Safety and efficacy of selective RIPK1 inhibitor SIR1-365 in hospitalized patients with severe COVID-19: A multicenter, randomized, double-blind, phase 1b trial by Norberto Chavez-Tapia, Muneeba Ahsan Sayeed, Shobha Luxmi, Douglas J. Kasper, Fenchao Xue, Yang Shen, Weiliang Fan, Wei Yuan, Bin Du

“…This study was conducted to evaluate the safety and efficacy of a potent and selective inhibitor of RIPK1, SIR1-365, in hospitalized patients with severe coronavirus disease 2019 (COVID-19). …”
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Sodium Butyrate: A Multifaceted Modulator in Colorectal Cancer Therapy by Alexandra Laura Mederle, Alexandra Semenescu, George Andrei Drăghici, Cristina Adriana Dehelean, Nicolae-Valentin Vlăduț, Dragoş Vasile Nica

“…<i>Background and Objectives</i>: Sodium butyrate (NaB) is a potent modulator of cancer-related gene networks. …”
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Statistical optimization of pectinases from thermophilic Aspergillus fumigatus BT-4 employing response surface methodology through submerged fermentation using agricultural wastes by Imran Ali, Roheena Abdullah, Sana Saqib, Kinza Nisar, Afshan Kaleem, Mehwish Iqtedar, Irfana Iqbal, Xiaoming Chen

“…Conclusions The study successfully isolated and identified Aspergillus fumigatus BT-4 as a potent thermophilic pectinase producer. Optimization of the fermentation process using 1% grapefruit peel in M5 media significantly enhanced pectinase production. …”
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Insidens Riwayat Hipertensi dan Diabetes Melitus pada Pasien Penyakit Jantung Koroner di RS. Dr. M. Djamil Padang by Putri Yuriandini Yulsam, Fadil Oenzil, Efrida .

“…Ini merupakan penelitian deskriptif dengan rancangan potong lintang yang dilakukan di Bagian Rekam Medik RS. …”
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Think Pink! Una arquitectura queer: la cabaña de Derek Jarman en Dungeness by Miguel Mesa-del-Castillo

“…Este texto propone un examen de la arquitectura y el paisajismo de Prospect Cottage como un potente dispositivo político mediante el que su autor, en un momento crítico para la historia reciente del Reino Unido, desplegó una forma de medioambientalismo disidente logrando desencadenar una multitud de encuentros sensuales más-que-humanos entre plantas, insectos, residuos procedentes del mar, fuertes vientos, vínculos de afecto, grandes infraestructuras industriales, etc., que constituyen un dique de contención melancólico y de memoria ética de las vidas aplastadas por la represión thatcheriana y por la trágica epidemia de VIH en los años 80 del siglo pasado. …”
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Surgical decompression for endocrine ophthalmopathy: state-of-the-art by A.A. Krylova, O.I. Krivosheina

“…</i> </p> <p> <i>The choice of surgical strategy and surgical volume in endocrine ophthalmopathy depends on the s everity of clinical manifestations, expected clinical functional outcomes, and risks of potentional complications.</i> </p> <p> <i><b>Keywords</b>: endocrine ophthalmopathy, edematous exophthalmos, orbital decompression, external orbitotomy, trans-ethmoidal endonasal orbital decompression, internal orbital decompression.…”
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Hubungan Faktor Risiko yang dapat Dimodifikasi dengan Kejadian Penyakit Jantung Koroner di RS Dr. M. Djamil Padang by Suchi Ilmi Herman, Muhammad Syukri, Efrida .

“…Penelitian ini merupakan penelitian analitik dengan desain potong lintang yang dilakukan di RS Dr. M. Djamil Padang dari Desember 2012 sampai Mei 2013. …”
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Long-Term Therapeutic Effects of ²²⁵Ac-DOTA-E[c(RGDfK)]₂ Induced by Radiosensitization via G2/M Arrest in Pancreatic Ductal Adenocarcinoma by Mitsuyoshi Yoshimoto, Kohshin Washiyama, Kazunobu Ohnuki, Ayano Doi, Miki Inokuchi, Motohiro Kojima, Brian W. Miller, Yukie Yoshii, Anri Inaki, Hirofumi Fujii

“…<b>Results</b>: ²²⁵Ac-DOTA-RGD₂ demonstrated potent cytotoxicity against cells expressing α_vβ₃ or α_vβ₆ integrins and induced G2/M arrest and γH2AX expression as a marker of double-stranded DNA breaks. …”
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Innovative Deep Learning Architecture for the Classification of Lung and Colon Cancer From Histopathology Images by Menatalla M. R. Said, Md. Sakib Bin Islam, Md. Shaheenur Islam Sumon, Semir Vranic, Rafif Mahmood Al Saady, Abdulrahman Alqahtani, Muhammad E. H. Chowdhury, Shona Pedersen

“…However, with substantial technological advancements, deep learning (DL) has emerged as a potent tool in clinical settings, particularly in the realm of medical imaging. …”
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Genetically and chemically intraspecific variations of Ficus hirta provide novel insights into its protection and utilization by Jianling Chen, Qianqian Liu, Huihong Wang, Zhi Chao, Enwei Tian

“…Abstract Background Radix Fici Hirtae, the dry root of Ficus hirta, is a famous ethnomedicine and food that has been widely used by Yao and Zhuang nationalities in southern China for its potent antitumor, antifungal, and hepatoprotective effects. …”
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Calcitonin Gene-Related Peptide (Cgrp), Adrenomedullin (Am), Amylin, And Calcitonin (Ct) Receptors And Overlapping Biological Actions by J.A. Fischer, W. Born, R. Muff

“…Overlapping biological actions include inhibition of bone resorption obtained predominantly with CT, but also at high concentrations with CGRP, AM, and amylin. CGRP and AM are potent vasodilators, an effect shared with CT at pharmacological concentrations. …”
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XCL1-secreting CEA CAR-T cells enhance endogenous CD8+ T cell responses to tumor neoantigens to confer a long-term antitumor immunity by Kun Chen, Fei Zhao, Hong Zhao, Dongmei Wang, Chunfeng Qu, Zhiyuan Wu, Feifei Wang, Xing-Ning Li, Ruochan Zhang, Chentong Xiao, Yuliang Ran

“…On interaction with CT26.CEA-positive cells, 7XCL1-CAR T cells secreted higher levels of XCL1 and IL-7, effectively recruited the most potent cross-presenting cDC1s (type-I conventional dendritic cells), and sustained the antitumor activity of CAR-T cells. …”
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Safety, Tolerability, and Immunogenicity of the Invaplex_AR-Detox <i>Shigella</i> Vaccine Co-Administered with the dmLT Adjuvant in Dutch and Zambian Adults: Study Protoc... by Geert V. T. Roozen, Nsofwa Sukwa, Masuzyo Chirwa, Jessica A. White, Marcus Estrada, Nicole Maier, Kevin R. Turbyfill, Renee M. Laird, Akamol E. Suvarnapunya, Aicha Sayeh, Flavia D’Alessio, Candice Marion, Laura Pattacini, Marie-Astrid Hoogerwerf, Rajagopal Murugan, Manuela Terrinoni, Jan R. Holmgren, Sodiomon B. Sirima, Sophie Houard, Michelo Simuyandi, Meta Roestenberg

“…Additionally, a new vaccine might be less immunogenic in a highly endemic setting compared to a low endemic setting (“vaccine hyporesponsiveness”). The use of a potent adjuvant enhancing both mucosal and systemic immunity might overcome these problems. …”
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Rescue of Mutant CFTR Channel Activity by Investigational Co-Potentiator Therapy by Mafalda Bacalhau, Filipa C. Ferreira, Marcelo Folhadella M. F. Azevedo, Talita P. Rosa, Camilla D. Buarque, Miquéias Lopes-Pacheco

“…<b>Results:</b> We found that five compounds were able to increase p.Arg334Trp-CFTR activity with similar efficacy, but slightly greater potency promoted by LSO-150 and LSO-153 (EC₅₀: 1.01 and 1.26 μM, respectively). …”
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Synthesis, Characterization, and DNA-Binding Kinetics of New Pd(II) and Pt(II) Thiosemicarbazone Complexes: Spectral, Structural, and Anticancer Evaluation by Simon N. Mbugua, Lydia W. Njenga, Ruth A. Odhiambo, Shem O. Wandiga, Mervin Meyer, Nicole Sibuyi, Roger A. Lalancette, Martin O. Onani

“…The compounds had low to moderate anticancer potency with their spectral and structural properties correlating with the corresponding anticancer activity profiles. …”
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Overview of preclinical and phase II clinical studies on Pegmolesatide’s long-term erythropoiesis stimulating effect via EPOR-mediated signal transduction by Xiaoying Ma, Zhen Li, Lu Zhang, Hui Qian, Qinkai Chen, Ye Tao, Yunfan Li, Dandan Wang, Zhizhen Hu, Weili Luo, Ping Li, Hai Yu, Changlin Mei, Xueqing Yu, Yuanfeng Zhou

“…Discussion Preclinical and clinical evidence signifies that Pegmolesatide is a unique, potent PEGylated EPO-memetic peptide (EMP) with a prolonged PD efficacy and PK half-life and a good safety-tolerability profile. …”
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Enhancing growing rabbit heat stress resilience through dietary supplementation with natural antioxidants by Ibrahim Talat El-Ratel, Aml Mekawy, Sara H.M. Hassab, Sameh Abdelnour

“…Collectively, allicin emerged as a potent shield against heat stress, bettering lycopene and vitamins E and C in safeguarding the well-being of growing rabbits.…”
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Economic and Clinical Impact of Stroke and Warfarin Use for Patients with Non-valvular Atrial Fibrillation by Li Wang, Elyse Fritschel, Onur Baser

“…**Background:** Atrial fibrillation (AF) is a common clinical problem and potent risk factor for stroke. However, real-world effectiveness and outcomes for AF patients are not well described. …”
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Increased aqueous humor levels of endothelin-1 in patients with open angle glaucoma by Adam Hedberg-Buenz, Erin A. Boese, Angela W. Nyunt, Nathan C. Sears, Andrew E. Pouw, Kai Wang, John H. Fingert

“…Abstract Background Endothelin is a potent vasoconstrictor and contributes to the regulation of vascular perfusion. …”
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Emergence and clinical challenges of ST11-K64 carbapenem-resistant Klebsiella pneumoniae: molecular insights and implications for antimicrobial resistance and virulence in Southwes... by Linlin LI, Jiahui Liang, Huan Zhang, Jing Guo, Shan LI, Meng Li

“…Conclusion Our findings underscore the rising prevalence of ST11-K64 CRKP, characterized by high levels of antimicrobial resistance and the presence of potent resistance and virulence genes. This strain poses a significant clinical and therapeutic challenge, necessitating heightened vigilance, stringent infection control measures, and robust clinical management strategies.…”
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