Talentmenedzsment jelenléte a hierarchikus struktúrájú szervezetek mindennapjaiban egy empirikus vizsgálat eredményei alapján by Mónika Balogh

“…A kérdőív kitöltése önkéntes volt, anonim módon történt az adatfelvétel. A kutatási célhoz kapcsolódóan megfogalmazott hipotézisek igazolását, elvetését jellemzően egyszeres vagy többszörös feleletválasztásos kérdésekre kapott válaszok mentén vizsgálta a szerző. …”
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Design and development of novel 1,2,3-triazole chalcone derivatives as potential anti-osteosarcoma agents via inhibition of PI3K/Akt/mTOR signalling pathway by Su Qing, Xu Baolin, Tian Zhoubin, Gong Ziling

“…The most significant inhibitory activity was observed for compound 4e against all cell lines (MG-63, HepG2, A549 and HeLa), still somewhat lower to comparable to that of gedatolisib, but with the highest potency against MG-63 cells. Compound 4e was further tested for anti-cancer activity against other OS cells and showed to be equipo-tent to gedatolisib against U2OS and Saos-2 cells. …”
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Evaluation of Inflammatory Cytokine Secretion by Human Alveolar Macrophages by J. E. Losa García, F. M. Rodríguez, M. R. Martín de Cabo, M. J. García Salgado, J. P. Losada, L. G. Villarón, A. J. López, J. L. P. Arellano

“…Regarding the secretion of IL-1β, four observations were of interest: basal secretion was very low; LPS exerted a potent stimulatory effect; considerable within-group variability was observed; and there were no significant differences in the comparisons among groups. …”
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Kinomic profiling to predict sunitinib response of patients with metastasized clear cell Renal Cell Carcinoma by Jeannette C. Oosterwijk-Wakka, Liesbeth Houkes, Loes F.M. van der Zanden, Lambertus A.L.M. Kiemeney, Kerstin Junker, Anne Y Warren, Tim Eisen, Ulrich Jaehde, Marius T Radu, Rob Ruijtenbeek, Egbert Oosterwijk

“…Introduction: Treatment with Sunitinib, a potent multitargeted receptor tyrosine kinase inhibitor (TKI) has increased the progression-free survival (PFS) and overall-survival (OS) of patients with metastasized renal cell carcinoma (mRCC). …”
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Harnessing the Power of Machine Learning Guided Discovery of NLRP3 Inhibitors Towards the Effective Treatment of Rheumatoid Arthritis by Sidra Ilyas, Abdul Manan, Chanyoon Park, Hee-Geun Jo, Donghun Lee

“…The outcomes obtained can be used to design more potent and selective NLRP3 inhibitors as therapeutic agents for the treatment of inflammatory diseases such as RA. …”
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Plant growth-promoting endophytic consortium improved artemisinin biosynthesis via modulating antioxidants, gene expression, and transcriptional profile in Artemisia annua (L.) und... by Arpita Tripathi, Praveen Pandey, Shakti Nath Tripathi, Alok Kalra

“…., an important medicinal plant in traditional Chinese medicine, produces an array of secondary metabolites, most notably artemisinin, a potent anti-malarial phytomolecule. However, its low concentration restricts its supply, necessitating a sustainable approach for increasing in planta artemisinin biosynthesis. …”
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In vitro anticancer effects of frankincense and its nanoemulsions for enhanced cancer cell targeting by Rayya A. Al-Balushi, Aiswarya Chaudhuri, Raghuram Kandimalla, Ashanul Haque, Khalaf M. Alenezi, Mohd. Saeed, Mohammad Changez, Thuraya Al Harthy, Mohammed Al Hinaai, Samra Siddiqui, Ashish Kumar Agrawal, Farrukh Aqil, Farrukh Aqil

“…FO-NEs significantly improved cancer cell internalization, disrupted mitochondrial membrane potential, and increased ROS generation, leading to enhanced cytotoxic effects.DiscussionThe results demonstrate that nanoemulsion-based delivery significantly enhances the bioactivity and cellular uptake of frankincense oil compared to its free form. FO-NEs exhibit potent anticancer activity, particularly against drug-resistant cancer cell lines, suggesting their potential as a viable strategy for improving the therapeutic efficacy of frankincense in cancer treatment.…”
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Development of a Cationic Polymeric Micellar Structure with Endosomal Escape Capability Enables Enhanced Intramuscular Transfection of mRNA-LNPs by Siyuan Deng, Han Shao, Hongtao Shang, Lingjin Pang, Xiaomeng Chen, Jingyi Cao, Yi Wang, Zhao Zhao

“…Here, we present a cationic polymeric micelle (cPM) as a safe and potent co-delivery system with enhanced endosomal escape capabilities. …”
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Antiplasmodial and Cytotoxic Activities of Extracts of Selected Medicinal Plants Used to Treat Malaria in Embu County, Kenya by Bibianne Waiganjo, Gervason Moriasi, Jared Onyancha, Nelson Elias, Francis Muregi

“…It was concluded that T. brownii and S. africana aqueous extracts were potent antiplasmodial agents. Further focused studies geared towards isolation of active constituents and determination of in vivo toxicities to ascertain their safety are warranted.…”
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Surveillance of Mycoplasma agassizii in Texas tortoises (Gopherus berlandieri) for translocation with emphasis on treatment and recovery by Christin A. Moeller, Saren Perales, Wraith Rodriguez, Alynn M. Martin, Cord B. Eversole, Sandra Rideout-Hanzak, Paul Crump, Clayton D. Hilton, Scott E. Henke

“…Stressors, such as translocation, can cause Mycoplasma-seropositive tortoises to display clinical symptoms of URTD, which can abate without treatment, once the stressor subsides.ImplicationsDanofloxacin, the recommended treatment for Mycoplasma infection in tortoises, is too potent for Texas tortoises.…”
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PENGEMBANGAN DESAIN BAHAN AJAR FISIKA BERBASIS E-MODUL PADA MATERI MOMENTUM by Nadah Qolbi Shobrina, Indra Sakti, Andik Purwanto

“…This research was is a development research conducted in five stages, namely potention and problem, literature study and information gathering, product design, design validation, and tested design .The sample or data source of this research were the Physic Teacher and Student of SMAN 2 Bengkulu, class of X MIPA D. …”
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The Campylobacter jejuni BumS sensor phosphatase detects the branched short-chain fatty acids isobutyrate and isovalerate as direct cues for signal transduction by Nestor Ruiz, Jiawei Xing, Igor B. Zhulin, Chad A. Brautigam, David R. Hendrixson

“…Both isobutyrate and isovalerate are potent, direct cues for BumS, whereas butyrate is an indirect cue. …”
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Methodological aspects in gastroenteric methane evaluation trial in water buffalo by Maria Chiara La Mantia, Emanuela Rossi, Francesco Cenci, David Meo Zilio, Roberto Steri, Miriam Iacurto, Antonella Chiariotti

“… Methane (CH 4) is a potent greenhouse gas, and ruminants constitute a significant source of agricultural contributions. …”
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Serum Fibroblast Growth Factor 21 Levels Are Positively Associated with Metabolic Syndrome in Patients with Type 2 Diabetes by Ruo-Yao Gao, Bang-Gee Hsu, Du-An Wu, Jia-Sian Hou, Ming-Chun Chen

“…Fibroblast growth factor 21 (FGF21) acts as a potent metabolic regulator. Serum FGF21 levels were significantly higher in obesity and type 2 diabetes mellitus (T2DM) populations. …”
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The nonlinear association between lipoprotein(a) and major adverse cardiovascular events in acute coronary syndrome patients with three-vessel disease by Qianhui Li, Shuailei Xu, Junxian Shen, Fengnian Sun

“…Abstract Lipoprotein(a) [Lp(a)] is a lipoprotein with potent atherogenic and thrombogenic potential. Its role in patients with acute coronary syndrome (ACS) combined with three-vessel disease (TVD) remains unclear. …”
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A programação computacional e a Educação Matemática: aspectos da amanualidade na reorganização do pensamento by Daniel Tebaldi Santos, Silvana Claudia dos Santos, Sueli Liberatti Javaroni

“…Como resultados, os dados apontam viabilidades, a partir da apropriação de práticas de programação computacional, para o desenvolvimento de ações potentes que podem favorecer a produção de conhecimentos matemáticos. …”
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Comparative In vitro antibacterial activity of nemonoxacin and other fluoroquinolones in correlation with resistant mechanisms in contemporary methicillin-resistant Staphylococcus... by Pao -Yu Chen, Mao-Wang Ho, Po-Liang Lu, Hung-Jen Tang, Cheng Len Sy, Jann-Tay Wang, Taiwan Staphylococcus aureus Consortium (TSAC)

“…Using a tCBP defined by a higher parenteral daily dosage, nemonoxacin retained potency against moxifloxacin non-susceptible isolates. …”
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The expression of exosomal and cellular miRNAs in predicting oxaliplatin resistance in colorectal cancer cells: an in silico and in vitro study by Hoda Deli, Zeynab Vakili-Ghartavol, Yazdan Asgari, Gholamreza Tavoosidana, Ebrahim Eftekhar, Mohammad Hossein Ghahremani

“…The effectiveness of diagnostics and biomarker potency of miRNAs were evaluated by receiver operating characteristic (ROC) analysis. …”
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Revealing Sarcophyton extract's alleviating potential against gentamicin-induced renal and testicular toxicity in rat model by Nada S. Badr, Aml Talaat, Salwa A. El-Saidy, Aml Zaki Ahmed Ghoneim

“…Abstract Background Gentamicin (GEN) is a potent antibiotic known for inducing oxidative stress and causing adverse effects in the kidneys and testes. …”
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Role of Fcγ receptors in HER2-targeted breast cancer therapy by Hope S Rugo, Antonino Musolino, William J Gradishar, Jeffrey L Nordstrom, Edwin P Rock, Fernanda Arnaldez, Mark D Pegram

“…Margetuximab enhances Fc-dependent ADCC in vitro more potently than the combination of pertuzumab (another approved mAb directed against an alternate HER2 epitope) and trastuzumab. …”
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