Combined Graphene Oxide with 2-Methoxyestradiol for Effective Anticancer Therapy in-vitro Model by Uzdrowska K, Knap N, Konieczna L, Kamm A, Kuban-Jankowska A, Gierałtowska J, Belka M, Baran M, Chlanda A, Kowiorski KM, Żołnierski A, Gulczynski J, Lipińska L, Bączek T, Izycka-Swieszewska E, Górska-Ponikowska M

“…The presence of polar hydroxyl groups enables the binding of 2-ME to GO/rGO through hydrogen bonds with epoxy and hydroxyl groups located on the surface and carbonyl and carboxyl groups located at the edges of graphene flake sheets.Methods: The patented method of producing the subject of the invention and the research results regarding its anticancer effectiveness via cytotoxicity in an in vivo model (against A375 melanoma and 143B osteosarcoma cells) are described.Results: It was shown that the inhibition of PTP1B phosphotyrosine phosphatase is one of the mechanisms of action of GO functionalised with 2-ME (GO-2-ME). …”
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Novel and potent MICA/B antibody is therapeutically effective in KRAS LKB1 mutant lung cancer models by Shohei Koyama, Yujiro Naito, John D Minna, David E Gerber, Ryan R Kowash, Manoj Sabnani, Laura T Gray, Qing Deng, Nusrat U A Saleh, Luc Girard, Kentaro Masahiro, Zhiqian Lucy Liu, Hemanta Baruah, Esra A Akbay

“…Background Concurrent KRAS LKB1 (STK11, KL) mutant non-small cell lung cancers (NSCLC) do not respond well to current immune checkpoint blockade therapies, however targeting major histocompatibility complex class I-related chain A or B (MICA/B), could pose an alternative therapeutic strategy through activation of natural killer (NK) cells.Methods Expression of NK cell activating ligands in NSCLC cell line and patient data were analyzed. Cell surface expression of MICA/B in NSCLC cell lines was determined through flow cytometry while ligand shedding in both patient blood and cell lines was determined through ELISA. …”
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Effect of K-N-Humates on Dry Matter Production and Nutrient Use Efficiency of Maize in Sarawak, Malaysia by Auldry Chaddy Petrus, Osumanu Haruna Ahmed, Ab Majid Nik Muhamad, Hassan Mohammad Nasir, Make Jiwan

“…Common fertilization by surface application of T2 without any additives (acidic and high CEC materials) causes N and K to be easily lost. …”
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Distinguishable Immunologic Characteristics of COVID-19 Patients with Comorbid Type 2 Diabetes Compared with Nondiabetic Individuals by Ruxing Zhao, Yujing Sun, Yongyuan Zhang, Weili Wang, Shouyu Wang, Chuang Wang, Jinbo Liu, Ling Gao, Zhao Hu, Jianchun Fei, Xinguo Hou, Huizhen Zheng, Li Chen

“…Cellular immunity was assessed by flow cytometric determination of surface markers including CD3, CD4, CD8, CD19, CD16, and CD56 in peripheral blood. …”
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Predicting corneal decompensation in Fuchs endothelial corneal dystrophy with Scheimpflug tomography and clinical parameters by Nilufer Yesilirmak, Vaël Souédan, Aurélie Pison, Jean Louis Bourges

“…In addition, we extracted topographic measurements including central corneal thickness (CCT); corneal volumes (CVs) within 3, 5, and 7 mm diameters (CV3, CV5, CV7); corneal central-to-peripheral volume ratios (CPVRs) for 3/5 mm (CPVR-3/5) and 3/7 mm (CPVR-3/7); peripheral volume index; thinnest point; corneal thickness spatial profile at 2, 4, 6, and 8 mm (CTSP2, CTSP4, CTSP6, CTSP8); corneal central-to-peripheral thickness ratio at 4 mm (CPTR4); and percentage of thickness increase at 2, 4, and 6 mm (PTI2, PTI4, PTI6), loss of regular isopachs (LRI), displacement of the thinnest point (DTP), and focal posterior surface depression (FPSD). Results: Receiver operating characteristic curves revealed a CCT area under the curve (AUC) of 0.732, with an optimal threshold of 596.5 µm yielding 79.7% sensitivity and 63.6% specificity. …”
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Enterobacter-inoculation altered the C, N contents and regulated biomass allocation in Reaumuria soongorica to promote plant growth and improve salt stress tolerance by Xin-Guang Bao, Xin-Guang Bao, Pei-Fang Chong, Pei-Fang Chong, Cai He, Xue-Mei Lu, Xue-Ying Wang, Feng Zhang, Bing-Bing Tan, Jia-Li Yang, Li-Li Gao

“…We found that under NaCl stress, R. soongorica seedlings exhibit significant reductions in plant height, basal diameter, and root surface area (P<0.05). However, inoculation with strains P6, N20, and N21 reverses these trends. …”
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High temperature QDs organization and re-crystallization in glass supported MgO QDs doped PMMA film by Satya Pal Singh, Archana Kumari Singh, Suraj Vishwakarma

“…The anchoring of MgO QDs on the PMMA surface and vice-versa appears to provide thermal stability and mechanical strength to the nanocomposite films, as the MgO QDS-doped PMMA film form nanometer-sized particulates of PMMA. …”
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Chichimene field T2 sand: a successful application of cycles in a water injection project on heavy crude oil, enabled by a novel smart selective completion system adapted for water... by Pedro Luis Solorzano, Carlos Emilio Giosa, Carol Stephanny Rojas, Mónica Andrea Satizabal, Amelia Jhoanna Araque, Luisa Fernanda Falla, Walter Enrique Sanchez, Luis Oswaldo Castañeda, Mónica Alexandra Martínez, Diana Patricia Ahmedt

“…From a reservoir point of view, it has never been there, a surveillance in injectors with this level of quality to enhance performance, and on the surface, this technology has allowed an important reduction in the use of wirelines for well operations and improve some well cleaning interventions with coiled tubing.…”
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Injection Rate-Dependent Deflecting Propagation Rule of Hydraulic Fracture: Insights from the Rate-Dependent Fracture Process Zone of Mixed-Mode (I-II) Fracturing by Yuekun Xing, Bingxiang Huang

“…Both the deformation in FPZ and the generation of real fracture surfaces are tensile. On this basis, the rate-dependent mixed-mode (I-II) cohesive fracture model was proposed under quasistatic loading, and a couple of theoretical outcomes were obtained. …”
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SUSTAINABLE GROUNDWATER MANAGEMENT THROUGH GROUNDWATER IRRIGATION ADVISORY APPLICATION (GIAA) by Muhammad Mohsin Waqas

“…With the global population surpassing 7.9 billion, sustaining food production poses a formidable challenge, heavily reliant on groundwater for irrigation, particularly in regions with limited surface water. Concerns over groundwater sustainability are mounting as agricultural dependence grows, highlighting the need for robust management strategies to ensure long-term viability. …”
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Climate change and urban forests: generational differences in women’s perceptions and willingness to participate in conservation efforts by Rahim Maleknia, Raluca Elena Enescu, Tayebeh Salehi

“…Despite occupying a relatively small proportion of the Earth’s surface, cities contribute disproportionately to greenhouse gas emissions. …”
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Déjouer le spectacle de la violence. Représenter les événements du 11 septembre 2001 by Bertrand GERVAIS

“…Their contour and shape could be perceived due to a slight depression on the surface of the paper. Reproduced on the cover of In the Shadow of No Towers (2004), this image offered a minimalist version of the attacks, relying on the elimination of color and the limits of figuration. …”
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Development and utilization of Treponema pallidum expressing green fluorescent protein to study spirochete-host interactions and antibody-mediated clearance: expanding the toolbox... by Kristina N. Delgado, Crystal F. Vicente, Christopher M. Hennelly, Farhang Aghakhanian, Jonathan B. Parr, Kevin P. Claffey, Justin D. Radolf, Kelly L. Hawley, Melissa J. Caimano

“…Most notably, we assessed the ability of surface-bound antibodies to inhibit the growth of TPA in vitro and/or disrupt the spirochete’s fragile outer membrane. …”
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Hemodiafiltration with endogenous reinfusion for uremic toxin removal in patients undergoing maintenance hemodialysis: a pilot study by Renhua Lu, Yan Fang, Wangshu Wu, Xiaojun Zeng, Tingting Liu, Yue Qian, Yuanyuan Xie, Yijun Zhou, Leyi Gu

“…The primary efficacy endpoint was to compare uremic toxin levels of indoxyl sulfate (IS), λ-free light chains (λFLC), and β2-microglobulin (β2-MG) before and after HFR treatment. …”
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The Application of Biologically Active Components Derived from Mineral, Synthetic, Phyto- and Organic Sources for Developing Local Hemostatic Agents: Historical Traditions and Cont... by S. Abramov, S. Sokolovskyi, A. Gozhenko, I. Sobko, G. Titov, V. Gladyshev, M. Khmil, Ugis Kletnieks

“…Sokolovskiy R" of the manufacturer "Medpro Nutraceuticals" (Latvia) by order of LLC "Plantor" (Ukraine, Dnipro), the author and owner of the developed technology of the hemostatic agent - powder "PLANTOR" (TU U 20.4-44827581-001:2022) as an auxiliary means of revitalization, local coagulation, treated wound surfaces during emergency medical care for external bleeding. …”
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Phase transitions, Dirac and Weyl semimetal states in Mn1−x Ge x Bi2Te4 by A. M. Shikin, N. L. Zaitsev, T. P. Estyunina, D. A. Estyunin, A. G. Rybkin, D. A. Glazkova, I. I. Klimovskikh, A. V. Eryzhenkov, K. A. Kokh, V. A. Golyashov, O. E. Tereshchenko, S. Ideta, Y. Miyai, Y. Kumar, T. Iwata, T. Kosa, K. Kuroda, K. Shimada, A. V. Tarasov

“…It was shown that when Ge concentration increases, the bulk band gap decreases and reaches zero plateau in the concentration range of 45–60% while trivial surface states (TrSS) are present and exhibit an energy splitting of 100 and 70 meV in different types of measurements. …”
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Reloading mechanical characteristics of cemented tailings backfill after dynamic loading action by Xuepeng SONG, Bowen FAN, Shi WANG, Hongwei ZHANG

“…Increasing the impact amplitude has no significant effect on the failure mode of the dynamically damaged filling body, but the area of the surface collapse zone is increased and the degree of failure is significantly enhanced.…”
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Use of 3D-DXA in the assessment of bone structure among patients with chronic kidney disease by Martin Kužma, Zuzana Kužmová, Ludovic Humbert, Mirella Lopez Picazo, Roman Králik, Jakub Falat, Juraj Smaha, Peter Jackuliak, Zdenko Killinger, Juraj Payer

“…The proximal femur parameters such as cortical and trabecular volumetric (v)BMD, cortical thickness (CTh), and surface (s)BMD at the total hip (TH) and femoral neck (FN) were analyzed using 3D-Shaper software.ResultsComparison between the earlier stages (G1-G3a) and the later CKD stages (G3b-G5) showed significant differences in carboxy terminal collagen crosslinks (CTx) (386 vs.1053 ng/L), TH areal bone mineral density (aBMD; 0.991 vs. 0.859 g/cm2), cortical TH vBMD (831 vs. 795 mg/cm3), FN (837 vs. 788 mg/cm3), TH cortical sBMD (170 mg/cm2), and TH Cth (2.03 vs. 1.92 mm; all p < 0.05). …”
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Analysis of Mannose‐Binding Lectin Protein and mRNA Levels on Selected Chicken Breeds in South Africa by Peter Ayodeji Idowu, Takalani J. Mpofu, Oliver T. Zishiri, Khathutshelo A. Nephawe, Bohani Mtileni

“…ABSTRACT Background Mannose‐binding lectin (MBL) is a key component of the innate immune system that plays a crucial role in binding to the microbial sugar surface to recognize and eliminate pathogens by activating the complement system. …”
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Gene content of seawater microbes is a strong predictor of water chemistry across the Great Barrier Reef by Marko Terzin, Steven J. Robbins, Sara C. Bell, Kim-Anh Lê Cao, Renee K. Gruber, Pedro R. Frade, Nicole S. Webster, Yun Kit Yeoh, David G. Bourne, Patrick W. Laffy

“…Distinct seasonal variations in surface water chemistry were observed, with nutrient concentrations up to threefold higher during austral summer, explained by enhanced production of particulate organic matter (POM) by photoautotrophic picocyanobacteria, primarily Synechococcus. …”
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