Secreted PD-L1 alleviates inflammatory arthritis in mice through local and systemic AAV gene therapy by Wenjun Li, Wenjun Li, Junjiang Sun, Susi Feng, Ariana La Rosa, Panli Zhang, Eveline Y. Wu, Richard Loeser, Chengwen Li, Chengwen Li, Chengwen Li

“…To further improve efficacy, we explored AAV-mediated delivery of the soluble PD-L1 (sPD-L1) to CIA mice.ResultAfter intra-articular injection of AAV6 vectors expressing the optimal isoform of sPD-L1 (shPD-L1), more potency was observed when compared to wild type PD-L1, with a lower dose of AAV6/shPD-L1 needed for arthritis improvement. …”
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OXA β-lactamases from Acinetobacter spp. are membrane bound and secreted into outer membrane vesicles by Lucia Capodimonte, Fernando Teixeira Pinto Meireles, Guillermo Bahr, Robert A. Bonomo, Matteo Dal Peraro, Carolina López, Alejandro J. Vila

“…., particularly in polymicrobial infections, being a potent evolutionary advantage.…”
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Estradiol-dependent and independent effects of FGF21 in obese female mice by T. V. Jakovleva, A. Yu. Kazantseva, A. D. Dubinina, N. Yu. Balybina, K. O. Baranov, E. N. Makarova, N. M. Bazhan

“…FGF21 administration has potent benef icial effects on obesity and diabetes in humans, cynomolgus monkey, and rodents. …”
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Hubungan Status Gizi dengan Prestasi Belajar pada Siswa –Siswi SMA Negeri 1 Padang Tahun Ajaran 2013/2014 by Steffi Olivia Padriyani, Delmi Sulastri, Nur Afrainin Syah

“…Penelitian ini menggunakan desain studi potong lintang (cross sectional study) dengan populasi seluruh siswa kelas X dan XI SMA Negeri 1 Kota Padang. …”
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Borrelia burgdorferi radiosensitivity and Mn antioxidant content: antigenic preservation and pathobiology by Andrés F. Londoño, Ajay Sharma, Jared Sealy, Vipin S. Rana, Shelby D. Foor, Vera Y. Matrosova, Elena K. Gaidamakova, Robert P. Volpe, Michael J. Daly, Brian M. Hoffman, Utpal Pal, J. Stephen Dumler

“…These observations also provide an opportunity for innovative vaccine development strategies employing ionizing radiation to disrupt the B. burgdorferi genome, while maintaining antigenic potency. These fresh insights extend our understanding of the unique biology of B. burgdorferi and open new avenues for considering novel whole-cell Lyme disease vaccines using MDP and irradiation-based inactivation.IMPORTANCEThe study highlights that electron paramagnetic resonance (EPR) spectroscopy is sufficiently sensitive to detect small differences in radiation resistance among Borrelia burgdorferi strains based on their population of Mn2+-metabolite complexes (H-Mn). …”
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Survei Motivasi Masyarakat Kota Pekanbaru Melakukan Aktivitas Olahraga Rekreasi Melalui Program Car Free Day Tahun 2020 by Novia Nazirun, Dupri, Sri Wahyuningsih

“…Dengan jumlah sampel yang digunakan sebanyak 100 responden terbagi 4 kategori usia yaitu anak-anak 20 orang, remaja 50 orang, dewasa 15 orang, serta otang tua (lansia) 15 orang. Menggunakan rumus deskkriptif persentase (DP) untuk mencari jumlah sampel. …”
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The In Vitro Immunomodulatory Effects of Gold Nanocomplex on THP-1-Derived Macrophages by Duaa Abuarqoub, Nouf N. Mahmoud, Rand Zaza, Rana Abu-Dahab, Enam A. Khalil, Dima A. Sabbah

“…We can conclude that our nanocomplex is a potent effector that prevents tumoral progression by activating three main immunological strategies: switching the surface expression profile of the activated macrophages into a proinflammatory M1-like phenotype, downregulating the expression of proinflammatory cytokines, and upregulating the expression level of anti-inflammatory cytokines.…”
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Digestibility of pre-treated cassava peel as feed ingredient for Nile tilapia by , Mulyasari, Feri Kurniawati, Mia Setiawati

“…Cassava peel fermented with combined 10% mold showed the highest protein digestibility impliying it potency as feed ingredient for Nile tilapia diet.   …”
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Improvement in XIa Selectivity of Snake Venom Peptide Analogue BF9-N17K Using P2′ Amino Acid Replacements by Li Ding, Zhiping Zhai, Tianxiang Qin, Yuexi Lin, Zhicheng Shuang, Fang Sun, Chenhu Qin, Hongyi Luo, Wen Zhu, Xiangdong Ye, Zongyun Chen, Xudong Luo

“…In conclusion, through P2′ amino acid classification scanning with the snake venom Kunitz-type peptide scaffold, a new potent and selective XIa inhibitor, BF9-N17K-L19D, was discovered, which provides a new XIa-targeting lead drug template for the treatment of thrombotic-related diseases.…”
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Analysis of Learning Obstacles for Junior High School Students in Understanding SPLDV Concepts by Firda Luthfiatika Jannah, Neneng Aminah, Surya Amami Pramuditya, Cita Dwi Rosita, M. Subali Noto

“…Kendala-kendala yang dihadapi siswa antara lain yaitu (1) kesulitan dalam merumuskan ulang konsep sistem persamaan linear dua variabel dan kurangnya kemampuan untuk memberikan contoh SPLDV. (2)Kesulitan dalam menentukan titik potong saat membuat grafik SPLDV. (3) Kekeliruan dalam melakukan operasi hitung dan mengembangkan model matematika. (4) Kesulitan dalam merancang langkah-langkah yang diperlukan untuk menyelesaikan soal SPLDV. (5) Kesulitan dalam menyelesaikan soal yang berbeda dengan contoh soal yang diajarkan oleh guru. …”
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Antifungal activity and biocompatibility assessment with molecular docking and dynamic simulations of new pyrazole derivatives by Basma T. Abd-Elhalim, Ghada G. El-Bana, Ahmed F. El-Sayed, Ghada E. Abdel-Ghani

“…Objective The current work validates the results and pyrazole binding sites as potent antifungals by investigating many pyrazole derivatives as antifungal agents. …”
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Antik Çağın Sunakları: Rigveda’da Kurban ve İcrası by Mehmet Masatoğlu

“…Bulgular, Vedik ritüellerin yalnızca dini törenler olarak değil, eski Hindistan’ın kültürel ethosunu, toplumsal yapılarını ve dini doktrinlerini şekillendiren temel unsurlar olarak kalıcı etkisinin altını çizmektedir. …”
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TikTok medio de divulgación empleado por los viajeros que realizan turismo sostenible by Ariana Paola Herrera Pérez

“…El empleo de esta red social para la publicidad del turismo le da un giro productivo, convirtiéndola en una potente herramienta de divulgación. Limitaciones/implicaciones: Se considera oportuno realizar el análisis de las métricas de TikTok por país, debido a que la implementación de la plataforma se encuentra desarrollada en distintos niveles por parte de los usuarios y los establecimientos. …”
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Specifically blocking αvβ8-mediated TGF-β signaling to reverse immunosuppression by modulating macrophage polarization by Cuicui Guo, Hui Sun, Yulei Du, Xiaodong Dai, Yu Pang, Zhen Han, Xinhui Xiong, Shaowei Li, Junhua Zhang, Qingbing Zheng, Xun Gui

“…The specific αvβ8 antibody 130H2 demonstrated high affinity, specificity, and blocking potency in vitro. Cryo-EM analysis further revealed that 130H2 interacts exclusively with the β8 subunit, without binding to the αv subunit. …”
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Olutasidenib in combination with azacitidine induces durable complete remissions in patients with relapsed or refractory mIDH1 acute myeloid leukemia: a multicohort open-label phas... by Jorge E. Cortes, Gail J. Roboz, Maria R. Baer, Brian A. Jonas, Gary J. Schiller, Karen Yee, P. Brent Ferrell, Jay Yang, Eunice S. Wang, William G. Blum, Alice Mims, Hua Tian, Aaron Sheppard, Stéphane de Botton, Pau Montesinos, Antonio Curti, Justin M. Watts, the Olutasidenib Combination Therapy Study Group

“…Abstract Background Olutasidenib is a potent, selective, oral, small molecule inhibitor of mutant IDH1 (mIDH1) which induced durable remissions in high-risk, relapsed/refractory (R/R) mIDH1 AML patients in a phase 1/2 trial. …”
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Neobacillus driksii sp. nov. isolated from a Mars 2020 spacecraft assembly facility and genomic potential for lasso peptide production in Neobacillus by Asif Hameed, Francesca McDonagh, Pratyay Sengupta, Georgios Miliotis, Shobhan Karthick Muthamilselvi Sivabalan, Lukasz Szydlowski, Anna Simpson, Nitin Kumar Singh, Punchappady Devasya Rekha, Karthik Raman, Kasthuri Venkateswaran

“…Isolation of N. driksii from cleanrooms, Agave plants, and dryland wheat soils, suggested niche-specific ecology and resilience under various environmentally challenging conditions. The discovery of potent antimicrobial agents from novel N. driksii underscores the importance of genome mining and the isolation of rare microorganisms. …”
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Prospect use of Phaleria macrocarpa to prevent motile aeromonad septicaemia disease in Patin Catfish Pangasianodon hypophthalmus by D. Wahjuningrum, S.L. Angka, W. Lesmanawati, . Sa’diyah, M. Yuhana

“…This study was performed to determine antimicrobial of Phaleria macrocarpa (PM) and its potency against MAS disease caused by Aeromonas hydrophila.  …”
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Buffalo genetic improvement program in Vene- zuela by José A. Aranguren-Méndez, Rafael M. Román-Bravo, Ricardo A. Briceño-Rojas, Mauricio G. Briceño-Rojas, Luis A. Pacheco-Díaz

“…In conclusion, genetic improvement programs based on the selection index and the massive use of reproductive biotechnologies are potent tools that must simultaneously accelerate buffalo herds’ genetic progress. …”
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Decription of Students’ Learning Style by Laila Isrona

“…Penelitian ini menggunakan metode kuantitatif dengan pendekatan studi potong lintang dan mendeskripsikan tipe belajar empat orang mahasiswa. …”
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Disrupting EDEM3‐induced M2‐like macrophage trafficking by glucose restriction overcomes resistance to PD‐1/PD‐L1 blockade by Shaoyong Peng, Minshan Wu, Qian Yan, Gaopo Xu, Yumo Xie, Guannan Tang, Jinxin Lin, Zixu Yuan, Xiaoxia Liang, Ze Yuan, Jingrong Weng, Liangliang Bai, Xiaolin Wang, Huichuan Yu, Meijin Huang, Yanxin Luo, Xiaoxia Liu

“…Manipulationof glucose utilization by a fasting‐mimicking diet(FMD) plus 2‐DG treatmentsynergistically with PD‐1 antibody elicits potent antitumour activity byeffectively decreasing tumour glycosylated PD‐L1 expression, augmenting the CD8+effector T cell infiltration and activation while concurrently reducing the infiltration.TheCAFs‐EDEM3‐M2‐like macrophage axis plays a critical role in promotingimmunotherapy resistance. infiltration.TheCAFs‐EDEM3‐M2‐like macrophage axis plays a critical role in promotingimmunotherapy resistance. …”
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