Anti-Inflammatory Effects of Epoxyeicosatrienoic Acids by Scott J. Thomson, Ara Askari, David Bishop-Bailey

Get full text

Fetal Growth Restriction Prediction: How to Move beyond by Debora F. B. Leite, Jose G. Cecatti

Get full text

Gene Expression Profile Analysis in Epilepsy by Using the Partial Least Squares Method by Dong Wang, Xixiao Song, Yan Wang, Xia Li, Shanshan Jia, Zhijing Wang

Get full text

Nanoemulsion and Encapsulation Strategy of Hydrophobic Oregano Essential Oil Increased Human Prostate Cancer Cell Death via Apoptosis by Attenuating Lipid Metabolism by Haribalan Perumalsamy, Rajeshkumar Shanmugam, Jun-Ran Kim, Gokulanathan Anandapadmanaban, Md. Amdadul Huq, Kamal Dua, Dinesh Kumar Chellappan, Tae Hyun Yoon, Sri Renukadevi Balusamy

“…The toxicity and inhibitory concentration (IC50) of OENE toward prostate cancer by MTT analysis were performed. The lipid biogenesis mediated, molecular target pathway analyses were performed using fluorescence cellular staining techniques, real-time RT-PCR, or western blotting analysis. …”
Get full text

Anti-fatigue activity and mechanism of crocetin loaded nanoliposome in acute exercise-treated mice by Jian Nan, Jinglei Li, Haishan Wu, Haoran Cheng, HyunJin Park, Qingsheng Zhao, Liu Yang

“…It also increases mRNA expression of mitochondrial transcription factor A (TFAM) which promotes mitochondrial biogenesis. Additionally, CLN ameliorates the gut microbiota structure by increasing the abundance of genus such as Lactobacillus in fatigue mice. …”
Get full text

Uncovering proteome variations and concomitant quality changes of different drying methods Cordyceps sinensis by 4D-DIA structural proteomics by Mengjun Xiao, Chuyu Tang, Tao Wang, Min He, Yuling Li, Xiuzhang Li

“…Notably, there was a significant overlap between ribosome and ribosome biogenesis in eukaryotes pathways. The process of drying Cordyceps sinensis resulted in a significant upregulation of the expression of proteins linked to various metabolic pathways. …”
Get full text

Downregulation of PGC-1α Prevents the Beneficial Effect of EET-Heme Oxygenase-1 on Mitochondrial Integrity and Associated Metabolic Function in Obese Mice by Shailendra P. Singh, Lars Bellner, Luca Vanella, Jian Cao, John R. Falck, Attallah Kappas, Nader G. Abraham

“…EET-A is a potent inducer of PGC-1α, HO-1, mitochondrial biogenesis (cytochrome oxidase subunits 1 and 4 and SIRT3), fusion proteins (Mfn 1/2 and OPA1) and fission proteins (DRP1 and FIS1) (p<0.05), fasting glucose, BW, and blood pressure. …”
Get full text

CSE-8, a filamentous fungus-specific Shr3-like chaperone, facilitates endoplasmic reticulum exit of chitin synthase CHS-3 (class I) in Neurospora crassa by Samantha Verónica González-Téllez, Meritxell Riquelme

“…The current evidence suggests that the biogenesis of CHS exclusive to filamentous fungi may involve pathways independent of CSE-mediated receptors.…”
Get full text

Comparative genomics of Leptospira santarosai reveals genomic adaptations in bovine genital strains by Maria Isabel Nogueira Di Azevedo, Frederico Kremer, Camila Ezepha, João Pedro Gomes Greco, Isadora Cosenza Vieira da Silva, Pascale Bourhy, Walter Lilenbaum

“…A significant number of genes were exclusive of the genital strains, with emphasis on genes associated with cell wall/membrane/envelope biogenesis, mobilome: prophages and transposons, and signal transduction mechanisms. …”
Get full text

Brucella modulates secretory trafficking via multiple type IV secretion effector proteins. by Sebenzile Myeni, Robert Child, Tony W Ng, John J Kupko, Tara D Wehrly, Stephen F Porcella, Leigh A Knodler, Jean Celli

“…The intracellular pathogenic bacterium Brucella generates a replicative vacuole (rBCV) derived from the endoplasmic reticulum via subversion of the host cell secretory pathway. rBCV biogenesis requires the expression of the Type IV secretion system (T4SS) VirB, which is thought to translocate effector proteins that modulate membrane trafficking along the endocytic and secretory pathways. …”
Get full text

Analysis of MicroRNA Processing Machinery Gene DROSHA, DICER1, and XPO5 Variants Association with Atherosclerosis: A Case–control Study by Manar F. Atoum, Dalya Alowaisy, Ammar Ali Deeb

“…Genetic variations, especially single-nucleotide polymorphisms (SNPs) within microRNA (miRNA) machinery genes, impact miRNA biogenesis and play roles in atherosclerosis pathogenesis and progression. …”
Get full text

Opportunities and challenges of bacterial extracellular vesicles in regenerative medicine by Jiming Guo, Zhijie Huang, Qinjing Wang, Min Wang, Yue Ming, Weixing Chen, Yisheng Huang, Zhengming Tang, Mingshu Huang, Hongyu Liu, Bo Jia

“…This review provides a description of the biogenesis and pathophysiological functions of BEVs, and strategies for optimizing BEVs preparation to attain efficiency and safety are discussed. …”
Get full text

Physiological and pathological roles of PGAM5: An update and future trend by Weibin He, Wenlong He, Zhongchan Sun, Pengcheng He

“…Summary: PGAM5, a phosphatase found in mitochondria, is crucial for mitochondrial quality control (MQC) through its regulation on mitochondrial dynamics, biogenesis, and mitophagy. Previous studies have shown its involvement in multiple regulated cell deaths (RCDs), including apoptosis, necroptosis, and pyroptosis. …”
Get full text

Roles for Exosomes in the Pathogenesis, Drug Delivery and Therapy of Psoriasis by Yuchao Chen, Huazhen Liu, Yuming He, Bin Yang, Weihui Lu, Zhenhua Dai

“…In this review, we have summarized recent advances in the biogenesis of exosomes and their potential roles in the pathogenesis and treatment of psoriasis and further discussed their challenges and future directions in psoriasis treatment. …”
Get full text

Inherited Thrombocytopenia Related Genes: GPS2 Mediates the Interplay Between ANKRD26 and ETV6 by Valeria Capaci, Melania Eva Zanchetta, Giorgia Fontana, Daniele Ammeti, Roberta Bottega, Michela Faleschini, Anna Savoia

“…Mutations in 5′UTR of ANKRD26, leading to ANKRD26-RT, disrupt this regulation, resulting in the persistent expression of ANKRD26, which leads to impaired platelet biogenesis and an increased risk of leukemia. Although ANKRD26 and ETV6 exhibit inverse expression during megakaryopoiesis, ETV6 does not regulate the ANKRD26 expression. …”
Get full text

Sulforaphane acutely activates multiple starvation response pathways by Kendra S. Plafker, Constantin Georgescu, Nathan Pezant, Atul Pranay, Scott M. Plafker

“…SFN treatment (i) increased mitochondrial mass and resistance to oxidative stress, (ii) acutely suppressed markers of mTORC1/2 activity via inhibition of insulin signaling, (iii) upregulated autophagy and further amplified autophagic flux induced by rapamycin or nutrient deprivation while concomitantly promoting lysosomal biogenesis, and (iv) acutely decreased glucose uptake and lactate secretion followed by an adaptive rebound that coincided with suppressed protein levels of thioredoxin-interacting protein (TXNIP) due to early transcriptional down-regulation. …”
Get full text

Decoding TDP-43: the molecular chameleon of neurodegenerative diseases by Jixiang Zeng, Chunmei Luo, Yang Jiang, Tao Hu, Bixia Lin, Yuanfang Xie, Jiao Lan, Jifei Miao

“…We delve into TDP-43’s crucial functions in RNA metabolism, including splicing regulation, mRNA stability, and miRNA biogenesis. Particular emphasis is placed on recent discoveries regarding TDP-43’s involvement in DNA interactions and chromatin dynamics, highlighting its broader impact on gene expression and genome stability. …”
Get full text

Insulin-Like Growth Factor I Prevents Cellular Aging via Activation of Mitophagy by Xuwei Hou, Zhaohui Li, Yusuke Higashi, Patrice Delafontaine, Sergiy Sukhanov

“…IGF-1 increased mitophagy in aged cells, and this was associated with decreased expression of cyclin-dependent kinase inhibitors p16 and p21 and elevated levels of Nrf2 and Sirt3, regulators of mitophagy and mitochondrial biogenesis. SiRNA-induced inhibition of either Nrf2 or Sirt3 blocked IGF-1-induced upregulation of mitophagy, suggesting that the Nrf2/Sirt3 pathway was required for IGF-1’s effect on mitophagy. …”
Get full text

Beclin 1-Mediated Autophagy Is Potentiated by an Interaction with the Neuronal Adaptor FE65 by Wai Wa Ray Chan, Jessica Chow, Dennis Dik-Long Chau, Yuqi Zhai, Kwok-Fai Lau

“…A crucial step in autophagy is the formation of the class III phosphatidylinositol 3-kinase complex 1 (PI3KC3-C1), which is essential for initiating autophagosome biogenesis. Beclin 1 is the key component of PI3KC3-C1, and its interactors have been reported to affect autophagy. …”
Get full text

Multiomics Integrated Analysis Identifies SLC24A2 as a Potential Link between Type 2 Diabetes and Cancer by Qin Bian, Haijun Li, Xiaoyi Wang, Tingting Liang, Kai Zhang

“…Grey module negatively correlated with T2D and FPG and was markedly involved in ribosome biogenesis. Ten SLC24A2-related genes (RRP36, RPF1, GRWD1, FBL, EXOSC5, BCCIP, UTP14A, TWISTNB, TBL3, and SKIV2L) were identified as hub genes, based on which the LASSO model accurately predicts the occurrence of T2D (AUC=0.841). …”
Get full text