Oxypeucedanin hydrate alleviates rheumatoid arthritis by inhibiting the TLR4-MD2/NF-κB/MAPK signaling axis by Liu Mengdan, Huo Xueyan, Li Congcong, Hu Yunjie, Lei Haoran, Wang Dong, Zhu Lin, Gu Yucheng, Guo Dale, Huang Lijun, Deng Yun

“…Oxypeucedanin hydrate (OXH) is a natural coumarin known for its potent anti-inflammatory properties. …”
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Effect of Locally Delivered Melatonin as an Adjunct to Nonsurgical Therapy on GCF Antioxidant Capacity and MMP-9 in Stage II Periodontitis Patients: A Randomized Controlled Clinica... by Enji Ahmed, Olfat G. Shaker, Nermin Yussif, Dalia M. Ghalwash

“…The adjunctive use of topical melatonin gel with nonsurgical periodontal therapy has potent anti-inflammatory and antioxidant activity in the treatment of grade II periodontitis patients.…”
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Formulation development and evaluation, in silico PBPK modeling and in vivo pharmacodynamic studies of clozapine matrix type transdermal patches by Abdul Qadir, Syed Umer Jan, Muhammad Harris Shoaib, Muhammad Sikandar, Rabia Ismail Yousuf, Fatima Ramzan Ali, Fahad Siddiqui, Abdul Jabbar Magsi, Ghulam Mustafa, Muhammad Talha Saleem, Shafi Mohammad, Mohammad Younis, Muhammad Arsalan

“…Abstract Clozapine is a potent serotonin receptor antagonist and commonly used for the treatment of Schizophrenia. …”
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Evaluation of energy generation potential from municipal solid waste in the North-West province, South Africa by Mapereka Francis Chagunda , Ruhiiga Tabukeli Musigi , Palamuleni Lobina Gertrude *

“…As such, strategies which include waste- to-energy (WtE) generation to recover the potent energy from municipal waste could be a better option. …”
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¿Es posible medir el capital de movilidad para evaluar sus diferenciaciones sociodemográfica e intraurbana? El caso de los habitantes del Área Metropolitana de Santiago de Chile by Daniel Delaunay, Jean-Marc Fournier, Yasna Contreras

“…La ventaja heurística reside en la posibilidad de comparar la movilidad poten- cial y la movilidad efectiva. En este trabajo se pretende dar una realidad estadística a la noción de “capital de movilidad” con base en una encuesta cuantitativa que se llevó a cabo en Santiago de Chile en el año 2009. …”
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Microevolutionary differentiation of cereal tetraploid species by formation of recombinant genomes by N. I. Dubovets, Ye. A. Sycheva

“…Experimen tal data suggest that newly developed tetraploid forms interbreed easily forming a single hybrid zone, where permanent redistribution of genetic material of differential genomes and further range expansion of genotypic variability available to selection take place during alternation of generations whereby such a zone becomes a poten tial centre of speciation. Subsequent adaptive radiation of hybrid material in an ecologically separated environment occurs by selection of forms with different variants of the recombinant genome in various ecological niches.…”
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Testing the Multi-Theory Model for initiation and sustenance of smoking cessation at Kathmandu Metropolitan City, Nepal: A cross-sectional study by Sumitra SHARMA, Umesh R. ARYAL, Manoj SHARMA

“…Conclusion: MTM has the usefulness to assess both the initiation and sustenance behavior of SC. Poten- tial solutions using MTM constructs should be developed in future interventions to change behavior of SC.…”
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CONSUMO RESIDENCIAL DE ELECTRICIDAD Y EFICIENCIA ENERGÉTICA. Un enfoque de regresión cuantílica by Pedro Hancevic, Fernando Navajas

“…Esto se estudia aplican - do el método de regresión cuantílica a lo largo de todo el espectro de la distribución de consumo, lo que permite examinar las características mejor asociadas con niveles altos de consumo (condicionales a un modelo bien especificado) en donde poten - cialmente se encuentran hogares con niveles elevados de ineficiencia energética. …”
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‘Alexa, play metal’: exploring music selection and personal information management via voice assistants by Jochen Steffens, Jesse David Dinneen, Sascha Donner, Tom Potthoff

“…Voice interfaces to such services are becoming increasingly com-mon, for example through voice assistants on mobile and smart devices, and have the poten-tial to further change personal music management by introducing new beneficial features and new challenges. …”
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A soy glycinin derived octapeptide protects against MCD diet induced non-alcoholic fatty liver disease in mice by Peng Ma, Rongrong Huang, Yu Ou

“…Our data suggest that SGP8 may act as a novel and potent therapeutic agent against NAFLD.…”
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Deterrent Effects of Clary Sage Oil and Two Major Constituents against <em>Drosophila suzukii</em> (Diptera: Drosophilidae) by Yu Wang, Fengyi Wen, Xiangyi Zhou, Guoxing Chen, Chunxia Tian, Jiali Qian, Huiming Wu, Mengli Chen

“…Essential oils, considered potential alternatives to pesticidal strategies, exhibit potent toxic and sublethal behavioral effects against numerous pests, including <i>D. suzukii</i>. …”
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Plasma biomarkers for predicting heart failure in patients with acute myocardial infarction by Guihong Rong, Xiao Wang, Xinling Qin, Yanxia Wang, Meilian Quan, Chunfeng Xi

“…Therefore, the present study aimed to identify potent biomarkers for prognosticating the development of HF subsequent to AMI, and to devise early interception and therapeutic strategies. …”
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Hexagonal zinc oxide nanoparticles: a novel approach to combat multidrug-resistant Enterococcus faecalis biofilms in feline urinary tract infections by Alaa H. Sewid, Alaa H. Sewid, Mohamed Sharaf, Mohamed Sharaf, Azza S. El-Demerdash, Sherif M. Ragab, Fatimah O. Al-Otibi, Mohamed Taha Yassin, Chen-Guang Liu

“…Characterization studies revealed the successful encapsulation of streptomycin and MOLe within the ZnONPs.In vitro assays demonstrated that Str/MOLe@ZnONPs exhibited potent antibacterial and antibiofilm activities against the tested E. faecalis strains, significantly reducing bacterial growth and biofilm formation.DiscussionThe emergence of multidrug-resistant E. faecalis strains necessitates the development of novel therapeutic strategies. …”
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In situ template synthesized silver nanoparticulate banana fibre materials with antimicrobial and antibiotic release properties: Efficacy evaluation in ex vivo wound infection mode... by Pompi Das, Debajit Mahanta, Sharmila Giogi, Tarh Kaha, Ngurang Nisha, Sanjeeb Kalita

“…The biocomposites exhibited potent antibacterial activity against Escherichia coli, Staphylococcus aureus, and methicillin-resistant Staphylococcus aureus (MRSA), with inhibition zones ranging from 18.5 ± 1.2 mm to 22.3 ± 1.1 mm. …”
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Faith, Understanding, Proof by A. E. Razumov

“…One can also call the judgment of faith in a sufficiently finite number of expert checks to finally confirm the law relating to an infinite (in potency) number of cases. As a result of the movement on the topic, the author comes to the thought of immersing himself in the inner world of the individual. …”
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Evaluation of amoebicidal potential of Paneth cell cryptdin-2 against Entamoeba histolytica. by Simran Preet, Sanjay Bharati, Geeta Shukla, Ashwani Koul, Praveen Rishi

“…<h4>Methods/principal findings</h4>In the present study, cryptdin-2 exhibited potent in-vitro amoebicidal activity against E. histolytica in a concentration dependent manner at a minimum amoebicidal concentration (MAC) of 4 mg/L. …”
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Identification of signaling networks associated with lactate modulation of macrophages and dendritic cells by Rapeepat Sangsuwan, Bhasirie Thuamsang, Noah Pacifici, Phum Tachachartvanich, Devan Murphy, Abhineet Ram, John Albeck, Jamal S. Lewis

“…Although cancer immunotherapy breakthroughs have demonstrated improved potency for cancer treatment, only a fraction of patients effectively respond to these treatments. …”
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Design and performance analysis of portable solar powered cooler for vaccine storage by Vicent Marwa, Thomas Kivevele, Baraka Kichonge, Juma Selemani

“…These materials can undergo uneven melting and phase separation, leading to temperature instability and vaccine potency loss. In response to this challenge, the present study introduces a novel design of a portable, locally‐made solar‐powered cooler optimized for longer storage periods. …”
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Mesenchymal Stem Cell–Sourced Exosomes as Potentially Novel Remedies for Severe Dry Eye Disease by Carl Randall Harrell, Valentin Djonov, Ana Volarevic, Aleksandar Arsenijevic, Vladislav Volarevic

“…Since detrimental immune response is crucially responsible for the development and aggravation of DED, therapeutic agents which modulate phenotype and function of eye-infiltrated inflammatory immune cells could be used for the treatment of severe DED. Due to their potent immunomodulatory properties, mesenchymal stem cells (MSCs) represent potentially new remedies for the treatment of inflammatory eye diseases. …”
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Chemokine Profiles Are Affected in Serum of Patients with Acute Rejection of Kidney Allograft by Lenka Krupickova, Martina Fialova, Marek Novotny, Veronika Svachova, Kristyna Mezerova, Eva Cecrdlova, Ondrej Viklicky, Ilja Striz

“…In our in vitro model with TNF alpha induction, renal proximal epithelial cells seemed to be a more potent source of chemokines attracting neutrophils as compared to monocyte/macrophage cell line but the coculture of these cells potentiated release of neutrophilic chemokines CXCL5 and CXCL6. …”
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