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Therapeutic efficacy of a potent anti-Venezuelan equine encephalitis virus antibody is contingent on Fc effector function
Published 2024-12-01“…The development of specific, safe, and potent monoclonal antibodies (Abs) has led to novel therapeutic options for infectious disease. …”
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Absent in melanoma 2: a potent suppressor of retinal pigment epithelial-mesenchymal transition and experimental proliferative vitreoretinopathy
Published 2025-01-01“…The present study demonstrated that AIM2 functions as a potent suppressor of RPE cell proliferation and EMT to maintain retinal homeostasis. …”
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Development of cell lines with increased susceptibility to diverse adeno-associated viral vectors to enable in vitro potency assays
Published 2025-03-01“…Robust cell-based assays that demonstrate and quantify the potency of AAV vectors in expressing their transgene are needed for clinical development. …”
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Triterpene esters from Uncaria rhynchophylla hooks as potent HIV-1 protease inhibitors and their molecular docking study
Published 2024-12-01“…These compounds exhibited potent inhibition of HIV-1 protease (PR), one of the essential enzymes in the virus’s life cycle, with 3β-hydroxy-27-p-Z-coumaroyloxyurs-12-en-28-oic acid (8) showing the most potent inhibitory activity. …”
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Parasite-derived plasma microparticles contribute significantly to malaria infection-induced inflammation through potent macrophage stimulation.
Published 2010-01-01“…Here we demonstrate that MPs, derived from the plasma of malaria infected mice, but not naive mice, induce potent activation of macrophages in vitro as measured by CD40 up-regulation and TNF production. …”
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Sulfated Alkyl Glucopyranans with Potent Antiviral Activity Synthesized by Ring-Opening Copolymerization of Anhydroglucose and Alkyl Anhydroglucose Monomers
Published 2015-01-01“…Water-soluble sulfated glucopyranans with 2.8 and 4.7 mol% of 3-O-octadecyl group and lower molecular weights of M-n = 2.5 × 103–5.1 × 103 have potent anti-HIV activity at 0.05–1.25 μg/mL, even though sulfated polysaccharides with molecular weights below M-n = 6 × 103 had low anti-HIV activity. …”
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Exploring novel and potent glycogen synthase kinase-3β inhibitors through systematic drug designing approach
Published 2025-02-01“…The stability of the strongest molecule (most potent) was evaluated in the active site of the above-mentioned kinase keeping its apo-form as reference. …”
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RATIONAL DRUG DESIGN OF POTENT V600E-BRAF KINASE INHIBITORS THROUGH MOLECULAR DOCKING SIMULATION
Published 2019-12-01“…This compound (QAP6) were further used in designing novel and potent V600E-BRAF inhibitors by attaching substituents to the quinoline ring of the compound. …”
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Inherited metabolic diseases are a potent risk factor for cytomegalovirus infection in pediatric living donor liver transplantation
Published 2025-01-01“…Conclusions This study demonstrates that IMDs are a potent independent risk factor for CMV infection following pediatric liver transplantation. …”
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Synthesis, Antimalarial Activity and Molecular Dynamics Studies of Pipecolisporin: A Novel Cyclic Hexapeptide with Potent Therapeutic Potential
Published 2025-01-01“…Pipecolisporin, a cyclic hexapeptide isolated from <i>Nigrospora oryzae</i>, has emerged as a promising antimalarial candidate due to its potent biological activity and stability. This study explores the synthesis, antimalarial activity, and computational studies of pipecolisporin, aiming to better understand its therapeutic potential. …”
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Study on antifungal potency of Terminalia cattapa, Piper betle, Psidium guajava, and Andrographis peniculata on the growth of Aphanomyces in vitro
Published 2007-07-01“… An effort to prevent aquatic fungi Aphanomyces sp. infection on fish using natural material can be an economically way, easy to find the materials, easy to apply and safe for environment. The antifungal potency and efficacy of scalded-leaf extract of Terminalia cattapa, Piper betle, Psidium guajava and Andrographis peniculata on prevention of Aphanomyces sp. growth in vitro in GYA medium. …”
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Secure and efficient token based roaming authentication scheme for space-earth integration network
Published 2018-05-01Subjects: Get full text
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The Merits and Pitfalls of Participatory Action Research: Navigating Tokenism and Inclusion with Lived Experience Members
Published 2024-04-01Subjects: Get full text
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Toward an ecosystem of non-fungible tokens from mapping public opinions on social media
Published 2025-01-01“…Abstract As blockchain technology advances, non-fungible tokens (NFTs) are emerging as unconventional assets in the commercial market. …”
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