The CXCL16/CXCR6 axis is linked to immune effector cell-associated neurotoxicity in chimeric antigen receptor (CAR) T cell therapy by I-Na Lu, Louisa Müller-Miny, Carolin Krekeler, Phyllis Fung-Yi Cheung, Georgia Antonopoulou, Astrid Jeibmann, Andreas Schulte-Mecklenbeck, Kornelius Kerl, Simon Call, Christian Reicherts, Annalen Bleckmann, Matthias Stelljes, Georg Lenz, Heinz Wiendl, Gerd Meyer zu Hörste, Oliver M. Grauer

“…Abstract Background Immune effector cell-associated neurotoxicity syndrome (ICANS) is a common and potentially life-threatening complication of chimeric antigen receptor (CAR) T cell therapy. …”
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Clinical stabilization of a highly refractory acute myeloid leukaemia under individualized treatment with immune response modifying drugs by in vivo generation of dendritic cells o... by Giuliano Filippini Velázquez, Philipp Anand, Joudi Abdulmajid, Xiaojia Feng, Jan Frederic Weller, Klaus Hirschbühl, Helga Schmetzer, Christoph Schmid

“…Immune monitoring showed generation of mature DCleu, activation of leukaemia-directed effector and memory cells (including IFN-γ–producing and degranulating T and NK cells), downregulation of immune checkpoint (PD-1/CTLA-4) expressing T cells and blasts, and a reduction in regulatory B- and T cells. …”
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THE ROLE OF MECHANICAL PROPERTIES OF T-CELLS IN SHAPING THE IMMUNE RESPONSE by Grigory Gorshkov, Anatoliy Bykov, Oxana Svitich

“…AbstractRecent studies in immunology highlight the critical role of mechanical factors in shaping the immune response. Mechanoimmunology, as an emerging interdisciplinary field, investigates the influence of mechanical stimuli on immune cell behavior, particularly T-lymphocytes. …”
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A heat-shocked melanoma cell lysate vaccine enhances tumor infiltration by prototypic effector T cells inhibiting tumor growth by María Alejandra Gleisner, Cristián Pereda, Andrés Tittarelli, Mariela Navarrete, Camila Fuentes, Ignacio Ávalos, Fabian Tempio, Juan Pablo Araya, María Inés Becker, Fermín Eduardo González, Mercedes Natalia López, Flavio Salazar-Onfray

“…Background Immune checkpoint blocker (ICB) therapy has shown survival benefits for some patients with cancer. …”
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Dendritic cell vaccination and CD40-agonist combination therapy licenses T cell-dependent antitumor immunity in a pancreatic carcinoma murine model by Sjoerd H van der Burg, Thorbald van Hall, Heleen Vroman, Menno van Nimwegen, Christianne Groeneveldt, Priscilla Kinderman, Dana A M Mustafa, Nadine van Montfoort, Joachim Aerts, Melanie Lukkes, Sai Ping Lau, Casper H J van Eijck, Larissa Klaase, Mandy van Gulijk, Jasper Dumas, Sanne L A Lievense, Ralph Stadhouders, Yunlei Li, Andrew Stubbs, Koen A Marijt, Floris Dammeijer

“…Extensive analysis of the TME showed that anti-CD40 monotherapy did improve CD8 +T cell infiltration, but these essential effector cells displayed hallmarks of exhaustion, including PD-1, TIM-3 and NKG2A. …”
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Mechanisms of innate immunity in pathogenesis of psoriasis: approaches to targeted therapy by E. D. Merkushova, E. M. Khasanova, L. V. Gankovskaya

“…The study of molecular mechanisms of the innate immune system will reveal new approaches to prognosis and development of targeted therapy for psoriasis.…”
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Interleukin-12 encoded by the oncolytic virus VSV-GP enhances therapeutic antitumor efficacy by inducing CD8+ T-cell responses with a long-lived effector cell phenotype by Janine Kimpel, Dorothee von Laer, Theresa Schwaiger, Guido Wollmann, Jasmin Hatami, Krishna Das, Leonie Wolf, Andreas Aufschnaiter, Tobias Nolden, Liesa-Marie Schreiber, Brigitte Müllauer, Elke Podgorschek, Bart Spiesschaert, Knut Elbers, Zoltán Bánki

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Reduced circulating regulatory T cells in primary Sjögren’s syndrome: the contribution of enhanced apoptosis and impaired survival by Yanlin Wang, Yanlin Wang, Yanlin Wang, Yuhan Jia, Hui Guo, Hui Guo, Min Feng, Min Feng, Min Feng, Yan Qin, Yan Qin, Yan Qin, Zhaojun Liang, Zhaojun Liang, Zhaojun Liang, Xiangcong Zhao, Xiangcong Zhao, Xiangcong Zhao, Chong Gao, Jing Luo, Jing Luo, Jing Luo

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Tumor Immune Response as a Biomarker for Metastasis-Free Survival of Breast Cancer and Immune Checkpoint Inhibition Therapy: A Retrospective Cohort Study by Chung-Wu Lin, Kai-Ming Chang, Wen-Hui Ku, Kuo-Jang Kao

“…Our IR scores were linearly correlated with the Teschendorff, the T-effector and IFNg, and the T–cell inflamed signatures for IR or ICIT. …”
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Differential quantities of immune checkpoint-expressing CD8 T cells in soft tissue sarcoma subtypes by Cornelis Verhoef, Reno Debets, Yarne Klaver, Stefan Sleijfer, Dirk Grünhagen, Rebecca Wijers, Maud Rijnders, Astrid Oostvogels, Marcel Smid, Cor Lamers

“…Introduction Local T-cell immunity is recognized for its contribution to the evolution and therapy response of various carcinomas. …”
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Early changes in immune cell subsets with corticosteroids in patients with solid tumors: implications for COVID-19 management by Renee N Donahue, Jeffrey Schlom, James L Gulley, Lisa Cordes, Jennifer L Marté, Nicole J Toney

“…The affected subsets are essential for effective antiviral immunity. This may have implications for glucocorticoid therapy for COVID-19.…”
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CHARACTERISTICS OF CELLULAR COMPARTMENT CHANGES OF IMMUNE SYSTEM IN THE PATIENTS WITH CHRONIC POLYPOUS RHINOSINUSITIS DEPEND ON EFFICIENCY OF DRUG THERAPY by E. L. Savlevich, A. V. Zurochka, S. V. Khaidukov

“…In case of aggressive CRSwNP and failure of standard drug therapy, we observed a decrease in absolute numbers of effector cells, along with decreased Treg lymphocyte numbers which may explain inefficient immune regulation of inflammatory process and medical interventions in this group of patients.…”
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Regulatory T cell therapy promotes TGF-β and IL-6-dependent pro-inflammatory Th17 cell generation by reducing IL-2 by Hao Cheng, Fang Nan, Ning Ji, Xiao Ma, Jianan Zhang, Hantian Liang, Wei Zhang, Hiroko Nakatsukasa, Huiyuan Zhang, Wenwen Jin, Hong Jiang, Jiyu Tong, Xikun Zhou, Ning Li, Qi Zhang, Hongbo Hu, WanJun Chen, Hao Xu, Dunfang Zhang

“…However, the translation of regulatory T cell therapy into clinical practice poses substantial challenges. …”
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Features of T lymphocyte subpopulation profile in patients with ankylosing spondylitis undergoing genetically engineered biological therapy by A. A. Savchenko, O. D. Gritsenko, A. G. Borisov, I. V. Kudryavtsev, M. K. Serebriakova, A. A. Masterova, P. A. Shesternya

“…The most pronounced changes in T cell subsets were found in AS patients during anti-TNFα therapy was associated with decreased effector potential of Th cells and cytotoxic T lymphocytes. …”
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Integrative bulk RNA analysis unveils immune evasion mechanisms and predictive biomarkers of osimertinib resistance in non-small cell lung cancer by Ling Shi, Feng Qiu, Chao Shi, Guohua Zhang, Feng Yu

“…Batch effect analysis highlighted a marked reduction in effector immune cells, such as activated CD8 + T cells, alongside an increase in immunosuppressive populations, emphasizing the role of immune evasion in osimertinib resistance.We constructed a robust diagnostic model, nomoScore, based on the hub genes, achieving excellent predictive accuracy (AUC > 0.9) in training and validation datasets. …”
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Temporal optimization of CD25-biased IL-2 agonists and immune checkpoint blockade leads to synergistic anticancer activity despite robust regulatory T cell expansion by Blanka Rihova, Kathy Liu, Katerina Behalova, Vladyslav Mazhara, Milada Sirova, Marek Kovar, Irfan Baki Kilic, Petra Weberova, Derek VanDyke, Katerina Kubesova, Charina S Fabilane, Bohumil Ptacek, Jamie B Spangler

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Gene expression and molecular pathway analyses differentiate immunotherapy-induced myositis from spontaneous dermatomyositis by Magdalena Röckel, Luca Musella, Corinna Preusse, Josefine Radke, Lisa Zimmer, Kai-Martin Thoms, Florentia Dimitriou, Matthias Endres, Wolfgang Böhmerle, Waltraud Fröhlich, Sami Tayb-Boulahfa, Sarah Leonard-Louis, Yves Allenbach, Carola Berking, Werner Stenzel, Samuel Knauss, Julio Vera, Lucie Heinzerling

“…Abstract Immune checkpoint inhibitor therapy (ICI)-induced myositis (irMyositis) occurs in about 1% of patients treated with anti-PD1 or anti-CTLA-4 antibodies and can be debilitating or even fatal. …”
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BRAF inhibitor resistance of melanoma cells triggers increased susceptibility to natural killer cell-mediated lysis by Antoine Toubert, Eric Pasmant, Alexandra Frazao, Louise Rethacker, Géraldine Jeudy, Marina Colombo, Marie-Françoise Avril, Helene Moins-Teisserenc, Marie Roelens, Sophie Dalac, Eve Maubec, Anne Caignard

“…Immunotherapies that activate immune cytotoxic effectors induce long-lasting responses in 30% of patients. …”
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GPX4 is a key ferroptosis regulator orchestrating T cells and CAR-T-cells sensitivity to ferroptosis by Marta Kłopotowska, Iwona Baranowska, Szymon Hajduk, Anna Jurga, Natalia Leśniowska, Michał Łaźniewski, Monika Granica, Marta Krawczyk, Milena Dziewicka, Agnieszka Graczyk, Jan Słupski, Radosław Zagożdżon, Dariusz Plewczynski, Magdalena Winiarska, Malgorzata Bajor

“…Abstract Induction of ferroptosis, an iron-dependent form of regulated cell death, holds promise as a strategy to overcome tumor resistance to conventional therapies and enhance immunotherapy responses. …”
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Macrophages and tumor progression: on the way to macrophage-specific therapy by N. V. Cherdyntseva, I. V. Mitrofanova, M. A. Buldakov, M. N. Stakheeva, M. R. Patysheva, M. V. Zavjalova, J. G. Kzhyshkowska

“…Increasing the effectiveness of solid tumor therapy and reducing the possibility of recurrence requires not only the use of optimal individual schemes of therapy for each patient, but also the development of combined approaches aimed at both the destruction of tumor cells and antitumor programming of the microenvironment, where immune cells plays a prominent regulatory role. …”
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