An Insight of Vitamin E as Neuroprotective Agents by Hui-Min Yap, Kwan-Liang Lye

“…TRF was reported to possess potent antioxidant, anti-inflammation, anticancer and cholesterol-lowering properties. …”
Get full text

The Potential of Swiftlet Bird's Nest Extract (Aerodramus fucipaghus) as an Antioxidant and Serum Formulation by Naniek Widyaningrum, Chintiana Nindya Putri, Thendi Abdul Arief, Nada Aini Sofa, Monica Virdaus

“…Notably, the swiftlet bird's nest serum at a 40% concentration exhibited potent antioxidant activity, manifesting an IC50 value of 90.137 µg/mL…”
Get full text

Pegylated NIR Fluorophore-Conjugated OBHSA Prodrug for ERα-Targeted Theranostics with Enhanced Imaging and Long-Term Retention by Xiaohua Wang, Xiaofei Deng, Lilan Xin, Chune Dong, Guoyuan Hu, Hai-Bing Zhou

“…Experimental results show that, benefiting from overexpressed esterase in cancer cells, OBHSA-PEG-DCM can be efficiently hydrolyzed, releasing OBHSA and pegylated DCM. OBHSA demonstrated potent inhibition against MCF-7 cells (IC₅₀ = 1.09 μM). …”
Get full text

Lack of Clinically Meaningful Effect of Cariprazine on the Pharmacokinetics of a Combined Oral Contraceptive by Márta Erzsébet Rosa, Zoltán Juhász, Gabriella Pásztor Mészáros, Gabriella Magyar, Judit Harsányi, Balázs Szatmári, Zoltán Hujber, Máté Szabó, Margit Kapás

“…Abstract Introduction Cariprazine (CAR) is a potent dopamine receptor partial agonist antipsychotic approved by the EMA and the FDA. …”
Get full text

Anti-colorectal cancer effect of total minor ginsenosides produced by lactobacilli transformation of major ginsenosides by inducing apoptosis and regulating gut microbiota by Yunjiao Shen, Yunjiao Shen, Yansong Gao, Ge Yang, Zijian Zhao, Yujuan Zhao, Lei Gao, Shengyu Li

“…Fecal analysis revealed that TMG reconstructed the gut microbiota in colorectal cancer-affected mice by augmenting the abundance of the advantageous bacterium Lactobacillus and decreasing the abundance of the harmful bacterium Proteus.ConclusionTMG can exhibit potent anti-colorectal cancer effects through diverse apoptotic mechanisms, with their mode of action closely related to the regulation of gut microbiota.…”
Get full text

Perbedaan Kadar Natrium pada Packed Red Cell Berdasarkan Lama Penyimpanan di Bank Darah RSUP Dr. M. Djamil Padang by Hesty Rhauda Ashan

“…Metode: Penelitian ini adalah suatu penelitian analitik dengan rancangan potong lintang, dimulai dari bulan September 2016 sampai Oktober 2018. …”
Get full text

Antimicrobial activity of Monascus purpureus-derived red pigments against Salmonella typhimurium, Escherichia coli, and Enterococcus faecalis by Islam I. Teiba, Islam Mamdouh, Mokhtar I. Yousef, Ahmed Hussein, Emad H. El-Bilawy

“…These findings suggest that the Monascus purpureus-derived red dye extract represents a promising natural alternative to conventional antibiotics, demonstrating potent antibacterial activity and potential as a novel therapeutic agent in combating antimicrobial resistance.…”
Get full text

PET Study of Sphingosine-1-Phosphate Receptor 1 Expression in Response to Vascular Inflammation in a Rat Model of Carotid Injury by Hui Liu PhD, MD, Hongjun Jin PhD, Xuyi Yue PhD, Junbin Han PhD, Pamela Baum SRS, Dana R. Abendschein PhD, Zhude Tu PhD

“…Here, we report in vivo validation of [ 11 C]TZ3321, a potent S1PR1 radioligand, for imaging vascular inflammation in a rat model of carotid injury. …”
Get full text

The role of hybrid models in financial decision-making: Forecasting stock prices with advanced algorithms by Xiaoyi Zhu

“…This model’s adaptability and reliability in diverse and volatile market conditions are emphasized by this robust framework, which renders it a potent financial forecasting tool.…”
Get full text

Razkrivanje nepravilnosti v Evropski uniji in Republiki Sloveniji by Mirko Pečarič

“…Vse večji vpliv izvršilne oblasti in njeno poseganje na široka področja družbenega življenja za seboj potegne tudi dogodke, ki so lahko na meji zakonitosti oziroma so nevarni za javno zdravje ali življenje ljudi. …”
Get full text

ACUTE TOXICITY, PHYTOCHEMICAL SCREENING, AND ANTIMICROBIAL INVESTIGATION OF AQUEOUS EXTRACT OF SODOM APPLE TREE (Calotropis procera Ait.F) LEAF OBTAINED WITHIN ANCHOR UNIVERSITY, L... by Olatunde A Oseni, Hilda A Emmanuel-Akerele, Wuraola A Adebayo

“…The plant of <em>Calotropis procera</em> therefore showed that the aqueous extract of the plant contained viable phytochemicals compounds, potent antimicrobial activity to some organisms while the studied concentrations for acute toxicity were observed to be safe.…”
Get full text

Clinically Relevant Drug Interactions with Monoamine Oxidase Inhibitors by Amber N. Edinoff, Connor R. Swinford, Amira S. Odisho, Caroline R. Burroughs, Cain W. Stark, Walid A. Raslan, Elyse M. Cornett, Adam M. Kaye, Alan D. Kaye

“…Ranging from irreversible to reversible and selective to non-selective, these drugs target the monoamine oxidase (MAO) enzyme and prevent the oxidative deamination of various monoamines and catecholamines such as serotonin and dopamine, respectively. Tyramine is a potent releaser of norepinephrine (NE) and is found in high concentrations in foods such as aged cheeses and meats. …”
Get full text

Development and experimental validation of a machine learning model for the prediction of new antimalarials by Mukul Kore, Dimple Acharya, Lakshya Sharma, Shruthi Sridhar Vembar, Sandeep Sundriyal

“…One of the hits (compound 1) was a potent inhibitor of β-hematin, suggesting the involvement of parasite hemozoin (Hz) synthesis in the parasiticidal effect. …”
Get full text

Antimycobacterial Activity, Synergism, and Mechanism of Action Evaluation of Novel Polycyclic Amines against Mycobacterium tuberculosis by Erika Kapp, Jacques Joubert, Samantha L. Sampson, Digby F. Warner, Ronnett Seldon, Audrey Jordaan, Margaretha de Vos, Rajan Sharma, Sarel F. Malan

“…Compound selection was based on the presence of moieties with possible antimycobacterial activity, the inclusion of bulky lipophilic carriers to promote intracellular accumulation, and previously demonstrated bioactivity that potentially support inhibition of efflux pump activity. The most potent antimycobacterial demonstrated a minimum inhibitory concentration (MIC99) of 9.6 μM against Mycobacterium tuberculosis H37Rv. …”
Get full text

Genetic analysis and heterosis breeding of seed yield and yieldattributing traits in Indian mustard (Brassica juncea (L.) Czern & Coss.) by Sanghamitra Rout, Suvendu Kumar Roy, Rupsanatan Mandal, Saurav Singla, Mehdi Rahimi, Bijaya Sur, Naderla Umamaheswar, Moumita Chakraborty, Lakshmi Hijam, Sahanob Nath, Manoj Kanti Debnath, Tulsi Saran Ghimiray

“…Parental genotypes NPJ-194, DRMR-15-16, Kranti and NPJ-194 were identified as consistent and potent general combiners, indicating their potential to pass on favorable alleles to their offspring. …”
Get full text

Enhanced penetration and biofilm eradication by sophorolipid micelles encapsulating Honokiol: a comprehensive solution for biofilm-associated lung infections by Shiyu Lin, Xiaojuan Li, Wei Zhang, Gang Shu, Tim Tolker-Nielsen, Haohuan Li, Funeng Xu, Juchun Lin, Guangneng Peng, Li Zhang, Hualin Fu

“…Results This study describes the development of multifunctional micelles, HK-SL Ms, utilizing sophorolipid (SL) to encapsulate Honokiol (HK). HK-SL Ms potently disrupted the EPS barrier, killed some internal colonizing bacteria, and inhibited further bacterial adhesion. …”
Get full text

Safety and efficacy of oral administrated cepharanthine in non-hospitalized, asymptomatic or mild COVID-19 patients: a Double-blind, randomized, placebo-controlled trial by Jianyi Wei, Shupeng Liu, Yuexiang Bian, Lei Li, Biyun Qian, Zixuan Shen, Yan Zhang, Adila Abuduaini, Fuchen Dong, Xin Zhang, Jinhui Li, Yongpei Yu, Weituo Zhang, Jun Wang, Wei Zhai, Qixiang Song, Yu Zheng, Weihua Pan, Lanlan Yu, Qimin Zhan, Ning Zhang, Junhua Zheng, Shuming Pan, Chen Yao, Hai Li

“…Abstract Cepharanthine (CEP) is a natural remedy that potently inhibits SARS-CoV-2 activity both in vitro and in vivo. …”
Get full text

Disfunción renal: fármacos, medios de contraste radiológicos y sistema renina angiotensina by José Antonio Chipi Cabrera, Julio Alexander Silveira Echavarría, Aliuska Naranjo Hernández, Darnelys Méndez Lemus, Giraldo Hurtado Báez

“…El continuo envejecimiento poblacional, unido al incremento de la prevalencia de enfermedades crónicas no trasmisibles, entre las que se destacan la diabetes mellitus y la hipertensión arterial, como principales causas de deterioro de la función renal en las personas, ha hecho que con el paso de los años se introduzcan nuevos fármacos, más potentes, para la prevención y tratamiento de dichas entidades, lo que obliga a estar al día en el conocimiento de las características farmacocinéticas de estos medicamentos para evitar posibles efectos tóxicos, esto implica hacer una valoración previa de la función renal antes de introducir cualquier sustancia que pudiera ser potencialmente nefrotóxica. …”
Get full text

Phytochemical investigation and evaluation of antioxidant and antidiabetic activities in aqueous extracts of Cedrus atlantica by Idrissi Amine Mounadi, Mahraz Mohamed Adil, Drioua Soufiane, Assouguem Amine, Ali Essam A., Ibrahim Mohamed A., Mehta Chandra Mohan, Lahlali Rachid, Tlemcani Sara, Moussaoui Fatima, En-nabety Ghizlan, Eloutassi Noureddine, Lahkimi Amal

“…The CA extract showed potent α-amylase inhibition (IC50 307 ± 0.02 μg/mL) and remarkable α-glucosidase inhibition (IC50 70 ± 0.04 μg/mL), outperforming the FA and EA extracts. …”
Get full text

Antimalarial Activity of Tinospora baenzigeri against Plasmodium berghei-Infected Mice by Sakaewan Ounjaijean, Manas Kotepui, Voravuth Somsak

“…In conclusion, the aqueous crude extract of T. baenzigeri stem has demonstrated potent antimalarial activity against P. berghei-infected mice with prolonged mean survival time and prevention of body weight loss and packed cell volume reduction.…”
Get full text