Study protocol for a randomised-controlled study on emotion regulation training for adolescents with major depression: the KONNI study by Ellen Greimel, Lisa Feldmann, Charlotte Piechaczek, Frans Oort, Jürgen Bartling, Martin Schulte-Rüther, Gerd Schulte-Körne

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Safety and Efficacy in Mitral Regurgitation Management with the MitraClip^® G4 System: Insights from a Single-Center Study by Georgios E. Papadopoulos, Ilias Ninios, Sotirios Evangelou, Andreas Ioannidis, Vlasis Ninios

“…Background: Mitral regurgitation (MR) is a common valvular disorder linked to high morbidity and mortality. For patients unsuitable for surgery, transcatheter mitral edge-to-edge repair (TEER) with the MitraClip^® G4 system offers an alternative. …”
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Time to recovery of neonatal sepsis and its predictors in public hospitals of North Shoa Zone, Central Ethiopia by Befekadu Tesfaye Oyato, Teshome Ketema Sime, Tirunesh Debele, Husen Zakir Abasimel, Fikadu Tolesa Alemu, Samuel Boja Asfaw, Wuletaw Tadesse Mekonnin, Hana Israel Gesisa, Elleni Tesfaye Kebede

“…Abstract Background Neonatal sepsis remains one of the most common causes of morbidity and mortality among neonates in developing countries. …”
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IDH-mutant gliomas in children and adolescents - from biology to clinical trials by Louise Evans, Sarah Trinder, Sarah Trinder, Andrew Dodgshun, Andrew Dodgshun, David D. Eisenstat, David D. Eisenstat, David D. Eisenstat, James R. Whittle, James R. Whittle, James R. Whittle, Jordan R. Hansford, Jordan R. Hansford, Jordan R. Hansford, Santosh Valvi, Santosh Valvi, Santosh Valvi

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Cytoreductive Nephrectomy and Nephrectomy/Complete Metastasectomy for Metastatic Renal Cancer by Paul Russo, Mark Synder, Andrew Vickers, Varuni Kondagunta, Robert Motzer

“…Sixty-four percent of patients had a single site of metastatic disease, with lung the most common, followed by bone, adrenal, brain, and liver. Sixty-one patients (67%) had nephrectomy with removal of all metastatic sites (nephrectomy/complete metastasectomy) and 30 (33%) had cytoreductive nephrectomy alone. …”
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Immunologic and inflammatory consequences of SARS-CoV-2 infection and its implications in renal disease by Hiam Naiditch, Michael R. Betts, H. Benjamin Larman, Moshe Levi, Avi Z. Rosenberg

“…Early infection of both tissue and immune cells, such as macrophages, leading to pyroptosis-mediated inflammasome production in an organ system critical for systemic oxygenation likely plays a central role in the morbidity wrought by SARS-CoV-2. Delayed transcription of Type I and Type III interferons by SARS-CoV-2 may lead to early disinhibition of viral replication. …”
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Real‐world clinical diagnostics of heart failure patients with reduced or preserved ejection fraction by Jenni Huusko, Timo Purmonen, Iiro Toppila, Mariann Lassenius, Heikki Ukkonen

“…HFpEF {4580 [inter‐quartile range (IQR): 2065–9765] vs. 2900 [2065–9765] ng/L, P < 0.001}. Baseline co‐morbidities differed between HFpEF and HFrEF groups. …”
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P Wave Duration/P Wave Voltage Ratio Plays a Promising Role in the Prediction of Atrial Fibrillation: A New Player in the Game by E. Karacop, A. Enhos, N. Bakhshaliyev, R. Ozdemir

“…Identification of patients at risk for developing AF and the opportunity for early targeted intervention might have a significant impact on morbidity and mortality. Prolonged P wave duration and decreased P wave voltage have been shown to be independent predictors of AF. …”
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Investigation of natural infection of BALB C mice by Bartonella henselae by Luciene Silva dos Santos, Sayros Akyro Soares Martins, Francine Ramos Scheffer, Alexandre Seiji Maekawa, Rafaela de Paula Silva, Gabriel Rabelo de Araújo, Paulo Eduardo Neves Ferreira Velho, Marina Rovani Drummond

“…Specific Pathogen-Free (SPF) animals are bred and maintained to exclude pathogens associated with significant morbidity or mortality, which may pose a risk to research replicability. …”
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Changing consumption of resources for respiratory support and short-term outcomes in four consecutive geographical cohorts of infants born extremely preterm over 25 years since the... by Alicia J Spittle, Lex W Doyle, Peter J Anderson, Li Huang, Jeanie L Y Cheong, Alice C Burnett, Anjali Haikerwal, Merilyn Bear, Margaret Charlton, Janet Courtot, Noni Davis, Julianne Duff, Rachel Ellis, Marie Hayes, Elisha Josev, Elaine Kelly, Marion Mcdonald, Emma Mcinnes, Bronwyn Novella, Gillian Opie, Gehan Roberts, Katherine Scott, Penelope Stevens, Anne-marie Turner, Kim M Dalziel, Katherine Lee, Marissa Clark, Joy E Olsen, Rosemarie A Boland, Alice E Stewart, Leah M Hickey

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The Genetic Landscape of Human Glioblastoma and Matched Primary Cancer Stem Cells Reveals Intratumour Similarity and Intertumour Heterogeneity by Chiara Pesenti, Stefania Elena Navone, Laura Guarnaccia, Andrea Terrasi, Jole Costanza, Rosamaria Silipigni, Silvana Guarneri, Nicola Fusco, Laura Fontana, Marco Locatelli, Paolo Rampini, Rolando Campanella, Silvia Tabano, Monica Miozzo, Giovanni Marfia

“…Glioblastoma (GBM) is the most malignant human brain tumour, characterized by rapid progression, invasion, intense angiogenesis, high genomic instability, and resistance to therapies. …”
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Multiple and complex eye injuries in children by G.Sh. Arzhimatova, O.V. Karaseva, E.A. Koroleva, G.M. Chernakova

“…In the majority of instances, mechanical complex eye injuries are associated with traumatic brain injury (99%). </p> <p> <b>Keywords: </b>complex eye injuries, multiple injury, combined injury, mechanical complex eye injury, orbital fracture, orbital injury, morbidity pattern, damage to eye. …”
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Multiomics unravels the complexity of male obesity: a prospective observational study by Georgios E. Papadakis, Lucie Favre, Yassine Zouaghi, Nathalie Vionnet, Nicolas J. Niederländer, Michela Adamo, James S. Acierno, Dassine Berdous, Alexia Boizot, Jenny Meylan, Julijana Ivanisevic, Emmanuelle Paccou, Hector Gallart-Ayala, Tim Reyns, Elise Van Caeneghem, Bruno Lapauw, Jérôme Pasquier, Yasser Aleman, Styliani Mantziari, Olivier Salamin, Raul Nicoli, Tiia Kuuranne, Tom Fiers, Patric Hagmann, Federico Santoni, Andrea Messina, Nelly Pitteloud

“…Deep phenotyping, including targeted metabolomics, transcriptomics, and brain magnetic resonance imaging (MRI), was performed. …”
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Patients with neurological or psychiatric complications of COVID-19 have worse long-term functional outcomes: COVID-CNS—A multicentre case–control study by Rajish S. K. Shil, Adam Seed, Nkongho Egbe Franklyn, Brendan F. Sargent, Greta K. Wood, Yun Huang, Katherine C. Dodd, James B. Lilleker, Thomas A. Pollak, Sylviane Defres, Thomas M. Jenkins, Nicholas W. S. Davies, David A. Cousins, Michael S. Zandi, Thomas A. Jackson, Laura A. Benjamin, Ava Easton, Tom Solomon, John R. Bradley, Patrick F. Chinnery, Craig J. Smith, Timothy R. Nicholson, Alan Carson, Rhys H. Thomas, Mark Alexander Ellul, Nicholas W. Wood, Gerome Breen, Benedict Daniel Michael, the COVID-CNS Study Group

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Dual-modal super-resolution ultrasound and NIR-II fluorescence imaging of ischemic stroke with ICG-doped porous PLGA microspheres by Ziyue Li, Yu Qiang, Dongli Chen, Dehong Hu, Duyang Gao, Xiaohua Xu, Lei Sun, Yingjia Li, Weibao Qiu, Zonghai Sheng

“…Ischemic stroke, resulting from the obstruction of blood flow to the brain, remains a leading cause of morbidity and mortality worldwide. …”
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Sexual dimorphism in lung transcriptomic adaptations in fetal alcohol spectrum disorders by Vishal D. Naik, Dylan J. Millikin, Daniel Moussa, Hong Jiang, Alexander L. Carabulea, Joseph D. Janeski, Jiahui Ding, Kang Chen, Marta Rodriguez-Garcia, Sunil Jaiman, Stephen A. Krawetz, Gil Mor, Jayanth Ramadoss

“…Abstract Current fetal alcohol spectrum disorders (FASD) studies primarily focus on alcohol’s actions on the fetal brain although respiratory infections are a leading cause of morbidity/mortality in newborns. …”
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Contextual Vulnerability Should Guide Fair Subject Selection in Xenotransplantation Clinical Trials by Gianna Strand

“…Potential subjects have an interest in exploring alternatives to the high morbidity of a traditional allograft.  This subject population retains the autonomous choice to pursue a standard-of-care allograft or to enroll in xenograft research. …”
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