Effect of afzelin on inflammation and lipogenesis in particulate matter-stimulated C. acnes-treated SZ95 sebocytes by Ji Yeon Hong, Yong Hee Choi, Yoon Jin Roh, Mi-Kyung Lee, Christos C. Zouboulis, Kui Young Park

“…BackgroundAfzelin, a flavonoid (kaempferol 3-O-α-L-rhamnopyranoside) isolated from Thesium chinense, is known for its potent anti-inflammatory properties. However, its effects on the molecular aspects of inflammation and lipogenesis in SZ95 sebocytes has not been investigated.ObjectiveThis study aimed to (i) investigate inflammatory and sebum secretion changes when a Cutibacterium acnes-treated immortalized human sebocyte cell line (SZ95) is exposed to particulate matter (PM) and (ii) examine the effects of afzelin on these.MethodsTo investigate the effect of afzelin on PM- and C. acnes-treated SZ95 sebocytes, we injected heat-killed C. acnes into SZ95 cells to induce acne-like status. …”
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Mechanistic insights into Rho/MRTF inhibition-induced apoptotic events and prevention of drug resistance in melanoma: implications for the involvement of pirin by Bardees M. Foda, Bardees M. Foda, Annika E. Baker, Annika E. Baker, Annika E. Baker, Łukasz Joachimiak, Marzena Mazur, Richard R. Neubig, Richard R. Neubig, Richard R. Neubig

“…Both CCG-257081 enantiomers robustly suppressed development of Vem-resistant colonies with the S isomer being more potent (1 μM IC50).ConclusionCCG-257081 appears to target pre-resistant cells and Vem-induced resistant cells through enhanced apoptosis. …”
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Bacteria-Inspired Synthesis of Silver-Doped Zinc Oxide Nanocomposites: A Novel Synergistic Approach in Controlling Biofilm and Quorum-Sensing-Regulated Virulence Factors in <i>Pseu... by Abirami Karthikeyan, Manoj Kumar Thirugnanasambantham, Fazlurrahman Khan, Arun Kumar Mani

“…Rapid color changes in the reaction solution evidenced the biotransformation process. The potent isolated <i>Bacillus cereus</i> SASAK, identified via 16S rRNA sequencing and deposited in GenBank under accession number MH885570, facilitated the microbial-mediated synthesis of ZnO nanoparticles and silver-doped ZnO NCs. …”
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Viral infection induces expression of novel phased microRNAs from conserved cellular microRNA precursors. by Peng Du, Jianguo Wu, Jiayao Zhang, Shuqi Zhao, Hong Zheng, Ge Gao, Liping Wei, Yi Li

“…RNA silencing, mediated by small RNAs including microRNAs (miRNAs) and small interfering RNAs (siRNAs), is a potent antiviral or antibacterial mechanism, besides regulating normal cellular gene expression critical for development and physiology. …”
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A Retrospective Database Cohort Study Evaluating the Association Between Immune Suppressive Therapy and the Development of Cancer in Patients with Atopic Dermatitis Within UK Prima... by Simon Wan Yau Ming, Yi Zhou, Mike Smith, Jay Were

“…The index date was the date of first IST prescription within primary care for the IST cohort, and the date of first potent topical steroid prescription from January 2001 to May 2021. …”
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Formulation and development of Serratiopeptidase enteric coated tablets and analytical method validation by UV Spectroscopy by Vijay Kumar Panthi, Saurav Kumar Jha, Raghvendra Chaubey, Rudra Pangeni

“…Serratiopeptidase (SRP) is a proteolytic enzyme that emerged as one of the most potent anti-inflammatory and analgesic drugs. The purpose of the present study was to formulate and evaluate enteric-coated tablets for SRP and investigate their stability using a simple and validated analytical method by ultraviolet (UV) spectroscopy. …”
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Chemical Characterization and Differential Lipid-Modulating Effects of Selected Plant Extracts from Côa Valley (Portugal) in a Cell Model for Liver Steatosis by Ricardo Amorim, Mário Pedro Marques, Catarina Melim, Carla Varela, Vilma A. Sardão, José Teixeira, Maria Inês Dias, Lillian Barros, Paulo J. Oliveira, Célia Cabral

“…In the lipotoxicity model, <i>E. ramosissimum</i> decoction demonstrated the most potent effect, significantly reducing PA-induced neutral lipid accumulation in a dose-dependent manner, while other extracts showed varying degrees of activity. …”
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Advancement of Pt and Pd-based catalysis for green, sustainable energy and bio-medical applications by Nithyadharseni Palaniyandy, Sekhosana Kutloano, Lakshmi Devaraj, Xolile Fuku, Sathish Sundar Dhilip Kumar

“…Further, the antimicrobial properties of Pt and Pd nanoparticles are explored, showcasing their potent inhibition of bacterial growth, disruption of biofilm formation, and effectiveness against multidrug-resistant bacteria. …”
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Trying to Kill a Killer; Impressive Killing of Patient Derived Glioblastoma Cultures Using NK-92 Natural Killer Cells Reveals Both Sensitive and Highly Resistant Glioblastoma Cells by Jane Yu, Hyeon Joo Kim, Jordyn Reinecke, James Hucklesby, Tennille Read, Akshata Anchan, Catherine E. Angel, Euan Scott Graham

“…In addition, our imaging provides evidence that some NK-92 cells appear to be compromised early, which would be consistent with potent evasive mechanisms by the glioblastoma tumour cells. …”
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Synthesis and Pesticidal Activities of 5-(2-Cyclopropylaminopyrimidin-4-yl)-4-(thiophenyl)thiazole Derivatives by Won-Sik Choi, Seok-Woo Nam, Il-Doo Kim, Seung-Han Kim, Kun-Ho Park, In-Kyung Bae, Eun-Sil Park, Hwang-Ju Jeon, Sung-Eun Lee

“…Among the XIII-6~XV-7 chemicals, 5-(2-cyclopropylaminopyrimidin-4-yl)-4-(thiophen-2-yl)thiazol-2-amine (VIII-6) showed the most potent antifungal activity in vivo. While the EC50 value of the commercial fungicide dimethomorph was 4.26 μM, EC50 of VIII-6 was 0.94 μM. …”
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Novelty of Bioengineered Iron Nanoparticles in Nanocoated Surgical Cotton: A Green Chemistry by Bhavika Turakhia, Saujanya Chikkala, Sejal Shah

“…Out of 20 different chemicals, gingerol was found to be the most potent phytochemical with a retention time of 40.48 min. …”
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Enhanced detection of circulating tumor cells using a MUC1 promoter-driven recombinant adenovirus by Cheng Wang, Huihui Gu, Jia Cai, Chuandong Zhu, Qin Zheng, Hanfeng Xu, Lixue Wang, Yuan Wan

“…Moreover, rAdF35-MUC1 demonstrated reduced incidence of false positives in healthy PBMCs compared to rAdF35-hTERT.ConclusionIn brief, rAdF35-MUC1 emerges as a potent tool for the sensitive and specific identification of CTCs derived from breast cancer patients, holding clinical translation potential for advancing cancer (early) diagnosis, treatment monitoring, and prognosis.…”
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Evaluation of the C-reactive protein serum levels in periodontitis patients with or without atherosclerosis – A clinical study by Pooja Khatri, Kaustubh S Thakare, Minal Narendra Ganvir, Mitesh Khatri

“…One indicator of systemic inflammation caused by various triggers such as injuries, infections, and hypoxia is the highly potent C-reactive protein (CRP). Atherosclerosis is a progressive arterial disease that is characterized by the thickening of subintimal layers in muscular and elastic arteries of intermediate-to-large size due to the accumulation of athermanous plaque. …”
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An approach to predict and inhibit Amyloid Beta dimerization pattern in Alzheimer’s disease by Sreekanya Roy, Sima Biswas, Anirban Nandy, Dipanjan Guha, Rakhi Dasgupta, Angshuman Bagchi, Parames Chandra Sil

“…For that we used virtual screening and molecular docking simulations of the already existing anti-inflammatory drugs and studied their potency in resisting the formation of Aβ dimers. This is the first such report of drug repurposing for the treatment of AD, which might pave new pathways in therapy.…”
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A high-throughput platform for single-molecule tracking identifies drug interaction and cellular mechanisms by David Trombley McSwiggen, Helen Liu, Ruensern Tan, Sebastia Agramunt Puig, Lakshmi B Akella, Russell Berman, Mason Bretan, Hanzhe Chen, Xavier Darzacq, Kelsey Ford, Ruth Godbey, Eric Gonzalez, Adi Hanuka, Alec Heckert, Jaclyn J Ho, Stephanie L Johnson, Reed Kelso, Aaron Klammer, Ruchira Krishnamurthy, Jifu Li, Kevin Lin, Brian Margolin, Patrick McNamara, Laurence Meyer, Sarah E Pierce, Akshay Sule, Connor Stashko, Yangzhong Tang, Daniel J Anderson, Hilary P Beck

“…With this one experimental modality, we determined the potency, pathway selectivity, target engagement, and mechanism of action for identified hits. …”
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The Role of Invariant NKT in Autoimmune Liver Disease: Can Vitamin D Act as an Immunomodulator? by Daniel S. Smyk, Athanasios Mavropoulos, Giorgina Mieli-Vergani, Diego Vergani, Marco Lenzi, Dimitrios P. Bogdanos

“…Alpha-galactosylceramide (α-GalCer), a derivative of the marine sponge, is a potent stimulator of iNKT cells and has been proposed as a therapeutic iNKT cell activator. …”
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Gambaran Karakteristik Pengetahuan, Sikap dan Perilaku Risiko Covid-19 Dalam Kerangka Desa Adat di Desa Gulingan, Mengwi, Bali by Agus Indra Yudhistira Diva Putra, Made Sindy Astri Pratiwi, Made Violin Weda Yani, Gufran Rizaldy Danang Gunawan, Ghaniy Muhammad Ganesha, Agnes Maria Aprilia Evelyn Aminawati, I Putu Gede Dharma Wibhawa Aryana, I Gusti Agung Alit Suryawati

“…Metode: Ini adalah penelitian deskriptif dengan rancangan studi potong lintang dengan jumlah sampel yang memenuhi kriteria inklusi dan eksklusi sebanyak 144 sampel. …”
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Synthesis, Characterization and Antibacterial activity of Benzimidazole Derivatives and their Cu (ii),Ni (ii) and Co (ii) complexes by Haftom Welderufael, Dagne Addisu Kure, Endalkachew Asefa Moges, Lelisa File, Salah Hamza Sherif

“… Benzimidazole is one of the privileged nitrogen-containing heterocyclic compounds, which is found in many bioactive compounds, benzimidazole and its derivatives have evolved as an important heterocyclic system due to their potency in a wide range of biologically active compounds like anthelmintic, antibacterial, antifungals, anti-inflammatory, antiviral, and so on. …”
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Pesticidal Activity of Sundarban Mangrove Plant Extracts against Sitophilus Pests and Identification of Active Constituents Using LC-MS by Md. Abdur Rahman, Rinku Rani Paul, Chaina Biswas, Hakima Akter, Razina Rouf, Sushmita Nath, Jamil A. Shilpi, Lutfun Nahar, Stayajit D. Sarker, Shaikh Jamal Uddin

“…Three bark extracts from A. corniculatum, E. agallocha, and H. fomes showed potent and statistically significant insecticidal activity against both S. oryzae and S. zeamais pests (80–100% mortality). …”
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SMAC-armed oncolytic virotherapy enhances the anticancer activity of PD1 blockade by modulating PANoptosis by Fanghui Chen, Liwei Lang, Jianqiang Yang, Fan Yang, Sijia Tang, Zhenzhen Fu, Nabil F. Saba, Ming Luo, Yong Teng

“…Moreover, VSV-S reduces PDL1 levels in HNSCC cells and, in combination with PD1 blockade, produces a more potent antitumor effect than either therapy alone. …”
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