The Life Mission Theory IV. Theory on Child Development by Soren Ventegodt, Joav Merrick

“…The loss of ability takes the form of diminished social ability, psychosexual potency, joy, energy, and fantasy while playing, as well as diminished ability to concentrate, focus, and learn. …”
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The regulatory role of cystatin C in autophagy and neurodegeneration by T. A. Korolenko, A. B. Shintyapina, A. B. Pupyshev, A. A. Akopyan, G. S. Russkikh, M. A. Dikovskaya, V. A. Vavilin, E. L Zavjalov, M. A. Tikhonova, T. G. Amstislavskaya

“…Cystatin C is one of the potent regulators of autophagy. Changes in the expression and secretion of cystatin C in the brain have been shown in amyotrophic lateral sclerosis, Alzheimer’s and Parkinson’s diseases, and in some animal models of neurodegeneration, thus proving a protective function of cystatin C. …”
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Flavins and Flavoproteins in the Neuroimmune Landscape of Stress Sensitization and Major Depressive Disorder by Schrier MS, Smirnova MI, Nemeth DP, Deth RC, Quan N

“…However, the manner in which these factors interact with each other to induce their effects on MDD development has been less clear, but is beginning to be understood. Flavins are potent biomolecules that regulate many redox activities, including ROS generation and energy production. …”
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Cost-effectiveness Analysis of Lorlatinib in Patients Previously Treated with Anaplastic Lymphoma Kinase Inhibitors for Non-small Cell Lung Cancer in Greece by George Gourzoulidis, Oresteia Zisimopoulou, Nadia Boubouchairopoulou, Christina Michailidi, Chrissy Lowry, Charalampos Tzanetakos, Georgia Kourlaba

“…**Background:** Non-small cell lung cancer (NSCLC), which accounts for about 80%-85% of lungcancer cases, is a leading cause of cancer-related death worldwide. Lorlatinib is a potent third-generation anaplastic lymphoma kinase (ALK) inhibitor approved for the treatment of patients with advanced, ALK-positive NSCLC previously treated with at least one second-generation ALK tyrosine kinase inhibitor. …”
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Ultrasonic Assisted Environmentally Friendly Extraction of Natural Dyes From Beta vulgaris for the Coloration of Silk Fabric Using Different Mordants by Rony Mia, Tafsir Uddin, A. Z. M. Mofasser, Nadim Ibn Sayed, Al Mojnun Shamim, Sanjida Islam, Khandaker Akil Mahadi Ohi, Moonis Ali Khan, Burhan Uddin Banna

“…Furthermore, in silk dyeing with beetroot extract, lemon peel extract is a potent alternative to ferrous sulfate as a mordant.…”
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Establishing trust through home visits during pregnancy: a realist evaluation of a Danish breastfeeding support intervention by Anne Kristine Gadeberg, Ingrid Maria Susanne Nilsson, Ulla Christensen, Marie Honoré Jacobsen, Henriette Knold Rossau, Sarah Fredsted Villadsen

“…Especially for families in vulnerable positions, the pregnancy home visit seems to be a potent driver for enhancing the gains from breastfeeding support.…”
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Anti-Inflammatory, Antithrombotic, and Antioxidant Properties of Amphiphilic Lipid Bioactives from Shrimp by Alexandros Tsoupras, Paschalis Cholidis, Dimitrios Kranas, Evangelia Aikaterini Galouni, Anna Ofrydopoulou, Pavlos Efthymiopoulos, Katie Shiels, Sushanta Kumar Saha, George Z. Kyzas, Chryssa Anastasiadou

“…<b>Results:</b> TAC extracts, rich in phenolics, carotenoids, PL, and unsaturated fatty acids (UFAs), exhibited stronger anti-inflammatory and antithrombotic activities compared with TLC extracts, which showed potent antioxidant capacity. Significant amounts of UFAs, such as the monounsaturated fatty acid (MUFA) oleic acid (C18:1n9) and omega-3 (n3) polyunsaturated fatty acids (PUFAs) like eicosapentaenoic acid (EPA; C20:5n3) and docosahexaenoic acid (DHA; C22:6n3), were detected in the PLs of shrimp TAC extracts, with favorable anti-inflammatory values for their n6/n3 PUFA ratio. …”
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Dietary Exposure to Aflatoxins in Some Randomly Selected Foods and Cancer Risk Estimations of Cereals Consumed on a Ghanaian Market by Nii Korley Kortei, Theophilus Annan, Seidu A. Richard, Adjoa A. Boakye, Clement O. Tettey, Edward Ken Essuman, Enoch Aninagyei, Precious Agbemeseli

“…Furthermore, estimated daily intake (EDI) of 27.10–283.70 ng/kg·bw/day, margin of exposure (MOE) of 1.409–14.76, average potency of 0–0.00396 ng aflatoxins/kg·bw/day, and cancer risks with a range of 0.107–1.122 cases/100,000 person/yr were observed. …”
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Potentiation of Doxorubicin Cytotoxicity Utilizing Clarithromycin Loaded-PEGylated Liposomes by Islam Alfreahat MS, Hamdi Nsairat PhD, Ibrahim Deeb Aldeeb PhD, Ali Al-Samydai PhD, Walhan Alshaer PhD

“…Background Doxorubicin (DOX) is a potent chemotherapeutic agent for breast cancer, but its effectiveness is often diminished by resistance mechanisms, particularly through p-glycoprotein (P-gp) mediated drug efflux. …”
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Interleukin-10 exhibit dose-dependent effects on macrophage phenotypes and cardiac remodeling after myocardial infarction by Jing J. Zhang, Rodrigue Rizk, Xiaoping Li, Brandon G. Lee, Mason L. Matthies, Kennedy A. Bietz, Kang Kim, Kang Kim, Kang Kim, Johnny Huard, Yadong Wang, William C. W. Chen

“…IntroductionInterleukin-10 (IL-10) is a potent immunomodulatory cytokine widely explored as a therapeutic agent for diseases, including myocardial infarction (MI). …”
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Combination of Mangosteen (Garcinia mangostana L.) Pericarp Extract and Physical Exercise Decreases Atherosclerotic Lesions in Atherogenic Diet-Fed Rats by Andreas Arie Setiawan, . Sugiri, Awal Prasetyo, Eirin Yovita Kurniawan, Dominikus Evano Putra

“…The mangosteen pericarp (MP) has xanthone compounds, particularly alpha-mangostin (α-MG), which have been shown to exhibit potent antioxidant and anti-inflammatory activities. …”
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Open-label dose-extending placebos for opioid use disorder: a protocol for a randomised controlled clinical trial with methadone treatment by Annabelle M Belcher, Thomas O Cole, Aaron D Greenblatt, Stephen W Hoag, David H Epstein, Michael Wagner, Amy S Billing, Ebonie Massey, Kristen R Hamilton, Zofia K Kozak, Christopher J Welsh, Eric Weintraub, Emerson M Wickwire, Eric D Wish, Ted J Kaptchuk, Luana Colloca

“…Our study combines two promising clinical methodologies—conditioning/dose-extension and open-label placebo—to investigate whether placebo effects can increase the effective potency of methadone in treatment-seeking OUD patients.Methods and analysis A total of 120 newly enrolled treatment-seeking OUD patients will be randomly assigned to one of two different groups: either methadone plus daily placebo dose-extension (PDE; treatment group) or methadone/treatment as usual (control). …”
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Inhibition of S100A8/A9 ameliorates neuroinflammation by blocking NET formation following traumatic brain injury by Guihong Shi, Yiyao Cao, Jianye Xu, Bo Chen, Xu Zhang, Yanlin Zhu, Liang Liu, Xilei Liu, Luyuan Zhang, Yuan Zhou, Shenghui Li, Guili Yang, Xiao Liu, Fanglian Chen, Xin Chen, Jianning Zhang, Shu Zhang

“…S100A8/A9, also known as calprotectin or myeloid-related protein-8/14 (MRP8/14), is an alarmin primarily secreted by activated neutrophils with potent pro-inflammatory property. In this study, we explored the roles of S100A8/A9 in modulating neuroinflammation and influencing TBI outcomes, delving into the underlying mechanisms. …”
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Association between serum carotenoids levels and severe headache or migraine in adults: a cross-sectional study from NHANES by Tian Hu, Yufei Chen, Siyu Chen, Rui Xue

“…BackgroundCarotenoids are well-established for their potent antioxidant properties; however, their potential association with severe headaches or migraines remains largely unexamined. …”
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Identification and management of a novel Danshen leaf anthracnose caused by Colletotrichum karstii in Salvia miltiorrhiza Bunge in China by Haoyue Ma, Haoyue Ma, Liguo Huang, Lulu Guo, Lulu Guo, Shan Chen, Jiale Liu, Changyun Liu, Yanxia Dou, Xianchao Sun, Lin He, Guanhua Ma

“…Lastly, the efficacy of 15 chemical fungicides and six botanical fungiticide against C. karstii was evaluated in vitro, revealing fluazinam as the most potent inhibitor against mycelial growth with EC50 of 0.0725 mg/mL for mycelium and 0.0378 mg/mL for spore germination, respectively. …”
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Ex vivo biotransformation of lady’s mantle extracts via the human gut microbiota: the formation of phenolic metabolites and their impact on human normal and colon cancer cell lines... by Katarzyna Jakimiuk, Aleksandra Kruk, Marta Kinga Lemieszek, Jakub W. Strawa, Sebastian Granica, Adrian Wiater, Michał Tomczyk

“…The above results clearly indicate that microbial metabolism is a crucial factor that is potent in altering the biological activity of lady’s mantle extract.…”
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Phytochemical analysis, antioxidant, anti-inflammatory and enzyme inhibitory activities of bean pear (Pyrus calleryana fruit) by Huan Zhao, Huan Zhao, Qinqin Wang, Lanlan Yang, Lanlan Yang, Yuanquan Ran, Qiong Hu, Yi Hong, Minyi Tian, Minyi Tian, Minyi Tian

“…Interestingly, P. calleryana fruit WE and EE exhibited potent inhibition on α-glucosidase (0.60 ± 0.09 μg/mL and 0.48 ± 0.09 μg/mL, respectively) and tyrosinase (210.11 ± 2.59 μg/mL and 45.35 ± 0.96 μg/mL, respectively), which were superior to their respective positive controls acarbose (302.57 ± 22.09 μg/mL) and arbutin (243.07 ± 15.91 μg/mL). …”
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Evaluation of Antimicrobial Activity and Cytotoxicity of an Epoxy Resin-Based Endodontic Sealer Containing Nanoparticles Amorphous Calcium Phosphate by Bilal H. Ibrahim, Hussain Al-Huwaizi

“…Therefore, it is essential to use root canal sealers with potent antibacterial properties. These sealers play a vital role in eradicating any remaining microorganisms and preventing recontamination, especially in situations where there might be microleakage. …”
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Fortifying plant fortresses: siderophores in defense against Cercospora leaf spot disease in Vigna radiata L. by Anushree Kamath, Abhishek Sharma, Arpit Shukla, Arpit Shukla, Arpit Shukla, Paritosh Parmar, Dhara Patel

“…These findings underscore the dual role of siderophores in nutrient acquisition and as potent elicitors of plant defenses, highlighting their potential as bio-stimulants. …”
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Eski Uygurca Vimalakīrtinirdeśa-sūtra Tefsirine İlişkin Fragmanlar by Uğur Uzunkaya

“…Metnin Sanskritçesi yanında Çince, Tibetçe, Moğolca, Soğdca, Hoten Sakacası ve Eski Uygurca versiyonları da mevcuttur. …”
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