Salidroside promotes pro-angiogenesis and repair of blood brain barrier via Notch/ITGB1 signal path in CSVD Model by Tu Zhilan, Zhang Zengyu, Jin Pengpeng, Yang Hualan, Li Chao, Xi Yan, Guo Zimin, Hou Shuangxing, Li Weiwei

“…Objectives: The present study aims to explore the effects of salidroside in angiogenesis as well as repair of blood brain barrier (BBB) and its possible mechanisms. …”
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Development and Validation of a Novel Classification System and Prognostic Model for Open Traumatic Brain Injury: A Multicenter Retrospective Study by Yuhui Chen, Li Chen, Liang Xian, Haibing Liu, Jiaxing Wang, Shaohuai Xia, Liangfeng Wei, Xuewei Xia, Shousen Wang

“…Abstract Introduction Open traumatic brain injury (OTBI) is associated with high mortality and morbidity; however, the classification of these injuries and the determination of patient prognosis remain uncertain, hindering the selection of optimal treatment strategies. …”
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Immune dysfunction revealed by digital spatial profiling of immuno-oncology markers in progressive stages of renal cell carcinoma and in brain metastases by Wei Wei, Michael Hurwitz, Sabina Signoretti, Lucia Jilaveanu, Toni K Choueiri, David L Rimm, Adebowale Adeniran, Sandra Martínez, Harriet M Kluger, David A Schoenfeld, Myrto Moutafi, Dijana Djureinovic, Ross D Merkin, David A Braun, Fabio Parisi

“…Prior profiling studies, including single-cell transcriptomics, often involve limited sample sizes and lack spatial orientation. The TME of RCC brain metastases, a major cause of morbidity, also remains largely uncharacterized.Methods We performed digital spatial profiling on the NanoString GeoMx platform using 52 validated immuno-oncology markers on RCC tissue microarrays representing progressive stages of RCC, including brain metastases. …”
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Mortality trends of traumatic brain injuries in the adult population of the United States: a CDC WONDER analysis from 1999 to 2020 by Muhammad Hamza Dawood, Yusra Fazli, Sejal Lund, Shurjeel Uddin Qazi, Rija Tahir, Areehah Zafar Masood, Aiman Azam Qureshi, Saleha Safdar, Heraa Zaheer, Muhammad TayyabMuzaffar Chaychi

“…Abstract Background Traumatic Brain Injury (TBI) is a critical public health issue in the United States, contributing significantly to morbidity, mortality, and healthcare costs. …”
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Effects of Traumatic Stress Induced in the Juvenile Period on the Expression of Gamma-Aminobutyric Acid Receptor Type A Subunits in Adult Rat Brain by Cui Yan Lu, De Xiang Liu, Hong Jiang, Fang Pan, Cyrus S. H. Ho, Roger C. M. Ho

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Polydatin ameliorates early brain injury after subarachnoid hemorrhage through up-regulating SIRT1 to suppress endoplasmic reticulum stress by Yuwei Han, Guangzhi Hao, Song Han, Tingzhun Zhu, Yushu Dong, Ligang Chen, Xinyu Yang, Xiaoming Li, Hai Jin, Guobiao Liang

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Phosphodiesterase 4 inhibition as a novel treatment for stroke by Jiahong Zhong, Xihui Yu, Zhuomiao Lin

“…It has the characteristics of high morbidity, high disability rate and high recurrence rate. …”
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Rapid response electroencephalography decreases time to seizure diagnosis in pediatric acute care patients by Nevedha Rajan, Toni Kavanagh, Maite LaVega‐Talbott, Sandeep Gangadharan

“…Abstract Objectives Pediatric status epilepticus (SE) carries a high risk of morbidity and mortality and can result in neurologic injury. …”
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Post-injury treatment with 7,8-dihydroxyflavone attenuates white matter pathology in aged mice following focal traumatic brain injury by Georgios Michalettos, Fredrik Clausen, Elham Rostami, Niklas Marklund

“…Traumatic brain injury (TBI) is a major cause of morbidity and mortality, not least in the elderly. …”
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Effect of Baicalein on Cognitive Impairment in Diabetes Mellitus with Cerebral Small Vessel Disease by Li ZHOU, Zhengqi LU, Xiaoming YE, Wanxin YANG, Zhisheng WEI, Yi KONG, Xuming HUANG

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Coxiella Endocarditis as the Cause of Recurrent Fever and Brain Abscess in a Patient with Complex Congenital Heart Disease: A Case Report and Literature Review by Ioannis A. Ziogas, Alexandros P. Evangeliou, Olga Tsachouridou, Alexandra Arvanitaki, Afroditi Tsona, Vassilios Kamperidis, Marianthi Papagianni, Theofilos Panagiotidis, Ilias A. Tourtounis, George Giannakoulas, Symeon Metallidis

“…Laboratory blood tests were normal, blood cultures were negative, and brain imaging revealed an abscess. Cardiology consultation was requested, and transthoracic echocardiography revealed an intracardiac vegetation. …”
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Tangeretin offers neuroprotection against colchicine-induced memory impairment in Wistar rats by modulating the antioxidant milieu, inflammatory mediators and oxidative stress in t... by Olalekan Bukunmi Ogunro, Mojisola Esther Karigidi, Gideon Ampoma Gyebi, Areej Turkistani, Ahmad H. Almehmadi

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Xixin Decoction’s novel mechanism for alleviating Alzheimer’s disease cognitive dysfunction by modulating amyloid-β transport across the blood–brain barrier to reduce neuroinflamma... by Chaokai Yang, Enlong Zhao, Hu Zhang, Liqi Duan, Xinyue Han, Hongli Ding, Yan Cheng, Dengkun Wang, Dengkun Wang, Dengkun Wang, Xiaojing Lei, Xiaojing Lei, Xiaojing Lei, Yongchang Diwu, Yongchang Diwu, Yongchang Diwu

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Standardized Outcomes for Randomized Controlled Trials Targeting Early Interventions in Patients With Moderate-to-Severe Traumatic Brain Injury: Protocol for the Development of a C... by Raphael Cinotti, Yvan Derouin, Amandine Chenet, Lydia Oujamaa, Bertrand Glize, Yoann Launey, Claire Dahyot-Fizelier, Emmanuelle Cartron, Melodie Renvoise, Benedicte Sautenet, Veronique Sebille

“… Background: With more than 60 million new cases around the world each year, traumatic brain injury (TBI) causes substantial mortality and morbidity. …”
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Protective effect of brain and muscle arnt-like protein-1 against ethanol-induced ferroptosis by activating Nrf2 in mice liver and HepG2 cells by Yanan Zhao, Ranran Zhang, Ziheng Chen, Ziyi Wang, Shuang Guan, Jing Lu

“…Alcohol abuse has recently become a serious health concern worldwide, and the incidence of alcoholic liver disease (ALD) is rapidly increasing with high morbidity and mortality. Ferroptosis is a newly recognized form of regulated cell death caused by the iron-dependent accumulation of lipid peroxidation. …”
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Modulating delirium through stimulation (MoDeSt): study protocol for a randomized, double-blind, sham-controlled trial assessing the effect of postoperative transcranial electrical... by Sophie Leroy, Viktor Bublitz, Ulrike Grittner, Robert Fleischmann, Falk von Dincklage, Daria Antonenko

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Improving Patient Outcomes in mTBI: The Role of Integrated Nursing Interventions in the Emergency Department by Feng T, Zhao P, Wang J, Du X, Ai M, Yang J, Li J

“…Ting Feng, Peng Zhao, Jiao Wang, Xiaoye Du, Meimei Ai, Jing Yang, Junjie Li Department of Emergency, Xijing Hospital, Air Force Medical University, Xi’an, Shaanxi, 710032, People’s Republic of ChinaCorrespondence: Ting Feng, Department of Emergency, Xijing Hospital, Air Force Medical University, Xi’an, Shaanxi, 710032, People’s Republic of China, Email fengtingff24@163.comBackground: Traumatic brain injury (TBI) is a major cause of morbidity and mortality, often requiring emergency department (ED) management. …”
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Protective Mechanism of Alisol A 24-Acetate on Brain Microvascular Endothelial Cells in Mice with Cerebral Ischemia-Reperfusion Injury by TRPM2/Akt/GSK3β Pathway by LI Huihong, DENG Yunfei, WEI Wei, ZHAN Zengtu, LIN Libin, XUE Xiehua

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Comparison of neurodevelopmental outcome in late-preterm and term neonates at 9-month corrected age by Sarfaraz Nisar, Jitendra Chukkanakal, Salim Xalxo, Ankita Chandraker

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Impaired cognitive function and decreased monoamine neurotransmitters in the DNAJC12 gene knockout mouse model by Shunan Wang, Ming Shen, Bo Pang, Bo Zhou, Yuan Yuan, Mei Lu, Xiangling Deng, Min Yang, Shufang Liu, Qiong Wang, Mei Xue, Qisheng Xia, Zhixin Zhang

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