 only. …”
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Yenilik Kapsamında Turistik Ürün Çeşitlendirmesi ve Kurban Bayramı Örneği by Erkan Akgöz, Ramazan Göral, Yüksel Gürsoy

“…Turistik ürünün çeşitliliği de işletmelerin, bölgelerin veya ülkelerin altyapı, üstyapıolanaklarıile birlikte doğal, sosyal ve kültürel imkânlarıile daha kolay gerçekleşebilir. …”
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Removing Excess Iron from Sewage and Natural Waters: Selecting Optimal Sorbent by Ludmila A. Ivanova, Irina V. Timoshchuk, Alena K. Gorelkina, Ekaterina S. Mikhaylova, Nadezhda S. Golubeva, Evgeny N. Neverov, Tamara A. Utrobina

“…The Gibbs energy values were obtained from the Langmuir equation and equaled 11.93–20.66 kJ/mol, which indicated the physical nature of the adsorption process. …”
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Solving Phosphorus Fertilization-Related Drip Irrigation Emitter Clogging by Adding Mn²⁺ by Tianyu Xu, Sanlin Bao, Qiuyue Yu, Yu Gao

“…The APP was unable to lower the pH value and had the most serious blockage. The APP was coupled with three concentrations of Mn²⁺ (1, 2, and 3 mg/L) for drip irrigation, which could optimize the blockage problem and explore the efficacy of Mn²⁺. …”
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Airborne Levels of Lung Carcinogens at an Ascon Manufacturing Site by Kyeongmin Lee, Sungwon Choi, Miyeon Kim, Dongwoo Song, Ki-Youn Kim

“…The amounts of respirable dust and quartz by the vibrating screen totaled 12.362 and 1.645 mg m−3, respectively, and that of elemental carbon near a dryer burner equaled 0.001 mg m−3. …”
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Monetary Fines in EU Mergers: In Need for More Regulation by Nora Memeti

“…The first section analyses article 14(1) of the EUMR, which empowers the EC to impose a fine of up to 1% of the total turnover in the preceding business year on undertakings for breach of procedural matters, including, among others, for providing incorrect or misleading information. …”
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Peningkatan Kinerja Jaringan Dengan Menggunakan Multi-Rule Algorithm by Tanwir Tanwir, Parma Hadi Rantelinggi, Sri Widiastuti

“…To overcome this problem a combination of Multi-Rule Algorithm cache replacement algorithms is performed, in the form of a double combination algorithm FIFO-LRU and triple FIFO-LRU-LFU. …”
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Impacts of alfalfa nutrient concentrate on pellet physical attributes, growth performance, metabolism and nutritional quality of rainbow trout, Oncorhynchus mykiss by Hu Chen, Patrick C. Blaufuss, Dong-Fang Deng, Fabio Casu, Emma K. Kraco, Brian Shepherd, Wendy M. Sealey, Aaron M. Watson, Matthew F. Digman, Deborah A. Samac

“…Test diets contained varying ANC levels (0%, 5%, 10%, 15%, and 20%) to replace fishmeal (32% in the 0% ANC diet) to achieve equal digestible protein and were processed using a cooking extrusion method. …”
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Impact of late effects after treatment for bladder cancer with radical cystectomy on Quality of life: a case-control study by Rikke V. Milling, Ninna K. Nielsen, Charlotte Graugaard-Jensen, Peter Christensen, Helle Pappot, Jørgen B. Jensen

“…In spite of this, MIBC patients overall QoL was equal to that of the controls. …”
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Perinatal consequences of a category 1 caesarean section at term by Sailesh Kumar, Leah Grace, Ristan M Greer

“…Caucasian women were equally as likely to undergo a category 1 CS as a non-category 1 CS, while indigenous women and women of Asian ethnicity were more likely to undergo a category 1 CS. …”
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Anti-apoptosis Effect of Gualou Guizhi Granule on Neurons in Ischemic Stroke Rats and Primary Hippocampal Neurons by Yu LIN, Wei XU, Yuqin ZHANG, Huang LI, Wen XU

“…Objective:To investigate the anti-apoptosis effect of Gualou Guizhi granule(GLGZG)on neurons in ischemic stroke rats and primary hippocampal neurons, and then explore the involved protective mechanism of GLGZG, thus providing a theoretical basis for the treatment of stroke.Methods:Glutamate-induced primary hippocampal neurons excitotoxicity injury model and focal cerebral ischemic-reperfusion injury model were established. …”
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Oral pre-exposure prophylaxis implementation in South Africa: a case study of USAID-supported programs by Jerome Wendoh Milimu, Lauren Parmley, Mahlodi Matjeng, Mathata Madibane, Mandisi Mabika, Jacques Livingston, Joseph Lawrence, Orapeleng Motlhaoleng, Hasina Subedar, Rethabile Tsekoa, Zandile Mthembu

“…Since the introduction of oral pre-exposure prophylaxis (PrEP) in 2016, countries have successfully scaled-up PrEP to populations at risk of HIV acquisition, including key populations, serodiscordant couples and pregnant women. …”
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