Pharmacological potential of 6,11-dihydro[1,2,4]triazolo[4’,3’:1,6]-pyrido[3,4-b]-5-carboxylic acid and its esters by S. O. Fedotov, A. S. Hotsulia

“…The combination of the indole fragment, which demonstrates activity due to its aromatic structure, with the 1,2,4-triazole nucleus, which is characterised by chemical stability and the ability to form hydrogen bonds, creates a promising basis for the development of new therapeutic agents with improved properties. The active implementation of various modifications of indole and 1,2,4-triazole frameworks is aimed at optimizing the pharmacokinetic and pharmacodynamic characteristics of medicinal products. …”
Get full text

Development and validation of a machine learning-based risk prediction model for stroke-associated pneumonia in older adult hemorrhagic stroke by Yi Cao, Yi Cao, Haipeng Deng, Shaoyun Liu, Xi Zeng, Yangyang Gou, Weiting Zhang, Yixinyuan Li, Hua Yang, Min Peng

“…The results indicated that among the four machine learning algorithms (XGBoost, LR, SVM, and Naive Bayes), the LR model demonstrated the best and most stable predictive performance. …”
Get full text

Supporting self-management with an internet intervention for low back pain in primary care: a RCT (SupportBack 2) by Adam W A Geraghty, Taeko Becque, Lisa C Roberts, Jonathan Hill, Nadine E Foster, Lucy Yardley, Beth Stuart, David A Turner, Gareth Griffiths, Frances Webley, Lorraine Durcan, Alannah Morgan, Stephanie Hughes, Sarah Bathers, Stephanie Butler-Walley, Simon Wathall, Gemma Mansell, Malcolm White, Firoza Davies, Paul Little

“…Plain language summary Low back pain is very common; most people will experience it at some point in their lives. …”
Get full text

An artificial intelligence platform for predicting postoperative complications in metastatic spinal surgery: development and validation study by Weihao Jiang, Juan Zhang, Weiqing Shi, Xuyong Cao, Xiongwei Zhao, Bin Zhang, Haikuan Yu, Shengjie Wang, Yong Qin, Mingxing Lei, Yuncen Cao, Boyu Zhu, Yaosheng Liu

“…This predictive tool can assist healthcare professionals in making informed clinical decisions, ultimately improving patient outcomes and optimizing resource use. …”
Get full text

GIS Analysis Model Integration and Service Composition Prospects by L. Ding, P. Cai, W. Huang, H. Zhang, F. Ding, W. Zhao, D. Tang, Z. Wang

“…Key algorithms are systematically integrated to optimize outcomes in urban planning, disaster management, and precision agriculture. …”
Get full text