Glutathione peroxidase 8 negatively regulates caspase‐4/11 to protect against colitis by Jye‐Lin Hsu, Jen‐Wei Chou, Tzu‐Fan Chen, Jeh‐Ting Hsu, Fang‐Yi Su, Joung‐Liang Lan, Po‐Chang Wu, Chun‐Mei Hu, Eva Y‐HP Lee, Wen‐Hwa Lee

“…GPx8 binds covalently to caspase‐4/11 via disulfide bonding between cysteine 79 of GPx8 and cysteine 118 of caspase‐4 and thus restrains caspase‐4/11 activation, while GPx8 deficiency leads to caspase‐4/11‐induced inflammation during colitis and septic shock. …”
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Evaluation the Levels of Melatonin, Glutathione Peroxidase and Superoxide Dismutase Enzymes in Prediabetic Individuals by Zeena Abd Ali

“…Iraqi JMS. 2023; 21(1): 63-70. doi: 10.22578/IJMS.21.1.6…”
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Methylation characteristics and clinical significance of glutathione peroxidase 3 in malignant pleomorphic adenoma by LIU Xiao, SUN Jiangwei, ZHOU Jing

“…The proportion of GPX3 protein methylation in normal glandular tissues (7.3%, 4/55) was lower than that in SPA tissues (34.5%, 19/55) and MPA tissues (66.7%, 16/24) (P<0.001). …”
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Elevated serum glutathione peroxidase levels reducing the risk of acute upper gastrointestinal bleeding combined with acute coronary syndrome: Evidence from observational, interven... by Weibo Zhang, Hailing Zhang

“…Results: MR analysis showed no significant causal link between GSH-Px activity and UGIH-ACS risk (IVW OR: 0.966, 95 % CI: 0.873–1.069, p = 0.502), but the weighted median method suggested a marginal protective trend (OR: 0.958, 95 % CI: 0.918–1.000, p = 0.048). …”
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Nanofabricated Bacterial Cell Walls with Intrinsic Peroxidase‐Mimicking and Sonodynamic Activities for Cancer Combination Treatment by Meng Yang, Yang Meng, Junling Li, Liya Bai, Yuanyuan Cheng, Yuanyuan Liu, Mingxin Cao, Xiaoying Yang, Yinsong Wang, Yang Liu

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The influence of glutathione metabolism on alkaline adaptation of Amur ide (Leuciscus waleckii) and potential role of gut microbiota by Zou Yuting, Li Chenghao, Huang Jing, Yang Haochen, Luo Liang, Liew Honjung, Chang Yumei

“…In contrast, the DY group predominantly relied on upregulating chac1-mediated γ-glutamyltransferase activity to facilitate glutathione cycling. …”
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The effect of 12 weeks of HIIT and curcumin consumption on oxidative indices in obese men with type-2 diabetes mellitus by Hasan Naghizadeh, Faeze Heydari

“…The highest significant increase from pretest to posttest in paraoxonase-1 (19.26%, P=0.0001), superoxide dismutase (18.37%, P=0.011), glutathione peroxidase (17.20%, P=0.0001) and the most significant decrease in malondialdehyde (24.47%, P=0.014) was observed in the exercise alone with curcumin group. …”
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Monotropein Induced Ferroptosis to Alleviate the Progression of Hepatocellular Carcinoma via Regulating Nrf2/HO‐1/GPX4 Axis by Bing Shi, Yan‐Ping Li, Zhuo Gan, Pan Chen

“…Furthermore, Mon activated ferroptosis in HCC cells, characterized by elevated levels of Fe2+, reactive oxygen species (ROS), and malondialdehyde (MDA), alongside a reduction in glutathione (GSH) content and downregulation of nuclear factor E2‐related factor 2 (Nrf2), heme oxygenase‐1 (HO‐1), and glutathione peroxidase 4 (Gpx‐4). …”
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Sulfasalazine induces ferroptosis in osteosarcomas by regulating Nrf2/SLC7A11/GPX4 signaling axis by Qingqing Qin, Huaibin Zhang, Min Lai, Jiantong Wei, Jun Qian, Xingchao Chen, Xin Wang, Yongping Wang

“…Mechanistically, we found that SAS induced ferroptosis by downregulating the expression of NRF2, subsequently decreasing the expression of the light chain subunit of the cysteine/glutamate transporter system Xc- (SLC7A11) and glutathione peroxidase 4. Collectively, these findings demonstrate that SAS triggers ferroptosis through the NRF2/SLC7A11/GPX4 signaling axis, thereby inhibiting the biological activity of OS cells. …”
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Effects of pectic oligosaccharide on growth performance, organ indexes and intestinal health in broilers exposed to aflatoxin B1 by Zhengqi Ye, Yongzhi Qin, Haijun Zhang, Meitian Xian, Hui Ye, Qingyun Cao, Zemin Dong, Changming Zhang, Jianjun Zuo, Weiwei Wang

“…POS addition tended to elevate (P < 0.10) ADG and ADFI, as well as mitigated AFB1-induced elevation (P < 0.10) in spleen index and reduction (P < 0.05) of bursal index. …”
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TSPAN15 sustains ITGB1 stability to block gemcitabine-induced ferroptosis in pancreatic ductal adenocarcinoma through the FAK/AKT/Mtor-gpx4 cascade by Peng Nan, Xiao Wang, Anan Li, Yumei Ge, Zongting Gu, Yingying Wang, Ran Tao

“…Mechanistically, TSPAN15 directly interacts with integrin-β1 (ITGB1) and maintains its stability by inhibiting ITGB1 ubiquitination. …”
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Hsp90 C-terminal domain inhibition enhances ferroptosis by disrupting GPX4-VDAC1 interaction to increase HMOX1 release from oligomerized VDAC1 channels by Jieyou Li, Guibing Wu, Hairou Su, Manfeng Liang, Shengpei Cen, Yandan Liao, Xiangjun Zhou, Guantai Xie, Zihao Deng, Wenchong Tan, Yan Li, Wang Xiao, Lixia Liu, Jinxin Zhang, Zhenming Zheng, Yaotang Deng, Yaling Huang, Xiongjie Shi, Yilin Liu, Guowei Zhang, Xuemei Chen

“…The VDAC1 oligomerization promotes the release of Heme oxygenase-1 (HMOX1) from mitochondria into the cytoplasm, leading to iron overload and ultimately promoting ferroptosis. …”
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Lower serum GPX4 and GSH/GSSG ratio are associated with poor prognosis in severe community-acquired pneumonia by Wei Zhu, Kunyu Wang, Xiaolei Xing, Xinxin Xu, Yonghui Liang, Ke Wang

“…GPX4 was lower in COVID-19 cases (P = 0.022), while GSH/GSSG showed no such difference. …”
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Antibody-functionalized iron-based nanoplatform for ferroptosis-augmented targeted therapy of HER2-positive breast cancer by Jingchao Gao, Tong Ye, Hongkun Miao, Mingjiang Liu, Li Wen, Yi Tian, Zhiguang Fu, Li Sun, Lihong Wang, Yu Wang

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TIPE2 suppresses ferroptosis and pro-inflammatory polarization in macrophages triggered by SARS-CoV-2 spike protein by Simin Zhu, Wei Li, Yuqiu Hao, Lin Zhang, Peng Gao

“…Given the emerging evidence that macrophage polarization and dysfunction play pivotal roles in COVID-19 progression, we established a THP-1-derived macrophage model stimulated with the SARS-CoV-2 spike (S) protein to mimic the host immune response. …”
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Integrative proteomic and physiological analyses reveal differential responses between high- and low-Cd-accumulating wheat under Cd stress by Qing Wang, Yuenan Li, Yixiu Wang, Mengjiao Zhang, Yonghui Lv, Haibo Zhang, Na Liu, Hongyan Cheng

“…JM22’s lower Cd accumulation under high Cd stress may be attributed to the up-regulated of 2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one in the benzoxazine biosynthesis, as well as increased expression levels of glutathione reductase, glutathione dehydrogenase/transferase, and glutathione peroxidase in the glutathione metabolism. …”
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Biochemical neuroplasticity in the cerebellum after physical exercise: Systematic review and meta-analysis. by Marcio Gonçalves Corrêa, Thais Alves Lobão, Gabriel Mesquita da Conceição Bahia, Erica Miranda Sanches Aires, Rebeca da Costa Gomes, Jeffeson Hildo Medeiros de Queiroz, Marta Chagas Monteiro, Carlomagno Pacheco Bahia

“…Meta-analyses showed that moderate-volume PE significantly reduced LPO (SMD = -2.41; 95% CI: -3.89 to -0.93), while high-volume PE increased LPO (SMD = 4.55; 95% CI: 1.92 to 7.18). Low-intensity or low-volume PE did not significantly alter oxidative markers.…”
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Macrophages and macrophage extracellular vesicles confer cancer ferroptosis resistance via PRDX6-mediated mitophagy inhibition by Naisheng Zheng, Fuli Li, Qing Huang, Xian Huang, Tomasz Maj

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Bimetallic Plasmonic Nanozyme‐Based Microneedle for Synergistic Ferroptosis Therapy of Melanoma by Wei Duan, Keying Xu, Yue Gao, Sheng Huang, Xueqian Xia, Xiang Liu, Shuangxue Pan, Chunpeng Jiao, Weijian Cheng, Yong Guo, Jingwen Zhao, Jia‐Wei Shen

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The role and mechanism of the cGAS–STING pathway-mediated ROS in apoptosis and ferroptosis induced by manganese exposure by Zhimin Zhang, Jirui Yang, Qiongli Zhou, Shiyin Zhong, Jinghao Luo, Xueting Chai, Jingjing Liu, Xin Zhang, Xuhong Chang, Hui Wang

“…In addition, excessive activation of the cGAS–STING pathway drives ROS accumulation, which impairs iron homeostasis and induces ferroptosis by regulating the expression of solute carrier family 7 member 11 (SLC7A11), glutathione peroxidase 4 (GPX4), ferroptosis suppressor protein 1 (FSP1), dihydroorotate dehydrogenase (DHODH), and acyl-CoA synthetase long-chain family member 4 (ACSL4). …”
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