The association of gene polymorphisms in SREBP and its interaction with nutritional status on blood pressure phenotypes among children: a cross-sectional study by Yuan Zeng, Zehui Fan, Yulian Zhu, Hongju Tian, Mingxia Chen, Yue Gong, Bin Mao, Wanyun Xiang, Xiuqin Hong, Yide Yang

“…In boys, HBP risk increased by 101% for each additional G allele (OR = 2.01, 95% CI 1.15–3.53, P = 0.015), but not in girls. …”
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Earliness and morphotypes of common wheat cultivars of Western and Eastern Siberia by S. E. Smolenskaya, V. M. Efimov, Y. V. Kruchinina, B. F. Nemtsev, G. Y. Chepurnov, E. S. Ovchinnikova, I. A. Belan, E. V. Zuev, Chenxi Zhou, V. V. Piskarev, N. P. Goncharov

“…The revealed high frequency of the Vrn-B1c allele in the Western Siberian cultivars and the Vrn-B1a allele in the Eastern Siberian cultivars suggests their selectivity. …”
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Nature variations of OsNLP4 responsible for nitrogen use efficiency divergence in the two rice subspecies by Jie Wu, Ying Song, Guangyu Wan, Liangqi Sun, Jingxian Wang, Hongkai Wu, Shimei Wang, Chuanzao Mao, Peng Qin, Shigui Li, Chengcai Chu, Chengbin Xiang

“…Mechanistically, the indica allele’s stronger NRE-binding capacity synergistically modulates downstream pathways. …”
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Effect of Vitamin D Receptor Gene Polymorphism (ВsmI, FokI) and its Concentration on the Severity of Covid-Associated Lung Damage by A. M. Karachenova, E. N. Romanova

“…Analysis of the polymorphism of the vitamin D receptor gene VDR: 283 A>G showed the predominant inheritance of allele A and homozygote A/A in patients with a high level of damage to lung tissue due to COVID-19 infection — KT-3, 4. …”
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Fine mapping genetic variants affecting birth weight in sheep: a GWAS of 3007 individuals using low-coverage whole genome sequencing by Ran Li, Yuheng Bai, Maqiang Zhao, Xinyue Zhang, Haiyan Wang, Bo Feng, Shuo Zhang, Huanhuan Zhang, Gang Ren, Xihong Wang, Yu Jiang

“…Results LcWGS with high imputation accuracy (97.8% allelic concordance) enabled genome-wide association studies (GWAS) identifying two novel quantitative trait loci (QTLs) on chromosomes 6 and 9. …”
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Selfish mutations promote age-associated erosion of mtDNA integrity in mammals by Ekaterina Korotkevich, Daniel N. Conrad, Zev J. Gartner, Patrick H. O’Farrell

“…Single-cell DNA sequencing of mouse and human hepatocytes detected increases in abundance of mutant alleles in sequences governing mtDNA replication. …”
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SELECTION FOR BEHAVIOR AND CORRELATION WITH THE MACROGLOBULINE AND LYPOPROTEINE SYSTEMS IN THE AMERICAN MINK (NEOVISON VISON) by V. I. Ermolaev, M. A. Savina, N. C. Yudin, R. B. Aitnasarov, C. V. Nikitin, L. I. Trapezova, O. V. Trapezov

“…The populations differed in markers Lpm1, Lpm3, Lpm5, and Lpm10. Alleles with allotypes Lpm1 and Lpm3 were significantly associated with aggressive behavior, and allele Lpm non-10, with tame behavior. …”
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ROLE OF СD14 AND CYTOKINE GENE POLYMORPHISM IN CLINICAL FEATURES AND OUTCOMES OF NOSOCOMIAL PNEUMONIA by E. A. Baygosina, V. I. Sovalkin

“…A carriership of –511*Т аllele in the patients’ genotype predisposed for reduced terms of pneumonia evolution, like as development of acute respiratory distress syndrome and more pronounced acute phase response (leukocytosis and high levels of C-reactive protein). IL-RN*2 allele was associated with generally poor outcome, whereas presence of –308 (AG, AA) variant of TNFα polymorphic gene was connected with pulmonary and extrapulmonary complications of nosocomial pneumonia. …”
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MICROSATELLITE GENOTYPING OF DON LOCAL GRAPE (VITIS VINIFERA L.) VARIETIES by E. T. Ilnitskaya, S. V. Tokmakov, I. I. Suprun

“…The total number of different alleles per locus varied from 5 (VVS2, VMD7) to 11 (VVMD5) within the Don cultivars analyzed. …”
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Gene polymorphisms of IL-1β (C511T), IL-17A (G197A), IL-12B (A1188C), TNFα (G308A) and IL-4 (C589T) associated with threat of early reproductive losses by E. A. Tatarkova, A. R. Tuguz, A. A. Tsikunib, D. S. Shumilov, I. V. Smolkov, K. A. Rudenko, D. V. Muzhenya

“…SNP-typing of polymorphic variants of cytokine genes IL-1β, IL-17A, IL-12B, TNFα and IL-4 was carried out by PCR (polymerase chain reaction) with allele-specific primers and electrophoretic detection of results on test systems of (Litech, Moscow). …”
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Endogenous HLA-DQ8αβ programs superantigens (SEG/SEI) to silence toxicity and unleash a tumoricidal network with long-term melanoma survival by David Bradley, Peter Knopick, David Terman, Nathan Riha, Travis Alvine, Riley Larson, Cedric Badiou, Gerard Lina, John Ballantyne

“…Such toxicity has narrowed their therapeutic index while neutralizing antibodies have nullified their therapeutic effects.Methods Female HLA-DQ8 (DQA*0301/DQB*0302) tg mice expressing the human major histocompatibility complex II (MHCII) HLA-DQ8 allele on a high proportion of PBL, spleen and lymph node cells were used. …”
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Association of ZNF608 Polymorphisms With House Dust Mite‐Induced Allergic Rhinitis by Huiqin Li, Fang Gao, Xuyan Liu, Haoran Shen, Mulong Du, Lei Cheng, Huihui Zhang, Zhengdong Zhang, Meiping Lu, Rui Zheng

“…Additionally, both rs6862252 G allele and rs10042766 T allele elevated the expression of ZNF608 involving in state and perturbation of immune cells, such as B cell, T cell, and dendritic cell, contributing to HDM‐induced allergic rhinitis. …”
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THE RISK OF EARLY LIVER ALLOGRAFT DYSFUNCTION IS ASSOCIATED WITH THE TLR-4 GENE GENOTYPE IN THE RS913930 SEQUENCE AND IS IMPLEMENTED VIA HMGB1 NUCLEAR PROTEIN, KUPFFER CELLS AND IL... by A. E. Shcherba, A. M. Kustanovich, A. I. Kireyeva, D. Yu. Efimov, S. V. Korotkov, A. F. Minov, O. A. Lebedz, A. A. Koritko, D. A. Fedoruk, E. O. Santotsky, A. M. Dzyadzko, O. O. Rummo

“…Within rs5030717 there were identifi ed three genotypes: AA (81.6%) and two genotypes with the minor G-allele: AG (12.6%) and GG (5.6%). Within rs913930 there identi- fi ed three genotypes: TT (59.1%) and two genotypes with the minor C-allele: C/T (29.5%) and CC (11.2%). …”
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Case Report: Hypergonadotropic hypogonadism in an elite athlete with variant in FSH receptor gene—clinical and sports implications of proper diagnosis by Monika Skrzypiec-Spring, Agnieszka Zubkiewicz-Kucharska, Magdalena Pasińska, Michał Rabijewski, Robert Śmigiel, Adam Szeląg

“…We present the case of an elite athlete with the c.2039A>G variant in one allele of the FSHR gene resulting in hypergonadotropic hypogonadism, low testicular volume, and reduced semen parameters, placing particular emphasis on the diagnostic process and the importance of correct diagnosis in the context of possible treatment with gonadotropins, which can significantly improve fertility, increase testosterone levels, and, in the case of athletes, obtain approval from the anti-doping organization for treatment that increases testosterone levels.…”
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The role of polymorphism in TNF gene promotive area in the development of chronic obstructive pulmonary disease by G. N. Seitova, Ye. B. Bukreeva, S. V. Buykin, O. Yu. Bychkova, Ye. A. Dementyeva, S. V. Nesterovich, V. P. Puzyryov

“…Statistically significant difference in allele distribution rate at patients with COPD and in control groups has not been found (p > 0,5) including ethnic groups (Russians and Tatars). …”
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Interleukin-2 gene promoter polymorphism (T330G) and lymphocyte platelet adhesion in influenza A (H3N2) by G. A. Chuprova, A. N. Emel’yanova, A. S. Emel’yanov, Yu. A. Vitkovskii

“…It was found that in the group of patients with influenza the occurrence of polymorphic variants of IL-2 (T330G) significantly differed from the control group.The major T allele significantly prevailed in patients compared with the group of healthy individuals with the predominance of the homozygous T/T genotype of the IL-2 gene promoter (T330G) (2.2 times) compared with the control group.Conclusions. …”
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Pharmacogenetics and individualized approach to the therapy of bronchial asthma by Ivan I. Balabolkin, Vilya A. Bulgakova, Vsevolod G. Pinelis, Elena S. Tyumentseva

“…The contribution of genetic factors to the variability of therapeutic response in patients in each class of these antiasthmatic drugs is discussed in this article.Data describing Gly16 allele participation in phenotype formation with poor bronchial asthma course and decreased effectiveness of β2 -agonists therapy and inhaled glucocorticosteroids are also presented. …”
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The role of IFN-γ + 874T/A and IL-12 + 16974A/C polymorphisms in susceptibility to tuberculosis infection in a Sudanese population: a case-control study by Salma A. Moharrum, Naser Eldin Bilal, Najwa A. Mhmoud

“…No statistically significant differences were found in the genotype and allele frequencies of the IFN-γ+874T/A gene between patients and controls. …”
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The APOE–Microglia Axis in Alzheimer’s Disease: Functional Divergence and Therapeutic Perspectives—A Narrative Review by Aiwei Liu, Tingxu Wang, Liu Yang, Yu Zhou

“…Despite extensive research, the precise mechanisms by which <i>APOE</i> alleles contribute to AD pathology remain incompletely understood. …”
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Genetic polymorphisms in human CX3CR1-mediated macrophage dysregulation are associated with the worsening of hearing loss and cochlear degeneration after noise trauma: a study in a... by Dinesh Y. Gawande, Sree Varshini Murali, Shriti S. Thakur, Savlatjon Rahmatulloev, Emma J. Nicolaisen, Lyudmila Batalkina, Astrid E. Cardona, Tejbeer Kaur

“…Compared with those of mice carrying the CX3CR1 WT or KO allele, young hCX3CR1I249/M280 mice fostered under ambient noise presented early elevations in hearing thresholds at basal frequencies. …”
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