COMPARATIVE EFFICACY OF AMIODARONE AND BISOPROLOL IN TREATMENT OF VENTRICULAR PREMATURE BEATS IN PATIENTS WITH METABOLIC SYNDROME by V. M. Provotorov, M. L. Gluhovsky

“…A number of patients stopped therapy because of side effects was comparable in the both groups. Patient age younger than 42 years old in combination with a number of ventricular premature beats morphology less than 4 allowed predicting effective antiarrhythmic treatment for both drugs with sensitivity of 70.3% and specificity of 65.0%.Conclusion. …”
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Evaluating the efficacy of Internet-Based Exercise programme Aimed at Treating knee Osteoarthritis (iBEAT-OA) in the community: a study protocol for a randomised controlled trial by Abhishek Abhishek, Sameer Akram Gohir, Paul Greenhaff, Ana M. Valdes

“…We anticipate recruiting participants into equal groups. The intervention group (n=67) will exercise for 20–30 min daily for six consecutive weeks, whereas the control group (n=67) will follow GP-recommended routine care. …”
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TITERS OF ANTIBODIES TO Β1-ADRENOCEPTOR AND M2 CHOLINERGIC RECEPTORS IN PATIENTS WITH VENTRICULAR ARRHYTHMIAS WITHOUT AN ORGANIC CARDIOVASCULAR DISEASE AND THEIR POSSIBLE CLINICAL... by M. M. Rogova, N. A. Mironova, E. S. Rodionova, T. A. Malkina, K. A. Zykov, Zh. D. Bespalova, R. Sh. Bibilashvili, E. E. Efremov, S. P. Golitsyn

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Balancing ethics and statistics: machine learning facilitates highly accurate classification of mice according to their trait anxiety with reduced sample sizes by Johannes Miedema, Beat Lutz, Susanne Gerber, Irina Kovlyagina, Hristo Todorov

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Change in elevation predicts 100 km ultra marathon performance by Beat Knechtle, Katja Weiss, David Valero, Volker Scheer, Elias Villiger, Pantelis T. Nikolaidis, Marilia Andrade, Ivan Cuk, Robert Gajda, Thomas Rosemann, Mabliny Thuany

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Incidental findings on non-contrast abdominal computed tomography in an asymptomatic population: Prevalence, economic and health implications. by Alexander Ritter, Maximilian Sabev, Olivier Bonny, Gregoire Wuerzner, Thomas Ernandez, Florian Buchkremer, Stephan Segerer, Daniel G Fuster, Beat Roth, Nilufar Mohebbi, Lena Jellestad, Andreas M Hoetker, Carsten A Wagner, Harald Seeger

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Protocol for a randomised controlled trial to compare postoperative complications between minimally invasive and open DIStal PAnCreaTectomy (DISPACT-2 trial) by Thilo Hackert, Arianeb Mehrabi, Thomas Bruckner, Pascal Probst, Felix Nickel, Beat Peter Müller-Stich, Colette Dörr-Harim, Fabian Schuh, Anja Sander, Christina Klose, Inga Rossion, Markus W. Büchler, Markus K. Diener

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Pulsed-field ablation versus cryoballoon ablation in patients with persistent atrial fibrillation by Corinne Isenegger, Rebecca Arnet, Fabian Jordan, Sven Knecht, Philipp Krisai, Gian Völlmin, Jonas Brügger, David Spreen, Nicolas Schaerli, Behnam Subin, Beat Schär, Nicola Formenti, Felix Mahfoud, Christian Sticherling, Michael Kühne, Patrick Badertscher

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Evaluation of the role of transhepatic flow in postoperative outcomes following major hepatectomy (THEFLOW): study protocol for a single-centre, non-interventional cohort study by Karl Heinz Weiss, Mohammad Golriz, Anastasia Lemekhova, Elias Khajeh, Omid Ghamarnejad, Mohammed Al-Saeedi, Oliver Strobel, Beat Müller-Stich, Martin Schneider, Christoph Berchtold, Parham Tinoush, Philipp Mayer, De-Hua Chang, Katrin Hoffmann

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COVID-19 mortality in women and men in sub-Saharan Africa: a cross-sectional study by Claire Somerville, Isotta Triulzi, Giuseppe Turchetti, Benido Impouma, Olivia Keiser, Jyoti Dalal, Ananthu James, Benedict Nguimbis, Gabriela Guizzo Dri, Akarsh Venkatasubramanian, Lucie Noubi Tchoupopnou Royd, Sara Botero Mesa, Beat Stoll, Jessica Lee Abbate, Franck Mboussou, Flávio Codeço Coelho

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Profiling of insulin-resistant kidney models and human biopsies reveals common and cell-type-specific mechanisms underpinning Diabetic Kidney Disease by Abigail C. Lay, Van Du T. Tran, Viji Nair, Virginie Betin, Jennifer A. Hurcombe, Alexandra F. Barrington, Robert JP Pope, Frédéric Burdet, Florence Mehl, Dmytro Kryvokhyzha, Abrar Ahmad, Matthew C. Sinton, Philip Lewis, Marieangela C. Wilson, Rajasree Menon, Edgar Otto, Kate J. Heesom, Mark Ibberson, Helen C. Looker, Robert G. Nelson, Wenjun Ju, Matthias Kretzler, Simon C. Satchell, Maria F. Gomez, Richard J. M. Coward, BEAt-DKD consortium

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Pharmacoeconomic analysis of heart rate slowing drugs in patients with ischemic heart disease by E. I. Tarlovskaya, T. I. Chudinovskikh

“…Significant HR slowing was found in both groups by the end of observation. In group A baseline HR was 70.0±5.6 beats/min and in 6 weeks - 58.1±3.8 beats/min, while in group B - 69.5±5.2 and 60.5±3.9 beats/min respectively. …”
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Comparison between carotid corrected flow time changes in septic shock patients induced by fluid challenge tests by Islam Hamdy Elsayed Youssif, Tayseer Mohamed Zaytoun, Akram Muhammad Fayed, Haitham Saber Meligy, Mahmoud Abdelaziz Abdelnaby Ghalab

“…Design: A prospective, open-label, randomized, controlled, parallel-arm, and monocentric.Settings and patients This study was carried out on 200 septic shock cases.Intervention and main variable of interest Patients were randomized 1:1 as an intervention group receiving 500 ml of intravenous glucose 5% over 5 min and a standard group receiving 500 ml of intravenous saline solution over 5 min then carotid artery corrected flow time shift was compared between the baseline and after the fluid expanded to its final state.Results After treatment, average heart rate was 97 ± 11 and 102 ± 11 beat/min in the standard care and intervention groups of both cohorts decreased significantly in comparison (p < .001). …”
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A randomized trial of CES integrated with music on sleep improvement by Shengnan Zhang, Huifei Zhang, Xinhua Wei, Zibing Fang, Yuan Zhang, Yudan Lv

“…All participants have been divided into three such as control group with treatment-as-usual (TAU) alone, CES plus double beat added to TAU, CES plus Pink noise added to TAU. …”
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THE KARDIOKANON STUDY: A WAY TO SETTLE THE SUBJECT OF CLINICAL EQUIVALENCE OF GENERIC AND ORIGINAL DRUGS by S. Yu. Martsevich, N. P. Kutishenko, M. L. Ginzburg, G. V. Matyushin, V. V. Skibitskiy, L. A. Sokolova, A. V. Deev

“…Patients (n=120), aged 40–72 (58.7±7.7) years, 93 men and 27 women, with stable angina, functional class (FC) II (n=117, 97.5%) and III (n=3, 2.5%), were included in the multi-center open randomized study with parallel groups. Patients were randomized into 2 groups: group 1 (n=59) received therapy with original drugs only , and group 2 (n=61) — with generics ones only. …”
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Right Ventricular Dysfunction in Lung Disease/Hypoxia‐Associated Pulmonary Hypertension by Hideki Shima, Ichizo Tsujino, Toshitaka Nakaya, Junichi Nakamura, Ayako Igarashi‐Sugimoto, Takahiro Sato, Taku Watanabe, Hiroshi Ohira, Ryo Hisada, Masaru Kato, Satonori Tsuneta, Isao Yokota, Satoshi Konno

“…Similarly, whereas the group with PAH showed improvement in β and Ees/arterial elastance with pulmonary vasodilator therapy, such improvement was not observed in the group with lung disease/hypoxia‐associated PH. …”
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STUDY OF CLINICAL EFFICACY OF ORIGINAL AND GENERIC DRUGS OF IVABRADINE IN PATIENTS WITH STABLE ANGINA (СOMPARATIVE STUDY) by S. V. Povetkin, Ju. V. Luneva

“…A statistically significant decrease in heart rate (from 82.5±6.63 to 66.3±6.18 beats/minute in Group 1 and from 83.0±6.18 to 67.6±5.97 beats/min in the 2nd group, p&lt;0.01 for both) and in blood pressure level was found in groups during the first 4 weeks of follow-up. …”
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POSSIBILITIES OF IVABRADINE, A SELECTIVE INHIBITOR OF ION F-CHANNELS OF SINUS NODE, IN PREVENTION OF ANTHRACYCLINE CARDIOTOXICITY IN PATIENTS WITH BREAST CANCER by Yu. V. Vasyuk, V. V. Nesvetov, E. L. Shkolnik, L. D. Shkolnik, G. V. Varlan, G. E. Gendlin, E. I. Emelina

“…In the main group a decrease in heart rate was observed already by the first month (from 83.6±9.5 to 67.1±7.5 beats/min, p&lt;0.001) and persisted until the 6th month (74.2±14.9 beats/min, p&lt;0.001). …”
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Tandem CD19/CD22 CAR T-cells as potential therapy for children and young adults with high-risk r/r B-ALLResearch in context by Berta González-Martínez, Víctor Galán-Gómez, Alfonso Navarro-Zapata, Isabel Mirones-Aguilar, Marta Cobo, Alicia Pernas-Sánchez, Susana Vallejo, Elena Sánchez-Zapardiel, Odelaisy León-Triana, Carlos Echecopar, Isabel Martínez-Romera, Pilar Guerra-García, Sonsoles San Román-Pacheco, Adela Escudero, Elisa Izquierdo, Manuel Izquierdo, Sara Naharro, Alicia Martín-Ayuso, Halin Bareke, Andrés París-Muñoz, Peirong Hu, Dina Schneider, Rimas J. Orentas, Jordi Minguillón, Antonio Pérez-Martínez

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Lignocaine instilled through the suction channel of a subglottic suction drainage tracheal tube improves tube tolerance during extubation compared to intravenous lignocaine: A doub... by R Sripriya, Jyotsna Namburu, Ghansham Biyani, Nageswara Rao Tangirala, Vaishakh Tharavath, Raza S. Gouri

“…The heart rate immediately following extubation was significantly lower (P = 0.006) in Group SGL: 96 [standard deviation (SD): 19)] [95% confidence interval (CI): 90, 103] beats/min when compared with Group C: 107 (SD: 15) (95% CI: 102, 112) and Group IVL: 108 (SD: 18) (95% CI: 102, 114). …”
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