Engineered extracellular vesicles with sequential cell recruitment and osteogenic functions to effectively promote senescent bone repair by Lei Qi, Jing Wang, Jinge Yan, Weidong Jiang, Weiwen Ge, Xin Fang, Xudong Wang, Steve GF Shen, Lu Liu, Lei Zhang

“…To combine the advantages of Apt19s and miR-376b-5p, dual engineered extracellular vesicles (Apt-376b-EV) comprising both Apt19s and miR-376b-5p modifications were constructed. To further validate its function, Gelatin methacryloyl (GelMA) hydrogel was used as a carrier to construct the Apt-376b-EV@GelMA delivery system. …”
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