The Invasion and Metastasis of Colon Adenocarcinoma (COAD) Induced by SALL4 by Wenjuan Zhang, Yan Hu, Wenbing Zhang, Ke Yi, Xiaohui Xu, Zhihua Chen

“…The immunofluorescence staining confirmed the EMT phenotype. On the contrary, knocking out SALL4 gene reversed EMT, weakened cell proliferation and invasion, inhibited upregulation of Twist, vimentin, and N-cadherin expressions and downregulation of E-cadherin. …”
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Sexo de pago, pandemia y ley de extranjería by Carmen Meneses Falcón, Antonio Rúa Vieites, Olaya García Vázquez

“…Se concluye que las leyes migratorias restrictivas, que dificultan a las mujeres ser ciudadanas de pleno derecho, están directamente relacionadas con la actividad de la prostitución, tanto en su fase inicial como en su permanencia. Por lo tanto, es imperativo una profunda reflexión y revisión de las leyes de extranjería en el contexto político, para así abordar de manera efectiva las problemáticas de la población en contextos de prostitución en España.…”
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Efecto de la humedad del café crudo en las propiedades del café tostado by Campo Elías Riaño-Luna

“…Los granos de café pergamino, con una humedad inicial del 17 % y clasificados en malla 17, generan los granos tostados de mayor densidad, acidez, pérdida de peso, actividad acuosa y esfuerzo a la ruptura, sin que modifiquen sus atributos de calidad. …”
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Intervención educativa en salud bucal en niños y maestros by Alain Soto Ugalde, Nora M. Sexto Delgado, NIvia Gontán Quintana

“…<br /> <strong>Resultados</strong>: se obtuvieron diferencias significativas entre el estado inicial y final de los conocimientos y también con respecto al índice de higiene bucal. …”
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Contribution of Arginine Catabolic Mobile Element and Copper and Mercury Resistance Element in Methicillin-Resistant Staphylococcus aureus: A Vantage Point by Parya Shokrollahi, Alka Hasani, Mohammad Aghazadeh, Mohammad Yousef Memar, Akbar Hasani, Maryam Zaree, Mohammad Ahangarzadeh Rezaee, Javid Sadeghi

“…The presence of ACME increases fitness, thereby allowing bacteria to colonize the skin and mucous membrane while COMER contributes to genetic stability by knocking over the copper-mediated killing in macrophages. …”
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La pandemia de COVID 19 y sus implicaciones en la concepción, diseño e instrumentación didáctica de la educación médica superior cubana by José Aurelio Díaz Quiñones, María Lina Valdés Gómez

“…Para la actividad docente actual y futura, con vistas a su perfeccionamiento y sostenibilidad, nuestros directivos, profesores y tutores, en quienes descansa la dirección del aprendizaje de los estudiantes en nuestras universidades de ciencias médicas tanto en la formación inicial de pregrado como en las diferentes formas del posgrado, las conclusiones preliminares derivadas de la lectura crítica e inferencial de dicha pandemia exigen interpretaciones que deriven en concepciones, diseños curriculares, procesos docentes, trabajo metodológico, evaluaciones y actividad científica que contengan aquellas esencialidades que los autores catalogan como categorías primordiales y obligatorias que deben abarcar los diferentes procesos referidos de la educación médica superior cubana, objetivo pretendido de este trabajo. …”
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Collagen prolyl 4-hydroxylase subunit α member-induced head and neck squamous cell carcinoma aggressiveness is antagonized by LLGL2 via redu... by Xu Miao, Shi Run, Yang Jie, Chen Heng, Liu Shihua, Yu Shupei, Li Sasa, He Wenqiang, Sy Man-Sun, Lu Mingjian, Zhang Huixia, Li Chaoyang

“…In contrast, knocking down C-P4HA alone inhibits cell migration and invasion. …”
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Macrophage Infiltration and ITGB2 Expression in ESCC: A Novel Correlation by Tao Huang, Longqian Wei, Huafu Zhou, Jun Liu

“…Based on our findings and prior studies, we propose a novel hypothesis: inducing M1 macrophages in vitro, knocking out ITGB2, and then reinfusing these ITGB2‐knockout M1 macrophages into ESCC patients may represent a promising new immunotherapy strategy, providing a new avenue for ESCC immunotherapy.…”
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Atg5 deficiency in basophils improves metabolism in lupus mice by regulating gut microbiota dysbiosis by Jiaxuan Chen, Quanren Pan, Lu Lu, Xiaorong Huang, Shuting Wang, Xiaoxian Liu, Jiaqi Lun, Xiaowei Xu, Hongyong Su, Fengbiao Guo, Lawei Yang, Liuyong You, Haiyan Xiao, Wenying Luo, Hua-feng Liu, Qingjun Pan

“…Here, we investigated the effects of autophagic inhibition on the pathogenesis of basophils in SLE using Autophagy-related gene 5 (Atg5) knockout (Atg5 −/−) as an autophagic inhibitor. Specifically, we knocked out basophilic Atg5 in vivo to investigate its impact on lupus metabolism. …”
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Calpain 2 promotes Lenvatinib resistance and cancer stem cell traits via both proteolysis-dependent and independent approach in hepatocellular carcinoma by Xiaolu Ma, Kaixia Zhou, Tianqing Yan, Ling Hu, Suhong Xie, Hui Zheng, Ying Tong, Heng Zhang, Yanchun Wang, Zhiyun Gong, Cuncun Chen, Yanan Tian, Lin Guo, Renquan Lu

“…Further in vitro and in vivo experiments indicated that knocking down CAPN2 greatly sensitized HCC cells to Lenvatinib treatment, while overexpression of CAPN2 achieved opposite effects in a Lenvatinib-sensitive HCC cell line. …”
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Preferential Expression of B7-H6 in Glioma Stem-Like Cells Enhances Tumor Cell Proliferation via the c-Myc/RNMT Axis by Hanqing Chen, Yundi Guo, Jing Sun, Jun Dong, Qinghua Bao, Xueguang Zhang, Fengqing Fu

“…Extending this to 293T cells, we observed that knocking out of B7-H6 with CRISPR-Cas9 system also suppressed cell proliferation. …”
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Peptide P2 targeting Vibrio parahaemolyticus PirB toxins blocks the cytotoxic effects to shrimp Litopenaeus vannamei by Xin Zhang, Ting Chen, Chunhua Ren, Yanhong Wang, Xiao Jiang, Jiasheng Huang, Bo Ma, Boxiang Zhu, Jiayue Yin, Chaoqun Hu, Peng Luo

“…As a result, a total of 11 PirB binding peptides were screened, among which P2 was found to effectively improve the shrimp survival rate under VpAHPND challenge. And knocked down of Lv-APN1, candidate receptor for PirB toxin, rescued mortality under VpAHPND challenge. …”
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Comunidade de Educação Física: os Dispositivos Formativos e a Produção do Conhecimento Profissional Docente by Heitor Perrud Tardin, Janaína da Silva Ferreira, Samuel de Souza Neto

“…O estudo sugere que programas de formação inicial devem focar não apenas no aumento da prática, mas também no suporte necessário para que os residentes possam aplicar o CPD de forma contextualizada e eficaz. …”
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Incorporação da realidade aumentada em processos de aprendizagem ativa: desafios e olhares de professores estagiários by Vânia Graça, Paula Quadros-Flores

“…O presente artigo está integrado no Projeto IFITIC “Inovar com TIC na Formação Inicial docente para promover a renovação metodológica na Educação Pré-escolar e no 1.º e 2.º CEB” e envolveu estudantes em situação de estágio em mestrados de ensino. …”
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Diagnóstico del cáncer mediante biomarcadores circulantes by Álvaro Pablo Moina-Veloz, Johan Alexander Maldonado-Carrasco, Diana Carolina Chiluiza-Tubon, Virginia Monserrath Ortiz-Vásquez

“…Por lo que se realizó una consulta inicial en diversas bases de datos de revistas científicas de alto y mediano impacto. …”
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Immune-related gene SOX10 affects ferroptosis in pancreatic cancer and facilitates tumor progression by targeting CMTM7-mediated Wnt/β-catenin signaling pathway by Guixing Jiang, Bicheng Wu, Kaikai Wang, Xiaofan Pu, Senhao Zhou, Xin Zhong, Xiaolong Liu, Suihan Wang, Tianyu Lin

“…Dual-luciferase assay was performed to confirm the target-binding relationship of SOX10 and CMTM7. After knocking down SOX10 using lentiviral transfection, SOX10 action on Wnt/β-catenin pathway and ferroptosis, as well as its anti-tumor activity in tumor-bearing mice were explored. …”
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Antes (1927-28) e depois (1935) da casa modernista da rua Santa Cruz by Ana Paula Campos Gurgel, Tamires de Oliveira Cabral

“…Construída para sua família, a casa é por muitos considerada o marco inicial da aplicação das novas gramáticas compositivas vanguardistas. …”
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Activity-based chemical proteomics reveals caffeic acid ameliorates pentylenetetrazol-induced seizures by covalently targeting aconitate decarboxylase 1 by Guanjun Li, Ling Huang, Di Gu, Peili Wang, Letai Yi, Wenhua Kuang, Ying Zhang, Junzhe Zhang, Dandan Liu, Qiaoli Shi, Huan Tang, Jichao Sun, Guohua Zeng, Xin Peng, Jigang Wang

“…The anti-inflammatory effects of caffeic acid in LPS-activated BV2 cells was proved by knocking down the target protein. Results Here, we found that caffeic acid exhibits antiepileptic effects in pentylenetetrazol-induced epilepsy mice and exerts anti-neuroinflammation effect in vivo and in vitro. …”
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Tecnicatura Universitaria en Agroecología: una alternativa laboral para jóvenes de familias migrantes en Argentina by Susana Shoaie-Baker

“…También se puede mencionar que, aunque estas carreras ofrecen espacios colectivos para cuestionar el modelo productivo convencional, todavía persisten desafíos: el nivel de formación inicial y la adaptación de horarios por la necesidad de combinar el estudio y el trabajo. …”
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Mitofusin2 Promotes β Cell Maturation from Mouse Embryonic Stem Cells via Sirt3/Idh2 Activation by Li Lu, Li Zhitao, Cui Nannan, Huang Mingzhu, Hu Xiaoping, Hong Dongsheng, Pan Zongfu, Lu Xiaoyang

“…Moreover, its protein expression increased during mouse embryonic pancreas development and β cell differentiation from mouse embryonic stem cells. Knocking down Mfn2 reduced Urocortin3 (Ucn3) expression, GSIS, and ATP production in induced β cells, while overexpressing it had the opposite effect. …”
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