Temporal trends of the utilization patterns of sedative-hypnotic medications in children, adolescents and young adults: a 21-year population-based study with joinpoint regression a... by Carltin Chun Ting Kwok, Heidi Ka Ying Lo, Ching Yui Chan, Joe Kwun Nam Chan, Corine Sau Man Wong, Calvin Pak Wing Cheng, Chung Ho, Brian Man Ho Leung, Wilfred Shone Horn Wong, Zoe Hoi Shuen Yu, Edwin Ho Ming Lee, Wing Chung Chang

“…Judicious prescribing-practices and further investigation clarifying factors contributing to increased BZRA use are warranted.…”
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Combining single-cell analysis and molecular docking techniques to construct a prognostic model for colon adenocarcinoma and uncovering inhibin subunit βb as a novel therapeutic ta... by Qinqing Wu, Qinqing Wu, Lu Ye, Yuwei Wu, Mengyu Zhao, Mengyu Zhao, Jiaxin Lu, Yanping Yu, Yanping Yu, Yixiao Niu, Yixiao Niu, Luxiao Zhang, Peijun Zuo, Peijun Zuo

“…It also validates the key role of INHBB in the progression of COAD, establishing the foundation for future personalized treatment strategies.…”
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Blockchain-assisted improved interval type-2 fuzzy deep learning-based attack detection on internet of things driven consumer electronics by Rana Alabdan, Bayan Alabduallah, Nuha Alruwais, Munya A. Arasi, Somia A. Asklany, Omar Alghushairy, Fouad Shoie Alallah, Abdulrhman Alshareef

“…The Internet of Things (IoTs) revolutionizes the consumer electronics landscape by presenting a degree of personalization and interactivity that was previously unimaginable. …”
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The association of physical activity and carotid intima-media-thickness in adolescents—data of the prospective early vascular ageing-tyrol cohort study by Bernhard Winder, Bernhard Winder, Bernhard Winder, Sophia J. Kiechl, Sophia J. Kiechl, Benoît Bernar, Benoît Bernar, Nina Gande, Anna Staudt, Anna K. Stock, Anna K. Stock, Christoph Hochmayr, Ralf Geiger, Andrea Griesmacher, Stefan Kiechl, Stefan Kiechl, Ursula Kiechl-Kohlendorfer, Michael Knoflach, Michael Knoflach, the Early Vascular Ageing (EVA)-Tyrol Study Group, Carmen Reiter, Christina Schreiner Julia Klingenschmid, Julia Marxer, Martina Kothmayer, Maximilian Pircher, Manuela Bock-Bartl, Mandy Asare, Maximilian Bohl, Raimund Pechlaner

“…Our aim was to further investigate this unexpected association with two different measurement methods of PA and two established markers for Early Vascular Ageing: cIMT and carotid-femoral pulse-wave velocity (cfPWV).MethodsThe community-based Early Vascular Ageing-Tyrol cohort study included adolescents in western Austria and northern Italy. …”
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Disease burden of biliary tract cancer in 204 countries and territories, 1990–2021: A comprehensive demographic analysis of the Global Burden of Disease Study 2021 by Xuheng Sun, Jiangmei Liu, Wei Zhang, Yijun Wang, Yan Jiang, Lijun Wang, Yixin Zou, Yuxuan Xiao, Yongbing Xiang, Maolan Li, Maigeng Zhou, Yingbin Liu, Sihan Zhou, Xiuyuan Hao

“…This study provided a comprehensive comparison of differences in the burden of disease across populations and over time, and further presented evidence concerning the formulation of prevention and control policies and etiologic studies for BTCs and proposed logical hypotheses to investigate.…”
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Association between forced expiratory volume in 1 s and relapse-free survival in operable non-small cell lung cancer: a prospective cohort study with propensity score overlap weigh... by Jing Cheng, Yang Du, Karl Sylvester, Shaoping Wu, Suixin Liu, Yaoshan Dun, Baiyang You, Siqian Fu, Ning Xu, Jeffrey William Ripley-Gonzalez, Ni Cui

“…Results revealed 110 and 71 relapses and deaths per 1000 person-years for patients with FEV1 values of <82%pred and ≥82%pred, respectively. …”
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The multidisciplinary approach to the treatment of paediatric chronic pain: a qualitative analysis through focus groups by Aldana Paola Ercolano, Sabrina Galvan, Tessa Louise Marchesan, Alessia Gavioli, Gerardo Papa, Mariarita Todaro, Lidia Berforini D’Aquino, Alessia Zanatta, Andrea Vianello

“…Conclusions: The study highlights that a multidisciplinary and personalized approach is crucial in the management of pediatric chronic pain. …”
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Emergence of Self-Identity in Artificial Intelligence: A Mathematical Framework and Empirical Study with Generative Large Language Models by Minhyeok Lee

“…Additionally, it opens up new prospects for controlled adjustments of self-identity in contexts that demand different levels of personal involvement. Moreover, the mathematical underpinning of our framework serves as the basis for forthcoming investigations into AI, linking theoretical models to real-world applications in current AI technologies.…”
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Feasibility and therapeutic efficacy of a two-week low-level laser acupuncture therapy for shoulder and neck pain in office workers: Protocol for a pilot, single-blind, double-arme... by Carol Chunfeng Wang, Lisa Whitehead, Travis Cruickshank, Johnny Lo, Jianhong Cecilia Xia, Jun Wen

“…<h4>Background</h4>Shoulder and neck pain (SNP) is common in office workers and represents a serious public health problem given its detrimental impact on quality of life, physical functioning, personal finances, employers, and the health care system. …”
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Dual Role of &alpha;-MSH in Colitis Progression: Mediating Neutrophil Differentiation via Bone Marrow by Liao X, Liu H, Li Y, Zhang W, Dai Q, Wei H, Zhou J, Xie X, Zhou H

“…These findings offer vital guidance for optimizing personalized treatment of IBD, emphasizing the importance of carefully managing the timing and dosage of α-MSH for its effective clinical application.Keywords: IBD, α-MSH, hematopoietic stem cells, neutrophils, inflammation…”
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Quantifying the tumour vasculature environment from CD-31 immunohistochemistry images of breast cancer using deep learning based semantic segmentation by Tristan Whitmarsh, Wei Cope, Julia Carmona-Bozo, Roido Manavaki, Stephen-John Sammut, Ramona Woitek, Elena Provenzano, Emma L. Brown, Sarah E. Bohndiek, Ferdia A. Gallagher, Carlos Caldas, Fiona J. Gilbert, Florian Markowetz

“…Using these segmentations, we investigated the relationship between the various tissue types and the vasculature and studied the relationship of various vascular parameters with clinical parameters. …”
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Impact of Initial Heart Rate, Diastolic Pressure, and Pulse Pressure on Prognostic Outcomes in Heart Failure Patients with Mildly Reduced Ejection Fraction by Hu H, Liu Z, Zeng J, Jiang M

“…These findings provide valuable insights for risk stratification and may guide personalized management of HFmrEF patients.Keywords: heart failure with mildly reduced ejection fraction (HFmrEF), initial heart rate, diastolic pressure, pulse pressure, decision tree classification…”
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Unlocking the Potential of Receptor-Based Approaches in Diabetes Treatment by Mohsina Patwekar, Faheem Patwekar, J. Pavan Kumar, P. Dharani Prasad, Nazia Malik, A. Venkata Badarinath, Prashanth Parupathi, Konatham Teja Kumar Reddy, Selvaraja Elumalai, Zainul Abedeen Ab Samad

“…Pegbelfermin (BMS-986036), a fibroblast growth factor 21 (FGF21) analogue, is being investigated for its ability to regulate glucose and lipid metabolism, and potentially enhance glycemic control and lipid profiles. …”
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The analysis of the notions of Russian school principals about digital transformation by A. A. Deryabin, I. E. Boytsov, A. A. Popov, P. D. Rabinovich, K. E. Zavedensky, I. S. Tsarkov

“…It has become more obvious than ever that the digital transformation of a school is not limited to a simple technical update of its information resources but implies a fundamental rethinking of the school activities based on the capabilities of digital technologies.The aim of the study was to investigate the experience of digital transformation and the Russian school principals’ notions about it as a systemic process. …”
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Intelligent measurement of adolescent idiopathic scoliosis x-ray coronal imaging parameters based on VB-Net neural network: a retrospective analysis of 2092 cases by Jinlong Liu, Haoran Zhang, Pei Dong, Danyang Su, Zhen Bai, Yuanbo Ma, Qiuju Miao, Shenyu Yang, Shuaikun Wang, Xiaopeng Yang

“…In clinical practice, it is recommended to consider the discrepancy in parameters to enable a more accurate diagnosis and a personalized treatment plan.…”
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Effect of home environment on neuropsychiatric development in preterm infants discharged from NICU at 18 months corrected age by Yuan Tian, Chuncao Zhang, Li Shen, Haifeng Jiang, Feng Liu, Jinjin Chen, Xia Hong

“…Background There have been numerous intervention studies focusing on the development of preterm infants, but there has been limited investigation into the home environment as a determinant of developmental outcomes in preterm infants. …”
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Identification of Intracranial Germ Cell Tumors Based on Facial Photos: Exploratory Study on the Use of Deep Learning for Software Development by Yanong Li, Yixuan He, Yawei Liu, Bingchen Wang, Bo Li, Xiaoguang Qiu

“…ObjectiveThis study aimed to investigate the application of facial recognition technology in the early detection of iGCTs in children and adolescents. …”
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Multiple time points for detecting circulating tumor DNA to monitor the response to neoadjuvant therapy in breast cancer: a meta-analysis by Shuyi Niu, Tie Sun, Mozhi Wang, Litong Yao, Tianyi He, Yusong Wang, Hengjun Zhang, Xiang Li, Yingying Xu

“…The secondary endpoint was to investigate the relationship between ctDNA and prognosis. …”
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Piloting creative engagement strategies to explore themes of parenthood with fathers by Iryna Culpin, Iryna Culpin, Catherine Lamont-Robinson, Mark Billington, Matthew James, James Prewett, Gareth Ward, Mireia Bes Garcia, Giovanni Biglino, Giovanni Biglino

“…However, little is known about men's involvement in art-based participatory research. We aimed to investigate how men who are fathers may be engaged creatively to explore experiential aspects of fathering and parenthood.MethodsFathers collaborated with an artist, sharing individual perspectives around fatherhood by telephone and email, leading up to creative representations of fatherhood. …”
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Do coping strategies mediate the effects of childhood adversities and traumata on clinical high-risk of psychosis, depression, and social phobia? A cross-sectional study on patient... by Zhixiong Chang, Naweed Osman, Carolin Martha Doll, Theresa Katharina Lichtenstein, Marlene Rosen, Eva Meisenzahl, Hanna Kadel, Joseph Kambeitz, Kai Vogeley, Frauke Schultze-Lutter

“…However, these relations are likely mediated by personal coping behaviors. This cross-sectional study investigates the relationships between the main CAT domains, coping, CHR-P, depression, and social phobia. …”
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