Development of a Recombinant Fusion Vaccine Candidate Against Lethal <i>Clostridium botulinum</i> Neurotoxin Types A and B by Eun-Sun Choi, Seong-Wook Pyo, So-Hyeon Kim, Jun-Ho Jeon, Gi-Eun Rhie, Mi-Ran Yun, Hwajung Yi, Yoon-Seok Chung

“…Background: Botulinum neurotoxins (BoNTs), produced by <i>Clostridium botulinum</i>, are potent protein toxins that can cause botulism, which leads to death or neuroparalysis in humans by targeting the nervous system. …”
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Frameshift variation in the HMG-CoA reductase gene and unresponsiveness to cholesterol-lowering drugs in type 2 diabetes mellitus patients by Esmat Khaleqsefat, Khder Hussein Rasul, Ramiar Kamal Kheder, Sonia Baban, Jamil Baban

“…Statins, which inhibit 3-hydroxy-3-methylglutaryl-CoA reductase, are potent competitive inhibitors that reduce plasma cholesterol levels. …”
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Pengorganisasian Guru dalam Mendukung Program Projek Penguatan Profil Pelajar Pancasila by Nur Ikhlas, Nunuk Hariyati, Amrozi Khamidi

“…Hambatan pengorganisasian guru dalam mendukung program P5 meliputi; 1) Kurangnya pemahaman dan keterampilan guru terkait P5; 2) Kurangnya pelatihan guru tetang P5; 3) Keterbatasan waktu, sumber daya, dan fasilitas sekolah; 4) Kurangnya dukungan dan kolaborasi berupa kurangnya keterlibatan dan dukungan dari pihak sekolah, orang tua, dan masyarakat. …”
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Identification of ALEKSIN as a novel multi-IRF inhibitor of IRF- and STAT-mediated transcription in vascular inflammation and atherosclerosis by Aleksandra Antonczyk, Katarzyna Kluzek, Natalia Herbich, Mahdi Eskandarian Boroujeni, Bart Krist, Dorota Wronka, Anna Karlik, Lukasz Przybyl, Adam Plewinski, Joanna Wesoly, Hans A. R. Bluyssen

“…Under the same conditions, ALEKSIN also inhibited the phosphorylation of STATs, potentially through low-affinity STAT-SH2 binding but with lower potency than the known multi-STAT inhibitor STATTIC. …”
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Comparative study on the bioavailability and bioequivalence of rifapentine capsules in humans by Ying Qi, Pengfei Zhao

“…Introduction: Rifapentine, a potent semi-synthetic member of the rifamycin class, is approved for the treatment of tuberculosis due to its effective bactericidal properties. …”
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Is the topical application of sesame oil (Sesamum indicum L.) combined with standard care valuable and safe for managing infusion-related phlebitis: Evidence from a systematic revi... by Morteza Nasiri, Leila Amirmohseni, Mohammad Farzollah Abbasi, Fatemeh Yarahmadi, Sahar Zonoori, Mahya Torkaman, Elham Sadeghi Moghimi, Mehrnaz Ardaneh, Masoomeh Asadi

“…However, uncertainty remains because the evidence quality was moderate, some RCTs needed better methodological rigor, and most required to address the safety of the intervention or independent verification of SO used in terms of purity and potency. Thus, to build a valid conclusion about the efficacy and safety of SO in managing IRP, more high-quality RCTs must be conducted considering an active placebo control intervention along with a well-designed randomization and blinding approach, as well as a better description of safety parameters and the quality control information of the SO used. …”
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Distinct sex differences in ethanol consumption and operant self-administration in C57BL/6J mice with uniform regulation by glutamate AMPAR activity by Sara Faccidomo, Sara Faccidomo, Vallari R. Eastman, Taruni S. Santanam, Katarina S. Swaim, Seth M. Taylor, Clyde W. Hodge, Clyde W. Hodge

“…The AMPAR antagonist GYKI 52466 (0–10 mg/kg, IP) dose-dependently reduced EtOH-reinforced lever pressing in both sexes, with no differences in potency or efficacy.DiscussionThese findings confirm that female C57BL/6J mice consume more EtOH than males in home-cage conditions and exhibit reduced acute sedation, potentially contributing to higher EtOH intake. …”
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EVALUATION OF ANTIBACTERIAL ACTIVITY OF TRICHILIA DREGEANA SOND (MELIACEAE) CRUDE EXTRACTS AGAINST GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA by Tesfa Mossie, Temesgen Kasa, Bekesis Urge, Hilena Yifred

“…The methanol crude extract of plants is an effective antibacterial agent for treating bacterial infections since the extract showed significant antibacterial potency comparable with that of the standard antibiotic disk. …”
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Comprehensive Analysis Reveals PTK6 as a Prognostic Biomarker Involved in the Immunosuppressive Microenvironment in Breast Cancer by Lili Wang, Shuimei Luo, Ziming Wang, Yiqiang Huang, Yang Luo, Xianhe Xie

“…The significant mortality rate that is currently experienced by female breast cancer (BC) patients highlights the importance of locating potent and dependable biomarkers in BC patients. Over the past few years, a number of studies have demonstrated that PTK6 was dysregulated in a variety of cancers. …”
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The Use of Trichostatin A during Pluripotent Stem Cell Generation Does Not Affect MHC Expression Level by Sara Farahi, Sara Hosseini, Hossein Ghanbarian, Seyed Mahmoud Hashemi, Mohammad Salehi, Samaneh Hosseini

“…Pluripotent stem cells (PSCs) are considered as a potent tool for use in regenerative medicine. Highly efficient generation of PSCs through chromatin modulators such as trichostatin A (TSA) might change their MHC molecule expression profile. …”
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A novel oncolytic Vaccinia virus armed with IL-12 augments antitumor immune responses leading to durable regression in murine models of lung cancer by Lijuan Chen, Lijuan Chen, Pengju Wang, Carmela Di Gioia, Ming Yuan, Zhe Zhang, Jinxin Miao, Wenli Yan, Guanghao Zhao, Yangyang Jia, Na Wang, Zhongxian Zhang, Haoran Guo, Giulia Marelli, Louisa Chard Dunmall, Nicholas R. Lemoine, Nicholas R. Lemoine, Yaohe Wang, Yaohe Wang

“…Oncolytic vaccinia viruses (VVs) are potent stimulators of the immune system and induce immune-mediated tumor clearance and long-term surveillance against tumor recurrence. …”
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Sequential Therapy of Linezolid and Contezolid to Treat Hematogenous Lung Abscess Caused by Staphylococcus aureus in a Congenital Cerebral Hypoplasia Patient: A Case Report by Zhou S, Xin C, Liu W

“…Oxazolidinone antibiotics exhibit potent antibacterial activity against multidrug-resistant (MDR) S. aureus; however, the adverse effects of linezolid, particularly thrombocytopenia, limit its application. …”
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Synergistic Antifungal Activity of Terbinafine in Combination with Light-Activated Gelatin–Silver Nanoparticles Against <i>Candida albicans</i> Strains by Atif Ullah, Fawad Ali, Farman Ullah, Sajid Khan Sadozai, Saeed Ahmed Khan, Sajid Hussain, Abdulwahed Fahad Alrefaei, Sajid Ali

“…This research investigates the possibility of integrating silver nanoparticles (AgNPs) with Terbinafine to improve antifungal effectiveness. Terbinafine, while potent, faces challenges with specific fungal strains, highlighting the need for strategies to enhance its treatment efficacy. …”
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Super High Contrast USPIO-Enhanced Cerebrovascular Angiography Using Ultrashort Time-to-Echo MRI by Liam Timms, Tianyi Zhou, Ju Qiao, Codi Gharagouzloo, Vishala Mishra, Rita Maria Lahoud, John W. Chen, Mukesh Harisinghani, Srinivas Sridhar

“…Ferumoxytol (Ferahame, AMAG Pharmaceuticals, Waltham, MA) is increasingly used off-label as an MR contrast agent due to its relaxivity and safety profiles. However, its potent T2∗ relaxivity limits achievable T1-weighted positive contrast and leads to artifacts in standard MRI protocols. …”
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Faktor – Faktor yang Berhubungan dengan Kejadian Dismenore Primer pada Remaja Putri di SMAIT Raflesia Depok Tahun 2024 by Syafila, Iin Fatmawati Imrar, Sintha Fransiske Simanungkalit

“…Metode: Penelitian ini dilaksanakan di SMAIT Raflesia Depok bulan Februari 2024 dengan pendekatan kuantitatif menggunakan desain studi cross-sectional atau potong silang. Sampel penelitian mencakup 103 siswi kelas X dan XI berusia 14 hingga 17 tahun yang diambil berdasarkan metode stratified random sampling. …”
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Assessing the efficacy of iso-mukaadial acetate and betulinic acid against selected Plasmodium falciparum glycolytic pathway proteins: in silico and in vitro studies by Lindiwe Khumbuzile Zuma, Ofentse Jacob Pooe, Nonduduzo Hlengiwe Mabaso, John Alake, Vincent A. Obakachi, Sinethemba Yakobi, Nothando Gasa, Rajshekhar Karpoormath, Mthokozisi Simelane

“…Parasite inhibition studies confirmed potent antimalarial activity against the P. falciparum NF54 strains, with BA and IMA showing IC50 values of 1.27 µg/ml and 1.03 µg/ml against the asexual stage of P. falciparum, respectively. …”
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A Cost-Effective and Robust Cell-Based Bioassay Method for Evaluating the Bioactivity of Trastuzumab-like Antibodies by Pooja Bharali, Subhash Chand, Harish Chander

“…The biological activity of different trastuzumab biosimilars was found to be comparable to the WHO primary reference standard of trastuzumab in terms of its relative potency using the IOP assay and binding assay by flow cytometry. …”
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Response surface methodology and repeated-batch fermentation strategies for enhancing lipid production from marine oleaginous Candida parapsilosis Y19 using orange peel waste by AbdAllah M. Matouk, Gadallah M. Abu-Elreesh, Mohamed Ali Abdel-Rahman, Said E. Desouky, Amr H. Hashem

“…Results revealed that, twenty marine oleaginous yeasts were isolated, and the most potent lipid producer isolate was Candida parapsilosis Y19 according to qualitative screening test using Nile-red dye. …”
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Synthesis of chitosan/PVA/copper oxide nanocomposite using Anacardium occidentale extract and evaluating its antioxidant, antibacterial, anti-inflammatory and cytotoxic activities by Manickam Rajkumar, S. I. Davis Presley, Prabha Govindaraj, Dharmalingam Kirubakaran, Farha Farahim, Talat Ali, Mohd Shkir, Sellapillai Latha

“…The CS/PVA/CuONCs exhibited excellent anti-inflammatory potency against COX-1 (67.10 ± 0.58%) and COX-2 (76.39 ± 0.65%). …”
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Nucleotide receptor P2X7/STAT6 pathway regulates macrophage M2 polarization and its application in CAR-T immunotherapy by Qin Si, Lu Yang, Jie Liu, Hui Liu, Ruifang Bu, Na Cui

“…This investigation scrutinizes whether silencing of P2X7 receptor within macrophages could lead to augmented anti-tumor potency of CAR-T. Method: Human peripheral blood mononuclear cells were artificially differentiated into macrophages or M2 macrophage in vitro. …”
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