Risk Prediction of Liver Injury in Pediatric Tuberculosis Treatment: Development of an Automated Machine Learning Model by Zeng Y, Lu H, Li S, Shi QZ, Liu L, Gong YQ, Yan P

“…Ying Zeng,1,* Hong Lu,1,* Sen Li,2,* Qun-Zhi Shi,1 Lin Liu,1 Yong-Qing Gong,1 Pan Yan1 1Department of Pharmacy, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, 410004, People’s Republic of China; 2Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China*These authors contributed equally to this workCorrespondence: Pan Yan, Department of Pharmacy, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, People’s Republic of China, Email 2022050025@usc.edu.cnPurpose: Drug-induced liver injury (DILI) is one of the most common and serious adverse drug reactions related to first-line anti-tuberculosis drugs in pediatric tuberculosis patients. …”
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Uncovering the Heterogeneity of Signaling Pathways in Skin Cutaneous Melanoma: Insights into Prognostic Values and Immune Interactions by Liu Y, Li C, Deng W

“…Yufang Liu,1,* Chunyan Li,2,* Weiwei Deng2 1Department of Dermatology and Venereology, Fuyang People’s Hospital, Fuyang, Anhui, 236000, People’s Republic of China; 2Department of Dermatology and Venereology, Dermatology Hospital of Southern Medical University, Department of Dermatology, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Weiwei Deng, Email dengww@smu.edu.cnBackground: Signaling pathways play crucial roles in tumor cells. …”
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Injectable Nanocomposite Hydrogel for Accelerating Diabetic Wound Healing Through Inflammatory Microenvironment Regulation by Chen Y, Li Y, Song H, Liu X, Zhang H, Jiang J, Liu H, Zhuo R, Cheng G, Fang J, Xu L, Qi Y, Sun D

“…Yuhui Chen,1,* Ying Li,1,* Haoning Song,1,* Xiaochun Liu,1 Hongan Zhang,1 Jiaxin Jiang,2 Hongsheng Liu,2 Ribo Zhuo,1 Guoyun Cheng,1 Jia Fang,1 Lei Xu,1 Yong Qi,1 Dawei Sun1 1Department of Orthopedics and Traumatology, The Affiliated Guangdong second Provincial General Hospital of Jinan University, Guangzhou, Guangdong, 510315, People’s Republic of China; 2Guangdong Huayi Biomedical Science and Technology Center, Guangzhou, Guangdong, 511450, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lei Xu, Department of Orthopedics and Traumatology, Guangdong second Provincial General Hospital of Jinan University, No. 466 Xingang Middle Road, Haizhu District, Guangzhou, Guangdong, People’s Republic of China, Email orthoxl@163.com Dawei Sun, Department of Orthopedics and Traumatology, Guangdong second Provincial General Hospital of Jinan University, No. 466 Xingang Middle Road, Haizhu District, Guangzhou, Guangdong, People’s Republic of China, Email sundw@gd2h.org.cnBackground: A paramount issue in the realm of chronic wound healing among diabetic patients is the pervasive inflammatory response that persistently thwarts angiogenesis, thereby precipitating protracted delays in the healing process of such wounds. …”
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The dynamics of CD4+ T cell proliferation and regulation by Mingran Zhang, Junling Ma, Roderick Edwards, Meili Li

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Enhanced Antitumor Efficacy and Reduced Toxicity in Colorectal Cancer Using a Novel Multifunctional Rg3- Targeting Nanosystem Encapsulated with Oxaliplatin and Calcium Peroxide by Xie Y, Zhu M, Bao H, Chen K, Wang S, Dai J, Chen H, Li H, Song Q, Wang X, Yu L, Pei J

“…Yizhuo Xie,1 Ming Zhu,1 Han Bao,1 Kejia Chen,1 Shanshan Wang,1 Jingwen Dai,1 Hongzhu Chen,1 He Li,1 Qi Song,2 Xinlu Wang,2 Liangping Yu,2 Jin Pei1 1Department of Biopharmacy, School of Pharmaceutical Sciences, Jilin University, Changchun, People’s Republic of China; 2Department of Clinical Pharmacy, the First Hospital of Jilin University, Changchun, People’s Republic of ChinaCorrespondence: Jin Pei, Department of Biopharmacy, School of Pharmaceutical Sciences, Jilin University, No. 1163 Xinmin Street, Changchun, 130021, People’s Republic of China, Tel +86-431-85619725, Email peijin@jlu.edu.cn Liangping Yu, Department of Clinical Pharmacy, the First Hospital of Jilin University, No. 1 Xinmin Street, Changchun, 130061, People’s Republic of China, Tel +86 431 81879802, Email liangpingyu@jlu.edu.cnPurpose: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. …”
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Role of Aging in Ulcerative Colitis Pathogenesis: A Focus on ETS1 as a Promising Biomarker by Ni M, Peng W, Wang X, Li J

“…Man Ni,1,2 Weilong Peng,1,2 Xiaoguang Wang,1,2 Jingui Li1,2 1School of Veterinary Medicine, Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, People’s Republic of China; 2Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu, 225009, People’s Republic of ChinaCorrespondence: Jingui Li, School of Veterinary Medicine, Yangzhou University, No. 48, Daxue North Road, Hanjiang District, Yangzhou City, Jiangsu, 225009, People’s Republic of China, Email jgli@yzu.edu.cnPurpose: An increasing proportion of the aging population has led to a rapid increase in the number of elderly patients with ulcerative colitis (UC). …”
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A new conceptual model for seed germination and seedling tillering of winter wheat in the field by Jinping Chen, Peter A. Whalley, Zhongyang Li, Xiaoxian Zhang, Malcolm J. Hawkesford, W. Richard Whalley

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Russian Strategy for Eurasian Integration: Key Elements, Determinants and Prospects for Development by D. S. Alekseev

“…Eurasia is gradually turning into the point of intersection of various longterm political and economic initiatives undertaken by the leading actors of contemporary international relations, including the Russian Federation, the European Union, the United States and the People’s Republic of China. This trend compounded by a complicated dynamics of integration and disintegration processes in the post-Soviet states further exacerbates tensions in the region, already fraught with conflict. …”
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Advances in Focal Segmental Glomerulosclerosis Treatment From the Perspective of the Newest Mechanisms of Podocyte Injury by Zhu Y, Xu G

“…Yan Zhu,1,2 Gaosi Xu1,2 1Department of Nephrology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang City, Jiangxi Province, People’s Republic of China; 2Jiangxi Key Laboratory of Molecular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang City, Jiangxi Province, People’s Republic of ChinaCorrespondence: Gaosi Xu, Email gaosixu@163.comAbstract: Podocyte injury was widely recognized as a fundamental mechanism driving the progression of focal segmental glomerulosclerosis (FSGS). …”
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Investigation of reactive power referring to recent studies of time-averaged stored energy density by Jiangwei Chen, Jiacheng Qiu

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Metformin Ameliorates Ulcerative Colitis Through Inhibiting NLRP3 Inflammasome Activation by Cao R, Jing J, Ma Y, Qi W, Huang X, Zhang C, Lu Z, He J, Wang G, Ma Y, Zhang H

“…Run Cao,1,* Jing Jing,1,* Yuting Ma,1,2,* Wenqing Qi,1 Xinyu Huang,1 Chaofang Zhang,1 Zhizhuo Lu,1 Jiayi He,1 Guiling Wang,1 Yuanfang Ma,1 Hailong Zhang1 1Joint National Laboratory for Antibody Drug Engineering, the First Affiliated Hospital, Henan University, Kaifeng, Henan, People’s Republic of China; 2Xuzhou Central Hospital, Xuzhou, Jiangsu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hailong Zhang; Yuanfang Ma, Joint National Laboratory for Antibody Drug Engineering, the First Affiliated Hospital, Henan University, Kaifeng, Henan, People’s Republic of China, Email hailong6891@163.com; mayf@henu.edu.cnPurpose: Metformin (Met) is widely used to treat a variety of diseases, but its role in ulcerative colitis (UC) has not been fully elucidated. …”
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Analysis and Validation of Autophagy-Related Gene Biomarkers and Immune Cell Infiltration Characteristic in Bronchopulmonary Dysplasia by Integrating Bioinformatics and Machine Lea... by Xiao S, Ding Y, Du C, Lv Y, Yang S, Zheng Q, Wang Z, Zheng Q, Huang M, Xiao Q, Ren Z, Bi G, Yang J

“…Shuzhe Xiao,1,* Yue Ding,1,* Chen Du,1,* Yiting Lv,1 Shumei Yang,1,2 Qi Zheng,3 Zhiqiu Wang,3 Qiaoli Zheng,3 Meifang Huang,1 Qingyan Xiao,1 Zhuxiao Ren,2 Guangliang Bi,1 Jie Yang1,2 1Department of Neonatology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, People’s Republic of China; 2Department of Neonatology, Guangdong Women and Children Hospital, Guangzhou, 511442, People’s Republic of China; 3The First Clinical Medical College of Southern Medical University, Guangzhou, 510515, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jie Yang; Guangliang Bi, Email Jieyang0830@126.com; bader515@163.comBackground: Autophagy and immunity play important regulatory roles in lung developmental disorders. …”
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Phage vB_Kpn_HF0522: Isolation, Characterization, and Therapeutic Potential in Combatting K1 Klebsiella pneumoniae Infections by Yan T, Wang Q, Ma C, Teng X, Gong Z, Chu W, Zhou Q, Liu Z

“…Tao Yan,1,2 Qiuyan Wang,2 Chengcheng Ma,2 Xuan Teng,2 Zhen Gong,2 Wenwen Chu,2 Qiang Zhou,2 Zhou Liu1 1Department of Clinical Laboratory Center, Anhui Chest Hospital, Hefei, 230031, People’s Republic of China; 2Department of Clinical Laboratory, the Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, People’s Republic of ChinaCorrespondence: Zhou Liu, Department of Clinical Laboratory Center, Anhui Chest Hospital, Hefei, People’s Republic of China, Email liuzhou0112@ahmu.edu.cnPurpose: Klebsiella pneumoniae is a globally prevalent pathogen responsible for severe hospital- and community-acquired infections, and presents significant challenges for clinical management. …”
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Unusual Cutaneous Manifestations in a Patient with a History of Hepatitis B: A Case of Scleromyxedema and Literature Review by Gao A, Tian X, Lang D, Chen Y

“…Aili Gao, Xin Tian, Dexiu Lang, Yue Chen Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, Guangdong, People’s Republic of ChinaCorrespondence: Yue Chen, Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, People’s Republic of China, Tel/Fax +86-020-83593472, Email cheny767@mail3.sysu.edu.cnAbstract: Scleromyxedema (SM) is a rare primary cutaneous mucinosis characterized by systemic papules and scleroderma-like manifestations, often associated with monoclonal gammopathy. …”
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Non-Luminal Disease Score for Everolimus in Patients with Hormone Receptor‑positive and Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: A Mult... by Tan Y, Jiang H, Tian X, Ma F, Wang J, Zhang P, Xu B, Fan Y, Zhao W

“…Yujing Tan,1,* Hanfang Jiang,2,* Xinzhu Tian,1,* Fei Ma,1 Jiayu Wang,1 Pin Zhang,1 Binghe Xu,1 Ying Fan,1 Weihong Zhao3 1Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100021, People’s Republic of China; 2Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Breast Oncology, Peking University Cancer Hospital & Institute, Beijing, 100142, People’s Republic of China; 3Department of Medical Oncology, Chinese PLA General Hospital, Beijing, 100853, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ying Fan; Weihong Zhao, Email fanying@cicams.ac.cn; zhaowh0818@163.comPurpose: This study aims to explore the role of the non-luminal disease score (NOLUS) for everolimus in patients with hormone receptor-positive and human epidermal growth factor receptor 2-negative (HR+/HER2-) advanced breast cancer (ABC).Methods: NOLUS has previously been established as an algorithm: NOLUS (0– 100) = − 0.45 × ER(%) − 0.28 × PR(%) + 0.27 × Ki67(%) + 73. …”
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Identification of Anoikis-Related Genes in Chronic Kidney Disease Based on Bioinformatics Analysis Combined with Experimental Validation by Liu H, Mei M, Zhong H, Lin S, Luo J, Huang S, Zhou J

“…Hong Liu,1,* Manxue Mei,1,* Hua Zhong,2 Shuyin Lin,1 Jiahui Luo,1 Sirong Huang,1 Jiuyao Zhou1 1Department of Pharmacology, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China; 2Department of Gerontology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jiuyao Zhou, Department of Pharmacology, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China, Email yaoli@gzucm.edu.cn, zhoujiuyao@vip.tom.comBackground: Chronic kidney disease (CKD) is a progressive condition that arises from diverse etiological factors, resulting in structural alterations and functional impairment of the kidneys. …”
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Intervening Non-Small-Cell Lung Cancer Progression by Cell Membrane Coated Platycodin D via Regulating Hsa-miR-1246/FUT9/GSK3β Pathway by Zheng S, Xie Z, Zhou Z, Wang S, Xin Y, Lin J, Cheng K, Lu T, Qi R, Guo Y

“…Shuyu Zheng,1,2 Zejuan Xie,1 Ziao Zhou,1 Shanshan Wang,1 Yanlin Xin,1 Jiamin Lin,1 Keyu Cheng,1 Tianming Lu,1 Ruogu Qi,1 Yuanyuan Guo1 1Department of Biochemistry and Molecular Biology, School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, People’s Republic of China; 2Department of Neurosurgery, The Second Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang Province, 310009, People’s Republic of ChinaCorrespondence: Ruogu Qi; Yuanyuan Guo, Department of Biochemistry and Molecular Biology, School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, People’s Republic of China, Email rqi@njucm.edu.cn; guoyy@njucm.edu.cnPurpose: Metastatic non-small cell lung cancer (NSCLC) remains a global health threat, with patients facing inevitable disease progression despite standard-of-care therapy. …”
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Novel Insight into the Modulatory Effect of Traditional Chinese Medicine on Cerebral Ischemia-Reperfusion Injury by Targeting Gut Microbiota: A Review by Ren Y, Chen G, Hong Y, Wang Q, Lan B, Huang Z

“…Yisong Ren, Gang Chen, Ying Hong, Qianying Wang, Bo Lan, Zhaozhao Huang Department of Critical Care Medicine, Chengdu Pidu District Hospital of Traditional Chinese Medicine, Chengdu, Sichuan Province, 611731, People’s Republic of ChinaCorrespondence: Zhaozhao Huang, Department of Critical Care Medicine, Chengdu Pidu District Hospital of Traditional Chinese Medicine, No. 169, Zhongxin Avenue, Pidu District, Chengdu, Sichuan Province, 611731, People’s Republic of China, Email tcmhzz@126.comAbstract: Cerebral ischemia-reperfusion injury (CIRI) is clinically characterized by high rates of morbidity, disability, mortality, and recurrence as well as high economic burden. …”
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Cardiac Response Dynamics in Newly Diagnosed Light-Chain Amyloidosis Patients With Early and High-Quality Hematologic Response by Cheng-yang Xu, MD, Ai Guan, MD, Lu Zhang, MD, Zhuang Tian, MD, Dao-bin Zhou, MD, Kai-ni Shen, MD, Jian Li, MD

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Development and Validation of a Nosocomial Infection Nomogram Model in the NICU: A Novel and Nurse-Led Way to Prediction in Preterm Infants by Shang Y, Chen L, Hu X, Zhang K, Cheng Q, Shui X, Deng Z

“…Yanyan Shang,* Ling Chen,* Xindie Hu, Keqian Zhang, Qian Cheng, Xiaoyu Shui, Zhiyue Deng Department of Neonatology, Renmin Hospital of Wuhan University, Wuhan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhiyue Deng; Xiaoyu Shui, Department of Neonatology, Renmin Hospital of Wuhan University, Wuchang District, Jiefang Road, No. 99, Wuhan, Hubei, 430060, People’s Republic of China, Tel +86 18086403090, Email 2015302180361@whu.edu.cn; 15926276672@163.comPurpose: Nosocomial infections (NI) are a leading cause of mortality in preterm infants in the Neonatal Intensive Care Unit (NICU). …”
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