Antioxidant and Antibacterial Activities Evaluation, Phytochemical Characterisation of Rhizome from Angiopteris helferiana and Barks from Saurauia fasciculata in Nepal by Ram Kishor Yadav, Akriti Dhakal, Kalpana Timilsina, Priyanka Shrestha, Sandesh Poudel, Sindhu KC, Prabhat Kumar Jha, Rekha Bhandari, Khem Raj Joshi

“…The extract of A. helferiana and S. fasciculata exhibited potent antioxidant activity by scavenging 2,2-diphenyl-1-picrylhydrazyl radicals with an IC50 of 25.9 µg/ml and 31.07 µg/ml, respectively. …”
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Molecular Modeling Studies of Substituted 2,4,5-Trisubstituted Triazolinones Aryl and Nonaryl Derivatives as Angiotensin II AT1 Receptor Antagonists by Mukesh C. Sharma, D. V. Kohli, Smita Sharma

“…The information rendered by 3D-QSAR models may lead to a better understanding of structural requirements of triazolinone aryl and nonaryl derivatives and also aid in designing novel potent antihypertensive molecules.…”
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Effect of propofol and ciprofol in patients undergoing bronchoscopy: protocol for a double-blind, randomised controlled trial by Fang Chen, Cheng Li, Dongliang Li, Jinxuan Tang, Jiayu Huang

“…Ciprofol (HSK3486) is a propofol analogue with good clinical safety, high potency and some advantages over propofol, including lower injection pain and haemodynamic depression in patients undergoing gastroscopy and colonoscopy. …”
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A gram-positive enhancer matrix particles vaccine displaying swine influenza virus hemagglutinin protects mice against lethal H1N1 viral challenge by Yufei Zhang, Yufei Zhang, Yufei Zhang, Pei Zhang, Pei Zhang, Pei Zhang, Xiaoyue Du, Xiaoyue Du, Xiaoyue Du, Xiaona Shi, Xiaona Shi, Xiaona Shi, Jinling Wang, Jinling Wang, Jinling Wang, Shuying Liu, Shuying Liu, Shuying Liu

“…Therefore, there is an urgent need to develop a potent vaccine against EA H1N1.MethodsIn this study, we report the effective intramuscular (i.m.) and/or intranasal (i.n.) vaccination of mice with a subunit influenza vaccine utilizing safe adjuvant gram-positive enhancer matrix (GEM) particles derived from the food-grade bacterium Lactococcus lactis. …”
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4-Aminoquinoline as a privileged scaffold for the design of leishmanicidal agents: structure–property relationships and key biological targets by Angel H. Romero, Francisco Delgado

“…With that information, we seek to give useful guidelines for interested researchers to face the drug discovery and development process for selective and potent leishmanicidal agents based on 4-aminoquinolines.…”
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Targeting Siglec-E facilitates tumor vaccine-induced antitumor immunity in renal carcinoma by Yuchen Zhang, Junnian Zheng, Li Sun, Guangya Zhao, Yingxiang Shao, Bowen Lu, Jiage Ding, Yanyan Zheng, Renjin Chen, Dafei Chai, Jiawei Wang, Zichun Zhang, Xiaohui Xie

“…Importantly, the deletion of CD8+ T cells in vivo abolished the antitumor effect of the Ad-Siglec-E/CAIX vaccine, highlighting the essential role of functional CD8+ T cell responses. The potent therapeutic efficacy of the Ad-Siglec-E/CAIX vaccine was also observed in lung metastasis and orthotopic tumor models through tumor-specific CD8+ T cell immune responses.Conclusions Our results indicate that targeting Siglec-E enhances the therapeutic efficacy of Ad-CAIX against renal carcinoma, providing a promising therapeutic option for solid tumors.…”
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Investigation of the Proliferation, Apoptosis/Necrosis, and Cell Cycle Phases in Several Human Multiple Myeloma Cell Lines. Comparison of Viscum album QuFrF Extract with Vincristin... by Eva Kovacs

“…Interleukin-6 (IL-6) is a potent growth factor for the proliferation of these cells. …”
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Design and assessment of lipase-CuO nanoparticle conjugates for enhanced antimicrobial efficacy against clinical pathogens by Eman M. Handak, Dina H. Amin, Mai M. Elhateir

“…The results demonstrated a significant increase in antimicrobial potency compared to both CuO nanoparticles and lipase alone particularly against E. coli strain NRC B-3703 with remarkable increase of 373.6% and 75% followed by S. aureus with increase of 50 and 42.8%compared to that of individual CuO nanoparticles and lipase enzyme, respectively. …”
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Ascorbic Acid Reduces the Blood Boss After Total Knee Arthroplasty: Insights From a Randomized Controlled Trial by Pooya Hosseini-Monfared, MD, Alireza Mirahmadi, MD, Mohammad Mehdi Sarzaeem, MD, Soheil Pourshahryari, MD, Parisa Aminnia, MD, Mohammad Poursalehian, MD, Seyed Morteza Kazemi, MD

“…Background: Blood loss is among the main complications of total knee arthroplasty (TKA) and oxidative stress, and hemolysis caused by reactive oxygen species are one of the causes of hemoglobin (Hb) drop. Ascorbic acid is a potent antioxidant that can protect against reactive oxygen species. …”
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Effects of linsitinib on M22 and IGF:1-treated 3D spheroids of human orbital fibroblasts by Fumihito Hikage, Megumi Suzuki, Tatsuya Sato, Araya Umetsu, Toshifumi Ogawa, Nami Nishikiori, Masato Furuhashi, Hiroshi Ohguro, Megumi Watanabe

“…Administration of IGF1 and M22 induced increases of cellular metabolic functions with the effect on HOFs being much more potent than the effect on GHOFs, suggesting that IGF1R and TSHR of GHOFs may already be stimulated. …”
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Plant Growth Promoting Rhizobacteria (PGPR): Reports on Their Colonization, Beneficial Activities, and Use as Bioinoculant by Dew Biswas, Amit Kumar Chakraborty, Vikas Srivastava, Arunava Mandal

“…In this review, we have discussed about the colonization and potency of PGPR strains and how their well-planned application in agriculture could evidently reinforce the global economy. …”
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Tratamiento farmacológico de la obesidad. Situación actual y nuevos tratamientos by Julio Sagredo Pérez, Gonzalo Allo Miguel

“…. • Liraglutide and semaglutide, both based on incretins and capable of improving obesity, diabetes and other obesity-related conditions. The high potency and safety of these drugs has revolutionized the pharmacological treatment of obesity.New molecules will soon be marketed that will expand the treatment possibilities, which will also be reviewed in this article.…”
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Preclinical optimization of a GPC2-targeting CAR T-cell therapy for neuroblastoma by Nan Li, Haiying Qin, Rosa Nguyen, Mitchell Ho, Ming Sun, Eytan Ruppin, Michael C Kelly, Yingying Cao, Reona Okada, Jeyshka M Reyes-González, Hannah G Stack, Charlie Seibert, Carol J Thiele

“…Finally, we also showed that the CT3.28H.BBζ CAR we developed was more potent than a recently clinically tested GD2-targeted CAR to control NB growth in vivo.Conclusion Given the robust preclinical activity of CT3.28H.BBζ, these results form a promising basis for further clinical testing in children with NB.…”
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Effectiveness and Safety of Hair Growth Formulation Containing L.f (Teak) Leaf Extract: A Randomized, Double-Blind, Placebo-Controlled Study on Males with Androgenic Alopecia by Nutchaninad Tanuphol B.ATM, Neti Waranuch PhD, Vanuchawan Wisuitiprot PhD, Wudtichai Wisuitiprot PhD, Kamonlak Insumrong PhD, Prapapan Temkitthawon PhD, Nungruthai Suphrom PhD, Katechan Jampachaisri PhD, Corine Girard PhD, Kornkanok Ingkaninan PhD

“…Teak ( Tectona grandis L.f) leaf extract exhibited a potent S5AR inhibitory activity. To prove the effectiveness and safety of teak leaf extract as a hair growth promotor, a double-blind, randomized placebo-controlled trial was conducted. …”
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Antibacterial, Antifungal, and Antidiabetic Effects of Leaf Extracts from Persea americana Mill. (Lauraceae) by Mercy Makopa, Benjamin Mangiza, Benjamin Banda, Winnie Mozirandi, Molly Mombeshora, Stanley Mukanganyama

“…The acetone extract was the most potent extract against S. epidermidis with a minimum inhibitory concentration (MIC) of 50 μg/mL. …”
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Gambaran Infeksi Nontuberculous Mycobacteria (NTM) pada Penderita Suspek TB Paru Menggunakan Multiplex PCR (MPCR)-Universal Lateral Flow Assay (ULFA) Kit by Putri Wulan Akbar, Agustin Iskandar, Tri Wahju Astuti, Kristin Indriana

“…Metode: Penelitian ini merupakan studi deskriptif dengan pendekatan potong lintang yang dilaksanakan sejak April sampai Juli 2019. …”
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Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities by Ammara Riaz, Azhar Rasul, Ghulam Hussain, Muhammad Kashif Zahoor, Farhat Jabeen, Zinayyera Subhani, Tahira Younis, Muhammad Ali, Iqra Sarfraz, Zeliha Selamoglu

“…It is contemplated that astragalin could be subjected to structural optimization to ameliorate its chemical accessibility, to optimize its absorption profiles, and to synthesize its more effective analogues which will ultimately lead towards potent drug candidates.…”
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Antimicrobial effect of silver diamine fluoride (SDF) in arresting dentine caries of permanent teeth: A Systematic review [version 1; peer review: 2 approved] by Mamata Hebbal, Albandri Mohammed Alowid, Praveen Jodalli, Shahad Saad Alkait, Ghadeer Ghalab Almutairi, Fatimah Salim Almufarji

“…Background Silver diamine fluoride (SDF) is recognized for its potent antibacterial properties and is commonly used in dentistry to treat carious lesions. …”
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Exploring the anti-inflammatory effects of phytochemicals in attenuating interstitial cystitis-a literature review by Irfan Anjum, Ayesha Nasir, Faiza Naseer, Faiza Naseer, Ahsan Ibrahim, Bisma Rehman, Fawad Bashir, Qura Tul Ain

“…Phytochemicals derived from many medicinal plants have shown potent outcomes in protection against various pathological conditions including interstitial cystitis. …”
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Cinnamic acid conjugated with triazole acetamides as anti-Alzheimer and anti-melanogenesis candidates: an in vitro and in silico study by Amir Shervin Shokouhi Asl, Mohammad Hosein Sayahi, Mohammad Hashem Hashempur, Cambyz Irajie, Amir Hossein Alaeddini, Seyedeh Niloufar Ghafouri, Milad Noori, Navid Dastyafteh, Javad Mottaghipisheh, Mehdi Asadi, Bagher Larijani, Mohammad Mahdavi, Aida Iraji

“…Derivative 3-(3-methoxy-4-((1-(2-oxo-2-(p-tolylamino)ethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)acrylic acid (10d), bearing a 4-CH3 group, was identified as the most potent AChE inhibitor. In terms of tyrosinase inhibition, 3-(3-methoxy-4-((1-(2-((2-methyl-4-nitrophenyl)amino)-2-oxoethyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)acrylic acid (compound 10n), demonstrated 44.87% inhibition at a concentration of 40 µM. …”
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