Improving dexamethasone drug loading and efficacy in treating rheumatoid arthritis via liposome: Focusing on inflammation and molecular mechanisms by Mohammad Yasin Zamanian, Hamidreza Zafari, Maria K. Osminina, Alla A. Skakodub, Raed Fanoukh Aboqader Al‐Aouadi, Maryam Golmohammadi, Nikta Nikbakht, Iman Fatemi

“…Dexamethasone (DEX) is a potent glucocorticoid used to treat RA due to its anti‐inflammatory and immunosuppressive properties. …”
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Sculpting multi-epitope vaccine against Monkeypox viral strains using immunoinformatics by Zaira Rehman, Ammad Fahim, Maryam Irtash

“…The study results may lead towards identification of clinically effective vaccines against MPXV with better safety and potency profile.…”
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Curcumin Protects Human Umbilical Vein Endothelial Cells against H2O2-Induced Cell Injury by Jipeng Ouyang, Rong Li, Haiqin Shi, Jianping Zhong

“…Curcumin, one of the major ingredients of turmeric, has potent antioxidative and anti-inflammatory properties, but whether it could be used as a potential treatment for migraine remains to be explored. …”
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Dijital Oyunlarda Toplumsal Hafıza İnşasının Göstergebilimsel Analizi by Asiye Ceren Başal Yıldız

“…Toplumsal hafıza, törenler, ritüeller, bayramlar aracılığıyla inşa edilmektedir. …”
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An UPLC-MS/MS Method for Determination of Osimertinib in Rat Plasma: Application to Investigating the Effect of Ginsenoside Rg3 on the Pharmacokinetics of Osimertinib by Zhenzhen Ying, Jingyao Wei, Ruijuan Liu, Fang Zhao, Yifang Yu, Xin Tian

“…Osimertinib is a novel oral, potent, and irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) for treatment of advanced T790M mutation-positive advanced non-small cell lung cancer, which is commonly combined with ginsenoside Rg3 in clinic to enhance the efficacy and minimize adverse reactions. …”
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Impact of long-term cyanotoxin exposure on cattle: Biochemical, histological, and oxidative stress assessment by Mounira Bensalem, Amina Amrani, Hadjer Zaidi, Fateh Sedrati, Omar Laouar, Zhi Wang, Hichem Nasri

“…This study investigates the long-term effects of microcystins (MCs), potent cyanotoxins, on cattle at Lake des Oiseaux, a Ramsar-listed wetland in Algeria. …”
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A proof-of-concept analysis of data from the first NHS clinic for young adults with comorbid cannabis use and psychotic disorders by Marta Di Forti, Benjamin W. Bond, Edoardo Spinazzola, Giulia Trotta, Jodie Lynn, Richard Malkin, Naba Kamran Siddiqui, Sultan Demir, Titilayomi Opadokun, Perry B.M. Leung, Zhikun Li, Andrea Quattrone, Gabriella Baxter, Elizabeth Appiah-Kusi, Tom P. Freeman, Hannah Walsh, Tommaso Squeri, Daria Semikina, Felicity Amberson-Jones, Isabelle Austin-Zimmerman, Tim Meynen, Diego Quattrone, Robin M. Murray

“…Results A reduction in the mean CUDIT-R score was observed between T0 (mean difference = 17.10, 95% CI = 15.54–18.67) and T1, with 73.91% of participants achieving abstinence and 26.09% reducing the frequency and potency of their use. Significant improvements in all clinical and functional outcomes were observed, with 90.70% being in work or education at T1 compared with 8.70% at T0. …”
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Short path molecular distillation of the essential oil from Pinus roxburghii oleoresin affords volatile fractions with powerful antioxidant and antimicrobial activities comparable... by Muhammad Adnan Ayub, Hawraz Ibrahim M. Amin, Rameen Waseem, Kamaran Younis M. Amin, Muhammad Asif Hanif, Amjad Hussain, Kovan Dilawar Issa, Jorge Ramírez, Chabaco Armijos, Muhammad Zubair, Giovanni Vidari

“…The antioxidant and antimicrobial activities varied between fractions and subfractions; however, their overall potency makes the P. roxburghii oleoresin a potential source of valuable natural antimicrobial products employable against various foodborne microbes and molds, as well as a source of preservative agents against food oxidation. …”
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Post-treatment of rat aflatoxicosis by camel milk and silymarin by Nahla H. Hassaneen, Shabaan A. Hemeda, Abeer F. El Nahas, Ghadeer M. Albadrani, Muath Q. Al-Ghadi, Zuhair M. Mohammedsaleh, Sabreen E. Fadl, Eman M. El-Diasty, Hader I. Sakr, Hader I. Sakr

“…BackgroundAflatoxins are highly potent mycotoxins that can seriously harm the health of humans and a variety of animal species. …”
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The molecular receptor NKBB enhances the persistence and anti-hepatocellular carcinoma activity of GPC3 CAR-T cells by Minghao Sui, Tiantian Liu, Xuanli Song, Ji Li, Han Ding, Yuqian Liu, Xinyu Wang, Huimin Liu, Yuchan Xue, Jianni Qi, Miao Zhang, Songbo Zhao, Qiang Zhu

“…Overall, the molecular receptor NKBB significantly increased the persistence of GPC3 CAR-T cells, and GC3328z-NKBB CAR-T cells possessed potent anti-HCC activity in mice, providing a new strategy for the potential improvement of adoptive T cell therapy in the treatment of HCC.…”
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Mammalian mitochondrial inorganic polyphosphate (polyP) and cell signaling: Crosstalk between polyP and the activity of AMPK by Renata T. Da Costa, Anna Nichenko, Matheus M. Perez, Malgorzata Tokarska-Schlattner, Sheida Kavehmoghaddam, Vedangi Hambardikar, Ernest R. Scoma, Erin L. Seifert, Uwe Schlattner, Joshua C. Drake, Maria E. Solesio

“…Conclusions: This manuscript sheds new light on the regulation of AMPK and positions polyP as a potent regulator of mammalian cell physiology beyond mere bioenergetics, paving the road for using its metabolism as an innovative pharmacological target in pathologies characterized by dysregulated bioenergetics.…”
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Encapsulation of bioactive compounds from Sargassum ilicifolium: Influence of wall material type and loading content on the physicochemical and structural properties of micropartic... by Seyed Saeed Sekhavatizadeh, Mohammad Ganje, Seyedeh Sedigheh Hashemi, Mohammad Reza Mozafarian

“…Finally, the improved stability and solubility characteristics of the SIE powder, which is based on WPI and maltodextin, indicate its potential for use as a potent functional food additive.…”
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Size effect-based improved antioxidant activity of selenium nanoparticles regulating Anti-PI3K-mTOR and Ras-MEK pathways for treating spinal cord injury to avoid hormone shock-indu... by Peixin Liu, Xiaodong Liu, Zihao Wu, Kui Shen, Zhaofeng Li, Xiaowei Li, Qifeng Wu, Leung Chan, Zhong Zhang, Yutong Wu, Liwen Liu, Tianfeng Chen, Yi Qin

“…Owing to their ultra-small size, LNT-UsSeNPs exhibited strong spinal barrier penetration and potent antioxidative and anti-inflammatory effects without compromising immune function. …”
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Pseudomonas evades immune recognition of flagellin in both mammals and plants. by Bart W Bardoel, Sjoerd van der Ent, Michiel J C Pel, Jan Tommassen, Corné M J Pieterse, Kok P M van Kessel, Jos A G van Strijp

“…The building blocks of bacterial flagella, flagellin monomers, are potent stimulators of host innate immune systems. …”
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Proapoptotic and Antiangiogenic Activities of Arctium Lappa L. on Breast Cancer Cell Lines by Mohamad Taleb Agha, Hussein M. Baharetha, Majed Ahmed Al-Mansoub, Yasser M. Tabana, Nur Hidayah Kaz Abdul Aziz, Mun Fei Yam, Amin Malik Shah Abdul Majid

“…The antiangiogenic activity of EHX fraction showed potent inhibition of rat aorta microvessels with IC50 value: 4.34 ± 1.64 μg/mL. …”
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Green Synthesis of Iron Oxide Nanoparticles and Their Antibacterial Efficacy against Carbapenem-resistant Klebsiella pneumoniae in Bloodstream Infections by Rahul Harikumar Lathakumari, Leela Kakithakara Vajravelu, Jayaprakash Thulukanam, Vishnupriya Panneerselvam, Poornima Baskar Vimala, Dakshina Manoj Nair, Sujith Sri Surya Ravi

“…The green-synthesized IONPs demonstrated potent antibacterial activity against CRKP, with a MIC of 0.15 mg/mL, effectively reducing genomic resistance in the tested isolates. …”
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Genetic Markers Can Predict Chondrogenic Differentiation Potential in Bone Marrow-Derived Mesenchymal Stromal Cells by Masami Kanawa, Akira Igarashi, Katsumi Fujimoto, Yukihito Higashi, Hidemi Kurihara, Masaru Sugiyama, Tania Saskianti, Yukio Kato, Takeshi Kawamoto

“…The expression levels of CDKN2D, CD74, and TGM2 were >10-fold higher in highly potent MSCs (ilium MSCs) than in MSCs with limited potential (jaw MSCs). …”
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The effects of secretome of umbilical cord mesenchymal stem cells on regeneration of sciatic nerve defects in Sprague dawley rats. by Aryadi Kurniawan, Ismail Hadisoebroto Dilogo, Jeanne Adiwinata Pawitan, Wahyu Widodo, Ihsan Oesman, Ade Martinus

“…This study aims to assess the secretome's potency in regenerating peripheral nerve defects.<h4>Animals and methods</h4>Twenty-eight spraque dawley (SD) rats were divided into four groups, with a 10mm segmental sciatic nerve defect created. …”
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Structural basis for the inhibition of coronaviral main proteases by PF-00835231 by Zhou Xuelan, Lu Xiaolu, Lin Cheng, Zou Xiaofang, Li Wenwen, Zeng Xiangyi, Wang Jie, Zeng Pei, Wang Weiwei, Zhang Jin, Jiang Haihai, Li Jian

“…Here, we report the inhibitory potency of PF-00835231 against SARS-CoV-2 M^pro and seven M^pro mutants (G15S, M49I, Y54C, K90R, P132H, S46F, and V186F) from SARS-CoV-2 variants. …”
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Assessment of Brush Biopsy Findings and Salivary LDH Levels in Oral Mucosal Lesions of Tobacco Users by Sam P. Davidson, Senthil Kumar, Elangovan Somasundaram, Suman Jaishankar

“…Conclusion: Brush biopsy showed good potential in detecting premalignant lesions and salivary LDH levels showed a marked increase which can be used as a diagnostic biomarker and serve as a potent diagnostic aid for early detection of malignancy.…”
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