Exemplar Hospital Initiation Trial to Enhance Treatment Engagement (EXHIT ENTRE): protocol for CTN-0098 an open-label randomized comparative effectiveness trial of extended-release buprenorphine versus treatment as usual on post-hospital treatment engagement for hospitalized patients with opioid use disorder by Gavin Bart, Kelly S. Barth, Paulette Baukol, Eva Enns, Udi E. Ghitza, Jacklyn Harris, Eve Jelstrom, Jane M. Liebschutz, Kara M. Magane, Delia Voronca, Zoe M. Weinstein, P. Todd Korthuis

“…This protocol describes an open-label randomized comparative effectiveness trial comparing ACS treatment as usual (TAU) to a single injection of a 28-day formulation extended-release buprenorphine (XR-BUP) on MOUD engagement 34-days following hospital discharge. …”
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Do people residing in low socioeconomic areas engage with and benefit from digital mental health services? by Lauren G. Staples, Blake F. Dear, Olav Nielssen, Nickolai Titov

“…Psychological treatment delivered via the internet can overcome some of these barriers. …”
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Barriers and facilitators to injectable opioid agonist treatment engagement within a structural vulnerability context: a qualitative study of patient experiences in Vancouver, Canada by Samara Mayer, Nadia Fairbairn, Al Fowler, Jade Boyd, Thomas Kerr, Ryan McNeil

Subjects: “…Injectable opioid agonist treatment…”
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Self-care engagement profile for people with arterial hypertension by Giselle Andrade dos Santos Silva, Lucíola Gondim Ribeiro, Thais Cristina Santos Silva, Maria Lúcia Holanda Lopes

“… This descriptive study aims to verify the engagement profi le in self-care in hypertensive people attended in a Family Health Basic Unit. …”
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Integrating Technology into Teaching to Foster Student Engagement and Interaction by Jarudin Wastira, Edy Tekad Bronto Waluyo

“…ANCOVA results indicated a significant treatment effect on overall engagement (F(1, 98) = 15.27, p < .001, Hedges g = 0.63) and student-initiated interaction frequency (ΔM = 14.6 events per class, p = .002). …”
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Overcoming leukemia heterogeneity by combining T cell engaging bispecific antibodies by Madelyn Espinosa-Cotton, Sayed Shahabuddin Hoseini, Hong-fen Guo, Nai-Kong V Cheung

“…Several subtypes of leukemia are inherently more resistant to treatment despite intensive chemotherapy or targeted therapy.Methods Here we describe the generation of T cell engaging (CD3) bispecific antibodies (BsAbs) built on humanized IgG frameworks using the IgG(L)-scFv format against two targets expressed on acute lymphoblastic leukemia (ALL) and on acute myeloid leukemia (AML).Results Each BsAb mediated potent anti-leukemia effect against ALL (CD19) and AML (CD33) in vitro and in xenograft models. …”
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USE OF ROSUVASTATIN AS A GEROPROTECTOR IN PEOPLE ENGAGED IN NATURAL GAS PRODUCING by A. T. Abdrashitova, T. N. Panova, I. A. Belolapenko, M. V. Frenkel

“…To study the geroprotective properties of rosuvastatin in respect of people engaged in the gas producing. Material and Methods. …”
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ANTIBODY-TO-IMAGING PIPELINE TO MONITOR DRUG-TARGET ENGAGEMENT IN BREAST TUMORS

“… Monoclonal antibody-based therapies have become standard treatments for both hematological and solid malignancies. …”
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American Indian community engagement and the structural and social determinants of health: results from the THRIVE assessment by Kellie Webb, Sadie Posey, Katherine Hirchak, Emily Beamon, Kelley Milligan, Sharon Wagon, Bethany Fatupaito, Allyson Kelley

“…IntroductionEngaging community members in the process of documenting health inequities is the first step in addressing public health challenges. …”
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“The hardest part of what we’re doing”: research staff perspectives on engaging marginalized populations in substance use trials by Kaitlyn Jaffe, Celia B. Fisher

“…Abstract Background Randomized controlled trials (RCTs) are a critical component of the development of pharmacological treatment options for substance use disorders. Pragmatic trials, in particular, aim to enhance generalizability by testing interventions in real-world settings. …”
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Feasibility and acceptability of the Community Outpatient Psychotherapy Engagement Service for Self-harm (COPESS): randomised controlled trial by Pooja Saini, Anna Hunt, Caroline Clements, Mark Gabbay, Catherine Mills, Kari Kvamme-Mitchell, Naheed Tahir, Helen Mulholland, Cecil Kullu, Mark Hann, Rui Duarte, Andrea Murphy, Else Guthrie, Peter Taylor

“…Method We used a mixed-method approach and a single-blind randomised controlled trial design with 1:1 allocation to either COPESS plus treatment as usual or treatment as usual alone. Adults with depressive symptoms and self-harm in the past 6 months were recruited from general practices. …”
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Amplifying the voices of Black racial minorities in mental health research through public involvement and engagement: The importance of advisory roles by Juliana Onwumere, Anthony Gentle, Rachel Obanubi, Annette Davis, Moffat Karuga, Rubbia Ali, BeFine Study Team, Valentina Cardi

“…This is particularly relevant for Black racially minoritised groups who are less visible as research participants and in patient and public involvement and engagement (PPIE) roles. Our viewpoint article sought to discuss reflections and insights on their involvement experience, with particular attention to perceived barriers and enablers to PPIE involvement. …”
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Innovative Development of Research Engagement Manual: Strategies to Enhance Recruitment and Retention of Black Individuals in Clinical Trials for Substance Use Disorders by Geoffrey Obel, DeWanda Harris-Trimiar, Joshua S. Elmore, Taryn L. Mayes, Adrienne Mays, Angela Casey-Willingham, Srividya Vasu, Steven Shoptaw, Madhukar H. Trivedi

“…The focus groups identified financial incentives, potential treatment options, and potential for improved awareness about substance abuse treatment as factors that determine retention in a study. …”
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Citizen-engaged screening of 230 pesticides in the Lake Naivasha catchment, Kenya, using stir bar sorptive extraction and GC-QToF-HRMS by Caterina Cacciatori, Caterina Cacciatori, Giulio Mariani, Sara Comero, Enock Kiminta, Anham Salyani, Jackie Myers, Vincent Pettigrove, Bernd Manfred Gawlik

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Insights from fifteen years of real-world development, testing and implementation of youth digital mental health interventions by Shane Cross, Shaminka Mangelsdorf, Lee Valentine, Shaunagh O'Sullivan, Carla McEnery, Isabelle Scott, Tamsyn Gilbertson, Shona Louis, Jon Myer, Ping Liu, Niel Mac Dhonnagáin, Tom Wren, Eleanor Carey, Daniela Cagliarini, Ross Jacobs, Roos Pot-Kolder, Imogen Bell, Jennifer Nicholas, Lucia Valmaggia, John Gleeson, Mario Alvarez-Jimenez

“…Emerging innovations such as just-in-time adaptive interventions, extended reality (XR) therapies, stratified treatment models, and large language models offer promising future pathways for greater personalization, engagement, effectiveness, and scalability.Our findings highlight the potential value of context-sensitive, co-designed, and system-integrated DMHIs, while also emphasising enduring limitations such as variable engagement, implementation barriers, and population-specific adaptation. …”
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Factors Associated with Treatment Duration in a Trauma-Focused Community Mental Health Setting by Jason Fly, Erika Felix, Bita Ghafoori

“…Using the behavioral model of engagement in health services, the current study assessed client characteristics that may contribute to treatment duration in trauma-focused psychotherapy in a community clinic setting. …”
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Refusal of pharmacological treatment: prevalence and clinical importance by S. Yu. Martsevich, N. P. Kutishenko, E. P. Kalaydzhyan, Yu. V. Lukina, A. V. Zagrebelnyy, V. V. Tsaregorodtseva, O. S. Afonina, N. P. Zolotareva, M. L. Ginzburg, O. M. Drapkina

“…The frequency of complete discontinuation of treatment ranged from 1% to 10.1%. The main reasons for the complete discontinuation of medication included satisfactory health status, reluctance to engage in prolonged medication use, and high costs associated with treatment. …”
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Identifying trends in reporting on the ethical treatment of insects in research. by Craig D Perl, Cat Kissinger, R Keating Godfrey, Enrique M Castillo, Bob Fischer, Meghan Barrett

“…Transparent reporting on the ethical treatment of research animals (e.g., implementation of the 3Rs, replace, reduce, and refine) is recommended when publishing in peer-reviewed literature. …”
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Recent advances in oncolytic virus combined immunotherapy in tumor treatment by Xiaoli Zhou, Shunfeng Hu, Xin Wang

“…In this review, we systematically summarize the latest progress of OVs combined with immunotherapy in tumor treatment and highlight the future directions of the combination strategies, which will promote the clinical application of OVs in tumor therapy.…”
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Social Media in Urologic Healthcare: Transforming Treatment, Management, and Online Medical Communication by Jung Eun Yu, Jong Mok Park, Jung Yoon Kim

“…This review examines the role of social media in urologic care, focusing particularly on its impact on treatment, management, and professional engagement. …”
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