Report of joint hypermobility in malignant hyperthermia susceptible patients: Observational study with a case-control descriptive design by Rita CCS. Santos, Larissa FCDMS. Lima, Pâmela V. Andrade, Joilson M. Santos, Leonardo Galleni, Antonio FR. Junior, Lucas S. Souza, Beny Schmidt, Acary SB. Oliveira, José LG. Amaral, Mariz Vainzof, Helga CA. Silva

“…Hypermobility is present in nearly 100 % of congenital myopathy central core disease (CCD) patients but is sporadically described in the allelic disease malignant hyperthermia (MH). Our objective was to investigate the frequency/characteristics of hypermobility in MH susceptible patients as compared to a control group, aiming the identification of correlations between hypermobility and demographic/clinical findings in MH patients. …”
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Morphophysiological approach to heterosis in phosphorus use efficiency in popcorn by Rosimeire Barboza Bispo, Antônio Teixeira do Amaral Junior, Talles de Oliveira Santos, Valter Jário de Lima, Bruna Rohem Simão, Marta Simone Mendonça Freitas, Samuel Henrique Kamphorst, Carolina Macedo Carvalho, Danielle Leal Lamêgo, Flávia Nicácio Viana, Wallace de Paula Bernardo, Eliemar Campostrini, Ricardo Bressan-Smith

“…This study evaluated the genetic control and heterosis effects on growth traits, gas exchange, leaf pigments, chlorophyll fluorescence, and P efficiency in four popcorn maize inbred lines and their hybrids, including reciprocals. …”
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Modelling the epidemiological and economic impact of digital adherence technologies with differentiated care for tuberculosis treatment in Ethiopia by Richard White, Katherine L Fielding, Salome Charalambous, Nicola Foster, Degu Jerene, Andrew Mganga, Taye Letta, Job van Rest, Amare Worku Tadesse, Rein MGJ Houben, Ahmed Bedru, Kristian van Kalmthout, Christopher Finn McQuaid, Lara Goscé, Jense van der Wal, Martin J Harker, Norma Madden, Tofik Abdurhman, Demekech Gadissa, Tanyaradzwa N Dube, Jason Alacapa, Natasha Deyanova

“…We projected long-term TB incidence, mortality and costs to 2035 and conducted a threshold analysis to identify the maximum possible epidemiological impact of a DAT intervention by assuming 100% treatment completion for patients on DAT.Findings We estimated small and uncertain epidemiological benefits of the pillbox intervention compared with the standard of care in Ethiopia, with a difference of −0.4% (95% uncertainty interval (UI) −1.1%; +2.0%) incident TB episodes and −0.7% (95% UI −2.2%; +3.6%) TB deaths. However, our analysis also found large total provider and patient cost savings (US$163 (95% UI US$118; US$211) and US$3 (95%UI: US$1; US$5), respectively, over 2023–2035), translating to a 50.2% (95% UI 35.9%; 65.2%) reduction in total cost of treatment. …”
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Peripheral blood biomarkers as differential diagnostic markers of disease severity in neonates with hyperbilirubinemia by Dereje Mengesha Berta, Negesse Cherie, Berhanu Woldu, Aregawi Yalew, Elias Chane, Amare Mekuaninnit, Mebratu Tamir, Zufan Yiheyis, Abiy Ayele Angelo, Zewudu Mulatie, Adamu Kassie, Bisrat Birke Teketelew

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Protocol for the DisCoVeRy trial: multicentre, adaptive, randomised trial of the safety and efficacy of treatments for COVID-19 in hospitalised adults by Florence Ader, Jean-François Timsit, Yazdan Yazdanpanah, François-Xavier Lescure, Laetitia Moinot, Christelle Delmas, Hélène Espérou, Laurent Abel, Benjamin Leveau, Vinca Icard, Toni Alfaiate, Linda Wittkop, Charles Burdet, France Mentré, Marion Schneider, Nathan Peiffer-Smadja, Julien Poissy, Lila Bouadma, Bruno Lina, Florence Morfin-Sherpa, Maude Bouscambert, Alexandre Gaymard, Gilles Peytavin, Jeremie Guedj, Claire Andrejak, Cedric Laouenan, Drifa Belhadi, Axelle Dupont, Basma Basli, Anissa Chair, Samira Laribi, Julie Level, Marie-Capucine Tellier, Aline Dechanet, Dominique Costagliola, Sandrine Couffin-Cadiergues, Juliette Saillard, Claire Fougerou, Carole Cagnot, Soizic Le Mestre, Delphine Lebrasseur-Longuet, Ventzislava Petrov-Sanchez, Alpha Diallo, NoéMie Mercier, Sarah Tubiana, Benjamin Hamze, Ambre Gelley, Marion Noret, Eric D’Ortenzio, Oriane Puechal, Caroline Semaille

“…The objective of the trial is to evaluate the clinical efficacy and safety of different investigational re-purposed therapeutics relative to Standard of Care (SoC) in patients hospitalised with COVID-19.Methods and analysis DisCoVeRy is a phase III, open-label, adaptive, controlled, multicentre clinical trial in which hospitalised patients with COVID-19 in need of oxygen therapy are randomised between five arms: (1) a control group managed with SoC and four therapeutic arms with re-purposed antiviral agents: (2) remdesivir + SoC, (3) lopinavir/ritonavir + SoC, (4) lopinavir/ritonavir associated with interferon (IFN)-β−1a + SoC and (5) hydroxychloroquine + SoC. …”
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IL-23 tunes inflammatory functions of human mucosal-associated invariant T cells by Laetitia Camard, Tharshana Stephen, Hanane Yahia-Cherbal, Vincent Guillemot, Sébastien Mella, Victoire Baillet, Hélène Lopez-Maestre, Daniele Capocefalo, Laura Cantini, Claire Leloup, Julie Marsande, Katherine Garro, Juan Sienes Bailo, Ambre Dangien, Natalia Pietrosemoli, Milena Hasan, Huimeng Wang, Sidonia B.G. Eckle, Anne M. Fourie, Carrie Greving, Barbara Joyce-Shaikh, Raphaelle Parker, Daniel J. Cua, Elisabetta Bianchi, Lars Rogge

“…Integrated analysis of transcriptomes and chromatin accessibility, supported by CRISPR-Cas9 mediated deletion, shows that AP-1 transcription factors constitute a key regulatory node of the IL-23 pathway in MAIT cells. In conclusion, our findings indicate that MAIT cells are key mediators of IL-23 functions in immunity to infections and chronic inflammatory diseases.…”
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Does a complex intervention targeting communities, health facilities and district health managers increase the utilisation of community-based child health services? A before and af... by Joanna Schellenberg, Della Berhanu, Lars Åke Persson, Muluemebet Abera Wordofa, Araya Abrha Medhanyie, Fisseha Ashebir Gebregizabher, Habtamu Beyene, Ephrem Tekle Lemango, Abebe Bekele, Theodros Getachew, Mezgebu Yitayal, Yemisrach Behailu Okwaraji, Atkure Defar, Fitsum W/Gebriel, Alem Desta, Dawit Wolde Daka, Alemayehu Hunduma, Tigist Getahun, Amare Tariku Woldemariam, Desta Wolassa

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Gastroenteropancreatic Neuroendocrine Neoplasia Characterization in Portugal: Results from the NETs Study Group of the Portuguese Society of Endocrinology, Diabetes and Metabolism by A. P. Santos, J. Vinagre, P. Soares, I. Claro, A. C. Sanches, L. Gomes, I. Fernandes, A. L. Catarino, J. Preto, B. D. Pereira, A. P. Marques, F. Rodrigues, C. Amaral, G. Rocha, J. C. Mellidez, H. Simões, J. M. Lopes, M. J. Bugalho, On behalf of the NETs Study Group of the Portuguese Society of Endocrinology, Diabetes and Metabolism

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Detecção e isolamento de lentivírus caprino em células do cordão umbilical de cabras by Juscilânia Furtado Araújo, Alice Andrioli, Raymundo Rizaldo Pinheiro, Renato Mesquita Peixoto, Ana Lídia Madeira de Sousa, Ana Milena Cesar Lima, Cíntia Daudt, Gabriel Paula Amaral, Samara Cristina Rocha Souza, Maria Fátima da Silva Teixeira

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Spatial Characterization of Woody Species Diversity in Tropical Savannas Using GEDI and Optical Data by Franciel Eduardo Rex, Carlos Alberto Silva, Eben North Broadbent, Ana Paula Dalla Corte, Rodrigo Leite, Andrew Hudak, Caio Hamamura, Hooman Latifi, Jingfeng Xiao, Jeff W. Atkins, Cibele Amaral, Ernandes Macedo da Cunha Neto, Adrian Cardil, Angelica M. Almeyda Zambrano, Veraldo Liesenberg, Jingjing Liang, Danilo Roberti Alves De Almeida, Carine Klauberg

“…Data from Sentinel-2 optical imagery, ERA-5 climate data, SRTM-DEM imagery, and simulated GEDI data were selected for the characterization of diversity in four study areas. The integration of ancillary data can improve biodiversity metrics predictions. …”
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„... nenábožnost nynějšího věku ...“ Proměny zbožnosti ve druhé polovině 19. století očima katolických kněží by Hana Stoklasová

“…The observance of Sunday as a feast day, which is reserved for contemplation, was disturbed by a number of things starting from the fact that it was common that believers worked on a festive day, amused themselves, held drinking bouts or they just did not go to church services and ceremonies at all, alleging miscellaneous, sometimes almost quaint, reasons of their absence. …”
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Research Progress of Intelligent Evaluation and Virtual Reality Based Training in Upper Limb Rehabilitation afrer Stroke by XIE Qiurong, LIN Wanqi, ZHANG Qi, SHENG Bo, ZHANG Yanxin, HUANG Jia

“…In addition, systems developed using markerless sensing technology with high accuracy (Microsoft Azure Kinect and Leap Motion Controller devices) are inexpensive, portable, and suitable for community or home scenarios. …”
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Valeur du travail à la 3e section de l’hôpital de Villejuif : entre thérapie et instrument disciplinaire by Véronique Fau-Vincenti

“…Dès 1910, le Dr Henri Colin soulignait que le travail à la 3e section ne devait pas être considéré « à titre de distraction » ou « d’amusement » mais organisé également « de façon à compenser dans la plus large mesure possible, les frais occasionnés par leur assistance  par la fabrication d’objets destinés à être vendus ». …”
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Pengembangan Automated Image Analysis untuk Menentukan Jumlah Bakteri Tahan Asam (BTA) pada Kasus Tubercolosis by Safri Adam, Puji Astuti, Puspa Amalia, Fadli Sukandiarsyah

“…Noise in the image can be overcome using the gaussian blur filter and the CLAHE method to improve contrast. …”
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Construire des ressources relationnelles pour franchir des frontières multiples : Trajectoires de jeunes Tunisiens by Hasnia-Sonia Missaoui

“…These trajectories show us first of all the disenchantment of an age group with blurred contours that is linked to the situations of socio-economic injustice that they experience on a daily basis. …”
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Ìṣọwọ́lò Ète Ìfèdèyàwòrán Nínú Ìpolówó Ọjà Lórí Rédíò by Ìyábọ̀dé Baliquis Alága

“…Ìpolówó ọjà bẹ̀rẹ̀ nípaṣẹ̀ kí ọ̀pọ̀ ènìyàn máa ta tàbí ṣe irúfẹ́ ohun tó jọra wọ́n. Èyí ló mú kí a máa wá ète láti polówó. Ọ̀kan lára ète ìpolówó ni èdè ìpolówó jẹ́. …”
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Prevalence and determinants of post-neonatal mortality in East Africa: a multilevel analysis of the recent demographic and health survey by Alebachew Ferede Zegeye, Desale Bihonegn Asmamaw, Wubshet D. Negash, Wubshet D. Negash, Tadele Biresaw Belachew, Elsa Awoke Fentie, Atitegeb Abera Kidie, Tsegaw Amare Baykeda, Samrawit Mihret Fetene, Banchlay Addis, Sisay Maru Wubante, Abel Endawkie, Tadesse Tarik Tamir

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Prevalence and determinants of unintended pregnancy among rural reproductive age women in Ethiopia by Melak Jejaw, Kaleb Assegid Demissie, Misganaw Guadie Tiruneh, Kaleab Mesfin Abera, Yawkal Tsega, Abel Endawkie, Wubshet D. Negash, Amare Mesfin Workie, Lamrot Yohannes, Mihret Getnet, Nigusu Worku, Adina Yeshambel Belay, Lakew Asmare, Hiwot Tadesse Alemu, Demiss Mulatu Geberu, Asebe Hagos

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Biogenic silver nanoparticles produced by Trichoderma reesei inhibit SARS-CoV-2 infection, reduce lung viral load and ameliorate acute pulmonary inflammation by Marcus V.M.V. Amaral, Cláudia B. Carraro, Amanda C.C. Antoniêto, Mariana N. Costa, Thais F.C. Fraga-Silva, Ualter G. Cipriano, Rodrigo P.F. Abuná, Tamara S. Rodrigues, Ronaldo B. Martins, Andreia M. Luzenti, Glaucia R. Caruso, Priscyla D. Marcato, Vania L.D. Bonato, Dario S. Zamboni, Bergman M. Ribeiro, Sônia N. Báo, Joao S. da Silva, Flávio P. Veras, Roberto N. Silva

“…Additionally, AgNPs impair caspase-1 activation, lactate dehydrogenase release and IL-1β production by human monocytes. Moreover, our study reveals that AgNPs treatment significantly alleviated acute lung injury induced by SARS-CoV-2 infection in Syrian hamsters. …”
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Functional heterogeneity of mesenchymal stem cells and their therapeutic potential in the K18-hACE2 mouse model of SARS-CoV-2 infection by Kátia Nunes da Silva, Fernanda Martins Marim, Gisele Vieira Rocha, Zaquer Suzana Munhoz Costa-Ferro, Luciana Souza de Aragão França, Carolina Kymie Vasques Nonaka, Bruno Diaz Paredes, Erik Aranha Rossi, Erick Correia Loiola, Corynne Stephanie Ahouefa Adanho, Rachel Santana Cunha, Mayck Medeiros Amaral da Silva, Fernanda Ferreira Cruz, Vivian Vasconcelos Costa, Dalila Lucíola Zanette, Clarissa Araújo Gurgel Rocha, Renato Santana Aguiar, Patricia Rieken Macedo Rocco, Bruno Solano de Freitas Souza

“…Administration of hUCMSC to SARS-CoV-2-infected K18 mice expressing hACE2 was effective in improving lung histology and modulating of a panel of cytokines. Conclusions Our study assessed MSCs derived from various tissues, uncovering significant variability in their characteristics and immunomodulatory capacities. …”
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