Pseudogenes in the carcinogenesis: epithelial-to-mesenchymal transition process and cancer initiating cells by Tomasz Kolenda, Piotr Chałaj, Aleksandra Cichowicz, Aleksandra Trojańska, Andrzej Bałoniak, Malwina Kwaśniewska, Magda Odrobińska, Kacper Guglas, Joanna Kozłowska-Masłoń, Paulina Gieremek, Paulina Poter, Marlena Janiczek-Polewska, Anna Florczak-Substyk, Anna Przybyła, Patrycja Mantaj, Katarzyna Regulska, Beata Jadwiga Stanisz, Zefiryn Cybulski, Urszula Kazimierczak

Subjects: Get full text

Elevated Expression of AXL May Contribute to the Epithelial-to-Mesenchymal Transition in Inflammatory Bowel Disease Patients by Éva Boros, Zoltán Kellermayer, Péter Balogh, Gerda Strifler, Andrea Vörös, Patrícia Sarlós, Áron Vincze, Csaba Varga, István Nagy

“…Understanding the molecular mechanisms inducing and regulating epithelial-to-mesenchymal transition (EMT) upon chronic intestinal inflammation is critical for understanding the exact pathomechanism of inflammatory bowel disease (IBD). …”
Get full text

THE ROLE OF EPITHELIAL-TO-MESENCHYMAL TRANSITION AND AUTOPHAGY IN ANTITUMORAL RESPONSE OF MELANOMA CELL LINES TO TARGET INHIBITION OF MEK AND mTOR KINASES by A. S. Lozhkomoev, O. V. Bakina, A. N. Fomenko, A. V. Avgustinovich, S. G. Afanasyev, A. Yu. Dobrodeev, L. V. Spirina, A. S. Tarasova, U. B. Urmonov

“…Autophagy and the epithelial-to-mesenchymal transition (EMT) are closely interrelated and play a key role in tumor progression. …”
Get full text

Peritoneal Dialysis -Associated Fibrosis: Emerging Mechanisms and Therapeutic Opportunities by Narayan Prasad, Saurabh Chaturvedi, Harshit Singh, Mary Priyanka Udumula, Atul Rawat, Meyyappan Jeyakumar, Akhilesh Jaiswal, Sachin Kumar, Vikas Agarwal

“…The spectrum of PD-associated peritoneal fibrosis encompasses a diverse range of collective mechanisms: peritoneal fibrogenesis, epithelial to mesenchymal transition (EMT), peritonitis, angiogenesis, sub-mesothelial immune cells infiltration, and collagen deposition in the sub-mesothelial compact zone of the membrane that accompany deteriorating membrane function. …”
Get full text

Interplay of YEATS2 and GCDH regulates histone crotonylation and drives EMT in head and neck cancer by Deepak Pant, Parik Kakani, Rushikesh Joshi, Abin Sabu, Shruti Agrawal, Atul Samaiya, Sanjeev Shukla

“…Here, we investigated the interplay between a highly expressed epigenetic factor, YEATS2, and a metabolic enzyme, GCDH, in regulating epithelial-to-mesenchymal transition in head and neck cancer. …”
Get full text

Regulation of EMT-MET and chemoresistance by the Lc3Cer-synthase B3GNT5 by Laura E. Clark, Katherine Hylton Rorie, Amanda J. G. Dickinson, Santiago Lima

“…Abstract Background Glycosphingolipids (GSL) are essential components of the plasma membrane where they are known to play key structural and functional roles and are known to influence molecular processes involved in cancer malignancy, including multi-drug chemoresistance, the epithelial to mesenchymal transition (EMT), and the activation or receptor tyrosine kinases (RTK). …”
Get full text

The Role of the TIMP1/LINC01615 Axis as a Regulator of the EMT Pathway in Gastric Cancer by Jiying Liu, Yeganeh Olyaee, Khatere Mokhtari, Chaoxiang Lv, Niloufar Salimian, Maliheh Entezari, Afshin Taheriazam, Mehrdad Hashemi, Mazaher Maghsoudloo, Ling Yuan

“…Abstract Objective Gastric cancer (GCa) is a common malignancy where the epithelial-to-mesenchymal transition (EMT) pathway and lncRNAs are key to proliferation and metastasis. …”
Get full text

Hypoxia-induced genome-wide DNA demethylation by DNMT3A and EMT of cancer cells by Biswanath Chatterjee, Pritha Majumder, Chun-Chang Chen, Jing-Ping Wang, Po-Hsuan Su, Hung-Cheng Lai, Ching-Chen Liu, Hsin-Nan Lin, Chen-Hsin A. Yu, Hanna S. Yuan, Che-Kun James Shen

“…Abstract Background Despite the comprehensive advancement in the field of cancer therapeutics, there remains an urgent need to identify new pathophysiological mechanisms that can be targeted in isolation or in combination with existing therapeutic regimens. The epithelial-to-mesenchymal transitions (EMT) induced by hypoxia, cytokines, and growth factors involves acquisition of invasive and migratory properties by cancer cells. …”
Get full text

Chemerin Enhances Migration and Invasion of OC Cells via CMKLR1/RhoA/ROCK-Mediated EMT by Xiaojing Sun, Yi Guo

“…SK-OV-3 cells undergo morphological elongation characterized by epithelial-to-mesenchymal transition (EMT) and Ras homologous genome members A (RhoA)/Rho protein-related curl spiral kinase-1 (ROCK1) activation. …”
Get full text

Expression analysis of LINC00671 and LINC01913 long non-coding RNAs in gastric cancer patients and their correlation with EMT markers by Fatemeh Taghavinia, Negin Taghehchian, Iman Salahshourifar, Mohammad Reza Abbaszadegan

“…This study aimed to evaluate the expression profiles of LINC00671 and LINC01913 in GC patients and investigate their correlation with epithelial-to-mesenchymal transition (EMT) markers. Method The real-time PCR technique was applied to measure the expression levels of the selected lncRNAs (LINC01913 and LINC00671) and EMT-related mRNAs (MAMLs and MMP-13) in 83 tumor and adjacent normal tissues obtained from GC patients. …”
Get full text

Autophagy inhibition improves sensitivity to the multi-kinase inhibitor regorafenib in preclinical mouse colon tumoroids by Giulia Agostini, Giulia Agostini, Morgane Leprovots, Jérôme Jeandriens, Anne Lefort, Anne Lefort, Frédérick Libert, Frédérick Libert, Francesco Sclafani, Ingrid Langer, Alain Hendlisz, Marie-Isabelle Garcia

“…Transcriptomic analysis of Apc wild-type and Apc-deficient organoids treated with regorafenib revealed upregulation of epithelial-to-mesenchymal transition (EMT), alterations in the secretome, and increased activation of phosphorylated Erk1/2. …”
Get full text

Angiotensin II type 2 receptor–interacting protein 3a inhibits ovarian carcinoma metastasis via the extracellular HMGA2-mediated ERK/EMT pathway by Ping Huang, Liang Guo, Jie Xi, Donghui Wang

Get full text

The Wnt/β-catenin and PI3K/Akt signaling pathways promote EMT in gastric cancer by epigenetic regulation via H3 lysine 27 acetylation by Yue Song, Zhao-xia Li, Xi Liu, Rui Wang, Li-wei Li, Qingyu Zhang

Get full text

Small Nuclear RNA 64 (snoRNA64): A novel Tumor Biomarker for Pancreatic Cancer by Rana Alfardan

“…Together, snoRNA64 expression may participate in epithelial to mesenchymal transition (EMT) and mesenchymal to epithelial transition (MET), in which during metastasis these processes are crucial. …”
Get full text

CFTR ion transport deficiency primes the epithelium for partial epithelial-mesenchymal transition in cystic fibrosis by Cláudia S. Rodrigues, Matilde Canto, Raquel Torres, Violeta Railean, Sofia S. Ramalho, Carlos M. Farinha, Ines Pankonien, Margarida D. Amaral

“…CFTR dysfunction disrupts epithelial barrier integrity, drives progressive airway remodelling and has been associated with epithelial-to-mesenchymal transition (EMT), a process in which cells lose epithelial properties and acquire mesenchymal characteristics. …”
Get full text

Propionate reinforces epithelial identity and reduces aggressiveness of lung carcinoma by Vignesh Ramesh, Paradesi Naidu Gollavilli, Luisa Pinna, Mohammad Aarif Siddiqui, Adriana Martinez Turtos, Francesca Napoli, Yasmin Antonelli, Aldo Leal‐Egaña, Jesper Foged Havelund, Simon Toftholm Jakobsen, Elisa Le Boiteux, Marco Volante, Nils Joakim Færgeman, Ole N Jensen, Rasmus Siersbæk, Kumar Somyajit, Paolo Ceppi

“…Abstract The epithelial‐to‐mesenchymal transition (EMT) plays a central role in the development of cancer metastasis and resistance to chemotherapy. …”
Get full text

Comparative Transcriptomic Analyses of a Vero Cell Line in Suspension versus Adherent Culture Conditions by Marie-Angélique Sène, Yu Xia, Amine A. Kamen

“…Results show downregulation of the epithelial-to-mesenchymal transition (EMT) pathway, highlighting the dissociation between the adaptation to suspension process and EMT. …”
Get full text

Therapeutic limitations of oncolytic VSVd51-mediated miR-199a-5p delivery in triple negative breast cancer models by Guillaume St-Cyr, Lauren Daniel, Hugo Giguère, Rayanna Birtch, Carolina S. Ilkow, Lee-Hwa Tai

“…Abstract Triple-negative breast cancer (TNBC) metastasis is driven, in part, by the epithelial-to-mesenchymal transition (EMT), a process critical for cancer cell migration and invasion. …”
Get full text

3D collagen high-throughput screen identifies drugs that induce epithelial polarity and enhance chemotherapy response in colorectal cancer by Sarah J. Harmych, Thomas P. Hasaka, Chelsie K. Sievers, Seung Woo Kang, Marisol A. Ramirez, Vivian Truong Jones, Zhiguo Zhao, Oleg Kovtun, Claudia C. Wahoski, Qi Liu, Ken S. Lau, Robert J. Coffey, Joshua A. Bauer, Bhuminder Singh

“…Abstract Loss of polarity is a hallmark of cancer, and the related epithelial-to-mesenchymal transition (EMT) phenotype impacts prognosis and therapy outcomes, particularly in colorectal cancer (CRC). …”
Get full text

Insights into the Molecular Mechanisms and Novel Therapeutic Strategies of Stenosis Fibrosis in Crohn’s Disease by Yuan Zhou, Huiping Chen, Qinbo Wang, Guozeng Ye, Yingjuan Ou, Lihong Huang, Xia Wu, Jiaxi Fei

“…Emerging evidence highlights the multifactorial nature of stenosis-associated fibrosis, driven by profibrotic mediators and dysregulated crosstalk among immune, epithelial, and mesenchymal cells. Key pathways, including transforming growth factor (TGF-β), drosophila mothers against decapentaplegic protein (Smad) signaling, Wnt/β-catenin activation, epithelial–mesenchymal transition (EMT), and matrix metalloproteinase (MMP) and tissue inhibitors of metalloproteinase (TIMP)-mediated ECM remodeling, orchestrate fibrotic progression. …”
Get full text