Cinnamaldehyde Attenuates the Expression of IBA1 and GFAP to Inhibit Glial Cell Activation and Inflammation in the MPTP-Induced Acute Parkinson’s Disease Model by Panpan Jiao, Yingfeng An, Suhui Wu, Hanbing Li, Genlin Li

“…Furthermore, CA was observed to inhibit glial cell activation, leading to reduced levels of GFAP and IBA1 in the substantia nigra and striatum. …”
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Investigating size and surface modification to optimise the delivery of nanodiamonds to brain glial cells by Manami Takahashi, Ayaka Takada, Chihiro Suzuki, Kiichi Kaminaga, Masaki Yoshioka, Mariko Handa, Jeff Kershaw, Hiroshi Abe, Takeshi Ohshima, Ryuji Igarashi, Hiroyuki Takuwa

“…In this study, we investigated the intracellular uptake of NDs by glial cells (microglia and astrocytes) in the brain. …”
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Longitudinal accumulation of glial activation measured by TSPO-PET predicts later brain atrophy in multiple sclerosis by Nylund Marjo, Lehto Jussi, Matilainen Markus, Rajander Johan, Wahlroos Saara, Sucksdorff Marcus, Kuhlmann Tanja, Airas Laura

“…Activated glial cells express 18-kDa translocator protein (TSPO), and TSPO-binding radioligands and positron emission tomography (PET) imaging can be used to quantitate glial activation in vivo. …”
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Decoding Parkinson's Disease: The interplay of cell death pathways, oxidative stress, and therapeutic innovations by Tingting Liu, Xiangrui Kong, Junbo Qiao, Jianshe Wei

“…Additionally, regulating glial polarization (triggering receptor expressed on myeloid cells 2 (TREM2) agonists) may disrupt inflammation-redox-death loops. …”
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Contribution of glial inwardly rectifying potassium (Kir) channels to potassium buffering in insect neural systems by Rui Chen, Zhilin Li, Alyssa Johnson, Daniel R. Swale

“…Inward rectifier potassium (Kir) channels are known to drive K+ buffering in mammals, but cellular expression patterns and the physiological roles of neural or glial Kir channels in insects have remained undefined. …”
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Single−cell transcriptomic landscape of sciatic nerve after transection injury by Yiben Ouyang, Mingqian Yu, Tieyuan Zhang, Haofeng Cheng, Liang Zuo, Haolin Liu, Yanjun Guan, Ao Liu, Jiajie Chen, Ruichao He, Sice Wang, Tianqi Su, Yixiao Tan, Yuhui Cu, Xiaochun Zhang, Xiaoyang Fu, Junli Wang, Jinjuan Zhao, Jiang Peng, Yu Wang

“…Through unsupervised clustering, we identified four major cellular compartments—neurofibroblasts (NFs), glial cells (Glis), immune cells, and vascular cells—and delineated their dynamic trajectories during regeneration. …”
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GDNF attenuates a-synuclein aggregation-induced damage to VTA-NAc dopaminergic transmission and alleviates depression-like behaviors in mice by Jing Chen, Zhi Ling, Maokang Lv, Shengzhe Chen, Wei Xu, Lin Shao, Zifan Ma, Chuanxu Wang, Yuanjian Song, Chuanxi Tang

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ROLE OF SCHWANN CELLS-CANCER CELLS CROSSTALK IN TUMOUR PROGRESSION

“…Our findings demonstrate a bidirectional interaction between SCs and cancer cells. This emphasizes the importance of developing a deeper understanding of the glial component in the tumour microenvironment, as this could significantly impact tumour progression. …”
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PERICYTE INVOLVEMENT IN THE PATHOGENESIS OF COLVI-RELATED MYOPATHIES: INSIGHTS INTO NG2–COLVI AXIS

“…This study investigates the contribution of pericytes to COLVI-RM pathogenesis, with a focus on the interaction between COLVI and neural/glial antigen 2 (NG2), a proteoglycan involved in COLVI anchoring at the cell membrane2. …”
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Intestinal microbiome as effective regulator of enteral and central nervous system activity by V. T. Ivashkin, K. V. Ivashkin

“…These data presumes the presence of direct microbiota-induced responses of enteric nervous system as well as its development and intestinal glial cells hemostasis maintenance. No evidence of direct involvement of these neurotransmitters in regulation of proximal enteral neurons synaptic activity is obtained. …”
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Regulating astrocytic activity in the dorsal striatum mitigates L-dopa-induced dyskinesia in Parkinson’s disease by Young-Kyoung Ryu, Hye-Yeon Park, Ju-Eun Kim, Hyun-Hee Seo, Chul-Ho Lee, Kyoung-Shim Kim

“…Adeno-associated viruses (AAVs) were used to target designer receptors exclusively activated by designer drugs (DREADDs) in GFAP-expressing cells to modulate Gq- or Gi-mediated signaling and regulate astrocytic activity in the brain. …”
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Schwann cells modified to secrete MANF is a potential cellular therapy for peripheral nerve regeneration by Bhadrapriya Sivakumar, Caleb Hammond, Valeria Martinez, Nickson Joseph, Johnson V. John, Anil Kumar, Anand Krishnan

“…The limited knowledge of biomolecules that equally promote axon regeneration and glial cell dynamics, which are critical for nerve regeneration, poses a major challenge in developing effective therapies. …”
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Human Pluripotent Stem Cell‐Derived Skeletal Muscle Organoid Model of Aging‐Induced Sarcopenia by Seongjun Park, Min‐Kyoung Shin, Dong Seok Jeong, Xin Yi Yeo, Yeo Jin Kim, Junaid Muhammad, Minju Kim, Seongeun Gu, Jeoung Eun Lee, Yunjin Park, Su Bin Lim, Ji Young Mun, Sangyong Jung, Dong Ryul Lee, Junghyun Jo

“…Single‐nucleus RNA‐sequencing and extensive immunohistochemistry confirmed the presence of the myogenic lineage cell types (myogenic progenitors/SCs, myocytes, muscle fibres) and the neural lineage cell types (spinal‐derived interneurons, motor neurons, glial cells, Schwann cells). …”
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Upregulation of SQSTM1 Regulates Ferroptosis and Oxidative Stress in Müller Cells of the Diabetic Neural Retina by Modulating ACSL4 by Xinlu Li, Bai Li, Defei Feng, Han Hu, Binyang Tang, Jingying Yang, Huaiyan Jiang, Li Li, Xiaojing Dong, Ninghua Ni, Yan Mei

“…This condition is marked by neuronal apoptosis and glial activation. Müller glia are retinal cells highly susceptible to diabetic metabolic stress that may undergo ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation. …”
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P55 | ENDOTHELIAL THYMIDINE PHOSPHORYLASE DEFICIENCY TRIGGERS MORPHO-FUNCTIONAL DEGE-NERATION OF ENTERIC NEURONS AND REDUCES INTESTINAL STEM CELL PROLIFERATION

“…Immunofluorescence and live imaging revealed neurite fragmentation and increased glial and fibroblast proliferation, while neuronal counts remained stable. …”
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Persistent type I interferon signaling within the brain of people with HIV on ART with cognitive impairment. by Yuyang Tang, Ling Xie, Ciniso Sylvester Shabangu, Dajiang Li, Gabriela da Silva Prates, Ashokkumar Manickam, Lilly M Wong, Antoine Chaillon, Edward P Browne, Sara Gianella, Wenzhe Ho, David M Margolis, Xian Chen, Wenhui Hu, Guochun Jiang

“…Together, our findings point to persistent IFN-I activation in glial and endothelial cells in the brain, which may contribute to neuroinflammation and cognitive disorders in PWH on ART.…”
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Role of astrocytes in the pathogenesis of perinatal brain injury by Ling Li, Xuewei Cui, Baoli Zhu, Lele Zhou, Yaya Guo, Tianjing Liu, Yongyan Shi

“…Abstract Astrocytes, the most abundant glial cells in the central nervous system (CNS), play critical roles in blood–brain barrier (BBB) maintenance, synaptogenesis, neurotransmission, and metabolic regulation. …”
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Lipidomic and proteomic insights from extracellular vesicles in the postmortem dorsolateral prefrontal cortex reveal substance use disorder-induced brain changes by Chioma M. Okeoma, Wasifa Naushad, Bryson C. Okeoma, Carlos Gartner, Yulica Santos-Ortega, Calvin Vary, Savio Lima-Bastos, Victor Corasolla Carregari, Martin R. Larsen, Alessio Noghero, Consuelo Walss-Bass, Rodrigo Grassi-Oliveira

“…We assessed the interactions and bioactivity of EVs by evaluating their uptake by glial cells. We further assessed the effects of EVs on complement mRNA expression in glial cells and on microglial migration. …”
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Mechanism and application of immune interventions in intracerebral haemorrhage by Xiaoxiao Xu, Yuanwei Li, Shiling Chen, Xuan Wu, Jiarui Li, Gaigai Li, Zhouping Tang

“…In this review, we aim to clarify unique immunological features of stroke, and consider the evidence for immune interventions. In acute ICH, activation of glial cells and cell death products trigger an inflammatory cascade that damages vessels and the parenchyma within minutes to hours of the haemorrhage. …”
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Effect of involuntary and voluntary exercise in an enrichment environment on astrogliosis reaction of hippocampus white matter in type 3 diabetic rat models by Masoud Jamshidi, Mohammadreza Kordi, Fatemeh Shabkhiz

“…Astrocytes are one of the most abundant types of glial cells that change and become hypertrophy in response to any damage to the central nervous system (CNS). …”
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